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Journal Articles

Pivotal role of PDK1 in megakaryocyte cytoskeletal dynamics and polarization during platelet biogenesis

Sascha Geue, Katja Aurbach, Mailin-Christin Manke, Georgi Manukjan, Patrick Münzer, David Stegner, Caroline Brähler, Britta Walker-Allgaier, Melanie Märklin, Carla E. Borst, Leticia Quintanilla-Fend, Dominik Rath, Tobias Geisler, Helmut R. Salih, Peter Seizer, Florian Lang, Bernhard Nieswandt, Meinrad Gawaz, Harald Schulze, Irina Pleines, Oliver Borst
Journal: Blood
Blood (2019) 134 (21): 1847–1858.
DOI: https://doi.org/10.1182/blood.2019000185
Published: 2019
Includes: Multimedia, Supplemental data
Journal Articles

Rive-CLL: Phase 1 Trial of Rituximab, Idelalisib, and Venetoclax in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia

John McKay, DO, Taha Al-Juhaishi, MD, Lai Guanhua, MD PhD, Maciej Kmieciak, PhD, Roy Sabo, PhD, Ariel Sindel, DO, Victor Yazbeck, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5482.
DOI: https://doi.org/10.1182/blood-2019-126335
Published: 2019
Journal Articles

No Evidence for Hematopoietic Stem Cell Self-Renewal in-Vivo Following Inflammatory Challenge

Ruzhica Bogeska, PhD, Paul Kaschutnig, PhD, Stella V Paffenholz, MSc, Julia Knoch, Jan-Philipp Mallm, PhD, Malak Fawaz, MSc, Florian Buettner, PhD, Dagmar Walter, PhD, Felix Frauhammer, MSc, Tim Holland-Letz, PhD, Noboru Asada, MD PhD, Ana-Matea Mikecin Drazic, PhD, Marleen Buechler-Schaff, MSc, Martha Correno-Gonzalez, Melanie Ball, Sina Staeble, MSc, Julius Gräsel, PhD, Simon Haas, PhD, Daniel B. Lipka, MD, Karsten Rippe, PhD, Benedikt Brors, PhD, Paul S. Frenette, MD, Michael A. Rieger, Marieke A. G. Essers, PhD, Michael D. Milsom, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 456.
DOI: https://doi.org/10.1182/blood-2019-125744
Published: 2019
Journal Articles

PIG-a Mutations in a Brazilian Cohort of Patients with Paroxysmal Nocturnal Hemoglobinuria

Patricia Eiko Yamakawa, MD, Ana Rita Da Fonseca, MD, Caio Perez Gomes, Agatha Mendes, Fabiana Bettoni, PhD, Vinicius Campos de Molla, MD, Martha Mariana Arruda, MD PhD, Maria Stella Figueiredo, MD PhD, Joao Bosco Pesquero, PhD, Celso Arrais-Rodrigues, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 944.
DOI: https://doi.org/10.1182/blood-2019-132033
Published: 2019
Journal Articles

RASA3 Is Essential for Early Mammalian Hematopoiesis and Modulates ERK Signaling in Terminal Erythropoiesis

Elena C. Brindley, BS, Raymond F. Robledo, PhD, Steven L. Ciciotte, MS, Joel H. Graber, PhD, Yue Zhao, Emily Hartman, BS, Julien Papoin, MS, Lionel Blanc, PhD, Luanne L. Peters, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3505.
DOI: https://doi.org/10.1182/blood-2019-130328
Published: 2019
Journal Articles

A GPI-Anchored Protein, CD109, Protects Hematopoietic Progenitor Cells from Erythroid Differentiation Induced By TGF-β

Tanabe Mikoto, MD, Nguyen Hoang Maianh, MD, Kohei Hosokawa, MD PhD, Noriharu Nakagawa, MD, Luis Espinoza, MD PhD, Hirohito Yamazaki, MD PhD, Shinji Nakao, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3736.
DOI: https://doi.org/10.1182/blood-2019-126677
Published: 2019
Journal Articles

Clinical Characteristics of Brazilian Patients with Paroxysmal Nocturnal Hemoglobinuria and Changing Prognosis with Eculizumab

Patricia Eiko Yamakawa, MD, Ana Rita Da Fonseca, MD, Iara Baldim Rabelo Gomes, MD PhD, Vinicius Campos de Molla, MD, Andre Domingues Pereira, MD, Roberta Shcolnik Szor, MD, Martha Mariana Arruda, MD PhD, Maria Stella Figueiredo, MD PhD, Celso Arrais-Rodrigues, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2222.
DOI: https://doi.org/10.1182/blood-2019-132023
Published: 2019
Journal Articles

Superoxide Drives PI3 Kinase Mediated Mitochondria Transfer from the Bone Marrow Microenvironment to Hematopoietic Stem Cells in Response to Salmonella Typhimurium

Jayna J Mistry, BSc, Christopher R Marlein, PhD, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Iain Macauley, PhD BSc, Naiara Beraza, PhD, Yu Sun, BSc, MSc, PhD, Adam Morfakis, BSc, Angela Patterson, PhD, Rebecca H Horton, Devina Divekar, Christopher J Morris, PhD, Anna Haestier, Bsc, PgD MBBS, MRCOG, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2490.
DOI: https://doi.org/10.1182/blood-2019-128241
Published: 2019
Journal Articles

Syk Plays an Essential Role in Phagosome-Lysosome Fusion By Facilitating Actin-Remodeling in Complement-Mediated Phagocytosis

Yumi Tohyama, PhD, Hiroyuki Tabata, PhD, Kaoru Tohyama, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2315.
DOI: https://doi.org/10.1182/blood-2019-125061
Published: 2019
Journal Articles

Complement C3a Not C4a Activates Osteoclasts By Regulating the PI3K/PDK1/SGK3 Pathway in Patients with Multiple Myeloma

Rong Fu, Jr., PhD, Fengjuan Jiang, Hui Liu, Zhaoyun Liu, Siyang Yan, Jin Chen, Zonghong Shao, MD, Qing Shao
Journal: Blood
Blood (2019) 134 (Supplement_1): 4416.
DOI: https://doi.org/10.1182/blood-2019-127022
Published: 2019
Journal Articles

Evaluation of Patients with PNH Treated By Eculizumab: Real World Data from Turkey

Fatma Keklik Karadag, MD, Mustafa Nuri Yenerel, MD, Yılmaz Mehmet, MD, Hava uskudar Teke, MD, Vildan Ozkocaman, MD, Tulin Tuglular, MD, Fuat Erdem, MD, Ali Unal, MD, Orhan Ayyildiz, MD, Gulsum Ozet, MD, Melda Ozkan, MD, Emin Kaya, MD, Mesut Ayer, MD, Ozan Salim, MD, Birol Güvenç, MD, Hakan Ozdogu, MD, Özgür Mehtap, MD, Mehmet Sönmez, MD, Nil Güler, MD, Sibel Kabukcu Hacioglu, MD, Ismet Aydogdu, MD, Ozlen Bektas, MD, Selami Kocak Toprak, MD, Lale Kaynar, MD, Munci Yagci, MD, Salih Aksu, MDPROF., Anil Tombak, MD, Volkan Karakus, MD, Irfan Yavasoglu, MD, Birgül Öneç, MD, Mehmet Ali Özcan, MD, Levent Ündar, MD, Rıdvan Ali, MD, Celalettin Ustun, MD, Osman Ilhan, MD, Guray Saydam, MD, Fahri Sahin, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4805.
DOI: https://doi.org/10.1182/blood-2019-128743
Published: 2019
Journal Articles

Critical Requirement of U2AF1 in the Maintenance and Function of Hematopoietic Stem Cells

Avik Dutta, PhD, Yue Yang, PhD, Bao Le, Golam Mohi, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1195.
DOI: https://doi.org/10.1182/blood-2019-132007
Published: 2019
Journal Articles

Disruption of the Akt-FoxO Axis As a Safeguard Mechanism for the Hematopoietic Stem Cell Compartment during Chronic Metabolic Stress

Vinothini Govindarajah, PhD, Jung-Mi Lee, PhD, Michael Solomon, Bryan Goddard, Ramesh C. Nayak, PhD, Jose A Cancelas, MD, Damien Reynaud
Journal: Blood
Blood (2019) 134 (Supplement_1): 1201.
DOI: https://doi.org/10.1182/blood-2019-127222
Published: 2019
Journal Articles

A Naturally Occurring Canine Model of Peripheral T-Cell Lymphoma Not Otherwise Specified

Lauren Harris, VMD, Emily Rout, DVM, Janna Yoshimoto, BS, Anne Avery, VMD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4105.
DOI: https://doi.org/10.1182/blood-2018-99-120034
Published: 2018
Journal Articles

SHIP1 Inhibition As Novel Therapeutic Approach in Chronic Lymphocytic Leukemia

Veronika Ecker, MSc, Martina Braun, Tanja Neumayer, Markus Muschen, MD, Jürgen Ruland, Maike Buchner, Dr.
Journal: Blood
Blood (2018) 132 (Supplement 1): 894.
DOI: https://doi.org/10.1182/blood-2018-99-117053
Published: 2018
Journal Articles

Bcor Mutations Cooperate with Tet2 Deficiency to Promote RAS Transformation of Mouse Hematopoietic Progenitors

Iman Fares, PhD, Rahul S. Vedula, MD, Shabbir M. Vahanvaty, Christopher S Waters, Marlise R. Luskin, MD, Priti Kumari, M.S., Marie McConkey, PhD, Anne Charles, BS, Kevin Copson, MA, Gregory A. Abel, MDMPH, Richard M. Stone, MD, Benjamin L. Ebert, MDPhD, R. Coleman Lindsley, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 888.
DOI: https://doi.org/10.1182/blood-2018-99-120096
Published: 2018
Journal Articles

The Combination of Duvelisib, a PI3K-δ,γ Inhibitor, and Romidepsin Is Highly Active in Relapsed/Refractory Peripheral T-Cell Lymphoma with Low Rates of Transaminitis: Results of Parallel Multicenter, Phase 1 Combination Studies with Expansion Cohorts

Steven M. Horwitz, MD, Alison J. Moskowitz, MD, Eric D Jacobsen, MD, Neha Mehta-Shah, MD, Michael S Khodadoust, MDPhD, David C. Fisher, MD PhD, Patricia Myskowski, MD, Erica B.K. Wang, MD, Marianne Tawa, RN, MSN, ANP, Theresa Davey, MMSc, PA-C, William Blouin, MBA, Helen Hancock, NP, Nivetha Ganesan, MPH, Natasha Galasso, BA, Evan Marzouk, BA, Alexandra Bahgat, BS, Hallie Jester, BA, Sophia Fong, BS, Abeer Butt, BS, Ahmet Dogan, MD PhD, Youn H. Kim, MD, David M Weinstock, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 683.
DOI: https://doi.org/10.1182/blood-2018-99-115241
Published: 2018
Journal Articles

Phosphatidylinositol-3,4-Bisphosphate-Akt Signaling Pathway Promotes Platelet Activation

Jasna Marjanovic, Brad Rumancik, Luke Weber, Felix Wangmang, Dane Fickes, Dmitri Postnov, Dung Nguyen, Yoon Lee, Richard Ngo-Lam, Monita Wilson
Journal: Blood
Blood (2018) 132 (Supplement 1): 1131.
DOI: https://doi.org/10.1182/blood-2018-99-115066
Published: 2018
Journal Articles

The Importance of Eculizumab in Paroxysmal Nocturnal Hemoglobinuria: A Cohort Study

Mustafa Nuri Yenerel, MD, Simge Erdem, MD, Metban Mastanzade, Meliha Nalcaci
Journal: Blood
Blood (2018) 132 (Supplement 1): 4876.
DOI: https://doi.org/10.1182/blood-2018-99-119480
Published: 2018
Journal Articles

Initial Results from a Phase 1 Clinical Study of bb21217, a Next-Generation Anti Bcma CAR T Therapy

Nina Shah, MD, Melissa Alsina, MD, David S Siegel, MD PhD, Sundar Jagannath, MD, Deepu Madduri, MD, Jonathan L Kaufman, MD, Ashley Turka, Lyh Ping Lam, PharmD, RPh, Monica Massaro, MPH, Kristen Hege, MD, Fabio Petrocca, MD, Jesus G. Berdeja, MD, Noopur Raje, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 488.
DOI: https://doi.org/10.1182/blood-2018-99-116953
Published: 2018