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Journal Articles

The Combination of Dexamethasone and Ruxolitinib Synergistically Attenuates Disease Manifestations in a Preclinical Model of Hemophagocytic Lymphohistiocytosis

Lauren K. Meyer, Katherine Verbist, PhD, Sabrin Albeituni, PhD, Rachel Bassett, Michelle L. Hermiston, MD PhD, Kim E. Nichols, MD

Blood (2019) 134 (Supplement_1): 81.

https://doi.org/10.1182/blood-2019-129112

Published: 2019

Journal Articles

Defective Platelet Thromboxane A2 Signaling and Serotonin Release in the Pathogenesis of Bleeding during Viral Infection

Roberto Aiolfi, PhD, Giovanni Sitia, Matteo Iannacone, Luca Guidotti, Zaverio M. Ruggeri, MD

Blood (2019) 134 (Supplement_1): 1074.

https://doi.org/10.1182/blood-2019-128940

Published: 2019

Journal Articles

Sca-1 As a Marker of Stress-Induced Thrombopoiesis in Mice

Yosuke Morodomi, MD PhD, Roberto Aiolfi, PhD, Eric Won, MD, Sachiko Kanaji, MD PhD, Paul Schimmel, PhD, Zaverio M. Ruggeri, MD, Taisuke Kanaji, MD

Blood (2019) 134 (Supplement_1): 1068.

https://doi.org/10.1182/blood-2019-127446

Published: 2019

Journal Articles

Calming the storm in HLH

Matt S. Zinter, Michelle L. Hermiston

Blood (2019) 134 (2): 103–104.

https://doi.org/10.1182/blood.2019001333

Published: 2019

Journal Articles

Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis

Sabrin Albeituni, Katherine C. Verbist, Paige E. Tedrick, Heather Tillman, Jennifer Picarsic, Rachel Bassett, Kim E. Nichols

Blood (2019) 134 (2): 147–159.

https://doi.org/10.1182/blood.2019000761

Published: 2019

Includes: Supplemental data

Journal Articles

Targeting Sec23b in COPII Vesicles Regulates T Cell Immunity

Stephanie Kim, BS, Rami Khoriaty, MD, Rajesh Valanparambil, PhD, Julia Wu, PhD, Austin Taylor, BS, Hideaki Fujiwara, MD, Dan Peltier, MD, Yaping Sun, MD PhD MS, Israel Henig, MD, Cynthia Zajac, Katherine Oravecz-Wilson, BS, MS, Stuart Brabbs, Rafi Ahmed, PhD, David Ginsburg, MD, Pavan Reddy, MD

Blood (2018) 132 (Supplement 1): 859.

https://doi.org/10.1182/blood-2018-99-111628

Published: 2018

Journal Articles

Therapeutic Candidate Alpn-101, a Dual ICOS/CD28 Antagonist, Potently Suppresses Human/NSG Mouse Xenograft Graft Vs. Host Disease (GvHD) in a Dose Ranging Study and Reduces Disease Activity in a Mouse Model of Hemophagocytic Lymphohistiocytosis (HLH)

Stacey R. Dillon, PhD, Katherine E. Lewis, PhD, Katherine Verbist, PhD, Paige Tedrick, PhD, Sabrin Albeituni, PhD, Ryan Swanson, B.S., Lawrence S. Evans, B.S., Steven D Levin, PhD, Mark W. Rixon, PhD, Stanford L. Peng, MD, PhD, Kim E. Nichols, MD, Kristine M. Swiderek, PhD

Blood (2018) 132 (Supplement 1): 2037.

https://doi.org/10.1182/blood-2018-99-110001

Published: 2018

Journal Articles

Overcoming Leukemia-Induced Immune Suppression in BCR-ABL+ Acute Lymphoblastic Leukemia

Michael Farrar, PhD, Can Hekim, MSc,PhD, Manlove S. Luke, PhD, Vaiva Vezys, PhD, Marc K Jenkins, PhD

Blood (2017) 130 (Supplement 1): 3881.

https://doi.org/10.1182/blood.V130.Suppl_1.3881.3881

Published: 2017

Journal Articles

HIF1A Is a Critical Downstream Mediator for Hemophagocytic Lymphohistiocytosis

Blood (2017) 130 (Supplement 1): 3565.

https://doi.org/10.1182/blood.V130.Suppl_1.3565.3565

Published: 2017

Journal Articles

TET2 Regulates CD4 + T Follicular Helper Differentiation

Mercy Gohil, Martha S Jordan, PhD, Shannon A. Carty, MD

Blood (2017) 130 (Supplement 1): 3578.

https://doi.org/10.1182/blood.V130.Suppl_1.3578.3578

Published: 2017

Journal Articles

Combined Treatment with Ruxolitinib and Dexamethasone Curtails Inflammation and Lessens Disease in Preclinical Studies of Hemophagocytic Lymphohistiocytosis

Sabrin Albeituni, PhD, Katherine Verbist, PhD, Paige Tedrick, Heather Tillman, PhD, Kim E. Nichols, MD

Blood (2016) 128 (22): 4894.

https://doi.org/10.1182/blood.V128.22.4894.4894

Published: 2016

Journal Articles

The Methylcytosine Dioxygenase TET2 Regulates CD8 + T Cell Memory Differentiation

Shannon A. Carty, MD, Mercy Gohil, Lauren B. Banks, MD PhD, Matthew E Johnson, PhD, Erietta Stelekati, PhD, Andrew D Wells, PhD, E. John Wherry, PhD, Gary A. Koretzky, MD PhD, Martha S Jordan, PhD

Blood (2016) 128 (22): 3692.

https://doi.org/10.1182/blood.V128.22.3692.3692

Published: 2016

Journal Articles

Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis

Rupali Das, Peng Guan, Leslee Sprague, Katherine Verbist, Paige Tedrick, Qi Angel An, Cheng Cheng, Makoto Kurachi, Ross Levine, E. John Wherry, Scott W. Canna, Edward M. Behrens, Kim E. Nichols

Blood (2016) 127 (13): 1666–1675.

https://doi.org/10.1182/blood-2015-12-684399

Published: 2016

Includes: Supplemental data

Journal Articles

ST2 contributes to T-cell hyperactivation and fatal hemophagocytic lymphohistiocytosis in mice

Julia E. Rood, Sheila Rao, Michele Paessler, Portia A. Kreiger, Niansheng Chu, Erietta Stelekati, E. John Wherry, Edward M. Behrens

Blood (2016) 127 (4): 426–435.

https://doi.org/10.1182/blood-2015-07-659813

Published: 2016

Includes: Supplemental data

Journal Articles

Clearance of Incompatible RBC Is Compromised during Persistent Viral Infection

Connie Maridith Arthur, PhD, Andreas Weiland, PhD, Harold Clifford Sullivan, MD, Rafi Ahmed, PhD, Sean R. Stowell, MD PhD

Blood (2015) 126 (23): 1149.

https://doi.org/10.1182/blood.V126.23.1149.1149

Published: 2015

Journal Articles

Excessive Anti-Viral CD8 T Cell Activation Inverts the IL-2 Consumptive Hierarchy Triggering Regulatory T Cell Collapse in Mouse Model for Hemophagocytic Lymphohistiocytosis

Stephanie Humblet-Baron, MDPhD, Dean Franckaert, MSc, Simon Bornschein, MSc, Bénédicte Cauwe, PhD, Susann Schonefeldt, MSc, Carine Wouters, MD PhD, Patrick Matthys, PhD, Frederic Baron, MD PhD, Adrian Liston, PhD

Blood (2015) 126 (23): 1025.

https://doi.org/10.1182/blood.V126.23.1025.1025

Published: 2015

Journal Articles

TET2 Regulates CD8 + T Cell Responses to Acute and Chronic Viral Infection

Shannon A. Carty, MD, Mercy Gohil, Erietta Stelekati, PhD, Lauren B. Banks, E. John Wherry, PhD, Gary A. Koretzky, MD PhD, Martha S Jordan, PhD

Blood (2015) 126 (23): 2227.

https://doi.org/10.1182/blood.V126.23.2227.2227

Published: 2015

Journal Articles

Kras Is Critical for CD8 T Cell Antiviral Function

Yuhong Chen, PhD, Yongwei Zheng, PhD, Xiaona You, PhD, Gang Xin, PhD, Mei Yu, PhD, Guoping Fu, PhD, Fen Zhou, Wen Zhu, Weiguo Cui, PhD, Jing Zhang, PhD, Renren Wen, PhD, Demin Wang, PhD

Blood (2015) 126 (23): 284.

https://doi.org/10.1182/blood.V126.23.284.284

Published: 2015

Journal Articles

A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice

Fernando E. Sepulveda, Sophia Maschalidi, Christian A. J. Vosshenrich, Alexandrine Garrigue, Mathieu Kurowska, Gael Ménasche, Alain Fischer, James P. Di Santo, Geneviève de Saint Basile

Blood (2015) 125 (9): 1427–1434.

https://doi.org/10.1182/blood-2014-09-602946

Published: 2015

Includes: Supplemental data

Journal Articles

Fas Controls Neutrophil Lifespan during Bacterial and Viral Infection

Joanne A. O'Donnell, Catherine L Kennedy, PhD, Marc Pellegrini, Cameron Nowell, PhD, Louise H. Cengia, Seth L. Masters, Elizabeth L. Hartland, PhD, Motti Gerlic, Andrew W. Roberts, MBBS, PhD, Ben A Croker

Blood (2014) 124 (21): 1579.

https://doi.org/10.1182/blood.V124.21.1579.1579

Published: 2014

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The Combination of Dexamethasone and Ruxolitinib Synergistically Attenuates Disease Manifestations in a Preclinical Model of Hemophagocytic Lymphohistiocytosis

Defective Platelet Thromboxane A2 Signaling and Serotonin Release in the Pathogenesis of Bleeding during Viral Infection

Sca-1 As a Marker of Stress-Induced Thrombopoiesis in Mice

Calming the storm in HLH

Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis

Targeting Sec23b in COPII Vesicles Regulates T Cell Immunity

Therapeutic Candidate Alpn-101, a Dual ICOS/CD28 Antagonist, Potently Suppresses Human/NSG Mouse Xenograft Graft Vs. Host Disease (GvHD) in a Dose Ranging Study and Reduces Disease Activity in a Mouse Model of Hemophagocytic Lymphohistiocytosis (HLH)

Overcoming Leukemia-Induced Immune Suppression in BCR-ABL+ Acute Lymphoblastic Leukemia

HIF1A Is a Critical Downstream Mediator for Hemophagocytic Lymphohistiocytosis

TET2 Regulates CD4 + T Follicular Helper Differentiation

Combined Treatment with Ruxolitinib and Dexamethasone Curtails Inflammation and Lessens Disease in Preclinical Studies of Hemophagocytic Lymphohistiocytosis

The Methylcytosine Dioxygenase TET2 Regulates CD8 + T Cell Memory Differentiation

Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis

ST2 contributes to T-cell hyperactivation and fatal hemophagocytic lymphohistiocytosis in mice

Clearance of Incompatible RBC Is Compromised during Persistent Viral Infection

Excessive Anti-Viral CD8 T Cell Activation Inverts the IL-2 Consumptive Hierarchy Triggering Regulatory T Cell Collapse in Mouse Model for Hemophagocytic Lymphohistiocytosis

TET2 Regulates CD8 + T Cell Responses to Acute and Chronic Viral Infection

Kras Is Critical for CD8 T Cell Antiviral Function

A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice

Fas Controls Neutrophil Lifespan during Bacterial and Viral Infection

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American Society of Hematology

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