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Journal Articles

Identification of FASN-Dependent Onco-Metabolic Regulation of the Pentose Phosphate Pathway (PPP) and Nucleotide Metabolism in Non-Hodgkin Lymphoma (NHL)

Ravi Dashnamoorthy, PhD, Afshin Beheshti, PhD, Xiaoyang Su, PhD, Ying Chen, PhD, Maisarah Mokhtar, B.S, Gregory Dolnikowski, Frederick Lansigan, MD, William B Kinlaw, III, MD, Sandeep Dave, MD, Andrew M. Evens, DO, MSc

Blood (2019) 134 (Supplement_1): 1573.

https://doi.org/10.1182/blood-2019-126382

Published: 2019

Journal Articles

Elucidating the Non-Catalytic Function of Fatty Acid Synthase and Its Autophagy-Dependent Degradation in Acute Myelocytic Leukemia Differentiation Therapy

Magali Humbert, PhD, Severin Mosimann, Vreni Rentsch, Mario P. Tschan, PhD

Blood (2018) 132 (Supplement 1): 2624.

https://doi.org/10.1182/blood-2018-99-112068

Published: 2018

Journal Articles

Cyclin D1 Driven CDK4 Activity Is Responsible for Hypersensitivity to NOXA Inducing Combination Treatment in Mantle Cell Lymphoma (MCL) Cells

Simon Heine, MSc, Elisabeth Silkenstedt, MD, Michael A Dengler, PhD, Kleih Markus, MSc, German Ott, MD, Neus Giménez Carabaza, B.Pharm, Colomer Dolors, PhD, Heiko van der Kuip, PhD, Walter E. Aulitzky, MD

Blood (2017) 130 (Supplement 1): 2811.

https://doi.org/10.1182/blood.V130.Suppl_1.2811.2811

Published: 2017

Journal Articles

Lysosomal Acid Lipase Is a Potential Therapeutic Target for Controlling Gvhd after Allogeneic Hematopoietic Cell Transplantation in Mice

Sandeepkumar Kuril, MD, Hung D Nguyen, PhD, Hong Du, MD, Cong Yan, MD, Xue-Zhong Yu, MD MS

Blood (2017) 130 (Supplement 1): 206.

https://doi.org/10.1182/blood.V130.Suppl_1.206.206

Published: 2017

Journal Articles

Overexpression of CD36, Driven By STAT3, Mediates Free Fatty Acid Uptake in CLL Cells

Uri Rozovski, MD, David M. Harris, Ping Li, PhD, Zhiming Liu, Preetesh Jain, MBBS,MDDM,PhD, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Prithviraj Bose, MD, Philip A Thompson, MBBS, Nitin Jain, MD, William G Wierda, MD PhD, Michael J. Keating, MD, Zeev Estrov, MD

Blood (2017) 130 (Supplement 1): 4301.

https://doi.org/10.1182/blood.V130.Suppl_1.4301.4301

Published: 2017

Journal Articles

Acute Multiple Deep Venous Thrombosis (DVTs) As a Probable Adverse Event of the Use of Human Chorionic Gonadotropin (HCG) for Weight Loss

H. Parikh, MD, Lisa Thomas, MD, R. English, MD, C Raguckas, MD, Qi Shi, MD

Blood (2015) 126 (23): 4725.

https://doi.org/10.1182/blood.V126.23.4725.4725

Published: 2015

Journal Articles

Dual Targeting of NOXA/MCL-1 Synergistically Induces Cell Death in Mantle Cell Lymphoma (MCL) Cells

Elisabeth Höring, German Ott, MD, Christine Bayha, Kleih Markus, Matthias C. Voehringer, MD, Heiko van Der Kuip, Walter E. Aulitzky, MD

Blood (2015) 126 (23): 2757.

https://doi.org/10.1182/blood.V126.23.2757.2757

Published: 2015

Journal Articles

Lipid Addiction of Diffuse Large B-Cell Lymphoma (DLBCL): Fatty Acid Synthase (FASN) and PI3K Dependent Cell Death Identifies a Novel Therapeutic Paradigm

Ravi Dashnamoorthy, PhD, Afshin Beheshti, PhD, Nassera Abermil, MS, PharmD, Frederick Lansigan, MD, William Kinlaw, MD, Ron Gartenhaus, MD, Graham Jones, PhD DSc, Lynn Hlatky, PhD, Andrew M. Evens, DO, MSc

Blood (2015) 126 (23): 1284.

https://doi.org/10.1182/blood.V126.23.1284.1284

Published: 2015

Journal Articles

The Lipid Addiction of Diffuse Large B-Cell Lymphoma (DLBCL) and Potential Treatment Strategies with Novel Fatty Acid Synthase (FASN) Small Molecule Inhibitors

Ravi Dashnamoorthy, PhD, Nassera Abermil, MS, PharmD, Afshin Behesti, PhD, Paige Kozlowski, BS, Frederick Lansigan, MD, William B Kinlaw, MD, Ronald Gartenhaus, MD, Graham Jones, PhD DSc, Lynn Hlatky, PhD, Andrew M. Evens, DO, MSc

Blood (2014) 124 (21): 4490.

https://doi.org/10.1182/blood.V124.21.4490.4490

Published: 2014

Journal Articles

FASN Is Critical for Maintenance of NUP98 Fusion-Induced Leukemias

Yutaka Shima, PhD, Issay Kitabayashi, PhD

Blood (2014) 124 (21): 2377.

https://doi.org/10.1182/blood.V124.21.2377.2377

Published: 2014

Journal Articles

The Phenotype High Noxa mRNA/Low NOXA Protein Levels Constitutes a Critical Achilles Heel Of Mantle Cell Lymphoma (MCL) Cells

Michael A. Dengler, Andrea Weilbacher, Matthias Gutekunst, Annette M. Staiger, Heike Horn, German Ott, MD, Heiko van der Kuip, Walter E. Aulitzky

Blood (2013) 122 (21): 644.

https://doi.org/10.1182/blood.V122.21.644.644

Published: 2013

Journal Articles

Targeting The Interactions Of Fatty Acid Metabolism With PI3K/mTOR and MAPK As a Novel Therapeutic Strategy In Diffuse Large B-Cell Lymphoma (DLBCL)

Ravi Dashnamoorthy, PhD, Frederick Lansigan, MD, Wilson L Davis, III, B.S., William B Kinlaw, III, MD, Ronald Gartenhaus, Andrew M Evens, DO, MSc

Blood (2013) 122 (21): 5133.

https://doi.org/10.1182/blood.V122.21.5133.5133

Published: 2013

Journal Articles

Diffuse Large B-Cell Lymphomas Utilize Endogenous and Exogenous Fatty Acids for Cell Growth and Survival

Frederick Lansigan, MD, Wilson L Davis, III, B.S., Nancy Kuemmerle, DO, PhD, Leslie E Lupien, B.A., Valeriya Posternak, B.S., Prabhjot Kaur, MD, Nicole C Smits, Ph.D., B.S.C., Ravi Dashnamoorthy, Ph.D., Andrew M. Evens, DO, MSc, William B Kinlaw, III, MD

Blood (2012) 120 (21): 1581.

https://doi.org/10.1182/blood.V120.21.1581.1581

Published: 2012

Journal Articles

Fatty Acid Metabolism in Diffuse Large B-Cell Lymphoma (DLBCL): Interaction with Oncogenic Cell Signaling Pathways and the Identification of a Novel Treatment Paradigm.

Ravi Dashnamoorthy, Ph.D., Frederick Lansigan, MD, Wilson L Davis, III, B.S., Nancy Kuemmerle, DO, PhD, William B Kinlaw, III, MD, Andrew M. Evens, DO, MSc

Blood (2012) 120 (21): 2711.

https://doi.org/10.1182/blood.V120.21.2711.2711

Published: 2012

Journal Articles

Altered Lipid and Mitochondrial Metabolism Are Viable Targets in Acute Leukemia,

Timothy Pardee, MD, PhD, Laura M DeFord-Watts, PhD, Erica Peronto, BS, Denise A Levitan, MD, David Duane Hurd, MD, Steven Kridel, PhD

Blood (2011) 118 (21): 3618.

https://doi.org/10.1182/blood.V118.21.3618.3618

Published: 2011

Journal Articles

Cyclin D1 Over-Expressing Mantle Cell Lymphoma Cells Are Hypersensitive to Inhibition of Fatty Acid Synthase (FASN)

Michael A. Dengler, Matthias Gutekunst, Stephanie Kopacz, Heike Horn, Ute Hofmann, Matthias Schwab, German Ott, MD, Heiko van der Kuip, Walter E. Aulitzky

Blood (2011) 118 (21): 1656.

https://doi.org/10.1182/blood.V118.21.1656.1656

Published: 2011

Journal Articles

Pharmacological Inhibition of Fatty Acid Oxidation as a Novel Therapeutic Concept for Acute Myeloid Leukemia.

Michael Andreeff, MD, PhD, Michael Fiegl, PhD, Marina Konopleva, MD, PhD, Borys Korchin, Kumar Kaluarachchi, PhD, William G. Bornmann, PhD, Patrick H. Guthrie, BS, Romain Harmancey, PhD, Heinrich Taegtmeyer, MD, PhD, Ismael J. Samudio, PhD

Blood (2009) 114 (22): 3779.

https://doi.org/10.1182/blood.V114.22.3779.3779

Published: 2009

Journal Articles

Overexpression of Lipases Enables Specific Cytotoxicity by the Lipase Inhibitor Orlistat in Chronic Lymphocytic Leukemia Cells.

Christian P. Pallasch, MD, Janine Schwamb, Alexandra Schulz, Svenja Debey, PhD, David Kofler, MD, Joachim L. Schultze, MD, Michael Hallek, MD, Alfred Ultsch, PhD, Clemens M. Wendtner, MD

Blood (2006) 108 (11): 2800.

https://doi.org/10.1182/blood.V108.11.2800.2800

Published: 2006

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Identification of FASN-Dependent Onco-Metabolic Regulation of the Pentose Phosphate Pathway (PPP) and Nucleotide Metabolism in Non-Hodgkin Lymphoma (NHL)

Elucidating the Non-Catalytic Function of Fatty Acid Synthase and Its Autophagy-Dependent Degradation in Acute Myelocytic Leukemia Differentiation Therapy

Cyclin D1 Driven CDK4 Activity Is Responsible for Hypersensitivity to NOXA Inducing Combination Treatment in Mantle Cell Lymphoma (MCL) Cells

Lysosomal Acid Lipase Is a Potential Therapeutic Target for Controlling Gvhd after Allogeneic Hematopoietic Cell Transplantation in Mice

Overexpression of CD36, Driven By STAT3, Mediates Free Fatty Acid Uptake in CLL Cells

Acute Multiple Deep Venous Thrombosis (DVTs) As a Probable Adverse Event of the Use of Human Chorionic Gonadotropin (HCG) for Weight Loss

Dual Targeting of NOXA/MCL-1 Synergistically Induces Cell Death in Mantle Cell Lymphoma (MCL) Cells

Lipid Addiction of Diffuse Large B-Cell Lymphoma (DLBCL): Fatty Acid Synthase (FASN) and PI3K Dependent Cell Death Identifies a Novel Therapeutic Paradigm

The Lipid Addiction of Diffuse Large B-Cell Lymphoma (DLBCL) and Potential Treatment Strategies with Novel Fatty Acid Synthase (FASN) Small Molecule Inhibitors

FASN Is Critical for Maintenance of NUP98 Fusion-Induced Leukemias

The Phenotype High Noxa mRNA/Low NOXA Protein Levels Constitutes a Critical Achilles Heel Of Mantle Cell Lymphoma (MCL) Cells

Targeting The Interactions Of Fatty Acid Metabolism With PI3K/mTOR and MAPK As a Novel Therapeutic Strategy In Diffuse Large B-Cell Lymphoma (DLBCL)

Diffuse Large B-Cell Lymphomas Utilize Endogenous and Exogenous Fatty Acids for Cell Growth and Survival

Fatty Acid Metabolism in Diffuse Large B-Cell Lymphoma (DLBCL): Interaction with Oncogenic Cell Signaling Pathways and the Identification of a Novel Treatment Paradigm.

Altered Lipid and Mitochondrial Metabolism Are Viable Targets in Acute Leukemia,

Cyclin D1 Over-Expressing Mantle Cell Lymphoma Cells Are Hypersensitive to Inhibition of Fatty Acid Synthase (FASN)

Pharmacological Inhibition of Fatty Acid Oxidation as a Novel Therapeutic Concept for Acute Myeloid Leukemia.

Overexpression of Lipases Enables Specific Cytotoxicity by the Lipase Inhibitor Orlistat in Chronic Lymphocytic Leukemia Cells.

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