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Journal Articles

ATRA Could Correct the Defective S1P-Mediated Cytoskeletal Reorganization in Proplatelet Formation of ITP

Qiu-Sha Huang, Jing Xue, Chen-Cong Wang, Ya-Zhen Qin, Lan-Ping Xu, Kaiyan Liu, Xiao-Jun Huang, MD, Xiao-Hui Zhang
Journal: Blood
Blood (2019) 134 (Supplement_1): 218.
https://doi.org/10.1182/blood-2019-126384
Published: 2019
Journal Articles

VPS4A mutations Cause a Syndrome with Dyserythropoiesis, Hemolytic Anemia, and Neurodevelopmental Delay

Katie Giger Seu, PhD, Lisa Trump, PhD, Sana Emberesh, MBBS, Robert B. Lorsbach, MD PhD, Clarissa E. Johnson, MD, Jessica Meznarich, MD, Hunter Underhill, MD PhD, Haripriya Sakthivel, Omar Niss, MD, Shannon Nortman, Lionel Blanc, PhD, Wenying Zhang, MD PhD, Carolyn Lutzko, PhD, Theodosia A. Kalfa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 339.
https://doi.org/10.1182/blood-2019-128230
Published: 2019
Journal Articles

Single Chain Variable Fragment Linker Length Regulates CAR Biology and T Cell Efficacy

Nathan Singh, MD, Noelle V. Frey, MD, Boris Engels, PhD, David M. Barrett, Olga Shestova, PhD, Pranali Ravikumar, MS, Amy Shyu, Steven Highfill, PhD, Linlin Zhao, Liaomin Peng, Brian Granda, Melissa Ramones, Xeuqing Maggie Lu, David A Christian, PhD, Jessica Perazzelli, Simon F Lacey, PhD, Nathan Roy, Janis K Burkhardt, PhD, Florent Colomb, Mohamed Abdel-Mohsen, Regina M Young, PhD, Jennifer Brogdon, PhD, Stephan Grupp, MD PhD, Carl H June, MD, Shannon L. Maude, MD PhD, Saar I. Gill, MD PhD, Marco Ruella, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 247.
https://doi.org/10.1182/blood-2019-131024
Published: 2019
Journal Articles

In Vivo Assessment of the Next Generation Microtubule-Destabilizing Agent AB8939 in Patient-Derived Xenograft Models of Acute Myeloid Leukemia

Armelle Goubard, PhD, Martine Humbert, PhD, Colin Mansfield, PhD, Olivier Hermine, MD PhD, Patrice Dubreuil, PhD, The AB8939 Study Group
Journal: Blood
Blood (2019) 134 (Supplement_1): 5142.
https://doi.org/10.1182/blood-2019-127143
Published: 2019
Journal Articles

Preclinical Development of an Anti-CD38 Antibody-Drug Conjugate for Treatment of Hematological Malignancies

Lingna Li, PhD, Wenyong Tong, PhD, Megan Lau, BS, Katherine Fells, PhD, Tong Zhu, PhD, Yingqing Sun, PhD, Ernest Kovacs, PhD, Alisher Khasanov, PhD, Zheng Yan, PhD, Dalun Deng, PhD, Ken Takeshita, MD, Gunnar F. Kaufmann, PhD, Henry Ji, PhD, Hui Li, PhD, Hong Zhang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5621.
https://doi.org/10.1182/blood-2019-132062
Published: 2019
Journal Articles

AB8939, a Microtubule-Destabilizing Agent with Potential to Overcome Multidrug Resistance, Is Active across the Range (M0-M7) of Acute Myeloid Leukemia Subtypes

Armelle Goubard, PhD, Martine Humbert, PhD, Colin Mansfield, PhD, Olivier Hermine, MD PhD, Patrice Dubreuil, PhD, The AB8939 Study Group
Journal: Blood
Blood (2019) 134 (Supplement_1): 5154.
https://doi.org/10.1182/blood-2019-127021
Published: 2019
Journal Articles

Outcome of Relapsed DLBCL Patients, Treated with Polatuzumab-BR or Polatuzumab-R: Real Life Data

Yafit Segman, MD, Elena Ribakovsky, MD, Abraham Avigdor, MD, Vladimir Vainstein, MD, Neta Goldschmidt, MD, Shimrit Ringelstein Harlev, MD, Odit Gutwein, Uri Abadi, MD, Anatoly Nemets, MD, Orit Sofer, Najib Dally, MD, Kalman Filanovsky, MD, Merav Leiba, MD, Nadav Sarid, MD, Noam Benyamini, MD, Yair Herishanu, MD, Ron Ram, MD, Chava Perry, MD PhD, Irit Avivi
Journal: Blood
Blood (2019) 134 (Supplement_1): 5321.
https://doi.org/10.1182/blood-2019-124164
Published: 2019
Journal Articles

A Phase 2 Study of Retreatment with Brentuximab Vedotin in Patients with cHL, sALCL or Other CD30-Expressing PTCL

Sairah Ahmed, MD, Julie Lisano, PharmD, Trevor Newhook, MS
Journal: Blood
Blood (2019) 134 (Supplement_1): 4054.
https://doi.org/10.1182/blood-2019-121523
Published: 2019
Journal Articles

Synergistic Activity of Belantamab Mafodotin (anti-BCMA immuno-conjugate) with PF-03084014 (gamma-secretase inhibitor) in Bcma-Expressing Cancer Cell Lines

Stephen Eastman, BS, MS, Christopher Shelton, Ira Gupta, Julie Krueger, Christina Blackwell, Paul M Bojczuk
Journal: Blood
Blood (2019) 134 (Supplement_1): 4401.
https://doi.org/10.1182/blood-2019-123705
Published: 2019
Journal Articles

Brentuximab Vedotin in Front-Line Therapy of Hodgkin Lymphoma (HL) and CD30-Expressing Peripheral T-Cell Lymphoma (PTCL) in Adults Age 60 and Above

Christopher A. Yasenchak, MD, Rodolfo Bordoni, MD, Victor Yazbeck, MD, Dipti Patel-Donnelly, MD, Timothy Larson, MD, Trevor Newhook, MS, Linda Ho, Matthew Mei, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2852.
https://doi.org/10.1182/blood-2019-122968
Published: 2019
Journal Articles

Pediatric Preclinical Testing Consortium Evaluation of the Novel Anti-Microtubule Drug E7130 in Xenograft Models of Early T-Cell Precursor Acute Lymphoblastic Leukemia

Richard B. Lock, PhD, Kathryn Evans, Connor D Jones, Narimanne El-Zein, Katerina Bendak, PhD, Cara E Toscan, PhD, Chelsea Mayoh, Stephen W Erickson, PhD, Beverly A Teicher, PhD, Malcolm A Smith, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3875.
https://doi.org/10.1182/blood-2019-123867
Published: 2019
Journal Articles

Exploitation of a Newly Characterized Metabolic-Cytoskeletal Axis for Effective Combination Therapy of Iron Restricted Anemia

Adam N Goldfarb, MD, Katie Freeman, BA, Alejandro Ariel Gru, MD, Zollie White, III, MS, Lorrie L Delehanty, BS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2233.
https://doi.org/10.1182/blood-2019-129172
Published: 2019
Journal Articles

Anti-Bcma PBD MEDI2228 Combats Drug Resistance and Synergizes with Bortezomib and Inhibitors to DNA Damage Response in Multiple Myeloma

Lijie Xing, MD, Liang Lin, PhD, Tengteng Yu, MD PhD, Yuyin Li, PhD, Kenneth Wen, BS, Shih-Feng Cho, MD PhD, Phillip A Hsieh, Krista Kinneer, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1817.
https://doi.org/10.1182/blood-2019-127163
Published: 2019
Journal Articles

Anticancer Activity of a Highly Potent Small Molecule Tubulin Polymerization Inhibitor, AB8939

Martine Humbert, PhD, Armelle Goubard, PhD, Colin Mansfield, PhD, Olivier Hermine, MD PhD, Patrice Dubreuil, PhD, The AB8939 Study Group
Journal: Blood
Blood (2019) 134 (Supplement_1): 2075.
https://doi.org/10.1182/blood-2019-122540
Published: 2019
Journal Articles

Dreamm-5: Platform Trial Evaluating Belantamab Mafodotin (a BCMA-directed Immuno-conjugate) in Combination with Novel Agents in Relapsed or Refractory Multiple Myeloma (RRMM)

Paul G. Richardson, MD, Swethajit Biswas, Beata Holkova, Nicola Jackson, Thelma Netherway, Weichao Bao, Geraldine Ferron-Brady, Anne Yeakey, Chris Shelton, Rocio Montes De Oca, PhD, Chris Ahlers, Sonia Franco, Marc Ballas, Elaine Paul, Katarina Luptakova, Ira Gupta, Joanna Opalinska
Journal: Blood
Blood (2019) 134 (Supplement_1): 1857.
https://doi.org/10.1182/blood-2019-129879
Published: 2019
Journal Articles

KIFC1 Mediates Centrosome Clustering Prior to Proplatelet Formation from Megakaryocytes

Adrian R. Wilkie, PhD, Leila J. Noetzli, PhD, Genevieve Couldwell, Anthony R. Sciaudone, Anjana Ray, PhD, Kellie R. Machlus, PhD, Joseph E. Italiano, Jr., BS, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 721.
https://doi.org/10.1182/blood-2019-130803
Published: 2019
Journal Articles

Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress

Richard Burt, Aditi Dey, Sarah Aref, Melanie Aguiar, Ayse Akarca, Katharine Bailey, William Day, Steven Hooper, Amy Kirkwood, Kristina Kirschner, Soo-Wah Lee, Cristina Lo Celso, Jiten Manji, Marc R. Mansour, Teresa Marafioti, Rachel J. Mitchell, Robert C. Muirhead, Kenton Cheuk Yan Ng, Constandina Pospori, Ignazio Puccio, Krisztina Zuborne-Alapi, Erik Sahai, Adele K. Fielding
Journal: Blood
Blood (2019) 134 (17): 1415–1429.
https://doi.org/10.1182/blood.2019001398
Published: 2019
Includes: Supplemental data
Journal Articles

High Prevalence of PPM1D Mutations in Therapy-Related AML/MDS Is Due to Context-Specific Clonal Hematopoiesis

Joanne Hsu, BS, Tajhal Dayaram, Ayala Tovy, PhD, Etienne De Braekeleer, PhD MSc, Mira Jeong, PhD, Jason H. Rogers, MS, Feng Wang, PhD, Jianhua Zhang, PhD, Guillermo Garcia-Manero, MD, Hagop M. Kantarjian, MD, George S. Vassiliou, Andrew Futreal, PhD, Lawrence Donehower, Koichi Takahashi, MD, Margaret Goodell, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 746.
https://doi.org/10.1182/blood-2018-99-115007
Published: 2018
Journal Articles

CD37 Expression in Acute Myeloid Leukemia Provides New Target for Directed Therapy

Karilyn Larkin, MD, Erin Guth, MS, Bonnie K. Harrington, DVM, Nicole Grieselhuber, MD PhD, Natarajan Muthusamy, DVM, PhD, John C. Byrd, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4056.
https://doi.org/10.1182/blood-2018-99-117262
Published: 2018
Journal Articles

Polycomb Group Proteins Recruit TET1 to Remove Aberrant DNA Methylation in Murine Embryonic Stem Cells

Yong Lei, PhD, Margaret A. Goodell, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2571.
https://doi.org/10.1182/blood-2018-99-116841
Published: 2018