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Journal Articles

YWHAE/14-3-3ε expression impacts the protein load, contributing to proteasome inhibitor sensitivity in multiple myeloma

Yan Xu, Mariateresa Fulciniti, Mehmet K. Samur, Matthew Ho, Shuhui Deng, Lanting Liu, Kenneth Wen, Tengteng Yu, Zuzana Chyra, Sanika Dereibal, Li Zhang, Yao Yao, Chandraditya Chakraborty, Eugenio Morelli, Na Li, Michael A. Lopez, Tommaso Perini, Shidai Mu, Gang An, Rafael Alonso, Giada Bianchi, Yu-Tzu Tai, Kenneth C. Anderson, Lugui Qiu, Nikhil C. Munshi
Journal: Blood
Blood (2020) 136 (4): 468–479.
DOI: https://doi.org/10.1182/blood.2019004147
Published: 2020
Includes: Supplemental data
Journal Articles

GPS2 promotes erythroid differentiation by control of the stability of EKLF protein

Wen-Bing Ma, Xiao-Han Wang, Chang-Yan Li, Huan-Huan Tian, Jie Zhang, Jun-Jie Bi, Guang-Ming Ren, Shou-Song Tao, Xian Liu, Wen Zhang, Dong-Xu Li, Hui Chen, Yi-Qun Zhan, Miao Yu, Chang-Hui Ge, Xiao-Ming Yang, Rong-Hua Yin
Journal: Blood
Blood (2020) 135 (25): 2302–2315.
DOI: https://doi.org/10.1182/blood.2019003867
Published: 2020
Includes: Supplemental data
Journal Articles

A master erythroid regulator gets its own GPS

Lily Jun-shen Huang, James J. Bieker
Journal: Blood
Blood (2020) 135 (25): 2209–2210.
DOI: https://doi.org/10.1182/blood.2020005882
Published: 2020
Journal Articles

Kydar Multicenter Trial of Quadruple Regimen for Induction Resistant Myeloma Combined with Translational Single-Cell Analysis Identifies Potential Drivers of Advanced Resistance, Including Novel Immune Checkpoints

Yael C Cohen, MD, Mor Zada, MSc, Moshe E. Gatt, MD, Noa Lavi, MD, Chezi Ganzel, MD, Shuang-Yin Wang, Assaf Weiner, PhD, Guy Ledergor, MD, Evgeni Chubar, MD, Ory Rouvio, MD, Iuliana Vaxman, MDBA, Mouna Ballan, MD, Tamar Tadmor, MD, Anatoly Nemets, MD, Osnat Jarchowcky Dolberg, Olga Shvetz, MD, Ofer Shpilberg, MD MPH, Nagib Deli, MD, Irit Avivi, Ido Amit, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 982.
DOI: https://doi.org/10.1182/blood-2019-129618
Published: 2019
Journal Articles

Bioavailable Dual-Protein Degraders of CK1α and Transcriptional Kinase CDK9 As Potential Therapeutics for Hematological Malignancies

Leah Fung, PhD, Aparajita Hoskote Chourasia, PhD, Eduardo Torres, MSc, Imelda Lam, BSc, Paul Erdman, MSc, David Hecht, PhD, Robert Sullivan, PhD, Brooke McElwee, BSc, Normand Richard, MSc, Avanthika Venkatachalam, MSc, Irit Snir-Alkalay, PhD, Kyle WH Chan, PhD, Frank Mercurio, PhD, Yinon Ben-Neriah, MD PhD, David I Stirling, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4643.
DOI: https://doi.org/10.1182/blood-2019-131834
Published: 2019
Journal Articles

A Discrete Event Simulation Model to Evaluate the Impact of Treatment Sequences on Long-Term Patient Outcomes in Multiple Myeloma (MM)

Jinan Liu, PhD, Daniel Moldaver, PhD, Xinmei Zhu, PhD, Allen Zhou, BASc, Eric M Maiese, PhD, Sarah Hollmann, M.Biotech
Journal: Blood
Blood (2019) 134 (Supplement_1): 4737.
DOI: https://doi.org/10.1182/blood-2019-123804
Published: 2019
Journal Articles

Comprehensive Geriatric Assessment in Consecutive Newly-Diagnosed Elderly Multiple Myeloma Patients in China: A Multicentered, Prospective, Non-Interventional Study

Yuan Yao, Dehui Zou, Aijun Liao, Xiaoxia Chu, Wei Wang, Xinan Cen, Lijuan Chen, MD PhD, Li Bao, Rong Fu, Jr., PhD, Hui Liu, Chunyan Sun, MD PhD, Luqun Wang, MD, Fengyan Jin, MD PhD, Hua Yan, Chenglu Yuan, Liangming Ma, Guangxun Gao, Jinqiao Zhang, MD, Da Gao, MD, Jianda Hu, PhD, Jianxia He, Ai-lin Zhao, Lu Zhang, MD, Dao-Bin Zhou, Jian Li, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5493.
DOI: https://doi.org/10.1182/blood-2019-125447
Published: 2019
Journal Articles

Re-Constructing and Exploiting Transcriptional Regulatory Networks in Multiple Myeloma Drug Resistance

Rafael Renatino-Canevarolo, PhD, Praneeth Reddy Sudalagunta, PhD, Maria D Coelho Siqueira Silva, MSc, Mark B. Meads, PhD, Alexandre Tungesvik, MD, Gabriel De Avila, Alugubelli Raghunandan Reddy, Minerva Nong, Jamie Teer, PhD, Eric A. Welsh, PhD, Tint Lwin, MD PhD, Amit Kulkarni, PhD, Hongyue Dai, PhD, William S. Dalton, PhDMD, Kenneth H. Shain, MD PhD, Ariosto Siqueira Silva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5544.
DOI: https://doi.org/10.1182/blood-2019-128442
Published: 2019
Journal Articles

The Role of Proteasome Activator PA28α in Multiple Myeloma

Yanyan Gu, MD PhD, Benjamin G Barwick, PhD, Mala Shanmugam, PhD, Craig C Hofmeister, MDMPH, Jonathan L. Kaufman, MD, Ajay K Nooka, MDMPH, Vikas A. Gupta, MD PhD, Madhav V Dhodapkar, MBBS, Lawrence H. Boise, PhD, Sagar Lonial
Journal: Blood
Blood (2019) 134 (Supplement_1): 5499.
DOI: https://doi.org/10.1182/blood-2019-128216
Published: 2019
Journal Articles

Phase I/II Study of Carfilzomib, Ruxolitinib and Low-Dose Dexamethasone for Carfilzomib-Refractory Multiple Myeloma (CarJak)

Shebli Atrash, MD, Myra Robinson, MS, Manisha Bhutani, MD, Jeffrey A. Zonder, Reed Friend, MD, Barry Paul, MD, Daniel Auclair, Jordan Robinsons, Ami P Ndiaye, NP, Kelly Bumgarner, Sarah Norek, James T. Symanowski, PhD, Peter M. Voorhees, MD, Saad Z. Usmani, MDMBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 5570.
DOI: https://doi.org/10.1182/blood-2019-130290
Published: 2019
Journal Articles

Carfilzomib-Pomalidomide-Dexamethasone (KPD) in Relapsed/Refractory Multiple Myeloma Patients - an Institutional Retrospective Analysis

Pallavi Mehta, MD DM, Neha Yadav, BDS , MBA, Mohan Bhaarat, Sumeet Prakash Mirgh, MBBS, MDDM, Vishvdeep Khushoo, MBBS, MDDM, Shinto Francis Thekuddan, MBBS, MDDM, Narendra Agrawal, MD DM, Rayaz Ahmed, MDDM, Dinesh Bhurani, MD DM, FRCPA
Journal: Blood
Blood (2019) 134 (Supplement_1): 5572.
DOI: https://doi.org/10.1182/blood-2019-131674
Published: 2019
Journal Articles

Incidence of Second Primary Malignancies and Peripheral Sensory Neuropathy in Patients with Multiple Myeloma Receiving Daratumumab Containing Regimen

Thura Win Htut, MBBS, MRCP, Donald P. Quick, MD, Myint Aung Win, MDMBBS, Sriman Swarup, MDMBBS, Anita Sultan, MD, Somedeb Ball, MD, Ei Moe Phyu, MD, Nyein Htway Yu, MBBS, MD, Myat Min Han, MD, Yin Mon Myat, MD, Fred Hardwicke, MD, Nicholas D'Cunha, MD, Sanjay Awasthi, MD, Kyaw Zin Thein, MDMBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 5550.
DOI: https://doi.org/10.1182/blood-2019-123156
Published: 2019
Journal Articles

Infectious Complications Following Venetoclax-Proteasome Inhibitor Based Regimens in Relapsed Myeloma: A Single Center Retrospective Analysis

Christopher Tor Sauter, MD, Luca L Bernabei, BA, Adam Waxman, MD, Adam D. Cohen, MD, Alfred L. Garfall, MD, Dan T. Vogl, MD, Sara Whittington,, RN, MPH, Colleen Harker Erb, CRNP, Patricia Mangan, CRNP, Mary Sanchez, CRNP, Edward A. Stadtmauer, MD FACP
Journal: Blood
Blood (2019) 134 (Supplement_1): 5598.
DOI: https://doi.org/10.1182/blood-2019-132087
Published: 2019
Journal Articles

A Comprehensive Analysis of Single-Cell Chromatin Accessibility and Gene Expression Identifies Intra-Tumor Heterogeneity and Molecular Treatment Responses in Relapsed/Refractory Multiple Myeloma

Alexandra M Poos, PhD, Jan-Philipp Mallm, PhD, Stephan M Tirier, PhD, Nicola Casiraghi, PhD, Hana Susak, PhD, Nicola Giesen, MD, Katharina Bauer, Anja Baumann, Lukas John, MD, Isabelle Lander, BSc, Jing Xu, PhD, Moritz Przybilla, BSc, Anja Kunze, PhD, Carsten Mueller-Tidow, MD, Benedikt Brors, PhD, Oliver Stegle, PhD, Hartmut Goldschmidt, MD, Karsten Rippe, PhD, Marc S Raab, MD PhD, Niels Weinhold, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 575.
DOI: https://doi.org/10.1182/blood-2019-130051
Published: 2019
Journal Articles

Identification of Thrombospondin-1 As a Novel Substrate of Cereblon Responsible for IMiDs-Induced Venous Thromboembolism

Kiwamu Hatakeyama, MD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 631.
DOI: https://doi.org/10.1182/blood-2019-125670
Published: 2019
Journal Articles

TRIP13 Modulates Protein Deubiquitination to Promote Myeloma Progression

Can Li, MD, Reinaldo Franqui-Machin, Jiliang Xia, PhD, Gregory S. Thomas, Yogesh Jethava, MBBS,MDFRCPath,MRCP, Fangping Chen, MD PhD, Ivana Frech, DSc, PhD MBA, Guido J. Tricot, MD PhD, Fenghuang Zhan, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 854.
DOI: https://doi.org/10.1182/blood-2019-123818
Published: 2019
Journal Articles

Exploiting the Zinc Finger Degrome Targeted By Lenalidomide to Engineer Reversible Off-Switch Degradable Chimeric Antigen Receptors

Max Jan, MD PhD, Ana Castano, MD, Amanda Walker, BA, Andrew A Guirguis, MD PhD, Jessica A Gasser, PhD, Amanda A Bouffard, Mikolaj Slabicki, PhD, Alexander Tepper, Daniel E Grinshpun, Taeyoon Kyung, PhD, Quinlan Sievers, MD PhD, Michael E Birnbaum, PhD, Marcela V Maus, MD PhD, Benjamin L. Ebert, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 866.
DOI: https://doi.org/10.1182/blood-2019-124210
Published: 2019
Journal Articles

CC-92480, a Novel Cereblon E3 Ligase Modulator, Is Synergistic with Dexamethasone, Bortezomib, and Daratumumab in Multiple Myeloma

Lilly Wong, Rama Krishna Narla, Jim Leisten, Daniel Bauer, Matthew Groza, Bonny Gaffney, Courtney G. Havens, Justin Choi, Jack Houston, Antonia Lopez-Girona, Joshua Hansen, Brian E. Cathers, James Carmichael, Daniel W. Pierce
Journal: Blood
Blood (2019) 134 (Supplement_1): 1815.
DOI: https://doi.org/10.1182/blood-2019-124345
Published: 2019
Journal Articles

Integrated Systems Level Examination of Proteasome Inhibitor Stress Recovery in Myeloma Cells Reveals Druggable Vulnerabilities Linked to Multiple Metabolic Processes

Paula Saavedra-Garcia, PhD, Hibah A Al-Sadah, MSc, Lucy Penfold, PhD, Xiaobei Xiong, MRes, Elena Lopez-Jimenez, PhD, Katarzyna Parzych, PhD, Valentina S Caputo, Kevin Blighe, PhD, Martin F. Kaiser, Paolo Piazza, PhD, Vesela Encheva, PhD, Ambrosius P Snijders, PhD, Hector C Keun, DPhil, Diego Oyarzun, PhD, Denise Thiel, MSc, Zijing Liu, PhD, Mauricio Barahona, PhD, Holger W Auner, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1818.
DOI: https://doi.org/10.1182/blood-2019-121549
Published: 2019
Journal Articles

Hexokinase-2 Regulates Hypoxia-Inducible Autophagy, Leading to Enhance Anti-Apoptotic Capability of Refractory Multiple Myeloma

Sho Ikeda, MD PhD, Fumito Abe, MD PhD, Matsuda Yuka, Akihiro Kitadate, MD PhD, Takahiro Kobayashi, MD PhD, Naoto Takahashi, MD PhD, Hiroyuki Tagawa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1787.
DOI: https://doi.org/10.1182/blood-2019-123360
Published: 2019