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Journal Articles

FXII inhibition: multipronged benefits

Helen Philippou
Journal: Blood
Blood (2021) 138 (2): 107–109.
https://doi.org/10.1182/blood.2021011032
Published: 2021
Journal Articles

Tolerogenic anti–IL-2 mAb prevents graft-versus-host disease while preserving strong graft-versus-leukemia activity

Qingxiao Song, Xiaoning Wang, Xiwei Wu, Hanjun Qin, Yingfei Li, Arthur D. Riggs, Paul J. Martin, Yuan-Zhong Chen, Defu Zeng
Journal: Blood
Blood (2021) 137 (16): 2243–2255.
https://doi.org/10.1182/blood.2020006345
Published: 2021
Includes: Supplemental data
Journal Articles

Phase 1 study of lenzilumab, a recombinant anti–human GM-CSF antibody, for chronic myelomonocytic leukemia

Clinical Trials & Observations
Mrinal M. Patnaik, David A. Sallman, Abhishek A. Mangaonkar, Rachel Heuer, Jeffery Hirvela, Darci Zblewski, Aref Al-Kali, Moritz Binder, Maria E. Balasis, Hannah Newman, Christopher Letson, Traci L. Kruer, Naseema Gangat, Rami S. Komrokji, Ayalew Tefferi, Adrian Lo, Ted Shih, Cameron Durrant, Alan F. List, Eric Padron
Journal: Blood
Blood (2020) 136 (7): 909–913.
https://doi.org/10.1182/blood.2019004352
Published: 2020
Includes: Supplemental data
Journal Articles

Pathogenic Bhlhe40 + GM-CSF + CD4 + T cells promote indirect alloantigen presentation in the GI tract during GVHD

Clint Piper, Vivian Zhou, Richard Komorowski, Aniko Szabo, Benjamin Vincent, Jonathan Serody, Maria-Luisa Alegre, Brian T. Edelson, Reshma Taneja, William R. Drobyski
Journal: Blood
Blood (2020) 135 (8): 568–581.
https://doi.org/10.1182/blood.2019001696
Published: 2020
Includes: Supplemental data
Journal Articles

A new role for an old cytokine: GM-CSF amplifies GVHD

Edmund K. Waller
Journal: Blood
Blood (2020) 135 (8): 520–521.
https://doi.org/10.1182/blood.2019004681
Published: 2020
Journal Articles

JAK2 ex13InDel drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera

Ami B. Patel, Anca Franzini, Emilie Leroy, Soo Jin Kim, Anthony D. Pomicter, Lidvine Genet, Michael Xiao, Dongqing Yan, Jonathan M. Ahmann, Archana M. Agarwal, Phillip Clair, Juanah Addada, Jonathan Lambert, Matthew Salmon, Gerald J. Gleich, Nicholas C. P. Cross, Stefan N. Constantinescu, Thomas O’Hare, Josef T. Prchal, Michael W. Deininger
Journal: Blood
Blood (2019) 134 (26): 2388–2398.
https://doi.org/10.1182/blood.2019001385
Published: 2019
Includes: Supplemental data
Journal Articles

Sickle Cell Hemoglobin Impairs Lysosomal Processing in Macrophages Leading to Inflammasome Activation and Inflammation

Marina Jerebtsova, PhD, Xiaomei Niu, MD, Sharmin Diaz, NP, Namita Kumari, PhD, Sergei Nekhai, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 979.
https://doi.org/10.1182/blood-2019-130741
Published: 2019
Journal Articles

Dysregulated IL-6/GP130/JAK Signaling in Calreticulin Mutated Myeloproliferative Neoplasms (MPN)

Manjola Balliu, PhD, Laura Calabresi, PhD, Niccolò Bartalucci, PhDBSc, Laura Maggi, PhD, Francesco Annunziato, PhD, Paola Guglielmelli, MD PhD, Alessandro M. Vannucchi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 471.
https://doi.org/10.1182/blood-2019-123685
Published: 2019
Journal Articles

PRMT5 Inhibition Modulates E2F1 Methylation and Gene Regulatory Networks Leading to Therapeutic Efficacy in JAK2VF Mutant MPN

Friederike Pastore, MD, Neha Bhagwat, PhDBS, Aishwarya Krishnan, Alessandro Pastore, Bing Li, MD, Robert L Bowman, PhD, Wenbin Xiao, MD PhD, Aaron D Viny, MDMS, Abdul Karzai, Anouar Zouak, Young C Park, Keith Cordner, Stephanie Braunstein, Alexander Grego, Jaanvi Mehta, Benjamin H Durham, MD, Richard P. Koche, PhD, Jesper Maag, Peggy Scherle, PhD, Kris Vaddi, PhD, Ross L. Levine, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 473.
https://doi.org/10.1182/blood-2019-127122
Published: 2019
Journal Articles

Response to High Dose G-CSF Treatment (20µg/kg/d or Higher) of Patients with Congenital Neutropenia: An Analysis By the Scnir in Europe

Cornelia Zeidler, Natali Gerschmann, Sabine Mellor-Heineke, Fabian Frömling, Julia Skokowa, MD PhD, Karl Welte
Journal: Blood
Blood (2019) 134 (Supplement_1): 1225.
https://doi.org/10.1182/blood-2019-129844
Published: 2019
Journal Articles

Phase I Clinical Trial of CK0801 (cord blood regulatory T cells) in Patients with Bone Marrow Failure Syndrome (BMF) Including Aplastic Anemia, Myelodysplasia and Myelofibrosis

Tapan M. Kadia, MD, Hongbing Ma, MD PhD, Ke Zeng, MD PhD, Mitsutaka Nishimoto, MD PhD, Mi-Ae Lyu, PhD, Meixian Huang, Musa Yilmaz, MD, Courtney D. DiNardo, MDMSc, Ghayas C. Issa, MD, Simrit Parmar, MBBS, Swami P. Iyer, MD, Parameswaran Hari, MBBS, MD, Naval G. Daver, MD, Elias Jabbour, MD, Gautam M. Borthakur, MD, Srdan Verstovsek, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1221.
https://doi.org/10.1182/blood-2019-127702
Published: 2019
Journal Articles

Growth Factor-Dependent Activation of a MYC-Induced Latent AML Program in Human Hematopoietic Cells

Elizabeth Bulaeva, Davide Pellacani, PhD, Naoto Nakamichi, MD PhD, Philip Beer, MD PhD, Colin Hammond, Alireza Lorzadeh, Michelle Moksa, Annaick Carles, Misha Bilenky, Sylvain Lefort, PhD, Jeremy Shu, Brian T. Wilhelm, PhDBSc, Andrew P. Weng, MD PhD, Martin Hirst, PhD, Connie J. Eaves, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2533.
https://doi.org/10.1182/blood-2019-122768
Published: 2019
Journal Articles

Single Cell Signaling Responses Stratify Immune and Leukemia Cell Populations in Acute Myeloid Leukemia

Kathryn I Sunthankar, MD, Benjamin J Reisman, BS, Candace H Cote, BS, Paul Brent Ferrell, Jr., MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2680.
https://doi.org/10.1182/blood-2019-129602
Published: 2019
Journal Articles

Gene Expression and Cytokine Analyses Identify Markers of Progression from CLL-like Monoclonal B-Cell Lymphocytosis to Chronic Lymphocytic Leukemia

Gonzalo Blanco, PhD, Anna Puiggros, PhD, Barbara Sherry, PhD, Lara Nonell, Eulalia Puigdecanet, Pui Yan Chiu, Yasmine Kieso, MSCR, Gerardo Ferrer, PhD, Magdalena Arnal, María Rodríguez-Rivera, Eva Gimeno, MD PhD, Eugenia Abella, Kanti R Rai, MD, Pau Abrisqueta, MD PhD, Xavier Calvo, MD PhD, Francesc Bosch, MD PhD, Ana Ferrer, MD PhD, Nicholas Chiorazzi, MD, Blanca Espinet, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3027.
https://doi.org/10.1182/blood-2019-122038
Published: 2019
Journal Articles

Relative Depletion of Soluble Interleukin 6 Receptors Abolished the Development of Cytokine Release Syndrome after CART19/22 and Lenalidomide Treatment for Lymphoma

Caixia Li, Changfeng Zhang, PhD, Xiaochen Chen, Ying Zhang, Jia Chen, MD, Liqing Kang, Xiaoyan Lou, Jin Zhou, Xiangping Zong, Zhen Yang, Jiaqi Li, Wei Qi, Lei Yu, Depei Wu, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5313.
https://doi.org/10.1182/blood-2019-126821
Published: 2019
Journal Articles

Dynamic Analysis of Cytokine Profile for Cytokine Release Syndrome in Multiple Myeloma Patients after CAR-T Cell Therapy

Shuangshuang Yang, MD, Lijuan Chen, MD PhD, Jie Xu, MD PhD, Frank Xiao-Hu Fan, MD PhD, Sun Yan, PhD, Wen Wu, MD PhD, Yan Wang, MD, Jin Wang, MD PhD, Shiwei Jin, MD, Yuebo Zhou, Yuanfang Liu, MD PhD, Yan Zhuang, PhD, Wu Zhang, PhD, Jun-Min Li, Jian Hou, PhD MD, Jian-Yong Li, MD PhD, Zhu Chen, PhD, Jian-Qing Mi, MD PhD, Sai-Juan Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5617.
https://doi.org/10.1182/blood-2019-131799
Published: 2019
Journal Articles

High-Throughput RNA Sequencing Analysis Reveals Distinct Molecular Signature in NRAS and PTPN11 JMML Patients

Pier Paolo Leoncini, PhD, Alessandro Domenico Silvestris, PhD, Patrizia Vitullo, PhD, Marco Zecca, MD, Christian Flotho, MD PhD, Charlotte M. Niemeyer, MD, Angela Gallo, PhD, Alice Bertaina, MD PhD, Franco Locatelli, MD PhD, Pietro Merli, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4229.
https://doi.org/10.1182/blood-2019-129965
Published: 2019
Journal Articles

A Phase 1 Study of Lenzilumab, a humaneered recombinant Anti-Human Granulocyte-Macrophage Colony- Stimulating Factor (anti-hGM-CSF) Antibody, for Chronic Myelomonocytic Leukemia (CMML)

Mrinal M Patnaik, MDMBBS, David A Sallman, MD, Abhishek A Mangaonkar, MBBS, Rachel Heuer, Jeffery Hirvela, Darci Zblewski, APRN, C-NP, Aref Al-Kali, MD, Deanna Kanne, Rahil Ismail, Rami S. Komrokji, MD, Adrian Lo, Maria E Balasis, Cameron Durrant, Dale Chappell, Omar Ahmed, Alan F. List, MD, Eric Padron, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4234.
https://doi.org/10.1182/blood-2019-131181
Published: 2019
Journal Articles

Phenotypic Characterization of Leukemia-Initiating Stem Cells in Chronic Myelomonocytic Leukemia (CMML)

Gregor Eisenwort, MD PhD, Alexandra Keller, Michael Willmann, Irina Sadovnik, Greiner Georg, MD PhD, Karoline V. Gleixner, MD, Daniel Ivanov, MSc, Daniela Berger, Gabriele Stefanzl, Christiana Winding, DVM, Gregor Hoermann, Wolfgang R. Sperr, MD, Heinz Sill, MD, Peter Bettelheim, MD, Klaus Geissler, MD, Michael W. Deininger, Thomas Rülicke, Peter Valent, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4223.
https://doi.org/10.1182/blood-2019-122530
Published: 2019
Journal Articles

Allogeneic Anti-Bcma CAR-T Cells Show Tumour Specific Killing Against Primary Multiple Myeloma Cells from Different Genomic Sub-Groups

Ana M Metelo, PhD, Ieuan Walker, BSc, MSc, MBBS, Agnieszka Jozwik, PhD, Charlotte Graham, MRCP, BSc, MBBS, Charlotte Attwood, BMedSci, MBBS, MRCP, FRCPath, Katy Sanchez, BSc, MSc, Alan Dunlop, BSc, MSc, Kirsty Cuthill, FRCPath,MBBS,MRCP,PhD, Carmel Rice, FRACP, FRCPA, MBBS, Matthew Streetly, MD, Trevor Bentley, BSc, Bijan Boldajipour, PhD, Cesar Sommer, PhD, Barbra Sasu, PhD, Reuben Benjamin, FRCPath, MRCP, MBBS, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1834.
https://doi.org/10.1182/blood-2019-124312
Published: 2019