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Journal Articles

Discovery and characterization of targetable NTRK point mutations in hematologic neoplasms

Sunil K. Joshi, Kristin Qian, William H. Bisson, Kevin Watanabe-Smith, Ariane Huang, Daniel Bottomly, Elie Traer, Jeffrey W. Tyner, Shannon K. McWeeney, Monika A. Davare, Brian J. Druker, Cristina E. Tognon

Blood (2020) 135 (24): 2159–2170.

https://doi.org/10.1182/blood.2019003691

Published: 2020

Includes: Supplemental data

Journal Articles

Discovery & Characterization of Therapeutically Targetable Ntrk Point Mutations in Leukemia

Sunil K Joshi, BA, William Bisson, PhD, Kristin Qian, Ariane Huang, Kevin Watanabe-Smith, PhD, Jeffrey W. Tyner, Monika Ashok Davare, PhD, Shannon K. McWeeney, PhD, Cristina E. Tognon, Brian J. Druker

Blood (2019) 134 (Supplement_1): 1256.

https://doi.org/10.1182/blood-2019-125908

Published: 2019

Journal Articles

Brain-Derived Neurotrophic Factor Induces Platelet Aggregation

Rahma Boulahya, PhD, Audrey Béliveau, BSc, Asmaa Harim, Fabio Luiz Bandeira Ferreira, BPharm, MSc, Jean-François Tanguay, MD, Yahye Merhi, PhD, Marie Lordkipanidzé, BPharm, PhD

Blood (2017) 130 (Supplement 1): 3612.

https://doi.org/10.1182/blood.V130.Suppl_1.3612.3612

Published: 2017

Journal Articles

Characterization of Ntrk fusions and Therapeutic Response to Ntrk Inhibition in Hematologic Malignancies

Blood (2017) 130 (Supplement 1): 794.

https://doi.org/10.1182/blood.V130.Suppl_1.794.794

Published: 2017

Journal Articles

Comprehensive Molecular Characterization of Myeloid Malignancies with 9q Deletion

Luise Hartmann, PhD, Torsten Haferlach, MD, Manja Meggendorfer, PhD, Annette Fasan, PhD, Anna Stengel, PhD, Melanie Zenger, Kathleen Zieschang, Wolfgang Kern, MD, Claudia Haferlach, MD

Blood (2017) 130 (Supplement 1): 2953.

https://doi.org/10.1182/blood.V130.Suppl_1.2953.2953

Published: 2017

Journal Articles

Coexisting Oncogenic Signaling Pathway Mutations in Cnl/Acml/CMML/MPN-U

Haijiao Zhang, Daniel Bottomly, Libbey K. White, Beth Wilmot, PhD, Shannon Mcweeney, PhD, Jeffrey W. Tyner, PhD

Blood (2017) 130 (Supplement 1): 4213.

https://doi.org/10.1182/blood.V130.Suppl_1.4213.4213

Published: 2017

Journal Articles

Characterization of Transforming NTRK2 and NTRK3 Mutations Identified in Leukemia Patient Samples

Kristin Qian, Cristina E. Tognon, Jacob Wagner, BSc, Monika Davare, PhD, Brian J. Druker, MD

Blood (2016) 128 (22): 1566.

https://doi.org/10.1182/blood.V128.22.1566.1566

Published: 2016

Journal Articles

High Peripheral Blood Circulating BDNF Levels Are Associated with Good Prognosis in CLL Patients; A CXCR-4 Dependent Effect?

David Azoulay, PhD, Yair Herishanu, MD, Mika Shapiro, PhD, Yarden Brenshaft, Celia Suriu, MD, Luiza Akria, MD, Andrei Braester, MD

Blood (2016) 128 (22): 5562.

https://doi.org/10.1182/blood.V128.22.5562.5562

Published: 2016

Journal Articles

Mutational Landscape of Del(9q) Acute Myeloid Leukemia (AML)

Anna Dolnik, PhD, Sundaram R. Chakkarappan, PhD, Tamara J. Blätte, Sibylle Cocciardi, Jan Krönke, MD, Corbacioglu Andrea, PhD, Karlheinz Holzmann, PhD, Peter Paschka, MD, Frank G. Rücker, MD, Silke Kapp-Schwoerer, MD, Verena I. Gaidzik, MD, Richard F. Schlenk, MD, Hartmut Döhner, Prof. Dr., Konstanze Döhner, MD, Lars Bullinger, MD

Blood (2015) 126 (23): 3844.

https://doi.org/10.1182/blood.V126.23.3844.3844

Published: 2015

Journal Articles

An Integrative Network Approach for Genomic Discovery and Personalized Therapy in Relapsed Multiple Myeloma

Ben Readhead, MBBS, Krishan Kania, Caroline Eden, Deepak Perumal, PhD, Vickram Gidwani, Ajai Chari, MD, Hearn Jay Cho, MD PhD, Sundar Jagannath, MD, Pei-Yu Kuo, MS, Brian Kidd, PhD, Joel Dudley, PhD, Samir Parekh

Blood (2014) 124 (21): 3426.

https://doi.org/10.1182/blood.V124.21.3426.3426

Published: 2014

Journal Articles

Differential Activity of Brain Derived Neurotrophic Factor (BDNF) and RANKL in Promoting Osteoclast Activity in Multiple Myeloma Patients with or without Bone Disease

Bhagavathi A Narayanan, PhD, Cronstein Bruce, MD, Mediero Aranzazu,, PhD, Amitabha Mazumder, MD

Blood (2014) 124 (21): 2058.

https://doi.org/10.1182/blood.V124.21.2058.2058

Published: 2014

Journal Articles

Activation of TRKB receptor in murine hematopoietic stem/progenitor cells induced mastocytosis

Min Yang, Kezhi Huang, Guntram Büsche, Arnold Ganser, Zhixiong Li

Blood (2014) 124 (7): 1196–1197.

https://doi.org/10.1182/blood-2014-03-560466

Published: 2014

Includes: Supplemental data

Journal Articles

Investigating Synthetic Lethality Between mTOR Hyperactivation and Cap-Dependent mRNA Translation In a Receptor Tyrosine Kinase Driven Model Of Acute T-Cell Leukemia

Adrian Schwarzer, MD PhD, Helmut Holtmann, PhD, Celina Schauerte, M.Sc., Nomme Benn, Jan Völkel, Sabine Knöß, Johannes Zuber, MD, Zhixiong Li, MD, Axel Schambach, MD PhD, Christopher Baum, MD

Blood (2013) 122 (21): 3913.

https://doi.org/10.1182/blood.V122.21.3913.3913

Published: 2013

Journal Articles

Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis

Wen-Ming Peng, Laura Maintz, Jean-Pierre Allam, Ulrike Raap, Ines Gütgemann, Jutta Kirfel, Eva Wardelmann, Sven Perner, Wei Zhao, Rolf Fimmers, Klaus Walgenbach, Johannes Oldenburg, Lawrence B. Schwartz, Natalija Novak

Blood (2013) 122 (10): 1779–1788.

https://doi.org/10.1182/blood-2012-12-469882

Published: 2013

Includes: Supplemental data

Journal Articles

Brain-Derived Neurotrophic Factor Enhances Osteoclastogenesis in Multiple Myeloma via Upregulation of RANKL/OPG Ratio Both in Vitro and in a Murine Model of Myeloma Bone Disease

Li-Sha Ai, Chun-Yan Sun, Tao Guo, Ya-Dan Wang, Lu Zhang, You Qin, Lei Chen, Han Yan, Wei Zeng, Jun Fang, Yu Hu

Blood (2012) 120 (21): 568.

https://doi.org/10.1182/blood.V120.21.568.568

Published: 2012

Journal Articles

Brain-Derived Neurotrophic Factor Is a Potential Osteoclast Stimulatory Factor In Multiple Myeloma

Chun-Yan Sun, Yu Hu, Xiao-Mei She, You Qin, Lu Zhang, Lei Chen, Li-Sha Ai, Jun Fang

Blood (2010) 116 (21): 1917.

https://doi.org/10.1182/blood.V116.21.1917.1917

Published: 2010

Journal Articles

Silencing of BDNF Expression by shRNA Down-Regulates Stroma-Derived VEGF Secretion and Inhibits In Vivo Multiple Myeloma Growth and Angiogenesis in the Bone Marrow Milieu.

Lu Zhang, Yu Hu, Chun-yan Sun, Jun Fang, Jiang Li, Zhang-bo Chu

Blood (2009) 114 (22): 423.

https://doi.org/10.1182/blood.V114.22.423.423

Published: 2009

Journal Articles

High-affinity neurotrophin receptors and ligands promote leukemogenesis

Zhixiong Li, Gernot Beutel, Mathias Rhein, Johann Meyer, Christian Koenecke, Thomas Neumann, Min Yang, Jürgen Krauter, Nils von Neuhoff, Michael Heuser, Helmut Diedrich, Gudrun Göhring, Ludwig Wilkens, Brigitte Schlegelberger, Arnold Ganser, Christopher Baum

Blood (2009) 113 (9): 2028–2037.

https://doi.org/10.1182/blood-2008-05-155200

Published: 2009

Includes: Supplemental data

Journal Articles

Leukemia Induced by Altered TRK-Signaling Is Sensitive to Rapamycin Treatment in a Preclinical Model

Mathias Rhein, Min Yang, Volkhard Kaever, PhD, Johann Meyer, PhD, Christopher Baum, MD, Zhixiong Li, MD

Blood (2008) 112 (11): 2851.

https://doi.org/10.1182/blood.V112.11.2851.2851

Published: 2008

Journal Articles

Neurotrophin Receptors and Ligands Are Highly Expressed in Acute Leukemia and Promote Leukemogenesis.

Zhixiong Li, MD, Gernot Beutel, MD, Johann Meyer, PhD, Christian Koenecke, MD, Thomas Neumann, Min Yang, Juergen Krauter, MD, Mathias Rhein, Msc, Nils von Neuhoff, PhD, Michael Heuser, MD, Helmut Diedrich, MD, Ludwig Wilkens, MD, Brigitte Schlegelberger, MD, Arnold Ganser, MD, Christopher Baum, MD

Blood (2007) 110 (11): 696.

https://doi.org/10.1182/blood.V110.11.696.696

Published: 2007

NARROW

Discovery and characterization of targetable NTRK point mutations in hematologic neoplasms

Discovery & Characterization of Therapeutically Targetable Ntrk Point Mutations in Leukemia

Brain-Derived Neurotrophic Factor Induces Platelet Aggregation

Characterization of Ntrk fusions and Therapeutic Response to Ntrk Inhibition in Hematologic Malignancies

Comprehensive Molecular Characterization of Myeloid Malignancies with 9q Deletion

Coexisting Oncogenic Signaling Pathway Mutations in Cnl/Acml/CMML/MPN-U

Characterization of Transforming NTRK2 and NTRK3 Mutations Identified in Leukemia Patient Samples

High Peripheral Blood Circulating BDNF Levels Are Associated with Good Prognosis in CLL Patients; A CXCR-4 Dependent Effect?

Mutational Landscape of Del(9q) Acute Myeloid Leukemia (AML)

An Integrative Network Approach for Genomic Discovery and Personalized Therapy in Relapsed Multiple Myeloma

Differential Activity of Brain Derived Neurotrophic Factor (BDNF) and RANKL in Promoting Osteoclast Activity in Multiple Myeloma Patients with or without Bone Disease

Activation of TRKB receptor in murine hematopoietic stem/progenitor cells induced mastocytosis

Investigating Synthetic Lethality Between mTOR Hyperactivation and Cap-Dependent mRNA Translation In a Receptor Tyrosine Kinase Driven Model Of Acute T-Cell Leukemia

Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis

Brain-Derived Neurotrophic Factor Enhances Osteoclastogenesis in Multiple Myeloma via Upregulation of RANKL/OPG Ratio Both in Vitro and in a Murine Model of Myeloma Bone Disease

Brain-Derived Neurotrophic Factor Is a Potential Osteoclast Stimulatory Factor In Multiple Myeloma

Silencing of BDNF Expression by shRNA Down-Regulates Stroma-Derived VEGF Secretion and Inhibits In Vivo Multiple Myeloma Growth and Angiogenesis in the Bone Marrow Milieu.

High-affinity neurotrophin receptors and ligands promote leukemogenesis

Leukemia Induced by Altered TRK-Signaling Is Sensitive to Rapamycin Treatment in a Preclinical Model

Neurotrophin Receptors and Ligands Are Highly Expressed in Acute Leukemia and Promote Leukemogenesis.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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