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Journal Articles

The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis

Manasa K. Nayak, Madankumar Ghatge, Gagan D. Flora, Nirav Dhanesha, Manish Jain, Kathleen R. Markan, Matthew J. Potthoff, Steven R. Lentz, Anil K. Chauhan

Blood (2021) 137 (12): 1658–1668.

DOI: https://doi.org/10.1182/blood.2020007140

Published: 2021

Includes: Supplemental data

Journal Articles

Donor cell engineering with GSK3 inhibitor–loaded nanoparticles enhances engraftment after in utero transplantation

Stavros P. Loukogeorgakis, Camila G. Fachin, Andre I. B. S. Dias, Haiying Li, Li Tang, Aimee G. Kim, Jesse D. Vrecenak, John D. Stratigis, Nicholas J. Ahn, Ilana Nissim, Izhtak Nissim, Antonio F. Moron, Jose L. Martins, William H. Peranteau, Paolo De Coppi, Darrell J. Irvine, Alan W. Flake

Blood (2019) 134 (22): 1983–1995.

DOI: https://doi.org/10.1182/blood.2019001037

Published: 2019

Includes: Supplemental data

Journal Articles

Combined Inhibition of HDAC and AKT As a Strategy to Overcome Multi-Drug Resistance in Patients with Multiple Myeloma

Mitsuhito Hirano, MD, Yoichi Imai, MD PhD, Takahiko Murayama, PhD, Kota Sato, MD PhD, Junichi Yamamoto, PhD, Takumi Ito, PhD, Muneyoshi Futami, MD PhD, Masaki Ri, Hiroshi Yasui, MD PhD, Noriko Gotoh, MD, Shinsuke Iida, MD PhD, Tadao Ishida, MD PhD, Hiroshi Handa, MD PhD, Arinobu Tojo, MD PhD

Blood (2019) 134 (Supplement_1): 4325.

DOI: https://doi.org/10.1182/blood-2019-122662

Published: 2019

Journal Articles

Inducible Phase Separation of GSK3α As a Mechanism for Asparaginase Resistance in Acute Leukemias

Laura Hinze, Sabine Schreek, Andre Zeug, PhD, Evgeni Ponimaskin, PhD, Roxane Labrosse, MD FRCPC, James Degar, Gabriela Chiosis, PhD, Sung-Yun Pai, MD, Kristen E. Stevenson, MS, Donna S Neuberg, ScD, Beat Bornhauser, PhD, Jean-Pierre Bourquin, MD PhD, Martin Stanulla, MD, Alejandro Gutierrez, MD

Blood (2019) 134 (Supplement_1): 169.

DOI: https://doi.org/10.1182/blood-2019-126633

Published: 2019

Journal Articles

Targeting GSK3: beyond the mitotic spindle?

C. Steidl

Blood (2019) 134 (4): 333–334.

DOI: https://doi.org/10.1182/blood.2019001638

Published: 2019

Journal Articles

Targeting glycogen synthase kinase 3 for therapeutic benefit in lymphoma

Xiaosheng Wu, Mary Stenson, Jithma Abeykoon, Kevin Nowakowski, Lianwen Zhang, Joshua Lawson, Linda Wellik, Ying Li, Jordan Krull, Kerstin Wenzl, Anne J. Novak, Stephen M. Ansell, Gail A. Bishop, Daniel D. Billadeau, Kah Whye Peng, Francis Giles, Daniel M. Schmitt, Thomas E. Witzig

Blood (2019) 134 (4): 363–373.

DOI: https://doi.org/10.1182/blood.2018874560

Published: 2019

Includes: Supplemental data

Journal Articles

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

Laura Hinze, Maren Pfirrmann, Salmaan Karim, James Degar, Connor McGuckin, Divya Vinjamur, PhD, Sacher Joshua, Kristen E. Stevenson, MS, Donna S Neuberg, ScD, Daniel E. Bauer, MD PhD, Florence Wagner, PhD, Kimberly Stegmaier, MD, Alejandro Gutierrez, MD

Blood (2018) 132 (Supplement 1): 891.

DOI: https://doi.org/10.1182/blood-2018-99-113794

Published: 2018

Journal Articles

Haploinsufficiency for NR3C1 Drives Glucocorticoid Resistance By Inactivation the PI3K/AKT/GSK3β/Bim Pathway in Adult Acute Lymphoblastic Leukemia

Xiao Haowen, MD PhD, Yingying Ding, Yang Gao, Limengmeng Wang, PhD, Huafang Wang, Xiaohong Yu, He Huang, MD PhD

Blood (2018) 132 (Supplement 1): 1328.

DOI: https://doi.org/10.1182/blood-2018-99-120089

Published: 2018

Journal Articles

FBXW7 Is Critical for B1 Cell Maintenance and Function

Parham Ramezani-Rad, PhD, Charlotte R Leung, MS, John R Apgar, PhD, Robert C Rickert, PhD

Blood (2018) 132 (Supplement 1): 2565.

DOI: https://doi.org/10.1182/blood-2018-99-120387

Published: 2018

Journal Articles

Changes in Subcellular Localization of GSK3β As a Novel Driver of AML

James ignatz-Hoover, Isaac Ghansah, Masumi Ueda, MD, Victoria Wang, Hillard M Lazarus, MD, Marcos de Lima, MD, David Wald, PhD MD

Blood (2017) 130 (Supplement 1): 1226.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1226.1226

Published: 2017

Journal Articles

Creatine Kinase Pathway Inhibition Alters GSK3 and WNT Signaling in EVI1-Positive Acute Myeloid Leukemia

Lina Benajiba, Gabriela Alexe, Olivier Hermine, MD PhD, Michael Hemann, Alexandre Puissant, Kimberly Stegmaier, MD

Blood (2017) 130 (Supplement 1): 1191.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1191.1191

Published: 2017

Journal Articles

Targeted Therapy with BET Protein and β Catenin Antagonists Against Ruxolitinib Resistant Post-Myeloproliferative Neoplasm (MPN) Secondary (s) AML Cells

Dyana T. Saenz, PhD, Warren Fiskus, BSc,PhD, Taghi Manshouri, Yimin Qian, PhD, Kanak Raina, PhD, David N Saenz, Christopher Peter Mill, PhD BA, Agnieszka J Nowak, Baohua Sun, MD PhD, Srdan Verstovsek, MD PhD, Craig M Crews, PhD, Kapil N. Bhalla, MD

Blood (2017) 130 (Supplement 1): 1239.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1239.1239

Published: 2017

Journal Articles

Exploiting an Asp-Glu "Switch" in Glycogen Synthase Kinase 3 to Design Paralog Selective Inhibitors for Acute Myeloid Leukemia Treatment

Blood (2017) 130 (Supplement 1): 2075.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.2075.2075

Published: 2017

Journal Articles

MAF protein mediates innate resistance to proteasome inhibition therapy in multiple myeloma

Ya-Wei Qiang, Shiqiao Ye, Yu Chen, Amy F. Buros, Ricky Edmonson, Frits van Rhee, Bart Barlogie, Joshua Epstein, Gareth J. Morgan, Faith E. Davies

Blood (2016) 128 (25): 2919–2930.

DOI: https://doi.org/10.1182/blood-2016-03-706077

Published: 2016

Includes: Supplemental data

Journal Articles

Inhibition of GSK-3 Signalling Enhances Sensitivity of Non-Promyelocitic Acute Myeloid Leukemia (AML) Cell to Chemotherapy

Paul Takam Kamga, PhD, Giada Dal Collo, MSc, Adriana Cassaro, PhD, Annalisa Adamo, MSc, Alessandro Gatti, MSc, Roberta Carusone, PhD, Mariano Di Trapani, PhD, Martina Midolo, MSc, Federica Resci, MD, Massimiliano Bonifacio, Mauro Krampera

Blood (2016) 128 (22): 1582.

DOI: https://doi.org/10.1182/blood.V128.22.1582.1582

Published: 2016

Journal Articles

Mitochondrial Fission 1 Regulates GSK3 and AMPK Signaling to Sustain Leukemia Stem Cell Function in Acute Myelogenous Leukemia

Shanshan Pei, PhD, Mohammad Minhajuddin, PhD, Biniam Adane, BS, Brett M Stevens, PhD, Nabilah Khan, PhD, Angelo D'alessandro, PhD, Travis Nemkov, Kirk C Hansen, PhD, Daniel A Pollyea, MD, Craig T Jordan, PhD

Blood (2016) 128 (22): 1703.

DOI: https://doi.org/10.1182/blood.V128.22.1703.1703

Published: 2016

Journal Articles

Role of Androgen Dependent TFPI-Regulating Protein (ADTRP) in Vascular Development and Function

Maulin Mukeshchandra Patel, Robert Silasi-Mansat, PhD, Ravi Shankar Keshari, PhD, Christopher L. Sansam, PhD, David A. Jones, PhD, Cristina Lupu, PhD, Florea Lupu, PhD

Blood (2016) 128 (22): 556.

DOI: https://doi.org/10.1182/blood.V128.22.556.556

Published: 2016

Journal Articles

BCR signaling inhibitors differ in their ability to overcome Mcl-1–mediated resistance of CLL B cells to ABT-199

Kamil Bojarczuk, Binu K. Sasi, Stefania Gobessi, Idanna Innocenti, Gabriele Pozzato, Luca Laurenti, Dimitar G. Efremov

Blood (2016) 127 (25): 3192–3201.

DOI: https://doi.org/10.1182/blood-2015-10-675009

Published: 2016

Includes: Supplemental data

Journal Articles

Glycogen Synthase Kinase-3 (GSK3) Inhibition with Lithium in Combination with Tretinoin Induces Differentiation in Non-Promyelocytic Acute Myeloid Leukemia (AML)

Masumi Ueda, MD, Paolo F. Caimi, MD, Tammy Stefan, Hillard M. Lazarus, MD, Brenda Cooper, MD, Marcos de Lima, MD, Stanton L. Gerson, MD, David N. Wald, MDPhD

Blood (2015) 126 (23): 1360.

DOI: https://doi.org/10.1182/blood.V126.23.1360.1360

Published: 2015

Journal Articles

Inhibition of SYK More Effectively Overcomes MCL-1 Mediated ABT-199 Resistance of BCR-Stimulated CLL Cells Than Inhibition of BTK or PI3Kdelta

Kamil Bojarczuk, PhD, Binu K Sasi, PhD, Stefania Gobessi, PhD, Idanna Innocenti, MD, Luca Laurenti, MD, Dimitar G Efremov, MD PhD

Blood (2015) 126 (23): 489.

DOI: https://doi.org/10.1182/blood.V126.23.489.489

Published: 2015

NARROW

The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis

Donor cell engineering with GSK3 inhibitor–loaded nanoparticles enhances engraftment after in utero transplantation

Combined Inhibition of HDAC and AKT As a Strategy to Overcome Multi-Drug Resistance in Patients with Multiple Myeloma

Inducible Phase Separation of GSK3α As a Mechanism for Asparaginase Resistance in Acute Leukemias

Targeting GSK3: beyond the mitotic spindle?

Targeting glycogen synthase kinase 3 for therapeutic benefit in lymphoma

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

Haploinsufficiency for NR3C1 Drives Glucocorticoid Resistance By Inactivation the PI3K/AKT/GSK3β/Bim Pathway in Adult Acute Lymphoblastic Leukemia

FBXW7 Is Critical for B1 Cell Maintenance and Function

Changes in Subcellular Localization of GSK3β As a Novel Driver of AML

Creatine Kinase Pathway Inhibition Alters GSK3 and WNT Signaling in EVI1-Positive Acute Myeloid Leukemia

Targeted Therapy with BET Protein and β Catenin Antagonists Against Ruxolitinib Resistant Post-Myeloproliferative Neoplasm (MPN) Secondary (s) AML Cells

Exploiting an Asp-Glu "Switch" in Glycogen Synthase Kinase 3 to Design Paralog Selective Inhibitors for Acute Myeloid Leukemia Treatment

MAF protein mediates innate resistance to proteasome inhibition therapy in multiple myeloma

Inhibition of GSK-3 Signalling Enhances Sensitivity of Non-Promyelocitic Acute Myeloid Leukemia (AML) Cell to Chemotherapy

Mitochondrial Fission 1 Regulates GSK3 and AMPK Signaling to Sustain Leukemia Stem Cell Function in Acute Myelogenous Leukemia

Role of Androgen Dependent TFPI-Regulating Protein (ADTRP) in Vascular Development and Function

BCR signaling inhibitors differ in their ability to overcome Mcl-1–mediated resistance of CLL B cells to ABT-199

Glycogen Synthase Kinase-3 (GSK3) Inhibition with Lithium in Combination with Tretinoin Induces Differentiation in Non-Promyelocytic Acute Myeloid Leukemia (AML)

Inhibition of SYK More Effectively Overcomes MCL-1 Mediated ABT-199 Resistance of BCR-Stimulated CLL Cells Than Inhibition of BTK or PI3Kdelta

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American Society of Hematology

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American Society of Hematology

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