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Journal Articles

A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies

Simon Timothy Abrams, PhD BSc, Ben Morton, MBChB, MD, Yasir Alhamdi, MBChB, PhD, Mohmad Alsabani, Zhenxing Cheng, Steven Lane, PhD, Ingeborg Welters, PhD, Guozheng Wang, MD PhD, Cheng-Hock Toh, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 440.
https://doi.org/10.1182/blood-2019-128493
Published: 2019
Journal Articles

CRISPR/Cas9 Mediated ELANE Knock-out Restores Survival and Granulocytic Differentiation of HL60 Cells Expressing Mutant Neutrophil Elastase: Is Neutrophil Elastase a Dispensible Granulocyte Protease?

Vahagn Makaryan, MD, Isabella N. Archibald, Merideth L. Kelley, MS, Breanna Fletcher, BSc, David C. Dale, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 435.
https://doi.org/10.1182/blood-2019-124988
Published: 2019
Journal Articles

Analysis of Metformin Effects on Bone Marrow Fibrosis and Disease Progression in Primary Myelofibrosis Patients: Preliminary Results of an Open Label Phase II Trial (FIBROMET)

Paula De Melo Campos, MD, Katia B Pagnano, MD PhD, Rubia Mancuso, Francisco Breno S. Teófilo, Juan L Coelho-Silva, BSc, MSc, Fernanda I Della Via, MSc, Leandro Luiz Lopes Freitas, MD PhD, Hernandes F. Carvalho, PhD, Fernando Ferreira Costa, MD PhD, Fabiola Traina, MD PhD, Sara T Olalla Saad, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 554.
https://doi.org/10.1182/blood-2019-130648
Published: 2019
Journal Articles

Cxcl8 Expands Hematopoietic Stem and Progenitor Cells and Alters Their Interaction with the Endothelial Niche

Donn L Calkins, BS, Jami L Shaffer, B.S., Emily M Teets, B.S., Alex M Belardo, Serine Avagyan, MD PhD, Leonard I Zon, MD, Bradley W Blaser, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 527.
https://doi.org/10.1182/blood-2019-126151
Published: 2019
Journal Articles

Increased Release of Soluble MD-2 in Sickle Cell Disease and Its Role in Pro-Inflammatory Signaling in Endothelial Cells

Ping Zhang, PhD, John D Belcher, PhD, Julia Nguyen, Fuad Abdulla, Gregory M Vercellotti, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 208.
https://doi.org/10.1182/blood-2019-122912
Published: 2019
Journal Articles

Identification of a Heme Activation Site on the MD-2/TLR4 Complex

John D Belcher, PhD, Ping Zhang, PhD, Julia Nguyen, Zachary Monroe Kiser, BS, PhD, John O Trent, PhD, Gregory M Vercellotti, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 209.
https://doi.org/10.1182/blood-2019-123788
Published: 2019
Journal Articles

Superior Efficacy of CAR-T Cells Using Marrow-Infiltrating Lymphocytes (MILs TM ) As Compared to Peripheral Blood Lymphocytes (PBLs)

Eric R. Lutz, PhD, Srikanta Jana, PhD, Lakshmi Rudraraju, MS, Elizabeth DeOliveira, Jing Zhou, Sean Mackay, Ivan M. Borrello, MD, Kimberly Noonan, PhD MPH
Journal: Blood
Blood (2019) 134 (Supplement_1): 4437.
https://doi.org/10.1182/blood-2019-130629
Published: 2019
Journal Articles

Stratification of Responders and Non-Responders in the Reach-1 Trial Based on Serum Proteomic Analysis

Sherry Owens, PhD, Michael A. Pratta, MSc, Hao Liu, PhD, Michael C. Arbushites, Chuan Tian, PhD, Michael D. Howell, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4531.
https://doi.org/10.1182/blood-2019-127147
Published: 2019
Journal Articles

The Influence of FLT3-ITD Mutation on Baseline Levels of Selected Cytokines and Soluble Adhesion Molecules in Acute Myeloid Leukemia with Mutated NPM-1

Tomas Kupsa, MD PhD, Jan M Horacek, MD PhD, Ladislav Jebavy, MD PhD, Pavel Zak, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5111.
https://doi.org/10.1182/blood-2019-126433
Published: 2019
Journal Articles

Markers of Initial and Long-Term Responses to Idecabtagene Vicleucel (Ide-Cel; bb2121) in the CRB-401 Study in Relapsed/Refractory Multiple Myeloma

Ethan G. Thompson, PhD, Yue Jiang, PhD, Timothy B. Campbell, MD PhD, Jaymes Fuller, PhD, Shari Kaiser, PhD, Afshin Mashadi-Hossein, MSc, Julie Rytlewski, PhD, Nathan Martin, PhD, Olivia Finney, PhD, Katja Kleinsteuber, PhD, Eric Alonzo, PhD, Chetanya Pandya, PhD, Amit Agarwal, MD PhD, Kristen Hege, Noopur S. Raje, MD, Nikhil C. Munshi, MD, Ronald J. Hause, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4328.
https://doi.org/10.1182/blood-2019-124998
Published: 2019
Journal Articles

Relative Depletion of Soluble Interleukin 6 Receptors Abolished the Development of Cytokine Release Syndrome after CART19/22 and Lenalidomide Treatment for Lymphoma

Caixia Li, Changfeng Zhang, PhD, Xiaochen Chen, Ying Zhang, Jia Chen, MD, Liqing Kang, Xiaoyan Lou, Jin Zhou, Xiangping Zong, Zhen Yang, Jiaqi Li, Wei Qi, Lei Yu, Depei Wu, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5313.
https://doi.org/10.1182/blood-2019-126821
Published: 2019
Journal Articles

Changes in the Multipotent Stromal Mesenchymal Cells from the Bone Marrow of the Patients with Hematological Diseases in Debut and after the Treatment

Irina N. Shipounova, PhD, Nataliya A. Petinati, MD PhD, Nina J. Drize, PhD, Aminat A. Magomedova, MD PhD, Ekaterina A. Fastova, MD, Sergey K. Kravchenko, MD PhD, Ekaterina Yu. Chelysheva, MD PhD, Oleg A. Shukhov, MD PhD, Anna G. Turkina, Prof., MD, Elena N. Parovichnikova, MD PhD, Valery G. Savchenko, MD PhD academician
Journal: Blood
Blood (2019) 134 (Supplement_1): 5014.
https://doi.org/10.1182/blood-2019-123396
Published: 2019
Journal Articles

Hispanic Ethnicity Is Associated with Low End of Induction Absolute Lymphocyte Count in Pediatric Acute Lymphoblastic Leukemia

Adriana Saavedra-Simmons, Wanda LeJeune, M.Sc., Geraldine Aubert, PhD, Kellen Gandy, PhD, Lisa R. Hartman, MD, Jill Hartley, MSN, RN, Rodrigo Erana, MD, Juan C. Bernini, MD, Olga Taylor, MPH, Philip J. Lupo, PhD MPH, Michael E. Scheurer, PhD MPH, Karen R. Rabin, MD PhD, Maria Monica Monica Gramatges, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5197.
https://doi.org/10.1182/blood-2019-131222
Published: 2019
Journal Articles

Altered Dynamics of Monocyte Subpopulations and Pro-Inflammatory Signaling Pathways in Polycythemia Vera Revealed By Mass Cytometry

Jared S Fowles, PhD, Daniel A.C. Fisher, PhD, Amy Zhou, MD, Stephen T. Oh, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4210.
https://doi.org/10.1182/blood-2019-131128
Published: 2019
Journal Articles

Integrated Genomic-Transcriptomic Study Highlights Accumulation of Genetic Variants and Activation of Inflammatory Pathways

Malathi Kandarpa, PhD, Kristen Pettit, MD, Tingting Qin, PhD, Yi-Mi Wu, PhD, Dan Robinson, PhD, Maureen Sartor, PhD, Arul Chinnaiyan, MD, Moshe Talpaz, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4212.
https://doi.org/10.1182/blood-2019-128301
Published: 2019
Journal Articles

T Cell Immunity Toward Viral- and Tumor-Antigens Is Preserved in MDS Patients

Hussein Hamad, MD, Wingchi K Leung, MD, Spyridoula Vasileiou, PhD, Shivani Mukhi, Quillan Huang, MD, George Carrum, MD, Carlos A. Ramos, MD, Rammurti Kamble, MD, LaQuisa C. Hill, MD, Ann M. Leen, PhD, Premal Lulla, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 4225.
https://doi.org/10.1182/blood-2019-126792
Published: 2019
Journal Articles

Preliminary Report of MANIFEST, a Phase 2 Study of CPI-0610, a Bromodomain and Extraterminal Domain Inhibitor (BETi), in Combination with Ruxolitinib, in JAK Inhibitor (JAKi) Treatment Naïve Myelofibrosis Patients

Claire N Harrison, Professor, Andrea Patriarca, MD, John Mascarenhas, MD, Marina Kremyanskaya, Ronald Hoffman, MD, Gary J. Schiller, MD, Brian Leber, MD, Timothy Devos, MD PhD, Sujan Kabir, MD, Adrian Senderowicz, MD, Jennifer Mertz, PhD, Patrick Trojer, PhD, James Shao, MS, Vikas Gupta, MD FRCP, FRCPath
Journal: Blood
Blood (2019) 134 (Supplement_1): 4164.
https://doi.org/10.1182/blood-2019-128211
Published: 2019
Journal Articles

Development of HHV-6-Specific Immunity after Cord Blood Transplantation in Adults Depends on Reconstitution of Thymopoiesis and Regeneration of CD4 + T Cells

Natalia M Tijaro-Ovalle, MD, Shuli Li, PhD, Zachariah Defilipp, MD, Ioannis Politikos, MD, Robin M. Joyce, MD, Philippe Armand, MD PhD, Vincent T. Ho, John Koreth, MBBS, DPhil, Sarah Nikiforow, MD PhD, Edwin P. Alyea, III, MD, David E. Avigan, MD, Jacalyn Rosenblatt, MD, Jami Brown, MS, Steven McAfee, MD, Bimalangshu Dey, MD, Areej El-Jawahri, MD, Thomas Spitzer, MD, Yi-Bin Chen, Robert J. Soiffer, MD, Joseph H. Antin, MD, Karen K. Ballen, MD, Corey S. Cutler, MD MPH, FRCPC, Jerome Ritz, MD, Vassiliki A Boussiotis, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3275.
https://doi.org/10.1182/blood-2019-129154
Published: 2019
Journal Articles

A Biomarker Signature to Predict Complete Response to Itacitinib and Corticosteroids in Acute Graft Versus Host Disease

Michael A. Pratta, MSc, Hao Liu, PhD, Sherry Owens, PhD, Ying Yan, PhD, Michael C. Arbushites, Michael D. Howell, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3279.
https://doi.org/10.1182/blood-2019-124069
Published: 2019
Journal Articles

Hematopoietic Stem and Progenitor Cells Manifest Direct Migration Towards Secreted DEK in a CXCR2- and G Protein Signaling-Dependent Manner

Maegan L. Capitano, PhD, Yasser Sammour, Maureen Legendre, Scott Cooper, MS, David Markovitz, MD, Hal E. Broxmeyer, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1196.
https://doi.org/10.1182/blood-2019-128738
Published: 2019