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Journal Articles

Maternal Embryonic Leucine Zipper Kinase Inhibitor OTSSP167 Inhibits Osteoclast Activity and Restores Osteoblast Activity in a Murine Model of Multiple Myeloma Bone Disease

Josephine Muller, Arnold Bolomsky, PhD, Kathrin Schonfelder, Frederic Baron, Yves Beguin, MD PhD, Heinz Ludwig, MD, Jo Caers, MD, Roy Heusschen, PhD

Blood (2017) 130 (Supplement 1): 4416.

https://doi.org/10.1182/blood.V130.Suppl_1.4416.4416

Published: 2017

Journal Articles

Targeting Maternal Embryonic Leucine Zipper Kinase with OTSSP167 Displays Anti-Tumor Activities in Chronic Lymphocytic Leukemia through Down-Regulation of FoxM1

Ya Zhang, MD, Xiangxiang Zhou, MD, Ying Li, MD, Yangyang Xu, MD, Xin Wang, MD PhD

Blood (2017) 130 (Supplement 1): 801.

https://doi.org/10.1182/blood.V130.Suppl_1.801.801

Published: 2017

Journal Articles

Maternal Embryonic Leucine Zipper Kinase (MELK) Drives a High-Risk Gene Network and Represents an Attractive Novel Drug Target in Multiple Myeloma

Arnold Bolomsky, PhD, Roy Heusschen, PhD, Karin Schlangen, PhD, Kathrin Schönfelder, MSc, Joséphine Muller, MSc, Wolfgang Schreiner, PhD, Niklas Zojer, MD, Jo Caers, Heinz Ludwig, MD

Blood (2016) 128 (22): 309.

https://doi.org/10.1182/blood.V128.22.309.309

Published: 2016

Journal Articles

Prognostic Methylation Markers for Survival in Cytogenetically Normal AML Patients Treated on SWOG Trials

Xiaoyu Qu, PhD, Megan Othus, PhD, Jerry Davison, PhD, Liying Yan, Elihu H. Estey, MD, Jerry Radich, MD, Harry P Erba, MD PhD, Frederick R. Appelbaum, MD, Min Fang, MD PhD

Blood (2015) 126 (23): 688.

https://doi.org/10.1182/blood.V126.23.688.688

Published: 2015

Journal Articles

Maternal Embryonic Leucine Zipper Kinase (MELK): a Novel Marker of Poor Prognosis and Attractive Drug Target in High-Risk Patients with Multiple Myeloma

Arnold Bolomsky, Karin Schlangen, Artur Köhler, Goran Mitulovic, Wolfgang Schreiner, Niklas Zojer, MD, Heinz Ludwig

Blood (2015) 126 (23): 1823.

https://doi.org/10.1182/blood.V126.23.1823.1823

Published: 2015

Journal Articles

Lack of glucocorticoid-induced leucine zipper (GILZ) deregulates B-cell survival and results in B-cell lymphocytosis in mice

Stefano Bruscoli, Michele Biagioli, Daniele Sorcini, Tiziana Frammartino, Monica Cimino, Paolo Sportoletti, Emanuela Mazzon, Oxana Bereshchenko, Carlo Riccardi

Blood (2015) 126 (15): 1790–1801.

https://doi.org/10.1182/blood-2015-03-631580

Published: 2015

Includes: Supplemental data

Journal Articles

Essential Roles of C/EBPβ in Survival of Ly6C – monocytes

Akihiro Tamura, MD, Hideyo Hirai, MD PhD, Asumi Yokota, PhD, Atsushi Sato, MD, Hisayuki Yao, MD PhD, Masaki Iwasa, MD, Aya Fujishiro, MD, Yasuo Miura, MD PhD, Taira Maekawa, MD PhD

Blood (2014) 124 (21): 224.

https://doi.org/10.1182/blood.V124.21.224.224

Published: 2014

Journal Articles

C/EBPβ Promotes Initial Expansion and Exhaustion of Hematopoietic Stem and Progenitor Cells in Response to Hematopoietic Stresses

Atsushi Sato, MD, Hideyo Hirai, MD PhD, Akihiro Tamura, MD, Asumi Yokota, PhD, Yoshihiro Hayashi, MD PhD, Hisayuki Yao, MD PhD, Masaki Iwasa, MD, Aya Fujishiro, MD, Eishi Ashihara, MD PhD, Yasuo Miura, MD PhD, Taira Maekawa, MD PhD

Blood (2014) 124 (21): 5126.

https://doi.org/10.1182/blood.V124.21.5126.5126

Published: 2014

Journal Articles

A Novel 2 Amino Acids Deletion in the Leucine Zipper Domain of C/EBPε Leads to Neutrophil-Specific Granule Deficiency (SGD)

Tadayuki Akagi, PhD, Taizo Wada, MD PhD, Masahiro Muraoka, MD, Tomoko Toma, MD, Kenzo Kaji, MD, Kazunaga Agematsu, MD, H. Phillip Koeffler, MD, Takashi Yokota, PhD, Akihiro Yachie, MD PhD

Blood (2014) 124 (21): 4101.

https://doi.org/10.1182/blood.V124.21.4101.4101

Published: 2014

Journal Articles

Cell-Intrinsic and Cell-Extrinsic Involvement Of C/EBPβ In The Regulation Of Hematopoietic Stem Cells

Akihiro Tamura, MD, Hideyo Hirai, MD, PhD, Yoshihiro Hayashi, MD, PhD, Asumi Yokota, PhD, Atsushi Sato, MD, Satoshi Yoshioka, MD, Masaki Iwasa, MD, Eishi Ashihara, MD, PhD, Yasuo Miura, MD, PhD, Taira Maekawa, MD, PhD

Blood (2013) 122 (21): 1202.

https://doi.org/10.1182/blood.V122.21.1202.1202

Published: 2013

Journal Articles

Tfeb Functions As a Tumor Suppressor That Harnesses Myc-Induced Lymphomagenesis By Provoking Senescence and Metabolic Catastrophe

Franz X Schaub, Mohammad Fallahi, Weimin Li, Stephanie K Demetriou, Chunying Yang, Antonio L Amelio, John L Cleveland

Blood (2013) 122 (21): 3784.

https://doi.org/10.1182/blood.V122.21.3784.3784

Published: 2013

Journal Articles

Reduced C/EBPα Expression Favors Monopoiesis Over Granulopoiesis

Alan D. Friedman, M.D., Ou Ma, Ph.D., SunHwa Hong, Ph.D.

Blood (2012) 120 (21): 1230.

https://doi.org/10.1182/blood.V120.21.1230.1230

Published: 2012

Journal Articles

Functional Enrichment Analysis by David in Transgenic MYCN Zebrafish Model

Li-Jing Shen, Fang-Yuan Chen, Lan-Fang Cao, Yong Zhang, Hua Zhong

Blood (2012) 120 (21): 5114.

https://doi.org/10.1182/blood.V120.21.5114.5114

Published: 2012

Journal Articles

C/EBPα, C/EBPα Oncoproteins, or C/EBPβ Preferentially Bind NF-κB p50 Compared with p65 Via Conserved Residues In the C/EBP Basic Region

Julia E. Dooher, Ph.D., Ido Paz-Priel, M.D., Simone Houng, Albert S. Baldwin, Jr., Ph.D., Alan D. Friedman, M.D.

Blood (2010) 116 (21): 708.

https://doi.org/10.1182/blood.V116.21.708.708

Published: 2010

Journal Articles

C/EBP and AP-1 Proteins Form Leucine Zipper Heterodimers and Reduce C/EBP Homodimer Formation During Monopoiesis.

SunHwa Hong, Ph.D., Alan D. Friedman, M.D.

Blood (2010) 116 (21): 2606.

https://doi.org/10.1182/blood.V116.21.2606.2606

Published: 2010

Journal Articles

Genome Wide Profiling of USF1 and USF2 Occupancy in Human Primary Erythroid Cells.

Laurie A Steiner, Vincent Schulz, Yelena Maksimova, David Tuck, Patrick G. Gallagher, MD

Blood (2009) 114 (22): 1456.

https://doi.org/10.1182/blood.V114.22.1456.1456

Published: 2009

Journal Articles

C/EBPα:C/EBPα and C/EBPα:Jun Leucine Zipper Complexes Are Detectable in Myeloid Cells Via Binding to Distinct DNA Elements.

SunHwa Hong, Ph.D., Alan D. Friedman, M.D.

Blood (2009) 114 (22): 1458.

https://doi.org/10.1182/blood.V114.22.1458.1458

Published: 2009

Journal Articles

C/EBPα or Its Leukemic Mutants Directly Activate nfkb1 Transcription and Displace HDAC1 or HDAC3 From Chromatin-Associated NF-κB p50 to Induce Anti-Apoptotic Genes.

Ido Paz-Priel, MD, Alan D. Friedman, MD

Blood (2009) 114 (22): 76.

https://doi.org/10.1182/blood.V114.22.76.76

Published: 2009

Journal Articles

C/Ebpβ Inhibits Apoptosis in Hematopoietic Cells Via Interaction with NF-κb p50.

Rebecca McFall, MD, Ido Paz-Priel, MD, Alan D. Friedman, MD

Blood (2008) 112 (11): 1332.

https://doi.org/10.1182/blood.V112.11.1332.1332

Published: 2008

Journal Articles

Array CGH Analysis of Chronic Lymphocytic Leukemia Reveals Frequent Cryptic Monoallelic and Biallelic Deletions of Chromosome 22q11.

William D. McClain, Shelly R. Gunn, Aswani R. Bolla, Lynn L. Barron, Mercedes E. Gorre, David W. Bahler, Clemens H. M. Mellink, Marinus H. J. van Oers, Michael J. Keating, Alessandra Ferrajoli, Kevin R. Coombes, Lynne V Abruzzo, MD, PhD, Ryan S. Robetorye

Blood (2008) 112 (11): 1050.

https://doi.org/10.1182/blood.V112.11.1050.1050

Published: 2008

NARROW

Maternal Embryonic Leucine Zipper Kinase Inhibitor OTSSP167 Inhibits Osteoclast Activity and Restores Osteoblast Activity in a Murine Model of Multiple Myeloma Bone Disease

Targeting Maternal Embryonic Leucine Zipper Kinase with OTSSP167 Displays Anti-Tumor Activities in Chronic Lymphocytic Leukemia through Down-Regulation of FoxM1

Maternal Embryonic Leucine Zipper Kinase (MELK) Drives a High-Risk Gene Network and Represents an Attractive Novel Drug Target in Multiple Myeloma

Prognostic Methylation Markers for Survival in Cytogenetically Normal AML Patients Treated on SWOG Trials

Maternal Embryonic Leucine Zipper Kinase (MELK): a Novel Marker of Poor Prognosis and Attractive Drug Target in High-Risk Patients with Multiple Myeloma

Lack of glucocorticoid-induced leucine zipper (GILZ) deregulates B-cell survival and results in B-cell lymphocytosis in mice

Essential Roles of C/EBPβ in Survival of Ly6C – monocytes

C/EBPβ Promotes Initial Expansion and Exhaustion of Hematopoietic Stem and Progenitor Cells in Response to Hematopoietic Stresses

A Novel 2 Amino Acids Deletion in the Leucine Zipper Domain of C/EBPε Leads to Neutrophil-Specific Granule Deficiency (SGD)

Cell-Intrinsic and Cell-Extrinsic Involvement Of C/EBPβ In The Regulation Of Hematopoietic Stem Cells

Tfeb Functions As a Tumor Suppressor That Harnesses Myc-Induced Lymphomagenesis By Provoking Senescence and Metabolic Catastrophe

Reduced C/EBPα Expression Favors Monopoiesis Over Granulopoiesis

Functional Enrichment Analysis by David in Transgenic MYCN Zebrafish Model

C/EBPα, C/EBPα Oncoproteins, or C/EBPβ Preferentially Bind NF-κB p50 Compared with p65 Via Conserved Residues In the C/EBP Basic Region

C/EBP and AP-1 Proteins Form Leucine Zipper Heterodimers and Reduce C/EBP Homodimer Formation During Monopoiesis.

Genome Wide Profiling of USF1 and USF2 Occupancy in Human Primary Erythroid Cells.

C/EBPα:C/EBPα and C/EBPα:Jun Leucine Zipper Complexes Are Detectable in Myeloid Cells Via Binding to Distinct DNA Elements.

C/EBPα or Its Leukemic Mutants Directly Activate nfkb1 Transcription and Displace HDAC1 or HDAC3 From Chromatin-Associated NF-κB p50 to Induce Anti-Apoptotic Genes.

C/Ebpβ Inhibits Apoptosis in Hematopoietic Cells Via Interaction with NF-κb p50.

Array CGH Analysis of Chronic Lymphocytic Leukemia Reveals Frequent Cryptic Monoallelic and Biallelic Deletions of Chromosome 22q11.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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