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Journal Articles

Association between Inflammatory Markers and Abnormal Neurological, Neurocognitive and Magnetic Resonance Imaging (MRI) Findings in Children with Sickle Cell Anemia in Uganda

Free
Amelia Boehme, PhD MSPH, Adiba Ashrafi, MS, Richard Idro, MMED, PhD, Paul Bangirana, MS, PhD, Deogratias Munube, MD, Robert Opoka, MMED, Philip Kasirye, MMED, Margaret T. Lee, MD, Nancy S. Green, MD, Mady Hornig, MA, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2300.
https://doi.org/10.1182/blood-2019-131560
Published: 2019
Journal Articles

An Adaptive Design Study to Evaluate the Efficacy, Safety and Pharmacokinetics of Emapalumab in Adult Patients with Non-Primary Hemophagocytic Lymphohistiocytosis

Free
Veronica Asnaghi, MD, Maria Ballabio, MD, Philippe Jacqmin, Kathy de Graaf, Cristina De Min, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2333.
https://doi.org/10.1182/blood-2019-123995
Published: 2019
Journal Articles

Infection Is a Driver of Dnmt3a-Mutant Clonal Hematopoiesis

Free
Daniel Hormaechea Agulla, PhD, Katie A Matatall, PhD, Duy Le, PhDcandidate, Bailee Nicole Kain, PhDcandidate, Roman Jaksik, PhD, Marek Kimmel, PhD DSc, Grant Challen, PhD, Katherine Y. King, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 817.
https://doi.org/10.1182/blood-2019-126831
Published: 2019
Journal Articles

Elucidating the Role of IL6 in Stress Erythropoiesis and in the Development of Anemia Under Inflammatory Conditions

Free
Sayantani Sinha, PhD, Ritama Gupta, PhD, Jianbing Zhang, PhD, Amaliris Guerra, PhD, Ping La, Sara Gardenghi, PhD, Stefano Rivella, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 940.
https://doi.org/10.1182/blood-2019-128826
Published: 2019
Journal Articles

Flotetuzumab, an Investigational CD123 x CD3 Bispecific Dart® Protein, in Salvage Therapy for Primary Refractory and Early Relapsed Acute Myeloid Leukemia (AML) Patients

Free
Geoffrey L. Uy, MD, Ibrahim Aldoss, MD, Matthew C Foster, MD, David A Sallman, MD, Kendra L. Sweet, MD, David A. Rizzieri, MD, Peter H. Sayre, MD PhD, Anjali S. Advani, MD, Ashkan Emadi, MD, Matthew J. Wieduwilt, MD PhD, Norbert Vey, MD PhD, Fabio Ciceri, MD, Matteo Giovanni Carrabba, MD, Tamara Moyo, MD PhD, Sarah E. Church, PhD, Michael P. Rettig, PhD, Martha L. Arellano, MD, John E. Godwin, MD, Bob Löwenberg, MD PhD, Gerwin Huls, MD PhD, Farhad Ravandi, MD, John Muth, MS, Kathy Tran, Mojca Jongen-Lavrencic, MD PhD, Erin Timmeny, Max S. Topp, MD, Stefania Paolini, MD PhD, Kuo Guo, MSc, Teia Curtis, Jian Zhao, PhD, Jayakumar Vadakekolathu, PhD, Jon M. Wigginton, MD, Ezio Bonvini, MD, Sergio Rutella, MDPhDFRCPath, Roland B. Walter, MD PhD MS, Jan K Davidson-Moncada, MD PhD, John F. DiPersio, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 733.
https://doi.org/10.1182/blood-2019-122073
Published: 2019
Journal Articles

A Unique Monocyte Transcriptome Discriminates Sickle Cell Disease from Other Hereditary Hemolytic Anemias and Shows the Particular Importance of Lipid and Interferon Signaling

Free
Annelies J. Van Vuren, MD, Stephanie van Straaten, MD PhD, Michal Mokry, PhD, Richard van Wijk, PhD, Eduard J. van Beers, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 980.
https://doi.org/10.1182/blood-2019-124070
Published: 2019
Journal Articles

CD38 Knockout Primary NK Cells to Prevent "Fratricide" and Boost Daratumumab Activity

Free
Yuya Nagai, MD, Meisam Naeimi Kararoudi, PhD DVM, Ezgi Elmas, MS, Marcelo Pereira, Syed Abbas Ali, MD, Philip Hollingsworth Imus, MD, Dean Anthony Lee, MD PhD, Gabriel Ghiaur, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 870.
https://doi.org/10.1182/blood-2019-129456
Published: 2019
Journal Articles

Integrated Epigenetic Profiling Identifies EZH2 As a Therapeutic Target to Re-Establish Immune Recognition of Leukemia Relapses with Loss of HLA Class II Expression

Free
Valentina Gambacorta, MSc, Daniela Gnani, PhD, Laura Zito, MSc, Stefano Beretta, PhD, Lucia Zanotti, PhD, Oliveira Giacomo, PhD, Davide Cittaro, PhD, Ivan Merelli, PhD, Fabio Ciceri, MD, Raffaella Di Micco, PhD, Luca Vago, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 514.
https://doi.org/10.1182/blood-2019-127395
Published: 2019
Journal Articles

IL-33 Therapy Prevents Acute Lung Injury after Transplantation Via IL-9-Producing Type 2 Innate Lymphoid Cells Induction

Free
Hua Jiang, PhD, Abdulraouf Ramadan, PhD, Becquet Laurine, MS, Tu Szu-Wei, Hong Liu, MS, Courtney Rowan, MD, Xiaowen Liu, PhD, Huanmei Wu, PhD, Jun Wan, PhD, Sophie Paczesny, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 583.
https://doi.org/10.1182/blood-2019-123821
Published: 2019
Journal Articles

T-Cell Derived Interferon Gamma Directly Targets Intestinal Epithelium to Induce Stem Cell Apoptosis in GI Gvhd

Free
Shuichiro Takashima, MD PhD, Maria L. Martin, PhD, Suze A. Jansen, Ya-Yuan Fu, PhD, Anastasiya Egorova, Chen Liu, MD PhD, Richard Kolesnick, MD, Caroline A. Lindemans, MD, Alan M. Hanash, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 585.
https://doi.org/10.1182/blood-2019-130811
Published: 2019
Journal Articles

BALB/c-hCD3E Transgenic Mice: An Ideal Animal Model for In Vivo Efficacy Study of CD3-Bispecific Antibodies

Free
Cunxiang Ju, PhD, Mingkun Zhang, Dongjing Jia, Jing Tang, PhD, Shuai Li, Jing Zhao, PhD, Demin Wang, PhD, Xiang Gao, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1048.
https://doi.org/10.1182/blood-2019-128781
Published: 2019
Journal Articles

Phase I Clinical Trial of CK0801 (cord blood regulatory T cells) in Patients with Bone Marrow Failure Syndrome (BMF) Including Aplastic Anemia, Myelodysplasia and Myelofibrosis

Free
Tapan M. Kadia, MD, Hongbing Ma, MD PhD, Ke Zeng, MD PhD, Mitsutaka Nishimoto, MD PhD, Mi-Ae Lyu, PhD, Meixian Huang, Musa Yilmaz, MD, Courtney D. DiNardo, MDMSc, Ghayas C. Issa, MD, Simrit Parmar, MBBS, Swami P. Iyer, MD, Parameswaran Hari, MBBS, MD, Naval G. Daver, MD, Elias Jabbour, MD, Gautam M. Borthakur, MD, Srdan Verstovsek, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1221.
https://doi.org/10.1182/blood-2019-127702
Published: 2019
Journal Articles

BTN2A, a New Immune-Checkpoint Targeting Vg9Vd2 T Cell Cytotoxicity

Free
Carla E Cano, PhD, Christine Pasero, Aude De Gassart, René Hoet, Emmanuel Scotet, Erwan Mortier, Agnes Quemeneur, Chirine Rafia, Antoine Briantais, Anne-Charlotte Le Floch, MBBS,MSc, Daniel Olive, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1044.
https://doi.org/10.1182/blood-2019-128658
Published: 2019
Journal Articles

Elispots and Ex Vivo Expansion of FVIII-Specific T-Cell Clones Confirm Specificity of CD4 + T-Cell Responses to Self-FVIII in Healthy Non-Hemophilic Blood Donors

Free
Ahmad Faisal Karim, PhD, Pooja Vir, PhD, Devi Gunasekera, MBBS, Allen I. Stering, MD, Kenneth Lieuw, MD PhD, Kathleen P. Pratt, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2413.
https://doi.org/10.1182/blood-2019-124803
Published: 2019
Journal Articles

Preclinical Assessment of Non-Virally Engineered CD33.CAR Cytokine-Induced Killer (CIK) Cells in Chemoresistant AML Patient-Derived Xenografts

Free
Maria Caterina Rotiroti, PhD, Chiara Buracchi, PhD, Silvia Arcangeli, PhD, Chiara F Magnani, PhD, Claudia Cappuzzello, PhD, Zsuzsanna Izsvak, PhD, Stefania Galimberti, PhD, Maria Grazia Valsecchi, PhD, Giuseppe Dastoli, MD, Marta Serafini, PhD, Ettore Biagi, MD, Andrea Biondi, MD, Sarah Tettamanti, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2665.
https://doi.org/10.1182/blood-2019-130399
Published: 2019
Journal Articles

The IRE1-XBP1s Pathway Impairment Underpins NK Cell Dysfunction in Hodgkin Lymphoma, That Is Partly Restored By PD-1 Blockade

Free
Karolina Bednarska, Jay Gunawardana, PhD, Frank Vari, PhD, Qingyan Cui, PhD, Gayathri Thillaiyampalam, MSc, BSc, Samantha Stehbens, PhD, Sally Mujaj, PhD, Jamie Nourse, PhD, Alexandre Cristino, PhD, Maher K. Gandhi, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2795.
https://doi.org/10.1182/blood-2019-126372
Published: 2019
Journal Articles

Genome-Wide microRNA Expression Profiling in Molecular Subgroups of Peripheral T-Cell Lymphoma Identified Role of Mir-126 in T-Cell Lymphomagenesis

Free
Waseem Lone, PhD, Alyssa Bouska, PhD, Tyler Herek, BS,MS, Catalina Amador, MD, Mallick Saumyaranajn, MD, Yu Jiayu, Tayla Heavican, Stefano A. Pileri, MD PhD, Timothy McKeithan, MD PhD, Wing C. Chan, MD, Javeed Iqbal, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2767.
https://doi.org/10.1182/blood-2019-129327
Published: 2019
Journal Articles

A Signature of T Cell Exhaustion Is Enriched in the Bone Marrow (BM) of AML Patients and Shared with Immune Exhaustion Signatures of Solid Tumors

Free
Hanna A. Knaus, MD, Hubert Hackl, Amanda Blackford, Sofia Berglund, Raul Montiel-Esparza, Joshua F Zeidner, MD, Ivana Gojo, MD, Leo Luznik, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2711.
https://doi.org/10.1182/blood-2019-128742
Published: 2019
Journal Articles

Cold Plasma with Immunomodulatory Properties Has Significant Anti-Lymphoma Activities in Vitro and In Vivo

Free
Fengdong Cheng, MD, Dayun Yan, PhD, Jie Chen, PhD, Michael Keidar, PhD, Eduardo Sotomayor, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5307.
https://doi.org/10.1182/blood-2019-131065
Published: 2019
Journal Articles

High Mobility Group A1 Chromatin Regulators: Key Epigenetic Switches and Therapeutic Targets Required for Leukemic Transformation in JAK2 Mutant MPN

Free
Liping Li, MD PhD, Wenyan Lu, PhD, Alison R. Moliterno, MD, Lingling Xian, MD PhD, Joseph Kim, BS, Ophelia Rogers, Jerry L. Spivak, MD, Linda Resar, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1680.
https://doi.org/10.1182/blood-2019-130262
Published: 2019