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Journal Articles

Impact of Bone Marrow Fibrosis Grade in Post-Polycythemia Vera and Post-Essential Thrombocythemia Myelofibrosis. a Study of the Mysec Group

Barbara Mora, Elisa Rumi, MD, Paola Guglielmelli, MD PhD, Margherita Maffioli, MD, Daniela Barraco, MD, Alessandro Rambaldi, MD, Marianna Caramella, MD, Rami S. Komrokji, MD, Jason Gotlib, MD MS, Jean-Jacques Kiladjian, MD PhD, Francisco Cervantes, MD, Timothy Devos, MD PhD, Francesca Palandri, PhD MD, Valerio De Stefano, MD, Marco Ruggeri, Richard T. Silver, MD, Giulia Benevolo, MD, Francesco Albano, MD, Chiara Cavalloni, MD, Silvia Uccella, MD, Claudia Siracusa, Tiziano Barbui, MD, Alessandra Iurlo, MD PhD, Lorenza Bertù, Michele Merli, MD, Mario Cazzola, MD, Alessandro M. Vannucchi, MD, Francesco Passamonti, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2946.
https://doi.org/10.1182/blood-2019-124854
Published: 2019
Journal Articles

Ruxolitinib (RUX) Induced Meaningful and Directional Changes in the Bone Marrow Microenvironment of Patients with Myelofibrosis Enrolled in the COMFORT-I Study

Hans Michael Kvasnicka, MD PhD, Juergen Thiele, MD PhD, Carlos E. Bueso-Ramos, MD PhD, Philomena Colucci, DO, MS, Dilan Paranagama, PhD, Srdan Verstovsek, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2948.
https://doi.org/10.1182/blood-2019-124343
Published: 2019
Journal Articles

The High Mobility Group A1 Chromatin Regulator Is Required for Pathologic Megakaryocyte Development and Progression to Myelofibrosis in JAK2V617F Murine Models

Alison R. Moliterno, MD, Donna Marie Williams, PhD, Liping Li, MD PhD, Lingling Xian, MD PhD, Li Luo, PhD, Amy S. Duffield, MD PhD, Ophelia Rogers, Jerry L. Spivak, MD, Linda Resar, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 472.
https://doi.org/10.1182/blood-2019-131432
Published: 2019
Journal Articles

Analysis of Metformin Effects on Bone Marrow Fibrosis and Disease Progression in Primary Myelofibrosis Patients: Preliminary Results of an Open Label Phase II Trial (FIBROMET)

Paula De Melo Campos, MD, Katia B Pagnano, MD PhD, Rubia Mancuso, Francisco Breno S. Teófilo, Juan L Coelho-Silva, BSc, MSc, Fernanda I Della Via, MSc, Leandro Luiz Lopes Freitas, MD PhD, Hernandes F. Carvalho, PhD, Fernando Ferreira Costa, MD PhD, Fabiola Traina, MD PhD, Sara T Olalla Saad, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 554.
https://doi.org/10.1182/blood-2019-130648
Published: 2019
Journal Articles

Megakaryocyte-Driven Myelofibrosis Leads to Progressive Osteosclerosis in G6b-B Knockout Mice

Mariya Stavnichuk, BSc, Zoltan Nagy, Yotis A. Senis, Svetlana V. Komarova
Journal: Blood
Blood (2019) 134 (Supplement_1): 4199.
https://doi.org/10.1182/blood-2019-124186
Published: 2019
Journal Articles

An Increased Bone Mineral Density As an Adverse Prognostic Factor in Patients with Systemic Mastocytosis

Mohamad Jawhar, Juliana Schwaab, Nicole Naumann, Georgia Metzgeroth, Alice Fabarius, PhD, Stefan O Schoenberg, Wolf-Karsten Hofmann, MD PhD, Philipp Riffel, Andreas Reiter
Journal: Blood
Blood (2019) 134 (Supplement_1): 4185.
https://doi.org/10.1182/blood-2019-129798
Published: 2019
Journal Articles

Shared and Distinctive Ultrastructural Abnormalities Expressed By Megakaryocytes in Bone Marrow and Spleen from Patients with Primary Myelofibrosis

Maria Zingariello, PhD, Vittorio Rosti, MD, Alessandro M. Vannucchi, MD, Paola Guglielmelli, MD PhD, Claudio Bardelli, PhD, Maria Mazzarini, Rosa Alba Rana, Giovanni Barosi, Anna Rita Rita Migliaccio, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4209.
https://doi.org/10.1182/blood-2019-123140
Published: 2019
Journal Articles

Transcriptional Landscape of the Microenvironment in Bone Marrow Fibrosis at Single Cell Level

Nils B. Leimkühler, Ronghui Li, MSc, Helene Gleitz, PhD, Inge Snoeren, MSc, Stijn Fuchs, Martina Crysandt, MD, Steffen Koschmieder, Christoph Kuppe, MD, Guntram Buesche, MD, Hans H Kreipe, MD PhD, Ivan Costa, PhD, Rafael Kramann, MD PhD, Rebekka K. Schneider, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1675.
https://doi.org/10.1182/blood-2019-126897
Published: 2019
Journal Articles

Phase 2 Study of Ruxolitinib (RUX) in Combination with 5-Azacitidine (AZA) in Patients (pts) with Myelofibrosis

Lucia Masarova, MD, Srdan Verstovsek, MD PhD, Prithviraj Bose, MD, Naveen Pemmaraju, MD, Jorge E. Cortes, MD, Elias Jabbour, MD, Maro Ohanian, DO, Lingsha Zhou, Sherry A. Pierce, BSN, BA, Romany Gergis, Gautam M. Borthakur, MD, Tapan M. Kadia, MD, Courtney D. DiNardo, MDMSc, Farhad Ravandi, MD, Marina Y Konopleva, MD PhD, Kiran Naqvi, MDMPH, Koji Sasaki, MD, Zeev E. Estrov, MD, Guillermo Garcia-Manero, MD, Carlos E. Bueso-Ramos, MD PhD, Hagop M. Kantarjian, MD, Naval G. Daver, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1656.
https://doi.org/10.1182/blood-2019-130691
Published: 2019
Journal Articles

Myelofibrosis osteoclasts are clonal and functionally impaired

Brief Report
Ivo Veletic, Taghi Manshouri, Asha S. Multani, C. Cameron Yin, Lei Chen, Srdan Verstovsek, Zeev Estrov
Journal: Blood
Blood (2019) 133 (21): 2320–2324.
https://doi.org/10.1182/blood-2018-10-878926
Published: 2019
Includes: Supplemental data
Journal Articles

Vitamin D receptor–mediated skewed differentiation of macrophages initiates myelofibrosis and subsequent osteosclerosis

Kanako Wakahashi, Kentaro Minagawa, Yuko Kawano, Hiroki Kawano, Tomohide Suzuki, Shinichi Ishii, Akiko Sada, Noboru Asada, Mari Sato, Shigeaki Kato, Kotaro Shide, Kazuya Shimoda, Toshimitsu Matsui, Yoshio Katayama
Journal: Blood
Blood (2019) 133 (15): 1619–1629.
https://doi.org/10.1182/blood-2018-09-876615
Published: 2019
Includes: Supplemental data
Journal Articles

Niche Heterogeneity Impacts Evolution of Myeloproliferative Neoplasms Driven By the Same Oncogenic Pathway

Claudia Korn, PhD, Justyna Rak, PhD, Andrés García-García, PhD, Claire Fielding, Reema Khorshed, PhD, Sara González-Antón, Juan Li, PhD, Ruggiero Norfo, PhD, E Joanna Baxter, PhD, Thomas McKerrell, MD PhD, Thomas Roberts, Hesham Eldaly, MD, Anna L Godfrey, PhD, Aracely Castillo-Venzor, Anjali Kusumbe, PhD, Adam J. Mead, MD PhD, Anthony R Green, David Kent, PhD, Cristina Lo Celso, PhD, Simon Mendez-Ferrer, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 98.
https://doi.org/10.1182/blood-2018-99-113495
Published: 2018
Journal Articles

Updated Results of Phase 2 Study of Ruxolitinib in Combination with 5-Azacitidine in Patients with Myelofibrosis

Lucia Masarova, MD, Srdan Verstovsek, MD PhD, Jorge E. Cortes, MD, Naveen Pemmaraju, MD, Prithviraj Bose, MD, Maro N. Ohanian, DO, Lingsha Zhou, Sherry A. Pierce, BSN, BA, Romany Gergis, Gautam Borthakur, MD, Zeev E. Estrov, MD, Guillermo Garcia-Manero, MD, Hagop M. Kantarjian, MD, Naval G. Daver, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 352.
https://doi.org/10.1182/blood-2018-99-120251
Published: 2018
Journal Articles

Neoplastic Monocyte-Derived Osteoclasts Are Highly Proliferative, but Sub-Functional in MPN-Associated Myelofibrosis

Ivo Veletic, MD, Taghi Manshouri, C. Cameron Yin, MD PhD, Kate J Newberry, PhD, Srdan Verstovsek, MD PhD, Zeev Estrov, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1664.
https://doi.org/10.1182/blood.V130.Suppl_1.1664.1664
Published: 2017
Journal Articles

MAF Induces Inflammatory Mediators Involved in the Pathogenesis of Primary Myelofibrosis

Samantha Ruberti, BSc, Elisa Bianchi, PhD, Tiziana Fanelli, MSc, Sebastiano Rontauroli, BSc, Valentina Pennucci, PhD, Giuditta Corbizzi Fattori, BSc, Carmela Mannarelli, MSc, PhD, Ruggiero Norfo, PhD, Chiara Rossi, BSc, Roberta Zini, PhD, Simona Salati, PhD, Zelia Prudente, PhD, Enrico Tagliafico, MDPhD, Paola Guglielmelli, MD PhD, Alessandro M. Vannucchi, MD, Rossella Manfredini, PhDBSc
Journal: Blood
Blood (2016) 128 (22): 3132.
https://doi.org/10.1182/blood.V128.22.3132.3132
Published: 2016
Journal Articles

Crispr-Cas9 Mediated Disruption of Dnmt3a in JakV617F Hematopoietic Stem Cells Accelerates Disease Phenotype and Induces Lethal Myelofibrosis

Sebastien Jacquelin, PhD, Emma Dishington, Therese Vu, Axia Song, Matthew Heidecker, Solene Guignes, Claudia Bruedigam, PhD, Joanne Sutton, Geoffrey R Hill, MD PhD, Nicole Cloonan, PhD, Dirk Heckl, PhD, Steven W Lane, PhD
Journal: Blood
Blood (2016) 128 (22): 794.
https://doi.org/10.1182/blood.V128.22.794.794
Published: 2016
Journal Articles

Multiplex Quantitative Imaging Analysis of Bone-Remodeling Cells in Patients with Myelofibrosis

Ivo Veletic, MD, Taghi Manshouri, PhD, Sanja Prijic, PhD, C. Cameron Yin, MD PhD, Joseph E Bove, IV, BS, Ying Zhang, MD MS, Srdan Verstovsek, MD PhD, Zeev Estrov, MD
Journal: Blood
Blood (2016) 128 (22): 4280.
https://doi.org/10.1182/blood.V128.22.4280.4280
Published: 2016
Journal Articles

HSC Hierarchy in Primary Myelofibrosis

Ioanna N Triviai, PhD, Silke Zeschke, Victoria Panagiota, MD, Michael Heuser, MD, Carol Stocking, Nicolaus Kroeger
Journal: Blood
Blood (2016) 128 (22): 4285.
https://doi.org/10.1182/blood.V128.22.4285.4285
Published: 2016
Journal Articles

Resolution of osteosclerosis after alloHCT in systemic mastocytosis

Celalettin Ustun, Elizabeth L. Courville
Journal: Blood
Blood (2016) 127 (14): 1836.
https://doi.org/10.1182/blood-2016-01-690669
Published: 2016
Journal Articles

A Paracrine Circuit Regulates Vascular Endothelial Growth Factor Production By Bone Marrow Plasma Cells in Patients with POEMS Syndrome

Chen Wang, MD, Qian-qian Cai, MD, Xin-xin Cao, MD, Dao-bin Zhou, MD, Jian Li, MD
Journal: Blood
Blood (2015) 126 (23): 1757.
https://doi.org/10.1182/blood.V126.23.1757.1757
Published: 2015