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Journal Articles

Inherited glycosylphosphatidylinositol defects cause the rare Emm-negative blood phenotype and developmental disorders

Romain Duval, Gaël Nicolas, Alexandra Willemetz, Yoshiko Murakami, Mahmoud Mikdar, Cedric Vrignaud, Hisham Megahed, Jean-Pierre Cartron, Cecile Masson, Samer Wehbi, Bérengere Koehl, Marie Hully, Karine Siquier, Nicole Chemlay, Agnes Rotig, Stanislas Lyonnet, Yves Colin, Giulia Barcia, Vincent Cantagrel, Caroline Le Van Kim, Olivier Hermine, Taroh Kinoshita, Thierry Peyrard, Slim Azouzi
Journal: Blood
Blood (2021) 137 (26): 3660–3669.
DOI: https://doi.org/10.1182/blood.2020009810
Published: 2021
Includes: Supplemental data
Journal Articles

Establishing a Link between Zinc Homeostasis and Globin Gene Expression

Oluwaseun Olaiya, DO, Halyna Fedosyuk, MS, Lesya V Novikova, PhD, Matthew P Parker, BS, Kenneth R Peterson, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3578.
DOI: https://doi.org/10.1182/blood-2019-130758
Published: 2019
Journal Articles

The Role of Hypoxia on ABL Tyrosine Kinase Inhibitor Resistant Chronic Myeloid Leukemia Cells

Seiichi Okabe, MD PhD, Yuko Tanaka, MD PhD, Mitsuru Moriyama, Akihiko Gotoh, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5369.
DOI: https://doi.org/10.1182/blood-2019-129768
Published: 2019
Journal Articles

Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms

Vasundhara Sharma, PhD, Lanzhu Yue, MD, Nathan P. Horvat, MDCandidate, Agni Christodoulidou, PhD, Afua Adutwumwa Akuffo, PhDCandidate, Mathew Beatty, PhD, Cem Murdun, MS, Julia Billington, PhDCandidate, William E Goodheart, MS, PhDCandidate, Eva Sahakian, PhD, Ling Zhang, MD, John J. Powers, BS, Narmin E. Amin, Que T. Lambert-Showers, Lancia Darville, PhD, Javier Pinilla Ibarz, MD PhD, Gary W. Reuther, Jennifer Lee, PhD, Xiaozhang Zheng, PhD, Pui Yee Ng, PhD, Mathew W. Martin, PhD, Gary C. Marshall, PhD, John M. Koomen, PhD, Ross L. Levine, MD, Amit Verma, MBBS, H. Leighton Grimes, PhD, Eduardo Sotomayor, MD, Zonghong Shao, MD, Kenneth Wright, PhD, Pearlie K. Epling-Burnette
Journal: Blood
Blood (2019) 134 (Supplement_1): 474.
DOI: https://doi.org/10.1182/blood-2019-127235
Published: 2019
Journal Articles

Eltrombopag Creates a Transient Chemical Phenocopy of TET2 Loss of Function That Contributes to Hematopoietic Precursor Expansion

Yihong Guan, PhD, Bhumika J. Patel, MD, Metis Hasipek, PhD, Dale Grabowski, BS, Hassan Awada, MD, Cassandra M Kerr, MS, Valeria Visconte, PhD, Aziz Nazha, MD, Yogenthiran Saunthararajah, MD, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski, MD PhD, Babal K. Jha, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 453.
DOI: https://doi.org/10.1182/blood-2019-131525
Published: 2019
Journal Articles

KLF4 Is Needed for Optimal Hydroxyurea Induction of Gamma-Globin in K562 Cells

Alireza Paikari, MD, Ankush Goyal, MA, Celeste K. Kanne, BA, Vivien A. Sheehan, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 971.
DOI: https://doi.org/10.1182/blood-2019-131214
Published: 2019
Journal Articles

The Multidrug Transporter MRP4/ABCC4 Involved in the Leukemia Clinical Course Specifies the Novel PEL Human Blood Group System

Slim Azouzi, PhD, Mahmoud Mikdar, MSc, Patricia Hermand-Tournamille, PhD, Emilie-Fleur Gautier, PhD, Virginie Salnot, PhD, Alexandra Willemetz, MSc, Gaël Nicolas, PhD, Cedric Vrignaud, MSc, Alexandre Raneri, Patrick Mayeux, PhD, Christine Bole-Feysot, PhD, Patrick Nitschke, PhD, Jean-Pierre Cartron, PhD, Yves Colin Aronovicz, PhD, Olivier Hermine, Gabriele Jedlitschky, PhD, Marc Cloutier, PhD, Jessica Constanzo-Yanez, Carole Ethier, Nancy Robitaille, MD, Maryse St-Louis, Caroline Le Van Kim, PhD, Thierry Peyrard, PharmD/PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 715.
DOI: https://doi.org/10.1182/blood-2019-124082
Published: 2019
Journal Articles

The Embryonic Program Activated during Blast Crisis of Chronic Myelogenous Leukemia (CML) Implicates a TCF7L2 and MYC Cooperative Chromatin Binding and Represents a Druggable Target

Christophe Desterke, PhD, Sarah Pagliaro, Pharm D, Patricia Hugues, Annelise Bennaceur-Griscelli, MD PhD, Ali G Turhan, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1632.
DOI: https://doi.org/10.1182/blood-2019-124796
Published: 2019
Journal Articles

The Interaction of Tumor Cells and Myeloid-Derived Suppressor Cells in Chronic Myelogenous Leukemia

Hui Xu, Zunmin Zhu, Xiaojian Zhu, Na Shen, Shu Zhou, Yicheng Zhang
Journal: Blood
Blood (2019) 134 (Supplement_1): 1636.
DOI: https://doi.org/10.1182/blood-2019-125563
Published: 2019
Journal Articles

Proteomic Analysis of Mitochondrial Membrane Protein FAM210B in Erythroid Cells

Chie Suzuki, Tohru Fujiwara, MD PhD, Hiroki Shima, Koya Ono, MD, Kei Saito, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Hisayuki Yokoyama, MD PhD, Shinichi Fujimaki, Yukio Nakamura, MD PhD, Hideo Harigae, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3523.
DOI: https://doi.org/10.1182/blood-2019-122618
Published: 2019
Journal Articles

Improved Bone Marrow Homing of NK Cells through PM21 Particle Stimulated Enhancement of Fucosylation of E-Selectin Ligand

Jeremiah Oyer, BSc, Nitin Chakravarti, PhD, Robert Igarashi, PhD, Deborah Altamore, PhD, Dean Anthony Lee, MD PhD, Alicja Joanna Copik, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3598.
DOI: https://doi.org/10.1182/blood-2019-131137
Published: 2019
Journal Articles

GATA2 Zinc Finger Mutations Influence Erythroid Differentiation and Chemotherapy Response

Georg Leubolt, MSc, Enric Redondo Monte, MSc, BSc, Anja Wilding, MSc, Paul Kerbs, MSc, Monica Cusan, MD, Johannes Bagnoli, Wolfgang Enard, PhD, Wolfgang Hiddemann, MD PhD, Christian Wichmann, MD, Gunnar Schotta, PhD, Philipp A. Greif, MD PD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1459.
DOI: https://doi.org/10.1182/blood-2019-128218
Published: 2019
Journal Articles

The Splicing Factor RBM17 Supports Leukemia Stem Cell Self-Renewal

Lina Liu, Ana Vujovic, Joshua Xu, Kristin Hope, PhD, Yu Lu, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1238.
DOI: https://doi.org/10.1182/blood-2019-126287
Published: 2019
Journal Articles

Functional Evaluation and Mechanism Study of Kel As an Oncogenic Driver in Acute Erythroleukemia

Hui Jin, Jianyong Li, MD, Zijuan Wu, Handong Sun, Wenjie Liu, MD, Yanfeng Liu, PhD, Ming Hong, MD PhD, Sixuan Qian, Wei Xu, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1246.
DOI: https://doi.org/10.1182/blood-2019-124607
Published: 2019
Journal Articles

Induction of Truncating ASXL1 Mutations in Human CD34+ HSPCs Mimics Human ASXL1-Mutated Clonal Hematopoiesis and Progression to Myeloid Malignancies

Thomas Koehnke, MD, Rajiv Sharma, PhD, Yusuke Nakauchi, MD PhD, Andreas Reinisch, MD PhD, Ravi Majeti, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 820.
DOI: https://doi.org/10.1182/blood-2019-130528
Published: 2019
Journal Articles

Off-Target HLA Cross-Reactivity By (Third Party) Virus-Specific T Cells Is Surprisingly Affected By HLA Restriction and HLA Background but Not By Virus Specificity

Wesley Huisman, MSc, Didier A.T. Leboux, Lieve E. van der Maarel, Lois Hageman, Derk Amsen, PhD, Fred Falkenburg, MD PhD, Inge Jedema, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4440.
DOI: https://doi.org/10.1182/blood-2019-124785
Published: 2019
Journal Articles

Aurora Kinase a/MDM2-Mediated SETD2 Loss of Function in Chronic Myeloid Leukemia Patients in Blast Crisis Can be Therapeutically Targeted Inducing Apoptotic Cell Death in a Caspase-Dependent Way

Manuela Mancini, PhD, Sara De Santis, Dr, Cecilia Monaldi, Dr, Luana Bavaro, Dr, Margherita Martelli, Dr, Gabriele Gugliotta, MD PhD, Fausto Castagnetti, MD PhD, Gianantonio Rosti, MD, Maria Chiara Fontana, PhD, Samantha Bruno, Dr, Elisa Dan, PhD, Barbara Sinigaglia, Dr, Alessandra Iurlo, MD PhD, Nicola Orofino, MD, Elisabetta Abruzzese, MD, Marzia Salvucci, MD, Patrizia Pregno, Antonella Gozzini, MD, Monica Crugnola, MD, Francesco Albano, MD, Massimiliano Bonifacio, MD, Elisabetta Calistri, MD, Mario Tiribelli, Gianni Binotto, MD, Annalisa Imovilli, Elena Trabacchi, MD, Sara Galimberti, MD PhD, Claudia Baratè, Elena Tenti, Michele Baccarani, MD, Giovanni Martinelli, MD, Michele Cavo, Simona Soverini, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4142.
DOI: https://doi.org/10.1182/blood-2019-126500
Published: 2019
Journal Articles

The SF3B1 K700E Mutation Induces R-Loop Accumulation and Associated DNA Damage

Shalini Singh, Doaa Ahmed, Hamid Dolatshad, Dharamveer Tatwavedi, Ulrike Schulze, Andrea Sanchi, Sarah Ryley, Ashish Dhir, Lee Carpenter, Suzanne M. Watt, Amal M. Abdel-Aal, Sohair K. Sayed, Somia A. Mohamed, Anna Schuh, PhD, Nicholas J. Proudfoot, Andriana G. Kotini, Eirini P. Papapetrou, Daniel Wiseman, FRCPath, Andrea Pellagatti, Jacqueline Boultwood
Journal: Blood
Blood (2019) 134 (Supplement_1): 4219.
DOI: https://doi.org/10.1182/blood-2019-126981
Published: 2019
Journal Articles

Dose-Dependent Iron Chelating Effects of Eltrombopag on in Vitro Human Megakaryopoiesis

Zhi-Jian Liu, PhD, Emoke Deschmann, MD, Haley E. Ramsey, PhDMSc, Henry Feldman, Bethan Psaila, MD PhD, Nichola Cooper, MD MRCP, Evangelia Vlachodimtropoulou Koumoutsea, MBBS,PhDBSc, John B. Porter, MA MDFRCP FRCPath, James B. Bussel, MD, Michael Georgieff, MD, Martha Sola-Visner, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2475.
DOI: https://doi.org/10.1182/blood-2019-131895
Published: 2019
Journal Articles

Novel ZBP1-IRF3 Dependency in Multiple Myeloma Mediated By IRF3-Driven Regulation of Cell Cycle Genes

Kanagaraju Ponnusamy, Maria-Myrsini Tzioni, MS, Murshida Begum, MS, Mark E Robinson, Valentina S Caputo, Alexia Katsarou, Nikolaos Trasanidis, Xiaolin Xiao, Ioannis V. Kostopoulos, Deena Iskander, MD, Irene Roberts, Pritesh Trivedi, MSc, Holger W Auner, MD PhD, Kikkeri Naresh, MD, Aristeidis Chaidos, Anastasios Karadimitris
Journal: Blood
Blood (2019) 134 (Supplement_1): 2521.
DOI: https://doi.org/10.1182/blood-2019-125768
Published: 2019