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Journal Articles

Strategy for Overcoming Crebbp and EP300 Mutations in Lymphoma: Development of First-in-Class HAT Activators

Yuxuan Liu, PhD, Jole Fiorito, PhD, Yulissa Gonzalez, Brian Estrella, PhD, Elisa Calcagno, PhD, Elisa Zuccarello, PhD, Howook Hwang, PhD, Barry Honig, PhD, Shixian Deng, PhD, Donald Landry, MD PhD, Owen A. O'Connor, MD PhD, Ottavio Arancio, PhD, Jennifer E Amengual, MD

Blood (2019) 134 (Supplement_1): 4068.

https://doi.org/10.1182/blood-2019-125983

Published: 2019

Journal Articles

PRMT5 Is a Key Epigenetic Regulator That Promotes Transcriptional Activation in Mantle Cell Lymphoma By Regulating the Lysine Methyltransferase SETD7 and MLL1 Activity

JI Hyun Chung, PhD, Shelby Sloan, BS, Peggy Scherle, PhD, Kris Vaddi, PhD, Said Sif, PhD, Rosa Lapalombella, PhD, Robert A Baiocchi, MD PhD

Blood (2019) 134 (Supplement_1): 2777.

https://doi.org/10.1182/blood-2019-131020

Published: 2019

Journal Articles

Conventional Chemotherapy Treatment Induces Unique Patterns of Clonal Evolution in a North American Adult T Cell Leukemia/Lymphoma Cohort

Blood (2019) 134 (Supplement_1): 1551.

https://doi.org/10.1182/blood-2019-131107

Published: 2019

Journal Articles

Novel Therapeutic Rationale for Targeting HDAC1 and PIM2 in Multiple Myeloma

Takeshi Harada, MD PhD, Asuka Oda, Hiroto Ohguchi, MD PhD, Yohann Grondin, PhD, Hirofumi Tenshin, DDS, PhD, Masahiro Hiasa, DDS, PhD, Jumpei Teramachi, Masahiro Oura, MD, Kimiko Sogabe, MD, Shiro Fujii, MD PhD, Shingen Nakamura, MD PhD, Hirokazu Miki, MD PhD, Kumiko Kagawa, MD PhD, Shuji Ozaki, MD PhD, Teru Hideshima, MD PhD, Kenneth C. Anderson, MD, Masahiro Abe, MD PhD

Blood (2019) 134 (Supplement_1): 3111.

https://doi.org/10.1182/blood-2019-127679

Published: 2019

Journal Articles

Modulation of TET2 Activity By Ascorbic Acid and Factors Affecting Lysine Acetylation

Blood (2018) 132 (Supplement 1): 4346.

https://doi.org/10.1182/blood-2018-99-119712

Published: 2018

Journal Articles

Development of First-in-Class Histone Acetyltransferase (HAT) Activators for Precision Targeting of Epigenetic Derangements in Lymphoma

Yuxuan Liu, PhD, Jole Fiorito, PhD, Yulissa Gonzalez, Elisa Zuccarello, PhD, Elisa Calcagno, Adolfo Mazzeo, Nebiyu Ali Abshiru, PhD, Jeannie Camarillo, PhD, Neil L Kelleher, PhD, Changhong Qiao, Renu Nandakumar, PhD, Cremers Serge, PhD PharmD, Shixian Deng, PhD, Donald Landry, MD PhD, Owen A. O'Connor, MD, PhD, Ottavio Arancio, PhD, Jennifer E Amengual, MD

Blood (2018) 132 (Supplement 1): 37.

https://doi.org/10.1182/blood-2018-99-110447

Published: 2018

Journal Articles

A Case-Control Study to Compare the Survival Benefits of Patients Who Suffer from Peripheral T-Cell Lymphoma (PTCL) Treated with Chidamide, a Histone Deacetylase Inhibitor, in China with a Historical Matched Cohort of Patients Treated with Conventional Therapy in Taiwan: Survival Advantage Is Demonstrated

Bor-Sheng Ko, MD PhD, Su-Peng Yeh, MD, Hsiao-Wen Kao, MD, Yuan-Bin Yu, MD, Shyh-Tyan Ou, PhD, Cheng-Shyong Chang, MD

Blood (2018) 132 (Supplement 1): 5367.

https://doi.org/10.1182/blood-2018-99-114738

Published: 2018

Journal Articles

Targeting Histone Acetyltransferase Gene Inactivation in Diffuse Large B Cell Lymphoma

Stefanie Meyer, PhD, Sofija Vlasevska, Laura Garcia Ibanez, PhD, Claudio Scuoppo, PhD, Riccardo Dalla-Favera, MD, Laura Pasqualucci, MD

Blood (2018) 132 (Supplement 1): 671.

https://doi.org/10.1182/blood-2018-99-117542

Published: 2018

Journal Articles

Epigenetic Regulation and Therapeutic Targeting in Myeloma

Jonathan D. Licht, MD

Blood (2018) 132 (Supplement 1): SCI-37.

https://doi.org/10.1182/blood-2018-99-109522

Published: 2018

Journal Articles

Nucleosome Binding Protein HMGN1 Promotes HSPC Competitive Advantage with Decreased Quiescence and Cooperates with AML Oncogenes to Block Differentiation and Increase Clonogenicity

Lucia Cabal-Hierro, PhD, Katsuhiro Togami, MD PhD, Kelly Higby, Andrew A. Lane, MD PhD

Blood (2018) 132 (Supplement 1): 2606.

https://doi.org/10.1182/blood-2018-99-119348

Published: 2018

Journal Articles

NUTM1 Is a Rare but Recurrent Fusion Gene Partner in B Cell Precursor Acute Lymphoblastic Leukemia Associated with Increased Expression of Genes on Cytoband 10p12.31

Femke M. Hormann, MSc, Alex Q. Hoogkamer, BSc, H. Berna Beverloo, PhD, Aurélie Boeree, BSc, Ronald W. Stam, PhD, Gabriele Escherich, Rob Pieters, MD PhD MSc, Monique L. Den Boer, PhD, Judith M. Boer, PhD

Blood (2018) 132 (Supplement 1): 2823.

https://doi.org/10.1182/blood-2018-99-112480

Published: 2018

Journal Articles

Loss of KDM6A/UTX Accelerate the Development of Multiple Myeloma

Daphne Dupere-Richer, PhD, Jianping Li, MD, Sayantan Maji, PhD, Crissandra Pipe, LATG, Sharon Norton, MS, Teresa Ezponda, PhD, Richard Lynn Bennett, PhD, Jonathan D. Licht, MD

Blood (2018) 132 (Supplement 1): 1004.

https://doi.org/10.1182/blood-2018-99-113835

Published: 2018

Journal Articles

CREBBP Histone Acetyltransferase Domain Mutations Result in Dexamethasone Resistance in B-Progenitor Acute Lymphoblastic Leukemia

Yunchao Chang, PhD, David W. Woessner, PhD MS, Wenwei Lin, PhD, Taosheng Chen, PhD, Beisi Xu, PhD, Yiping Fan, PhD, Haiyan Tan, PhD, Junmin Peng, PhD, Lawryn Kasper, PhD, Michelle L. Churchman, PhD, Mignon L. Loh, MD, Stephen P. Hunger, MD, Aman Seth, PhD, Karen Gascoigne, PhD, Paul K Brindle, PhD, Charles G. Mullighan, MBBS, MD

Blood (2017) 130 (Supplement 1): 560.

https://doi.org/10.1182/blood.V130.Suppl_1.560.560

Published: 2017

Journal Articles

MLL3 Deletion Enhances HSC Self-Renewal

Theresa O. Owuor, PhD, Shaina N. Porter, PhD, Andrew Cluster, MD, Jiyeon Ryoo, BS, Riddhi Patel, BS, Jeffrey A. Magee, MDPhD

Blood (2017) 130 (Supplement 1): 3756.

https://doi.org/10.1182/blood.V130.Suppl_1.3756.3756

Published: 2017

Journal Articles

ETO2 Regulates Cell-Fate Genes and Controls Relapse in Acute Myeloid Leukemia

Nickolas Steinauer, BA, Chun Guo, MS, Chunfa Huang, PhD, Yifan Tu, MD PhD, Carl E. Freter, MD PhD, Jinsong Zhang, PhD MS

Blood (2017) 130 (Supplement 1): 3808.

https://doi.org/10.1182/blood.V130.Suppl_1.3808.3808

Published: 2017

Journal Articles

Combined Treatment with JQ1 and Curcumin Synergically Modulates Apoptosis, Cell Cycle Features, Micrornas and Gene Expression in High-Risk Pediatric Acute Myeloid Leukemia (AML)

Patrizia Vitullo, PhD, Pier Paolo Leoncini, PhD, Valeria Tocco, Angela Pitisci, Daniela Montagna, Pigazzi Martina, PhD, Paolo Fadda, Pharm D, Dario Veneziano, PhD, Giovanni Nigita, PhD, Mario Scarpa, MS, Katia D'Ovidio, Rossella Rota, PhD, Alice Bertaina, MD PhD

Blood (2017) 130 (Supplement 1): 2698.

https://doi.org/10.1182/blood.V130.Suppl_1.2698.2698

Published: 2017

Journal Articles

North American Adult T Cell Leukemia Lymphoma (ATLL) Is Characterized By Distinct, Therapeutically Targetable Mutations in Epigenetic Modifiers

Blood (2017) 130 (Supplement 1): 1455.

https://doi.org/10.1182/blood.V130.Suppl_1.1455.1455

Published: 2017

Journal Articles

Somatic Variants Associated with MDS/AML Are Present in MYD88 Mutated Waldenstrom's Macroglobulinemia

Gloria Chan, MS, Joshua Gustine, Nickolas Tsakmaklis, BA, Lian Xu, Amanda Kofides, BS, Maria Demos, BS, Steven P Treon, MDPhDFRCP, Zachary Hunter, PhD

Blood (2017) 130 (Supplement 1): 4983.

https://doi.org/10.1182/blood.V130.Suppl_1.4983.4983

Published: 2017

Journal Articles

Molecular Insights at the Single Cell Level into the Reprogramming of Human Hematopoietic Stem Cells during Epigenetically Modified Ex Vivo Expansion

Peng Hua, PhD, Barbara Kronsteiner, PhD, Neil Ashley, PhD, Mark van der Garde, PhD, Diana Hernandez, PhD, Marina Tarunina, PhD, Lilian Hook, PhD, Yen Choo, PhD, Irene Roberts, MD, Adam J Mead, MD PhD, Suzanne M Watt, PhDFRCPath

Blood (2017) 130 (Supplement 1): 2425.

https://doi.org/10.1182/blood.V130.Suppl_1.2425.2425

Published: 2017

Journal Articles

Targeted Therapy for AML Expressing RUNX1 Mutation

Christopher Peter Mill, PhD BA, Warren Fiskus, BSc,PhD, Courtney D. DiNardo, MDMSc, Yimin Qian, PhD, Kanak Raina, PhD, Koichi Takahashi, MD, Tapan Kadia, MD, Dyana T. Saenz, PhD, Agnieszka J Nowak, Baohua Sun, MD PhD, Craig M Crews, PhD, Kapil N. Bhalla, MD

Blood (2017) 130 (Supplement 1): 2472.

https://doi.org/10.1182/blood.V130.Suppl_1.2472.2472

Published: 2017

NARROW

Strategy for Overcoming Crebbp and EP300 Mutations in Lymphoma: Development of First-in-Class HAT Activators

PRMT5 Is a Key Epigenetic Regulator That Promotes Transcriptional Activation in Mantle Cell Lymphoma By Regulating the Lysine Methyltransferase SETD7 and MLL1 Activity

Conventional Chemotherapy Treatment Induces Unique Patterns of Clonal Evolution in a North American Adult T Cell Leukemia/Lymphoma Cohort

Novel Therapeutic Rationale for Targeting HDAC1 and PIM2 in Multiple Myeloma

Modulation of TET2 Activity By Ascorbic Acid and Factors Affecting Lysine Acetylation

Development of First-in-Class Histone Acetyltransferase (HAT) Activators for Precision Targeting of Epigenetic Derangements in Lymphoma

Targeting Histone Acetyltransferase Gene Inactivation in Diffuse Large B Cell Lymphoma

Epigenetic Regulation and Therapeutic Targeting in Myeloma

Nucleosome Binding Protein HMGN1 Promotes HSPC Competitive Advantage with Decreased Quiescence and Cooperates with AML Oncogenes to Block Differentiation and Increase Clonogenicity

NUTM1 Is a Rare but Recurrent Fusion Gene Partner in B Cell Precursor Acute Lymphoblastic Leukemia Associated with Increased Expression of Genes on Cytoband 10p12.31

Loss of KDM6A/UTX Accelerate the Development of Multiple Myeloma

CREBBP Histone Acetyltransferase Domain Mutations Result in Dexamethasone Resistance in B-Progenitor Acute Lymphoblastic Leukemia

MLL3 Deletion Enhances HSC Self-Renewal

ETO2 Regulates Cell-Fate Genes and Controls Relapse in Acute Myeloid Leukemia

Combined Treatment with JQ1 and Curcumin Synergically Modulates Apoptosis, Cell Cycle Features, Micrornas and Gene Expression in High-Risk Pediatric Acute Myeloid Leukemia (AML)

North American Adult T Cell Leukemia Lymphoma (ATLL) Is Characterized By Distinct, Therapeutically Targetable Mutations in Epigenetic Modifiers

Somatic Variants Associated with MDS/AML Are Present in MYD88 Mutated Waldenstrom's Macroglobulinemia

Molecular Insights at the Single Cell Level into the Reprogramming of Human Hematopoietic Stem Cells during Epigenetically Modified Ex Vivo Expansion

Targeted Therapy for AML Expressing RUNX1 Mutation

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American Society of Hematology

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ASH Publications

American Society of Hematology

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