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Journal Articles

Type I interferon is induced by hemolysis and drives antibody-mediated erythrophagocytosis in sickle cell disease

Yunfeng Liu, Mouli Pal, Weili Bao, Patricia A. Shi, Cheryl A. Lobo, Xiuli An, Deepa Manwani, Hui Zhong, Karina Yazdanbakhsh
Journal: Blood
Blood (2021) 138 (13): 1162–1171.
https://doi.org/10.1182/blood.2021011629
Published: 2021
Includes: Supplemental data
Journal Articles

The Neurotransmitter Receptor Gabbr1 Regulates Proliferation and Function of Hematopoietic Stem and Progenitor Cells

Adedamola Elujoba-Bridenstine, MS, Lijian Shao, MD PhD, Katherine Zink, Laura Sanchez, PhD, Brian Cox, PhD, Kostandin Pajcini, PhD, Owen J Tamplin, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3707.
https://doi.org/10.1182/blood-2019-130627
Published: 2019
Journal Articles

Novel ZBP1-IRF3 Dependency in Multiple Myeloma Mediated By IRF3-Driven Regulation of Cell Cycle Genes

Kanagaraju Ponnusamy, Maria-Myrsini Tzioni, MS, Murshida Begum, MS, Mark E Robinson, Valentina S Caputo, Alexia Katsarou, Nikolaos Trasanidis, Xiaolin Xiao, Ioannis V. Kostopoulos, Deena Iskander, MD, Irene Roberts, Pritesh Trivedi, MSc, Holger W Auner, MD PhD, Kikkeri Naresh, MD, Aristeidis Chaidos, Anastasios Karadimitris
Journal: Blood
Blood (2019) 134 (Supplement_1): 2521.
https://doi.org/10.1182/blood-2019-125768
Published: 2019
Journal Articles

Type I Interferon Signaling before Hematopoietic Stem Cell Transplantation Lowers Donor T Cell Activation Via Reduced Allogenicity of Recipient Cells

Erik Thiele Orberg, MD PhD, Julius Clemens Fischer, Sascha Göttert, Florian Bassermann, MD PhD, Hendrik Poeck, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4431.
https://doi.org/10.1182/blood-2019-128784
Published: 2019
Journal Articles

Type I Interferon Response Identified through Phenotypic and Transcriptional Profiling of Circulating Immune Cells during Idiopathic Multicentric Castleman Disease Flare

Ruth-Anne Langan, BA, Alberto Japp, PhD, Michael Gonzalez, PhD, Rozena Rasheed, BS, Sheila K Pierson, MS, Charlly Kao, PhD, Hakon Hakonarson, MD PhD, Frits van Rhee, MD PhD, Michael Betts, PhD, Taku Kambayashi, MD PhD, David C Fajgenbaum, MDMBA,MSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 1046.
https://doi.org/10.1182/blood-2019-128994
Published: 2019
Journal Articles

Azacytidine Inhibits Megakaryopoiesis Via the Induction of Immunogenic RNA Species and Activation of Type-I Interferon Signaling

Ujunwa Cynthia Okoye-Okafor, MS,PhD, Komal Kumar Javarappa, PhD, Dimitrios Tsallos, BSc(Hons),MSc, Joseph J Saad, MSc, BSc, Lumie Benard, Victor Thiruthuvanathan, M.S, Sally Cole, Madhuri Tatiparthy, M.S., Stephen Ruiz, B.Sc, Stefanie DeFronzo, Celine Pallaud, PhD, Pedro Marques Ramos, PhD, Amit Verma, MBBS, Aditi Shastri, MD, Caroline A Heckman, PhD, Britta Will, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1280.
https://doi.org/10.1182/blood-2019-131461
Published: 2019
Journal Articles

Sca-1 As a Marker of Stress-Induced Thrombopoiesis in Mice

Yosuke Morodomi, MD PhD, Roberto Aiolfi, PhD, Eric Won, MD, Sachiko Kanaji, MD PhD, Paul Schimmel, PhD, Zaverio M. Ruggeri, MD, Taisuke Kanaji, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1068.
https://doi.org/10.1182/blood-2019-127446
Published: 2019
Journal Articles

Pharmacologic Inhibition of SUMO-Activating Enzyme (SAE) with TAK-981 Augments Interferon Signaling and Regulates T Cell Differentiation in Ex Vivo studies of Chronic Lymphocytic Leukemia (CLL)

Vi Lam, Scott R Best, BS, Nur Bruss, BS, Tingting Liu, Taylor Hashiguchi Rowland, BS, Dennis Huszar, PhD, Alexey Danilov, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1760.
https://doi.org/10.1182/blood-2019-127539
Published: 2019
Journal Articles

Excessive R-Loops Trigger an Inflammatory Cascade Leading to Aberrant Hematopoietic Stem and Progenitor Cell Expansion

Joshua Weinreb, MSc, Varun Gupta, Teresa V. Bowman, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 772.
https://doi.org/10.1182/blood-2019-124888
Published: 2019
Journal Articles

A Phase 1b/2 Study of TAK-981, a First-in-Class Sumoylation Inhibitor, in Combination with Rituximab in Patients with Relapsed/Refractory (r/r) CD20-Positive Non-Hodgkin Lymphoma (NHL)

Sarit Assouline, MD, Amitkumar Mehta, MD, Paolo F Caimi, MD, Bingxia Wang, PhD, Chirag Patel, Mi-Sook Kim, Dennis Huszar, Allison J Berger, PhD, Sharon Friedlander, Alejandro Gomez-Pinillos, Igor Proscurshim
Journal: Blood
Blood (2019) 134 (Supplement_1): 1593.
https://doi.org/10.1182/blood-2019-128773
Published: 2019
Journal Articles

Oncogenic Cooperation between EGR1 and BRD4 in Diffuse Large B Cell Lymphoma

Lixin Rui, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1508.
https://doi.org/10.1182/blood-2019-124839
Published: 2019
Journal Articles

Plasmacytoid Dendritic Cell Proportion Is Predictive of Risk and Outcomes in Myelodysplastic Syndromes

Alexander Chan, MD, Yanming Zhang, MD, Sean M. Devlin, PhD, Natasha Lewis, MD, Jeeyeon Baik, Maria E Arcila, MD, Virginia M. Klimek, MD, Mikhail Roshal, MD PhD, Wenbin Xiao, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5439.
https://doi.org/10.1182/blood-2019-122332
Published: 2019
Journal Articles

High Frequencies of Mutated EZH2 and IRF8 and Other Epigenetic Genes in Primary Bone Lymphomas Are Indicative of GCB-Phenotype

Ruben A.L. De Groen, Ronald Van Eijk, Tom van Wezel, Richard Raghoo, Anne-Roos Schrader, MD, Patty M. Jansen, MD PhD, Inge briaire-De Bruijn, Karin Kleiverda, Tom Vlasveld, Valeska Terpstra, Henriette Levenga, Aline Nicolae, Ward Posthuma, MD PhD, Isabelle Focke-Snieders, Lizan Hardi, Wietske den Hartog, Anke Van Den Berg, PhD, Arjan Diepstra, Pieternella Lugtenburg, MD PhD, Marie José Kersten, MD PhD, Steven T Pals, MD PhD, Hendrik Veelken, MD PhD, Judith Bovée, Arjen Cleven, MD PhD MSc, Joost Vermaat, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1484.
https://doi.org/10.1182/blood-2019-129832
Published: 2019
Journal Articles

Indoles derived from intestinal microbiota act via type I interferon signaling to limit graft-versus-host disease

Alyson Swimm, Cynthia R. Giver, Zachariah DeFilipp, Sravanti Rangaraju, Akshay Sharma, Alina Ulezko Antonova, Robert Sonowal, Christopher Capaldo, Domonica Powell, Muna Qayed, Daniel Kalman, Edmund K. Waller
Journal: Blood
Blood (2018) 132 (23): 2506–2519.
https://doi.org/10.1182/blood-2018-03-838193
Published: 2018
Includes: Supplemental data
Journal Articles

Gene Set Enrichment Analysis Suggests That Increased Rituximab-Mediated NK Cell Cytotoxicity after Vitamin D Substitution Is Driven By Upregulation of Interferon Alpha (IFN-a) Isoforms

Konstantinos Christofyllakis, MD, Frank Neumann, PhD, Stephan Stilgenbauer, Dominic Kaddu-Mulindwa, MD, Evi Regitz, Moritz Bewarder, MD, Andreas Keller, PhD MSc, Jörg Thomas Bittenbring, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3696.
https://doi.org/10.1182/blood-2018-99-111817
Published: 2018
Journal Articles

Therapeutic Targeting of the Ubiquitin Conjugating Enzyme UBE2N in Myeloid Malignancies

Laura Barreyro, PhD, Avery Sampson, BSc, Kathleen Hueneman, BSc, Lyndsey C Bolanos, BSc, Mario Pujato, PhD, Somchai Chutipongtanate, MD PhD, Michael Wyder, MS, Wendy Haffey, PhD, Kwangmin Choi, PhD, Yaseswini Neelamraju, MS, Molly A Smith, BSc, Madeline Niederkorn, BSc, Vighnesh Ramesh, Tomoya Muto, MD PhD, Eric O'Brien, BSc, Cem Meydan, PhD, Susanne Christie, BSc, Xiaona Liu, Francine Garret-Bakelman, MD PhD, Boris Bartholdy, PhD, Britta Will, PhD, Matthew T. Weirauch, PhD, Zartash Gul, MD, Stephen Medlin, MD, John Peter Perentesis, MD, Kenneth D Greis, PhD, William Seibel, PhD, Daniel T. Starczynowski, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4050.
https://doi.org/10.1182/blood-2018-99-115359
Published: 2018
Journal Articles

The Role of LAMP5 in Innate Immune Signaling Is Critical for the Survival of MLL Leukemias

Gabriel Gracia-Maldonado, BS, Jason Clark, MS, Philippe Pierre, PhD, James C. Mulloy, PhD, Ashish R Kumar, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3900.
https://doi.org/10.1182/blood-2018-99-120190
Published: 2018
Journal Articles

Arsenic Trioxide Induces Apoptosis and Regulatory Functions of Plasmacytoid Dendritic Cells

Yishan Ye, MD, Laure Ricard, MD, Nicolas Stocker, MD, Baptiste Lamarthée, PhD, Frédéric De Vassoigne, Eolia Brissot, MDPhD, Arsène Mekinian, MDPhD, Mohamad Mohty, MD PhD, Béatrice Gaugler, PhD, Florent Malard, MDPhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 514.
https://doi.org/10.1182/blood-2018-99-110717
Published: 2018
Journal Articles

MYC Functions As a Master Switch for Natural Killer Cell-Mediated Immune Surveillance of Lymphoid Malignancies

Srividya Swaminathan, PhD, Line Dam Heftdal, MS, Daniel F Liefwalker, PhD, Renumathy Dhanasekaran, MD, Anja Deutzmann, PhD, Crista Horton, BS, Adriane Mosley, BS, Mariola Liebersbach, BS, Holden T. Maecker, PhD, Dean Felsher, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2619.
https://doi.org/10.1182/blood-2018-99-110472
Published: 2018
Journal Articles

Proteomic Landscape of Neutrophils in Sickle Cell Anemia: An Unexpected Autoimmune Profile

Patricia Hermand-Tournamille, PhD, Slim Azouzi, PhD, Virginie Salnot, PhD, Emilie Fleur Gautier, PhD, Patrick Mayeux, PhD, Yves Colin, PhD, Vincent Bondet, PhD, Darragh Duffy, PhD, Pierre Louis Tharaux, MD PhD, Caroline Le Va Kim, Bérengère Koehl, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2357.
https://doi.org/10.1182/blood-2018-99-110806
Published: 2018