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Journal Articles

HDAC11 Deficiency or Inhibition Disrupts Oncogene-Induced Stress Hematopoiesis in Myeloproliferative Neoplasms

Lanzhu Yue, Vasundhara Sharma, Nathan P. Horvat, Afua A. Akuffo, Matthew S. Beatty, Cem Murdun, Christelle Colin, Julia Billington, William E. Goodheart, Eva Sahakian, Ling Zhang, John J. Powers, Narmin E. Amin, Que T. Lambert-Showers, Lancia N. Darville, Javier Pinilla-Ibarz, Gary Reuther, Kenneth Wright, Chiara Conti, Jennifer Y. Lee, Xiaozhang Zheng, Pui Yee Ng, Matthew W. Martin, C. Gary Marshall, John M. Koomen, Ross L. Levine, Amit Verma, H. Leighton Grimes, Eduardo M. Sotomayor, Zonghong Shao, Pearlie K. Epling-Burnette
Blood blood.2019895326.
DOI: https://doi.org/10.1182/blood.2019895326
Published: 2019
Journal Articles

Understanding How Fc-Modification Transforms a Pathogenic Heparin-Induced Thrombocytopenia (HIT)-like Monoclonal Antibody into a Novel Treatment for Sepsis

Kandace Gollomp, MD, Amrita Sarkar, PhD, Gowthami Arepally, MD, Douglas B. Cines, MD, M. Anna Kowalska, PhD, Lubica Rauova, MD PhD, Mortimer Poncz, MD
Blood (2019) 134 (Supplement_1): 10.
DOI: https://doi.org/10.1182/blood-2019-123132
Published: 2019
Journal Articles

Combination of CYC065, a Second Generation CDK2/9 Inhibitor, with Venetoclax or Standard Chemotherapies - a Novel Therapeutic Approach for Acute Myeloid Leukaemia (AML)

Wittawat Chantkran, MD MSc, Daniella Zheleva, PhD, Sheelagh Frame, PhD, Ya-Ching Hsieh, PhD, Mhairi Copland, PhD MBBChir, FRCP, FRCPath
Blood (2019) 134 (Supplement_1): 3938.
DOI: https://doi.org/10.1182/blood-2019-124072
Published: 2019
Journal Articles

Targeting Misfolded p53 and p53 Aggregation to Overcome Resistance to Apoptosis in Acute Myeloid Leukemia

Michael Andreeff, MD PhD, Jianfang Zeng, MD, Alice Soragni, PhD, Vivian Ruvolo, Bing Z Carter, PhD, Jo Ishizawa, MD PhD, Jared K. Burks, PhD, David Eisenberg, PhD
Blood (2019) 134 (Supplement_1): 3786.
DOI: https://doi.org/10.1182/blood-2019-130900
Published: 2019
Journal Articles

Effect of Avelumab to Immune Response in AML: A Phase I Study of Avelumab in Combination with Decitabine As First Line Treatment of Unfit Patients

Hong Zheng, MD PhD, Shin Mineishi, David F. Claxton, MD, Junjia Zhu, Chenchen Zhao, MD, Bei Jia, MD PhD, W. Christopher Ehmann, MD, Seema Naik, MD, Natthapol Songdej, Raymond J. Hohl
Blood (2019) 134 (Supplement_1): 3939.
DOI: https://doi.org/10.1182/blood-2019-125153
Published: 2019
Journal Articles

The Role of Decreased TIM-3 Expression of Natural Killer Cells in the Immune Pathogenesis of Severe Aplastic Anemia

Rong Fu, Jr., PhD, Shaoxue Ding, MD, Chunyan Liu, Bingnan Liu, Hui Liu, Liu Zhaoyun, Tong Chen, MD, Tian Zhang, Zonghong Shao, MD, Ting Wang
Blood (2019) 134 (Supplement_1): 3747.
DOI: https://doi.org/10.1182/blood-2019-127769
Published: 2019
Journal Articles

MLL1 Modulates IgM and Inflammatory Cytokines in Waldenstrom's Macroglobulinemia

Mona Karbalivand, MSc, BSc, Weiguo Han, PhD, Luciana L Almada, PhD, Stephen M Ansell, MD PhD, Martin Fernandez-Zapico, MD, Sherine F Elsawa, PhD
Blood (2019) 134 (Supplement_1): 3966.
DOI: https://doi.org/10.1182/blood-2019-125833
Published: 2019
Journal Articles

Inhibition of BMP-Smad Pathway Reduces Leukemic Stemness in Pediatric AML

Xin Long, PhD, Chris Man, PhD, Padmini Narayanan, PhD, Elizabeth Seashore, MD, Michele Redell, MD PhD
Blood (2019) 134 (Supplement_1): 3731.
DOI: https://doi.org/10.1182/blood-2019-129074
Published: 2019
Journal Articles

Latent Membrane Protein 1 Contributes to Deficient Cellular Immunity in NKTCL Patients

Xiaoyan Feng, Yue Song, Zhaoming Li, MD PhD, Xudong Zhang, Lugui Qiu, MD PhD, Mingzhi Zhang, MD PhD
Blood (2019) 134 (Supplement_1): 3969.
DOI: https://doi.org/10.1182/blood-2019-128622
Published: 2019
Journal Articles

Differentiation Therapy with Novel Epigenetic Inhibitors in Acute Myeloid Leukemia

Edurne San Jose, Naroa Gimenez-Camino, Obdulia Rabal, Estibaliz Miranda, Leire Garate, Fernando Garcia, Ana Alfonso Pierola, MD PhD, Sara Villar, Jose J. Rifon Roca, MD, Antonio Pineda-Lucena, Bruno Paiva, PhD, Javier Muñoz, Jesús San-Miguel, Julen Oyarzabal, PhD, Xabier Agirre, PhD, Felipe Prósper, MD PhD
Blood (2019) 134 (Supplement_1): 3762.
DOI: https://doi.org/10.1182/blood-2019-125578
Published: 2019
Journal Articles

Strategy for Overcoming Crebbp and EP300 Mutations in Lymphoma: Development of First-in-Class HAT Activators

Yuxuan Liu, PhD, Jole Fiorito, PhD, Yulissa Gonzalez, Brian Estrella, PhD, Elisa Calcagno, PhD, Elisa Zuccarello, PhD, Howook Hwang, PhD, Barry Honig, PhD, Shixian Deng, PhD, Donald Landry, MD PhD, Owen A. O'Connor, MD PhD, Ottavio Arancio, PhD, Jennifer E Amengual, MD
Blood (2019) 134 (Supplement_1): 4068.
DOI: https://doi.org/10.1182/blood-2019-125983
Published: 2019
Journal Articles

GSK1838705a, an IGF-1R/ALK Inhibitor, Overcomes Resistance to Crizotinib in ALK-Positive ALCL

Wenyu Shi, Jian-Yong Li, MD PhD
Blood (2019) 134 (Supplement_1): 4069.
DOI: https://doi.org/10.1182/blood-2019-130063
Published: 2019
Journal Articles

Phase 1 Results of Anti-PD-Ligand 1 (Durvalumab) & Lenalidomide in Patients with Cutaneous T Cell Lymphoma and Correlation with Programmed Death Ligand 1 Expression and Gene Expression Profile

Christiane Querfeld, MD PhD, Xiwei Wu, PhD, Tracy Stiller, MS, Joycelynne Palmer, PhD, James F Sanchez, PhD, Xochiquetzal Martinez, MD, Steven Rosen, MD, Jasmine Zain, MD
Blood (2019) 134 (Supplement_1): 4024.
DOI: https://doi.org/10.1182/blood-2019-126358
Published: 2019
Journal Articles

TNB-486, a Novel Fully Human Bispecific CD19 x CD3 Antibody That Kills CD19-Positive Tumor Cells with Minimal Cytokine Secretion

Harbani Malik, PhD, Ben Buelow, MD PhD, Udaya Rangaswamy, PhD, Aarti Balasubramani, Andrew Boudreau, Kevin Dang, Laura Davison, PhD, Shelley Force Aldred, Katherine Marie Harris, MD, Suhasini Iyer, PhD, Brett Jorgensen, PhD, Duy Pham, MBA, Kirthana Prabhakar, Ute Schellenberger, PhD, Harshad Ugamraj, Nathan Trinklein, PhD, Wim Van Schooten, PhD
Blood (2019) 134 (Supplement_1): 4070.
DOI: https://doi.org/10.1182/blood-2019-123226
Published: 2019
Journal Articles

Clinical Relevance of MYD88 L265P Mutation and Interleukin-10 Level in Cerebrospinal Fluid of Patients with Both Newly Diagnosed and Relapsed Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

Andres JM Ferreri, MD, Teresa Calimeri, MD PhD, Paolo Lopedote, MD, Ilaria Francaviglia, Rita Daverio, MD, Chiara Iacona, Cristina Belloni, BD, Sara Steffanoni, MD, Elena Anghileri, MD, Angelo Diffidenti, Annamaria Finardi, BD, Filipppo Gagliardi, MD, Nicoletta Anzalone, MD, Alessandro Nonis, Roberto Furlan, MD, Piera Angelillo, MD, Marianna Sassone, MD, Daniela De Lorenzo, BD, Maria Rosa Terreni, MD, Marco Foppoli, Elena Guggiari, MD, Vittoria Tarantino, MD, Marika Eoli, MD, Fabio Ciceri, MD, Claudio Doglioni, Massimo Locatelli, MD, Maurilio Ponzoni, MD, Maria Giulia Cangi
Blood (2019) 134 (Supplement_1): 4114.
DOI: https://doi.org/10.1182/blood-2019-128298
Published: 2019
Journal Articles

Targeted Delivery of Nanocarrier-Conjugated Doxorubicin to Widen the Therapeutic Window of the Most Active Drug in Lymphoma Therapeutics

Artavazd Arumov, BSc, Piumi Y. Liyanage, BS, Asaad Trabolsi, MD, Lingxiao Li, PhD, Evan R. Roberts, BS, Daniel Bilbao, PhD, Roger M. LeBlanc, PhD, Jonathan H. Schatz, MD
Blood (2019) 134 (Supplement_1): 4061.
DOI: https://doi.org/10.1182/blood-2019-122599
Published: 2019
Journal Articles

Binding of Factor VIII to D'D3 and A2 Domains of Von Willebrand Factor Facilitates Mechanical Unraveling of the A2 Domain

Wenjing Cao, MD,PhD, Wenpeng Cao, Wei Zhang, X. Long Zheng, MD, PhD, Xiaohui (Frank) Zhang, PhD
Blood (2019) 134 (Supplement_1): 95.
DOI: https://doi.org/10.1182/blood-2019-125115
Published: 2019
Journal Articles

X-Ray Crystallographic and Single-Molecule Fluorescence Studies of Beta-2 Glycoprotein I Reveal an Alternative Mechanism of Autoantibody Recognition

William Planer, M.S., Zhiwei Chen, M.S., Mathivanan Chinnaraj, PhD, Xiaobing Zuo, PhD, Vittorio Pengo, MD, Paolo Macor, PhD, Francesco Tedesco, MD, Nicola Pozzi, PhD
Blood (2019) 134 (Supplement_1): 91.
DOI: https://doi.org/10.1182/blood-2019-122064
Published: 2019
Journal Articles

Mim8 - a Next-Generation FVIII Mimetic Bi-Specific Antibody - Potently Restores the Hemostatic Capacity in Hemophilia a Settings in Vitro and In Vivo

Stine L Kjellev, PhDDVM, Henrik Østergaard, PhD, Per Jr Greisen, PhD, Mette B Hermit, PhD, Karina Thorn, PhD, Bjarne G Hansen, PhD, Rong Zhou, PhD, Jais Rose Bjelke, PhD, Marianne Kjalke, PhD, Jacob Lund, PhD, Thomas L Holm, PhD, Carsten Dan Ley, PhD, Daniel Elenius, PhD, Peter Thygesen, PhD, Mette Loftager, PhD, Morten G Rasch, PhD, Nikolai Lorenzen, PhD, Prafull S Gandhi, PhD, Kasper Lamberth, PhD, Thomas Egebjerg, Søren Lund, PhD, Anette Henriksen, PhD, Henrik Rahbek-Nielsen, PhD, Zhiru Yang, Ida Hilden
Blood (2019) 134 (Supplement_1): 96.
DOI: https://doi.org/10.1182/blood-2019-122817
Published: 2019
Journal Articles

PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation

Martin K. Safo, PhD, Piyusha P Pagare, PhD, Mohini Ghatge, PhD, Carla Casu, PhD, Valentina Ghiaccio, PhD, Nancy Anabaraonye, Xiaomeng Xu, MS, Stefano Rivella, PhD, Patrick C. Hines, MD PhD, Ke Liu, PhD, Yan Zhang, PhD, Jürgen Venitz, MD PhD, Osheiza Abdulmalik, DVM
Blood (2019) 134 (Supplement_1): 73.
DOI: https://doi.org/10.1182/blood-2019-128646
Published: 2019