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Journal Articles

Very long chain fatty acid metabolism is required in acute myeloid leukemia

Matthew Tcheng, Alessia Roma, Nawaz Ahmed, Richard W. Smith, Preethi Jayanth, Mark D. Minden, Aaron D. Schimmer, David A. Hess, Kristin Hope, Kevin A. Rea, Tariq A. Akhtar, Eric Bohrnsen, Angelo D’Alessandro, Al-Walid Mohsen, Jerry Vockley, Paul A. Spagnuolo
Journal: Blood
Blood (2021) 137 (25): 3518–3532.
DOI: https://doi.org/10.1182/blood.2020008551
Published: 2021
Includes: Supplemental data
Journal Articles

Superiority of IFN Versus HU Using a Novel Biomarker-Based Tool for Assessment of Disease Burden in MPNs

Vibe Skov, PhD, Marc JB Dam, Rasmus K Pedersen, Morten Andersen, PhD, Trine Alma Knudsen, MD, Zamra Sajid, Lasse Kjær, PhD, Christina Ellervik, MD PhD, Hans Hasselbalch, MD, Johnny T Ottesen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2972.
DOI: https://doi.org/10.1182/blood-2019-126819
Published: 2019
Journal Articles

Meds433, a New Dihydroorotate Dehydrogenase Inhibitor, Induces Apoptosis and Differentiation in Acute Myeloid Leukemia

Valentina Gaidano, MD, Paola Circosta, PhD, Alessandro Cignetti, MD PhD, Mohammad Houshmand, Nicoletta Vitale, PhD, Stefano Sainas, PhD, Agnese Pippione, PhD, Manuela Marraudino, PhD, Brigitta Bonaldo, MD, Marta Giorgis, PhD, Donatella Boschi, PhD, Marco Lucio Lolli, PhD, Giuseppe Saglio, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3942.
DOI: https://doi.org/10.1182/blood-2019-128085
Published: 2019
Journal Articles

The PRIME Trial: PARP Inhibition in IDH Mutant Effectiveness Trial. a Phase II Study of Olaparib in Isocitrate Dehydrogenase (IDH) Mutant Relapsed/Refractory Acute Myeloid Leukemia and Myelodysplastic Syndrome

Namrata S Chandhok, MD, Wei Wei, MD PhD, Ranjit Bindra, MD PhD, Stephanie Halene, MD, Yu Shyr, Jing Li, PhD, Michael Berens, PhD, Chris Karlovich, PhD, S. Percy Ivy, MD, Thomas Prebet, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3909.
DOI: https://doi.org/10.1182/blood-2019-129168
Published: 2019
Journal Articles

The GPR68/BCL2 Axis Remodels Metabolism in AML By Relocating Calcium

Xiaofei He, B.S., Caleb Hawkins, B.S., Lauren Lawley, B.S., Mark Wunderlich, MS, Benjamin Mizukawa, Xiang-ming Zha, PhD, Stephanie Halene, MD, Jing Fang, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2661.
DOI: https://doi.org/10.1182/blood-2019-125455
Published: 2019
Journal Articles

Discovery of a Novel Dihydroorotate Dehydrogenase Inhibitor That Induces Differentiation and Overcomes Ara-C Resistance of Acute Myeloid Leukemia Cells

Satoshi Kitazawa, PhD, Yukiko Ishii, PhD, Keiko Makita-Suzuki, Koichi Saito, PhD, Kensuke Takayanagi, Hiromi Sugihara, Shun Matsuda, PhD, Takayuki Yamakawa, PhD, Yasuhiro Tsutsui, Tadashi Tanaka, Tomohisa Hatta, PhD, Tohru Natsume, PhD, Toru Kondo, PhD, Yuichi Ishikawa, MD PhD, Shinji Hagiwara, PhD, Hitoshi Kiyoi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2663.
DOI: https://doi.org/10.1182/blood-2019-121869
Published: 2019
Journal Articles

Validation of Hemolytic Anemia Codes in the French Hospital Database

Julien Maquet, Hélène Derumeaux, MD PhD, Maryse Lapeyre-Mestre, MD PhD, Laurent Sailler, MD PhD, Guillaume Moulis, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3460.
DOI: https://doi.org/10.1182/blood-2019-124697
Published: 2019
Journal Articles

Hereditary Hemolytic Anemias Other Than Thalassemia: Single Center Experience

Gul Nihal Ozdemir, MD, Mehmet Akif Kilic, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4855.
DOI: https://doi.org/10.1182/blood-2019-121702
Published: 2019
Journal Articles

Hematologic Malignancies Exhibit Selective Vulnerability to Inhibition of De Novo Pyrimidine Biosynthesis By AG-636, a Novel Inhibitor of Dihydroorotate Dehydrogenase in Phase 1 Clinical Trials

Danielle Ulanet, Victor Chubukov, PhD, John Coco, BS, Gabrielle McDonald, PhD, Mya Steadman, BA, Rohini Narayanaswamy, MS, Sebastien Ronseaux, PhD, Sung Choe, PhD, Tabea Erdmann, PhD, Kevin Truskowski, BS, Kavitha Nellore, PhD, Siva Sanjeeva Rao, PhD, Hosahalli Subramanya, PhD, Georg Lenz, MD, Michael Cooper, MD, Josh Murtie, PhD, Kevin Marks, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1570.
DOI: https://doi.org/10.1182/blood-2019-123471
Published: 2019
Journal Articles

Risk Factors and Outcomes of Patients with Follicular Lymphoma Who Had Histologic Transformation at First Progression after First-Line Immunochemotherapy in the Gallium Study

Carla Casulo, Michael Herold, MD, Wolfgang Hiddemann, MD PhD, Sunil Iyengar, MD, Robert E. Marcus, FRCP, John F. Seymour, MBBS, PhD FRACP, Aino Launonen, MSc, Andrea Knapp, PhD, Tina G Nielsen, MD PhD, Farheen Mir, MBBS, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5268.
DOI: https://doi.org/10.1182/blood-2019-123466
Published: 2019
Journal Articles

Arsenic Trioxide Upregulates Cereblon mRNA Expression and Potentiates Sensitivity of SKM-1 and MDS-L Cells to Lenalidomide

Radka Bokorová, Ota Fuchs, PhD, Denisa Myslivcova, PhD, Jaroslav Cermak
Journal: Blood
Blood (2019) 134 (Supplement_1): 5397.
DOI: https://doi.org/10.1182/blood-2019-126443
Published: 2019
Journal Articles

Relationship of Host Genetic Factors with Severe Malaria in Nigerian Children

Olukemi Amodu, PhD, Binal N. Shah, Subulade Ademola, PhD, Bamidele Tayo, PhD, Victor R Gordeuk, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 942.
DOI: https://doi.org/10.1182/blood-2019-132190
Published: 2019
Journal Articles

Smooth Muscle Cytochrome b5 Reductase 3 Deficiency Accelerates Pulmonary Hypertension Development in Sickle Cell Mice

Katherine Wood, PhD BA, Brittany Durgin, PhD, Heidi M Schmidt, BSE, Scott Hahn, Jeffrey Baust, Tim Bachman, Dario A. Vitturi, PhD, Samit Ghosh, Solomon Fiifi Ofori-Acquah, Ana Mora, MD, Mark T Gladwin, MD, Adam Straub, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3619.
DOI: https://doi.org/10.1182/blood-2019-124159
Published: 2019
Journal Articles

Treosulfan Metabolite (S, S-EBDM) Pharmacokinetics Influences Regimen Related Toxicity in Patients with Beta Thalassaemia Major Undergoing HSCT

Aswin Anand PAI, MSc, John C Panetta, PhD, Ezhil Pavai Mohanan, PhD, Raveen Stephen Stallon Illangeswaran, MSc, Balaji Balakrishnan, PhD, Eunice Sindhuvi Edison, PhD, Kavitha M Lakshmi, MSc, Uday Prakash Kulkarni, MD DM, Anup Joseph Devasia, MD DM, Fouzia N., Anu Korula, MD DM, Aby Abraham, MD DM, Biju George, MDDM, Vikram Mathews, MD DM, Alok Srivastava, MD,FRACP,FRCPA, Poonkuzhali Balasubramanian, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1977.
DOI: https://doi.org/10.1182/blood-2019-125604
Published: 2019
Journal Articles

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Angela Su, Frank Ling, Camille Vaganay, Bryann Pardieu, Lina Benajiba, MD/PhD, Gaetano Sodaro, Justine Pasanisi, Kevin H Lin, BS, Justine Rutter, PhD, Christopher F. Bassil, Iléana Antony-Debre, PhD, Gabriela Alexe, PhD, Jean-François Benoist, MD, Yana Pikman, MD, Jun Qi, PhD, Herve Dombret, MD PhD, Claude Preudhomme, PharmD, PhD, Nina Fenouille, Hava M. Golan, Kimberly Stegmaier, MD, Camille Lobry, Kris C Wood, PhD, Raphael Itzykson, Alexandre Puissant, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 877.
DOI: https://doi.org/10.1182/blood-2019-131255
Published: 2019
Journal Articles

Longitudinal Effect of Hydroxyurea Therapy on Left Ventricular Diastolic Function in Sickle Cell Anemia

Parul Rai, MD, Guolian Kang, PhD, Ronak Naik, MD, Jason Goldberg, MD, Xiwen Zhao, MSPH, Kenneth I. Ataga, MD, Vijaya Joshi, MD, Jane S. Hankins, MD MS
Journal: Blood
Blood (2019) 134 (Supplement_1): 1006.
DOI: https://doi.org/10.1182/blood-2019-130905
Published: 2019
Journal Articles

Genetic Activation of NRF2 By KEAP1 Inhibition Induces Fetal Hemoglobin Expression and Triggers Anti-Oxidant Stress Response in Erythroid Cells

Dipti Gupta, Samuel Lessard, PhD, Nancy Moore, Jicheng Duan, PhD, Yukio Nakamura, MD PhD, Feng-Chun Yang, MD PhD, Alexandra Hicks, PhD, David R. Light, PhD, Sriram Krishnamoorthy, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 210.
DOI: https://doi.org/10.1182/blood-2019-129479
Published: 2019
Journal Articles

Transcriptional Regulation of Coenzyme Q Biosynthesis By TIF1γ Drives Erythropoiesis

Marlies P. Rossmann, MD PhD, Karen Hoi, Victoria Chan, Julie R. Perlin, PhD, Elliott J. Hagedorn, PhD, Brian J. Abraham, PhD, Song Yang, PhD, Lucas B. Sullivan, PhD, Curtis R. Warren, PhD, Sejal Vyas, PhD, Eugenia Custo-Creig, Bilguujin Dorjsuren, Chad Cowan, PhD, Marcia C. Haigis, PhD, Richard A. Young, PhD, Leonard I Zon, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 152.
DOI: https://doi.org/10.1182/blood-2019-126833
Published: 2019
Journal Articles

AGILE: A Phase 3, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Ivosidenib in Combination with Azacitidine in Adult Patients with Previously Untreated Acute Myeloid Leukemia with an IDH1 Mutation

Pau Montesinos Fernandez, MD PhD, Christian Recher, MD PhD, Vadim Doronin, MD, Rodrigo T. Calado, MD PhD, Jun Ho Jang, MD PhD, Yasushi Miyazaki, MD PhD, Jianxiang Wang, MD, Diego A Gianolio, PhD, Scott R. Daigle, MS, Thomas Winkler, MD, Vickie Zhang, PhD, Peter Paschka, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2593.
DOI: https://doi.org/10.1182/blood-2019-123045
Published: 2019
Journal Articles

Glycolytic Biomarkers Predictive of Transformation in Patients with Follicular Lymphoma

Ida Monrad, MSc, Charlotte Madsen, Kristina Lauridsen, Bent Honoré, Trine Lindhardt Plesner, Stephen Hamilton-Dutoit, MD, Francesco d'Amore, MD, Maja Ludvigsen, MSc, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2805.
DOI: https://doi.org/10.1182/blood-2019-122651
Published: 2019