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Journal Articles

CAR T Cells Derived from Healthy Mice Lead to Cytokine Release Syndrome (CRS) in the TCL1 Chronic Lymphocytic Leukemia Model; Mice with CLL Treated with Acalabrutinib or Ibrutinib Have Improved CAR T Cell Function without Increasing the Cytokines of CRS

Robin Sanderson, MRCP,FRCPath, Arantxa Romero-Toledo, MSc, John G. Gribben, MD DSc

Blood (2019) 134 (Supplement_1): 249.

DOI: https://doi.org/10.1182/blood-2019-125647

Published: 2019

Journal Articles

Elevated IL-1Ra Levels in the Stem Cell Product Is Associated with the Development of Engraftment Syndrome Following Autologous Stem Cell Transplantation for the Treatment of Multiple Myeloma and Lymphoma

Stacey L. Fanning, PhD, Kira Goldgirsh, MS, Dante B. Descalzi-Montoya, PhD, Rena Feinman, PhD, David S Siegel, MD PhD, Noa Biran, MD, David H. Vesole, MD PhD, Andre Goy, MD, Tatyana A. Feldman, MD, Lori A. Leslie, MD, Scott D. Rowley, MD, Alan P Skarbnik, MD, Phyllis McKiernan, Melissa Baker, MSN, ANP, Michele L. Donato, MD, Robert Korngold, PhD

Blood (2018) 132 (Supplement 1): 2131.

DOI: https://doi.org/10.1182/blood-2018-99-118763

Published: 2018

Journal Articles

Beyond Cytokine Storm: Optimizing Treatment Strategies to Target the Complex Interplay between CAR Mediated Inflammatory Response, Disseminated Intravascular Coagulation and Macrophage Activation Syndrome

Nirali N Shah, MD, Haneen Shalabi, DO, Bonnie Yates, RN, Eli Kane, Alina Dulau-Florea, MD, Anne Cullinane, BS, Cynthia Delbrook, RN, Michael Ombrello, MD, Amanda Ombrello, MD, Jay Nelson Lozier, MD PhD, Terry J. Fry, MD

Blood (2017) 130 (Supplement 1): 1277.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1277.1277

Published: 2017

Journal Articles

Development of Anti-IL-1R3 Monoclonal Antibodies for Treating Cancer and IL-1 Family-Mediated Inflammation

Jesper F Højen, MD, Megan K Taylor, Tania Azam, Stephan Fischer, Daniel A Pollyea, MD, Craig T Jordan, PhD, Charles A. Dinarello, MD

Blood (2016) 128 (22): 5224.

DOI: https://doi.org/10.1182/blood.V128.22.5224.5224

Published: 2016

Journal Articles

A Novel Mechanism of Cellular Activation Mediated By Antiphospholipid Antibody-Induced Extracellular Vesicles

Meifang Wu, MD, Suman Kundu, MBA, Venkaiah Betapudi, PhD, Keith R. McCrae, MD

Blood (2014) 124 (21): 100.

DOI: https://doi.org/10.1182/blood.V124.21.100.100

Published: 2014

Journal Articles

Clinical Presentation, Diagnosis, Treatment, and Outcome of Patients with Erdheim-Chester Disease: The Mayo Clinic Experience

Mithun Vinod Shah, MD PhD, Timothy G Call, MD, Carl C. Hook, MD, Patrick B. Johnston, MD PhD, Louis Letendre, MD, Joseph P. Colgan, MD, Animesh Pardanani, MBBS, PhD, Bart L. Clarke, MD, Karen L Grogg, MD, Ronald S. Go, MD

Blood (2014) 124 (21): 1405.

DOI: https://doi.org/10.1182/blood.V124.21.1405.1405

Published: 2014

Journal Articles

Role of Enhanced Microenvironmental Interleukin-1 (IL-1) Expression and Increased IL-1 Responsiveness in Persistence of Leukemia Stem Cells in TKI Treated CML Patients

Bin Zhang, PhD, YinWei Ho, Tinisha McDonald, B.S., Allen Lin, David S Snyder, MD, Vu N. Ngo, PhD, Tessa L. Holyoake, MD PhD, Ravi Bhatia, MD

Blood (2014) 124 (21): 4357.

DOI: https://doi.org/10.1182/blood.V124.21.4357.4357

Published: 2014

Journal Articles

Inhibition Of Microenvironmental Interleukin-1 Signaling Enhances TKI-Mediated Targeting Of Chronic Myelogenous Leukemia Stem Cells

Bin Zhang, PhD, Yin Wei Ho, Tessa L. Holyoake, PhD, Ravi Bhatia, MD

Blood (2013) 122 (21): 512.

DOI: https://doi.org/10.1182/blood.V122.21.512.512

Published: 2013

Journal Articles

Interplay Between IL-1, IL-6 and IL-17 in IL-1 Receptor Antagonist (IL-1Ra) Treated Multiple Myeloma Patients

Kathleen A. Donovan, PhD, Laurie L. Moon-Tasson, BA, John A Lust, MD, PhD

Blood (2012) 120 (21): 1874.

DOI: https://doi.org/10.1182/blood.V120.21.1874.1874

Published: 2012

Journal Articles

Disease Modeling and Drug Discovery Using Induced Pluripotent Stem Cells From CINCA Syndrome Patients

Takayuki Tanaka, MD, Akira Ohta, PhD, Masakatsu Yanagimachi, MD, PhD, Ryuta Nishikomori, MD, PhD, Toshio Heike, MD, PhD, Tatsutoshi Nakahata, MD, PhD, Shinya Yamanaka, MD, PhD, Megumu Saito, MD, PhD

Blood (2012) 120 (21): 4680.

DOI: https://doi.org/10.1182/blood.V120.21.4680.4680

Published: 2012

Journal Articles

Monocyte Shift to a Non-Classical CD14 dim /CD16 + Phenotype Correlates with Fetal Hemoglobin Levels in Sickle Cell Anemia Patients Treated with Hydroxyurea

Kleber Yotsumoto Fertrin, MD, PhD, Dulcinéia Martins Albuquerque, BSc, MSc, PhD, Carolina Lanaro, BSc, PhD, Carla Fernanda Franco-Penteado, PhD, Flavia Rubia Pallis, BSc, MSc, Sara T. Olalla Saad, MD, PhD, Fernando Ferreira Costa, MD, PhD

Blood (2012) 120 (21): 817.

DOI: https://doi.org/10.1182/blood.V120.21.817.817

Published: 2012

Journal Articles

α1 Anti-Trypsin (AAT) Mitigates Hematopoietic Injury and Enhances Bone Marrow Recovery After Total Body Irradiation (TBI)

Ekapun Karoopongse, MD, Sabina Janciauskiene, MD, Charles A. Dinarello, M.D., H. Joachim Deeg, A. Mario Q. Marcondes, MD, PhD

Blood (2012) 120 (21): 4142.

DOI: https://doi.org/10.1182/blood.V120.21.4142.4142

Published: 2012

Journal Articles

Hemophagocytic Lymphohistiocytosis in Adults: A Case Series of 30 Patients At a U.S. Tertiary Care Center

Sarah A. Buckley, MD, Daniel Egan, MD, Roland B. Walter, MD, PhD

Blood (2012) 120 (21): 4681.

DOI: https://doi.org/10.1182/blood.V120.21.4681.4681

Published: 2012

Journal Articles

Long Term Follow-up of IL-1 Receptor Antagonist and Dexamethasone Phase II Clinical Trial in Patients with Smoldering/Indolent Myeloma Shows Improved Survival in Responsive Patients: Implications for Targeting Interleukin-1 Induced IL-6 Production and the Myeloma Proliferative Component

John A Lust, MD, PhD, Martha Q Lacy, MD, Steven R Zeldenrust, MD, PhD, Angela Dispenzieri, MD, Morie A Gertz, MD, Philip R. Greipp, MD, Thomas E. Witzig, MD, Shaji Kumar, MD, Laurie L. Moon-Tasson, BA, S. Vincent Rajkumar, MD, Kathleen A. Donovan, PhD

Blood (2011) 118 (21): 2945.

DOI: https://doi.org/10.1182/blood.V118.21.2945.2945

Published: 2011

Journal Articles

Study of Polymorphisms in DNMT3B promoter and IL-1 Ra in Childhood Idiopathic Thrombocytopenic Purpura.

Eftichia Stiakaki, MD, PhD, Marilena Lourou, Margarita Pesmatzoglou, MD, Vassilis Vasjiourakis, Helen Dimitriou, PhD, Maria Kalmanti, MD, PhD

Blood (2010) 116 (21): 3705.

DOI: https://doi.org/10.1182/blood.V116.21.3705.3705

Published: 2010

Journal Articles

Remarkable Efficacy of IL-1 Receptor Antagonist In Schnitzler's Syndrome: a Series of 6 Cases

Helen J Lachmann, MD, FRCP, Stephen Harding, PhD, Ashutosh Wechalekar, MD, FRCPath, Julian D Gillmore, E. Nicole Amft, MD, PhD, FRCP, Philip N Hawkins

Blood (2010) 116 (21): 3958.

DOI: https://doi.org/10.1182/blood.V116.21.3958.3958

Published: 2010

Journal Articles

Preliminary Evidences of Circulating Inflammatory Markers Associated with Symptom Development In Patients with Multiple Myeloma During Induction Therapy

Xin Shelley Wang, MD, MPH, James M Reuben, Ph.D., Bang-Ning Lee, Ph.D., PA-C, Robert Z. Orlowski, MD, PhD, Valen E Johnson, Ph.D., Jacqueline Joy, MS, CCRP, Matthew Galland, Evan Cohen, Gary M Mobley, MA, Ping Liu, MS, Tito R Mendoza, PhD, Charles Cleeland, PhD

Blood (2010) 116 (21): 4734.

DOI: https://doi.org/10.1182/blood.V116.21.4734.4734

Published: 2010

Journal Articles

Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

Felix Meissner, Reinhard A. Seger, Despina Moshous, Alain Fischer, Janine Reichenbach, Arturo Zychlinsky

Blood (2010) 116 (9): 1570–1573.

DOI: https://doi.org/10.1182/blood-2010-01-264218

Published: 2010

Includes: Supplemental data

Journal Articles

The Stage-Specific Effect of Interleukin-1 Beta (IL-1β) during Human Natural Killer Cell Development

Tiffany L Hughes, Michael Brian Becknell, M.D., Ph.D., Aharon Freud, M.D., Ph.D., Susan E Schmidt, Jianhua Yu, PhD, Charlene Mao, Mikhail Gavrilin, Ph.D., Mark Wewers, M.D., Michael A. Caligiuri, MD

Blood (2008) 112 (11): 3746.

DOI: https://doi.org/10.1182/blood.V112.11.3746.3746

Published: 2008

Journal Articles

Environmental Mediated-Immune Resistance (EM-IR) to APO2L/TRAIL Mediated Apoptosis.

Lia E. Perez, MD, Nancy Parquet, BS, Marina Molisano, BS, Ken Shain, Ph.D, Melisa Alsina, MD, Claudio Anasetti, MD, William Dalton, Ph.D. MD

Blood (2007) 110 (11): 3521.

DOI: https://doi.org/10.1182/blood.V110.11.3521.3521

Published: 2007

NARROW

CAR T Cells Derived from Healthy Mice Lead to Cytokine Release Syndrome (CRS) in the TCL1 Chronic Lymphocytic Leukemia Model; Mice with CLL Treated with Acalabrutinib or Ibrutinib Have Improved CAR T Cell Function without Increasing the Cytokines of CRS

Elevated IL-1Ra Levels in the Stem Cell Product Is Associated with the Development of Engraftment Syndrome Following Autologous Stem Cell Transplantation for the Treatment of Multiple Myeloma and Lymphoma

Beyond Cytokine Storm: Optimizing Treatment Strategies to Target the Complex Interplay between CAR Mediated Inflammatory Response, Disseminated Intravascular Coagulation and Macrophage Activation Syndrome

Development of Anti-IL-1R3 Monoclonal Antibodies for Treating Cancer and IL-1 Family-Mediated Inflammation

A Novel Mechanism of Cellular Activation Mediated By Antiphospholipid Antibody-Induced Extracellular Vesicles

Clinical Presentation, Diagnosis, Treatment, and Outcome of Patients with Erdheim-Chester Disease: The Mayo Clinic Experience

Role of Enhanced Microenvironmental Interleukin-1 (IL-1) Expression and Increased IL-1 Responsiveness in Persistence of Leukemia Stem Cells in TKI Treated CML Patients

Inhibition Of Microenvironmental Interleukin-1 Signaling Enhances TKI-Mediated Targeting Of Chronic Myelogenous Leukemia Stem Cells

Interplay Between IL-1, IL-6 and IL-17 in IL-1 Receptor Antagonist (IL-1Ra) Treated Multiple Myeloma Patients

Disease Modeling and Drug Discovery Using Induced Pluripotent Stem Cells From CINCA Syndrome Patients

Monocyte Shift to a Non-Classical CD14 dim /CD16 + Phenotype Correlates with Fetal Hemoglobin Levels in Sickle Cell Anemia Patients Treated with Hydroxyurea

α1 Anti-Trypsin (AAT) Mitigates Hematopoietic Injury and Enhances Bone Marrow Recovery After Total Body Irradiation (TBI)

Hemophagocytic Lymphohistiocytosis in Adults: A Case Series of 30 Patients At a U.S. Tertiary Care Center

Long Term Follow-up of IL-1 Receptor Antagonist and Dexamethasone Phase II Clinical Trial in Patients with Smoldering/Indolent Myeloma Shows Improved Survival in Responsive Patients: Implications for Targeting Interleukin-1 Induced IL-6 Production and the Myeloma Proliferative Component

Study of Polymorphisms in DNMT3B promoter and IL-1 Ra in Childhood Idiopathic Thrombocytopenic Purpura.

Remarkable Efficacy of IL-1 Receptor Antagonist In Schnitzler's Syndrome: a Series of 6 Cases

Preliminary Evidences of Circulating Inflammatory Markers Associated with Symptom Development In Patients with Multiple Myeloma During Induction Therapy

Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

The Stage-Specific Effect of Interleukin-1 Beta (IL-1β) during Human Natural Killer Cell Development

Environmental Mediated-Immune Resistance (EM-IR) to APO2L/TRAIL Mediated Apoptosis.

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American Society of Hematology

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