1-20 of 434
molecular target
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

The neurotransmitter receptor Gabbr1 regulates proliferation and function of hematopoietic stem and progenitor cells

Lijian Shao, Adedamola Elujoba-Bridenstine, Katherine E. Zink, Laura M. Sanchez, Brian J. Cox, Karen E. Pollok, Anthony L. Sinn, Barbara J. Bailey, Emily C. Sims, Scott H. Cooper, Hal E. Broxmeyer, Kostandin V. Pajcini, Owen J. Tamplin
Journal: Blood
Blood (2021) 137 (6): 775–787.
https://doi.org/10.1182/blood.2019004415
Published: 2021
Includes: Supplemental data
Journal Articles

The Transmembrane Receptor Roundabout 1 (ROBO1) Is Necessary for Multiple Myeloma Proliferation and Homing to the Bone Marrow Niche

Giada Bianchi, MD, Peter G. Czarnecki, MD, Matthew Ho, PhD, Aldo M. Roccaro, MD PhD, Antonio Sacco, RN, Yawara Kawano, MD PhD, Anil Aktas Samur, PhD, Annamaria Gulla, MD, Tianzeng Chen, Kenneth Wen, Xinchen Wu, Yu-Tzu Tai, PhD, Gulden Camci-Unal, PhD, Irene M. Ghobrial, MD, Ruben D. Carrasco, MD PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 507.
https://doi.org/10.1182/blood-2019-128778
Published: 2019
Journal Articles

Homeostatic Regulation of Apoptosis Governs Thymus Regeneration

Sinéad Kinsella, MSc,PhD, Kirsten Cooper, Lorenzo Iovino, MD, Paul DeRoos, Reema Jain, PhD, Jarrod A Dudakov, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 587.
https://doi.org/10.1182/blood-2019-131513
Published: 2019
Journal Articles

The Transcriptome of Immunomodulator-Resistant Multiple Myeloma

Moritz Binder, MDMPH, S. Vincent Rajkumar, MD, Martha Q. Lacy, MD, Jessica L. Haug, Angela Dispenzieri, MD, Kimberly J. Henderson, Teresa K. Kimlinger, Shaji K. Kumar, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1772.
https://doi.org/10.1182/blood-2019-123407
Published: 2019
Journal Articles

Biomarker Profile for Prediction of Patient Response to Smac Mimetic Monotherapy in Pediatric Precursor B-Cell Acute Lymphoblastic Leukemia

Julia Zinngrebe, MD, Ferdinand Schlichtig, Malcolm Meyer, Johann M. Kraus, Elena Boldrin, PhD, Hans A. Kestler, Lüder Hinrich Meyer, MD, Pamela Fischer-Posovszky, Klaus-Michael Debatin, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2082.
https://doi.org/10.1182/blood-2019-130967
Published: 2019
Journal Articles

The Identification of Novel Epigenetic Therapies for ALK-Driven Haematological Malignancies

Stephen P. Ducray, BSc, Ricky Trigg, PhD, Andrew J. Bannister, PhD, Raymond Lai, MD PhD FRCP, Gerda Egger, PhD, Olaf Merkel, PhD, Lukas Kenner, MD, Suzanne Turner, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1483.
https://doi.org/10.1182/blood-2019-125648
Published: 2019
Journal Articles

FLT3-ITD Enhances Proliferation and Survival of AML Cells through Activation of RSK1 to Upregulate the mTORC1/eIF4F Pathway Cooperatively with PIM or PI3K and to Inhibit Bad and Bim

Ayako Nogami, MD PhD BPharm, Daisuke Watanabe, MD, Keigo Okada, MD, PhD, Hiroki Akiyama, MD, PhD, Yoshihiro Umezawa, MD, PhD, Toshikage Nagao, MD, PhD, Shuji Tohda, MD, PhD, Osamu Miura, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1425.
https://doi.org/10.1182/blood-2019-123183
Published: 2019
Journal Articles

Altered Iron Metabolism Is a New Targetable Hallmark for Multiple Myeloma

Can Li, MD, Xuelian Tan, Qierra Brockman, BA, Yogesh Jethava, MBBS,MDFRCPath,MRCP, Marta Chesi, PhD, P. Leif Bergsagel, MD, Fangping Chen, MD PhD, Ivana Frech, DSc, PhD MBA, Fenghuang Zhan, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3059.
https://doi.org/10.1182/blood-2019-123473
Published: 2019
Journal Articles

Casein Kinase 1 Delta Is a Novel Regulator of mRNA Translation and Druggable Target in Aggressive Lymphomas

Ipsita Pal, PhD, Sohani Das Sharma, PhD, Andre M. Grilo, PhD, Prabhjot S. Mundi, MD, Luigi Scotto, PhD, Abdullah Mahmood Ali, PhD, Luke E Berchowitz, PhD, Siddhartha Mukherjee, MD PhD, Owen O'Connor, MD PhD, Marko Jovanovic, PhD, Changchun Deng, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2864.
https://doi.org/10.1182/blood-2019-129528
Published: 2019
Journal Articles

Targeting Transcriptional Co-Activator PGC-1a for the Treatment of Sickle Cell Disease

Alawi Habara, MBBS, MSc, Cuong LE, PhD, David H.K. Chui, MD, Martin H. Steinberg, MD, Shuaiying Cui, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2254.
https://doi.org/10.1182/blood-2019-123959
Published: 2019
Journal Articles

A Signature of Differentially Expressed Micrornas in Lymphoblastoid Cells from Shwachman-Diamond Syndrome Patients Indicates Possible Molecular Targets for Mirna Therapeutics

Jessica Gasparello, PhD, Chiara Papi, Giulia Breveglieri, PhD, Elisabetta D'Aversa, PhD, Valentino Bezzerri, PhD, Giovanna D'Amico, BSc, PhD MSc, Marco Cipolli, MD, Roberto Gambari, PhD, Monica Borgatti, PhD, Alessia Finotti, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2504.
https://doi.org/10.1182/blood-2019-128607
Published: 2019
Journal Articles

Single Cell Profiling of DNMT3A-Mutant Progenitors Reveals LY86 As a Novel Pre-Leukemia Marker and Potential Therapeutic Target

Mira Jeong, PhD, Sangbae Kim, PhD, Yumei Li, PhD, Rui Chen, PhD, Premal Lulla, MBBS, Margaret Goodell, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2724.
https://doi.org/10.1182/blood-2019-123597
Published: 2019
Journal Articles

A Novel Chemical Compound Inhibiting Hematopoietic Cell Kinase (iHCK) Has a Synergic Effect with Azacytidine (Aza) or Cytarabine (Ara-C) for Acute Myeloid Leukemia Treatment

Fernanda Marconi Roversi, Maura Lima Pereira Bueno, undergraduate, Cristiane Okuda Torello, PhD, Fernanda I Della Via, MSc, Renata Giardini Rosa, PhD, Juares Ednaldo Romero Bianco, PhD, Adriana Silva Santos Duarte, PhD, Eduardo M Rego, MD PhD, Alessio Molinari, Maurizio Botta, Sara T Olalla Saad, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4650.
https://doi.org/10.1182/blood-2019-128959
Published: 2019
Journal Articles

Rapid Molecular Diagnostics for Acute Myeloid Leukemia Using Single-Molecule Sequencing

Esko A. Kautto, BS, Charles Thomas Gregory, BS, Caner Saygin, MD, Shelley Orwick, BS, James S. Blachly, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 374.
https://doi.org/10.1182/blood-2019-131366
Published: 2019
Journal Articles

Genomic Characterization of a Pediatric Cohort with Non-Malignant Lymphoproliferative Disorders

Olive S. Eckstein, MD, Nitya Gulati, MBBS, Lisa Forbes, MD, Erin Peckham-Gregory, PhD MPH, Nmazuo Wudo Ozuah, MBBS, M. Cecilia Poli, MD, PhD, Tiphanie Vogel, Emily M Mace, PhD, Jordan S Orange, MD PhD, Jason Caldwell, D.O., Stephen Jolles, Fracesco Saettini, Hey J Chong, Asbjørg Stray-Pedersen, Helen E. Heslop, MD DSc, Kala Kamdar, MD, Robert A. Krance, MD, Swati Naik, MBBS, Tami D John, MD, Rayne H. Rouce, MD, Donna Muzny, Shalini Jhangiani, Richard Gibbs, Zeynep Coban-Akdemir, James Lupski, Kenneth L. McClain, MD PhD, Carl E. Allen, MD PhD, Ivan Chinn
Journal: Blood
Blood (2019) 134 (Supplement_1): 83.
https://doi.org/10.1182/blood-2019-131884
Published: 2019
Journal Articles

Inhibiting Very Long Chain Acyl-CoA Dehydrogenase (VLCAD) Induces Selective Leukemia Cell Death

Matthew Tcheng, BSc, Alessia Roma, BSc, Nawaz Ahmed, MSc, Richard Smith, PhD, Preethi Jayanth, PhD, Mark D. Minden, MD PhD, Rose Hurren, BSc, Aaron D Schimmer, MD PhD, Gale Bozzo, PhD, David Hess, PhD, Kristin Hope, PhD, Kevin Rea, MSc, Tariq A. Akhtar, PhD, Al-Walid Mohsen, PhD, Jerry Vockley, MD PhD, Paul A. Spagnuolo, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3922.
https://doi.org/10.1182/blood-2019-122262
Published: 2019
Journal Articles

Genome-Wide CRISPR Library Screening Identifies CDK6 As Genetic Vulnerability in Adult T-Cell Leukemia/Lymphoma

Takashi Ishio, Joji Shimono, Sarvesh Kumar, Yuquan Lin, Emmanuel Bachy, Michael N. Petrus, Yandan Yang, Michiyuki Maeda, Hideki Goto, Satoshi Hashino, Takanori Teshima, MD, Thomas A. Waldmann, MD, Louis Staudt, MD, Masao Nakagawa
Journal: Blood
Blood (2019) 134 (Supplement_1): 3781.
https://doi.org/10.1182/blood-2019-124670
Published: 2019
Journal Articles

Targeting the p62-ZZ/N-End Rule Pathway in Multiple Myeloma Overcomes Proteasome Inhibitor-Resistance Via Induction of Necroptosis and Enhances the Bone Anabolic Effects of Proteasome Inhibitors

Silvia Marino, PhD, Daniela Nicoleta Petrusca, PhD, Edward Simpson, PhD, Judith L Anderson, BS, Xiang-Qun Xie, PhDMD,MBA, Yunlong Liu, PhD, John Chirgwin, PhD, G. David Roodman, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4391.
https://doi.org/10.1182/blood-2019-131865
Published: 2019
Journal Articles

NCAPD3 Regulates Tumor Growth and Predicts Prognosis in Diffuse Large B-Cell Lymphoma

Juan Yang, MM, Ying Li, MD, Ya Zhang, MD, Xiangxiang Zhou, MD, Yi Zhao, MM, Yang Han, MM, Jiarui Liu, MM, Xin Wang, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5045.
https://doi.org/10.1182/blood-2019-123910
Published: 2019
Journal Articles

Evolving Data on CAR T-Cell Therapy for Multiple Myeloma, Novel Targets, Conditioning Regimens and Novel Constructs: A Systematic Review

Yusra Shao, MD, Daniel S Carlson, DO, Faiz Anwer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5547.
https://doi.org/10.1182/blood-2019-122292
Published: 2019