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Journal Articles

Clonal evolution of acute myeloid leukemia with FLT3 -ITD mutation under treatment with midostaurin

Laura K. Schmalbrock, Anna Dolnik, Sibylle Cocciardi, Eric Sträng, Frauke Theis, Nikolaus Jahn, Ekaterina Panina, Tamara J. Blätte, Julia Herzig, Sabrina Skambraks, Frank G. Rücker, Verena I. Gaidzik, Peter Paschka, Walter Fiedler, Helmut R. Salih, Gerald Wulf, Thomas Schroeder, Michael Lübbert, Richard F. Schlenk, Felicitas Thol, Michael Heuser, Richard A. Larson, Arnold Ganser, Hendrik G. Stunnenberg, Saverio Minucci, Richard M. Stone, Clara D. Bloomfield, Hartmut Döhner, Konstanze Döhner, Lars Bullinger
Journal: Blood
Blood (2021) 137 (22): 3093–3104.
https://doi.org/10.1182/blood.2020007626
Published: 2021
Includes: Supplemental data
Journal Articles

New developments in diagnosis, prognostication, and treatment of advanced systemic mastocytosis

Andreas Reiter, Tracy I. George, Jason Gotlib
Journal: Blood
Blood (2020) 135 (16): 1365–1376.
https://doi.org/10.1182/blood.2019000932
Published: 2020
Journal Articles

Impact of NPM1 / FLT3 -ITD genotypes defined by the 2017 European LeukemiaNet in patients with acute myeloid leukemia

Clinical Trials & Observations
Konstanze Döhner, Christian Thiede, Nikolaus Jahn, Ekaterina Panina, Agnes Gambietz, Richard A. Larson, Thomas W. Prior, Guido Marcucci, Dan Jones, Jürgen Krauter, Michael Heuser, Maria Teresa Voso, Tiziana Ottone, Josep F. Nomdedeu, Sumithra J. Mandrekar, Rebecca B. Klisovic, Andrew H. Wei, Jorge Sierra, Miguel A. Sanz, Joseph M. Brandwein, Theo de Witte, Joop H. Jansen, Dietger Niederwieser, Frederick R. Appelbaum, Bruno C. Medeiros, Martin S. Tallman, Richard F. Schlenk, Arnold Ganser, Hubert Serve, Gerhard Ehninger, Sergio Amadori, Insa Gathmann, Axel Benner, Celine Pallaud, Richard M. Stone, Hartmut Döhner, Clara D. Bloomfield
Journal: Blood
Blood (2020) 135 (5): 371–380.
https://doi.org/10.1182/blood.2019002697
Published: 2020
Includes: Supplemental data
Journal Articles

How I treat acute myeloid leukemia in the era of new drugs

Courtney D. DiNardo, Andrew H. Wei
Journal: Blood
Blood (2020) 135 (2): 85–96.
https://doi.org/10.1182/blood.2019001239
Published: 2020
Includes: Supplemental data
Journal Articles

A Phase II Single-Arm Open-Labeled Study Evaluating Combination of Quizartinib and Omacetaxine Mepesuccinate (QUIZOM) in Newly Diagnosed or Relapsed/Refractory AML Carrying FlT3-ITD

Chunxiao Zhang, Garret MK Leung, MBBS, Sze Pui Tsui, MSc, Ho-Wan Ip, MBBS,FRCPA, Edmond S. K. Ma, MD, Chun Hang Au, PhD, Chris T.L. Chan, PhD, Ka Lam Nelson Ng, PhD, Sze Fai Yip, MD, Bonnie Kho, MD, Harold K K Lee, MD, Qing LIU, Thomas Wing Yan Leung, Yok Lam Kwong, MD FRCP, Anskar Yu Hung Leung, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3825.
https://doi.org/10.1182/blood-2019-126510
Published: 2019
Journal Articles

Development of Predictive Biomarker and Optimal Treatment Strategy with FLT3 Inhibitors in Acute Myeloid Leukemia

Jeong Hui Kim, Yasuhiko Harada, MD PhD, Yuichi Ishikawa, MD PhD, Naomi Kawashima, MD PhD, Marie Nakashima, MD, Yoko Ushijima, MD PhD, Takahiro Nishiyama, MD PhD, Tatsunori Goto, MD PhD, Nobuaki Fukushima, MD PhD, Rika Kihara, MD PhD, Tomohiro Kajiguchi, MD PhD, Koichi Watamoto, MD PhD, Akio Kohno, MD PhD, Kunio Kitamura, MD PhD, Yukiyasu Ozawa, MD PhD, Hitoshi Kiyoi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1418.
https://doi.org/10.1182/blood-2019-127610
Published: 2019
Journal Articles

A Feasibility Study of Biologically Focused Therapy for Myelodysplastic Syndrome Patients Refractory to Hypomethylating Agents

Michael A Spinner, Alexey Aleshin, MD MBA, Marianne A Santaguida, PhD, Steven A Schaffert, PhD, Taher Abbasi, MS, MBA, Jeffrey N Sanders, A Scott Patterson, MA, Diane Heiser, PhD, James L Zehnder, Peter L Greenberg, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4239.
https://doi.org/10.1182/blood-2019-129473
Published: 2019
Journal Articles

Streamline - Study of Relapse or Refractory (R/R) FLT3 -Mutated Acute Myeloid Leukemia (AML) Using Electronic Medical Records (EMR): First Analysis from a Multicenter, Retrospective Cohort Study

Amer M. Zeidan, MBBS, MHS, Adrienne Gilligan, PhD, Santosh Gautam, Nan Hu, David L. Grinblatt, Bhavik J. Pandya, PharmD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5082.
https://doi.org/10.1182/blood-2019-123535
Published: 2019
Journal Articles

ETH-155008, a Novel Selective Dual Inhibitor of FLT3 and CDK4/6 in Preclinical Treatment of Acute Myeloid Leukemia

Changnian Liu, PhD MD, Bin Liu, MSc, Chunping Xu, PhD, Pan Zhang, Bin Li, Bin Ji, Bin Zhang, Qingjun Liu, PhD, James Zhang, MSc, Chengzhi Yu, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5141.
https://doi.org/10.1182/blood-2019-123589
Published: 2019
Journal Articles

Analysis of FLT3-ITD and FLT3-ASP835 Mutations in De Novo Acute Myeloid Leukemia: Evaluation of Prevalence, Distribution Pattern and Correlation with FAB Subtype, and Cytogenetics from a Tertiary Referral Hospital in India

Shruti Mishra, MBBS, MD PDF Hematology, Kishore Kumar, MBBS, MD DM
Journal: Blood
Blood (2019) 134 (Supplement_1): 5172.
https://doi.org/10.1182/blood-2019-126423
Published: 2019
Journal Articles

MN1 Expression Is an Indepedent Prognostic Marker in FLT3-Mutated Acute Myeloid Leukemia and Is Involved in the Resistance to FLT3 Inhibitors

Diego A Pereira-Martins, MSc, Juan L Coelho-Silva, BSc, MSc, Isabel Weinhäuser, MSc, Carol Hassibe Thomé, César Alexander Ortiz Rojas, BSc, Luíse A A Simões, BSc, Fabiola Traina, MD PhD, Michael Heuser, MD, Arnold Ganser, MD, Antonio R. Lucena-Araujo, PhD, Eduardo M Rego, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1403.
https://doi.org/10.1182/blood-2019-131542
Published: 2019
Journal Articles

Clinical Utility of a Multi-Gene Next-Generation Sequencing Myeloid Panel in an Academic Hematology Practice

Pedro G Vianna, BSc,MD, Richard D. Press, MD PhD, Henning Stehr, PhD, Fei Yang, MD, Linda Gojenola, James L Zehnder, Jason Gotlib, MD MS
Journal: Blood
Blood (2019) 134 (Supplement_1): 1408.
https://doi.org/10.1182/blood-2019-124445
Published: 2019
Journal Articles

Characterization of Bypassing Kinases Inferred By Phosphoproteomics in a Midostaurin Resistant Myeloid Cell Line Model

Mahmoud Hallal, BSc, MSc, Sophie Braga-Lagache, MSc, Jovana Jankovic, Rémy Bruggmann, PhD, Ramanjaneyulu Allam, PhD MSc, BSc, Mario P. Tschan, PhD, Cédric Simillion, PhD, Manfred Heller, PhD, Nicolas Bonadies, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2079.
https://doi.org/10.1182/blood-2019-122337
Published: 2019
Journal Articles

RAC1 Inhibitor EHT1864 and Venetoclax Overcome Midostaurin Resistance in Acute Myeloid Leukemia

Andoni Garitano-Trojaola, PhD, Ana Sancho, Ralph Goetz, Susanne Walz, Hardikkumar Jetani, Eva Teufel, Nadine Rodhes, Matteo DaVia, MD, Larissa Haertle, PhD, Silvia Nerreter, Cornelia Vogt, MSc, Johannes Duell, MD, Raoul Tibes, MD PhD, Sabrina Kraus, Andreas Rosenwald, MD, Leo Rasche, MD, Michael Hudecek, MD, Markus Sauer, Hermann Einsele, MD, Jürgen Groll, Martin Kortüm, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1277.
https://doi.org/10.1182/blood-2019-129762
Published: 2019
Journal Articles

Phase II Randomized Trial of Gilteritinib Vs Midostaurin in Newly Diagnosed FLT3 Mutated Acute Myeloid Leukemia (AML)

Selina M. Luger, MD FRCPC, Zhuoxin Sun, PhD, Sanam Loghavi, MD, Hillard M Lazarus, MD, Jacob M. Rowe, MB, BS, Martin S. Tallman, MD, Keith W. Pratz, MD, Mark Litzow, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1309.
https://doi.org/10.1182/blood-2019-128377
Published: 2019
Journal Articles

Integrating Geriatric Assessment and Genetic Profiling to Personalize Therapy Selection in Older Adults with Acute Myeloid Leukemia (AML)

Vijaya R. Bhatt, MD, Christopher Wichman, PhD, Zaid S. Al-Kadhimi, MD, Thuy T. Koll, MD, Ann Berger, PhD APRN-CNS, AOCNS, FAAN, James O. Armitage, MD, Sarah A. Holstein, MD PhD, Krishna Gundabolu, MBBS, Lori J. Maness, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 120.
https://doi.org/10.1182/blood-2019-124375
Published: 2019
Journal Articles

IGF1R-IRS1/2 Signaling Pathway Is a Potential Target for FLT3-Mutated Acute Myeloid Leukemia

Juan L Coelho-Silva, BSc, MSc, Diego A Pereira-Martins, MSc, Virginia Campos Silvestrini, BSc, MSc, Eduardo M Rego, MD PhD, Vitor Marcel Faca, PhD, João Agostinho Machado-Neto, PhD, Fabiola Traina, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2689.
https://doi.org/10.1182/blood-2019-132129
Published: 2019
Journal Articles

UK Single Institution Experience of Mastocytosis: Guy's and St Thomas' NHS Foundation Trust

Clare Oni, MD, Mufaddal Moonim, MD, Joana Desterro, MD, Clive Grattan, MD, Natalia Curto-Garcia, MD, Claire Woodley, Monika Ciesielska, Deimante Drasutyte, Yvonne Francis, Jennifer O'Sullivan, MD, Thompson Olaoni, Anna Green, MD, Miki Yurina, MD, Mark Ong, MD, Nick C.P. Cross, Professor, Donal P. McLornan, MB, BCh (Hons), MRCP, PhD FRCPath, Deepti Radia
Journal: Blood
Blood (2019) 134 (Supplement_1): 2960.
https://doi.org/10.1182/blood-2019-130477
Published: 2019
Journal Articles

High Dependence on Medicare and Foundation Grant Assistance Among Patients with Hematologic Malignancies Receiving Novel Oral Therapeutics

Erlene K. Seymour, MD, Lucius Daniel, Eva Pointer, MS, Stephen T. Smith, Charles A. Schiffer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 64.
https://doi.org/10.1182/blood-2019-128905
Published: 2019
Journal Articles

The Ever-Changing Therapeutic Landscape of AML: A Real World Experience of Novel Therapies on Outcomes

Abhay Singh, MBBS, MPH, Sarah Sadek, MD, Mark G. Faber, DO, Jeffrey Baron, PharmD, James E. Thompson, MD, Amanda Przespolewski, DO, Elizabeth A. Griffiths, MD, Eunice S. Wang, MD, Swapna Thota, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5095.
https://doi.org/10.1182/blood-2019-132040
Published: 2019