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Journal Articles

L-Glutamine Decreases Opioid Use in Individuals with Sickle Cell Disease and Chronic Pain: A Case Series

Samuel Wilson, MD, Frances Wright, CPNP, Marcus A. Carden, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4849.
DOI: https://doi.org/10.1182/blood-2019-126179
Published: 2019
Journal Articles

Human PAR4 Is a More Potent Receptor for Activating Platelets Than Mouse PAR4

Stephanie Renna, Leonard C. Edelstein, PhD, Steven Edward McKenzie, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4883.
DOI: https://doi.org/10.1182/blood-2019-128250
Published: 2019
Journal Articles

Identify AMPK-Mediated Autophagy and Oxphos As a Novel Metabolic Vulnerability for Targeted Therapy in Mantle Cell Lymphoma

Yixin Yao, PhD, Yang Liu, MD, Hui Zhang, Angela Leeming, Joseph Mitchell McIntosh, Preetesh Jain, MBBS,MDDM,PhD, Liang Zhang, MD PhD, Krystle Nomie, PhD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1506.
DOI: https://doi.org/10.1182/blood-2019-126738
Published: 2019
Journal Articles

[ 18 f]-( 2S , 4R )-4-Fluoroglutamine As a New Positron Emission Tomography Tracer in Multiple Myeloma

Nicola Giuliani, Silvia Valtorta, PhD, Martina Chiu, PhD, Denise Toscani, PhD, Andrea Sartori, PhD, Angela Coliva, PhD, Arianna Brevi, Stefania Battaglia, MS, Emanuela Vicario, PhD, Giuseppe Taurino, MS, Matteo Grioni, Francesca Ferlenghi, PhD, Livia Ruffini, MD, Federica Vacondio, PhD, Franca Zanardi, PhD, Matteo Bellone, MD, Rosa Maria Moresco, PhD, Ovidio Bussolati, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5542.
DOI: https://doi.org/10.1182/blood-2019-127935
Published: 2019
Journal Articles

Interim Analysis of a Phase II Study of the Glutaminase Inhibitor Telaglenastat (CB-839) in Combination with Azacitidine in Advanced Myelodysplastic Syndrome (MDS)

Veronica A Guerra, MD, Jan A. Burger, MD PhD, Gautam M. Borthakur, MD, Elias Jabbour, MD, Naveen Pemmaraju, MD, Tapan M. Kadia, MD, Guillermo Garcia-Manero, MD, Hagop M. Kantarjian, MD, Marina Y Konopleva, MD PhD, Courtney D. DiNardo, MD MSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 567.
DOI: https://doi.org/10.1182/blood-2019-125970
Published: 2019
Journal Articles

Alterations of Gut Microbiome Accelerate Multiple Myeloma Progression By Increasing the Relative Abundances of Nitrogen Recycling Bacteria

Xingxing Jian, PhD, Yinghong Zhu, Jian Ouyang, Qian Lei, Jiliang Xia, PhD, Jingyu Zhang, Jiaojiao Guo, Jinuo Wang, MD, Jingchao Lin, Mingming Su, Yongjun Guan, Guancheng Li, PhD, Minghua Wu, PhD, Jian Li, MD, Juanjuan Xiang, PhD, Lu Xie, PhD, Lugui Qiu, MD PhD, Wei Jia, PhD, Wen Zhou, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 688.
DOI: https://doi.org/10.1182/blood-2019-125051
Published: 2019
Journal Articles

MYC Overexpressing Multiple Myeloma Are Dependent on GLS1

Katarina K Jovanovic, PhD, Léa Fléchon, MSc, Mairead Reidy, PhD, Jihye Park, BS, DVM, Xavier Leleu, MD PhD, Irene M. Ghobrial, MD, Thierry Facon, MD, Bruno Quesnel, Salomon Manier, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 853.
DOI: https://doi.org/10.1182/blood-2019-128484
Published: 2019
Journal Articles

Glutaminase Inhibition Overcomes Acquired Resistance to Mitochondrial Complex I in NOTCH1-Driven T-Cell Acute Lymphoblastic Leukemias (T-ALL) Via Block of Glutamine Driven Reductive Metabolism

Natalia Baran, PhDMD, Alessia Lodi, PhD, Shannon Renee Sweeney, PhD, Vinitha Mary Kuruvilla, MSc, Antonio Cavazos, Daniel Herranz, PharmD, Anna Skwarska, PhD, Marc Warmoes, PhD, Eric Davis, MD, Karine Harutyunyan, PhD, Ningping Feng, PhD, Jason P Gay, MS, Marcin Kaminski, PhD, Sergej Konoplev, Elias Jabbour, MD, Adolfo A. Ferrando, MD PhD, Maria E Di Francesco, PhD, Philip Lorenzi, Joseph R Marszalek, PhD, Stefano Tiziani, PhD, Marina Y Konopleva, MD PhD, Pandey Renu, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 806.
DOI: https://doi.org/10.1182/blood-2019-128930
Published: 2019
Journal Articles

Crizanlizumab Versus Placebo, with or without Hydroxyurea/Hydroxycarbamide, in Adolescent and Adult Patients with Sickle Cell Disease and Vaso-Occlusive Crises: A Randomized, Double-Blind, Phase III Study (STAND)

Miguel R. Abboud, MD, Jo Howard, MB, BChir, Rodolfo Cançado, Wally R Smith, MD, Birol Güvenç, MD, Noemi Espurz, Marine Weill, Mariane de Montalembert, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 998.
DOI: https://doi.org/10.1182/blood-2019-125775
Published: 2019
Journal Articles

Integrated Systems Level Examination of Proteasome Inhibitor Stress Recovery in Myeloma Cells Reveals Druggable Vulnerabilities Linked to Multiple Metabolic Processes

Paula Saavedra-Garcia, PhD, Hibah A Al-Sadah, MSc, Lucy Penfold, PhD, Xiaobei Xiong, MRes, Elena Lopez-Jimenez, PhD, Katarzyna Parzych, PhD, Valentina S Caputo, Kevin Blighe, PhD, Martin F. Kaiser, Paolo Piazza, PhD, Vesela Encheva, PhD, Ambrosius P Snijders, PhD, Hector C Keun, DPhil, Diego Oyarzun, PhD, Denise Thiel, MSc, Zijing Liu, PhD, Mauricio Barahona, PhD, Holger W Auner, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1818.
DOI: https://doi.org/10.1182/blood-2019-121549
Published: 2019
Journal Articles

L-Glutamine Increases IGF-1 Liver Expression to Prevent Bone Loss in Sickle Mice

Mykel D Green, Mitchell Schaffler, PhD, Gilda A Barabino, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3561.
DOI: https://doi.org/10.1182/blood-2019-128950
Published: 2019
Journal Articles

Rheological Effects of L-Glutamine in Patients with Sickle Cell Disease

Celeste K. Kanne, BA, Varun Reddy, Vivien A. Sheehan, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3567.
DOI: https://doi.org/10.1182/blood-2019-128891
Published: 2019
Journal Articles

Serum Metabolomic Profiling Correlated with ISS and Clinical Outcome for Multiple Myeloma Patients Treated with High Dose Melphalan and Autologous Stem Cell Transplantation

Ljupco Veskovski, MD, Per-Ola Andersson, MD PhD, Ingemar Turesson, MD PhD, Daniel Malmodin, PhD, Anders Pedersen, PhD, Ulf-Henrik Mellqvist, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1771.
DOI: https://doi.org/10.1182/blood-2019-121961
Published: 2019
Journal Articles

STAT3 Plays a Critical Role in Mitochondrial Function and Survival of Primary AML Cells

Maria L Amaya, MD PhD, Anagha Inguva, BSc, Courtney L Jones, PhD, Anna Krug, BS, Shanshan Pei, PhD, Phillip Reigan, PhD, Craig T Jordan, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1275.
DOI: https://doi.org/10.1182/blood-2019-127669
Published: 2019
Journal Articles

Pharmacokinetics of Ticagrelor in Infants and Toddlers Aged <24 Months with Sickle Cell Disease

Baba PD Inusa, MD, Adlette Inati, MD, Philip Maes, MD, Jessie Githanga, MBChB, MMed, Miguel R. Abboud, MD, Maurizio Miano, Elena Cela, Videlis Nduba, Mohammad Niazi, Magnus Åstrand, Kevin Persson, Anders Rikard Berggren, MD PhD, Glenn Carlson, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1005.
DOI: https://doi.org/10.1182/blood-2019-129855
Published: 2019
Journal Articles

Activated but Not Quiescent Hematopoietic Stem Cells Rely Readily on Glycolysis As Their Main Source of Energy

Tasleem Arif, PhD, Raymond Liang, PhD, Maio Lin, Msc, Svetlana Kalmikova, Msc, Artem Kasianov, PhD, Vijay Menon, PhD, Dmitri Papatsenko, PhD, Saghi Ghaffari, PhD MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 271.
DOI: https://doi.org/10.1182/blood-2019-129099
Published: 2019
Journal Articles

Glutamine Depletion By Addicted Myeloma Cells Inhibits Osteoblastic Differentiation of Bone Marrow Mesenchymal Stromal Cells Limiting Asparagine Availability: A Possible New Mechanism for Myeloma Bone Disease

Martina Chiu, PhD, Denise Toscani, PhD, Emanuela Vicario, PhD, Roberta Andreoli, PhD, Giuseppe Taurino, MS, Valentina Marchica, MS, Paola Storti, PhD, Massimiliano Bianchi, PhD, Ovidio Bussolati, MD PhD, Nicola Giuliani
Journal: Blood
Blood (2019) 134 (Supplement_1): 4339.
DOI: https://doi.org/10.1182/blood-2019-128034
Published: 2019
Journal Articles

Myeloma Cells Addicted to Glutamine for Biomass Production Are Sensitive to Lenalidomide

Sinto Chirackal, PhD, Esteban Braggio, PhD, Rahman Atiqur, PhD, Gregory J Ahmann, BS, Yuan Xiao Zhu, PhD, A. Keith Stewart, MB, ChB, Marta Chesi, PhD, P. Leif Bergsagel, MD, Rafael Fonseca, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4410.
DOI: https://doi.org/10.1182/blood-2019-124967
Published: 2019
Journal Articles

CXCR4 Blockade By BL-8040 in T Cell Acute Lymphoblastic Leukemia Decreases Mitochondrial Mass and Induces Non-Apoptotic Cell Death

Jun Xia, PhD, Stephanie Sun, Matthew RM Jotte, Geoffrey L. Uy, MD, Osnat Bohana-Kashtan, PhD, Ella Sorani, PhD, Abi Vainstein, Amnon Peled, PhD, Daniel C. Link, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2745.
DOI: https://doi.org/10.1182/blood-2019-128881
Published: 2019
Journal Articles

The Distinctive Metabolic Environment of the Bone Marrow Niche Drives Leukemia Chemoresistance

Nick van Gastel, PhD, Jessica B. Spinelli, PhD, Azeem Sharda, MS, Amir Schajnovitz, PhD, Ninib Baryawno, PhD, Catherine S Rhee, PhD, Toshihiko Oki, MD PhD, Eliane Grace, Heather J. Soled, Charles Vidoudez, PhD, Sunia A. Trauger, PhD, Marcia C. Haigis, PhD, David T. Scadden, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3725.
DOI: https://doi.org/10.1182/blood-2019-124789
Published: 2019