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Journal Articles

Loss of EZH2 Protein Expression in Myelodysplastic Syndrome Correlates with EZH2 Mutation and Portends a Worse Outcome

Ali Sakhdari, MD MSc, Caleb Class, PhD, Guillermo Montalban-Bravo, MD, Koji Sasaki, MD, Carlos E. Bueso-Ramos, MD PhD, Keyur P. Patel, MBBS, PhD, Joseph D. Khoury, MD, Hagop M. Kantarjian, MD, Guillermo Garcia-Manero, MD, L. Jeffrey Medeiros, MD, Rashmi Kanagal-Shamanna, MD

Blood (2019) 134 (Supplement_1): 3016.

https://doi.org/10.1182/blood-2019-131774

Published: 2019

Journal Articles

P38α/JNK Signaling Restrains Erythropoiesis By Suppressing Ezh2-Mediated Epigenetic Silencing of Bim

Ping Hu, MD PhD, Angel Nebreda, PhD, Helmut Hanenberg, MD, Garrett Kinnebrew, MD, Mircea Ivan, MD PhD, Mervin C. Yoder, MD, Marie-Dominique Filippi, PhD, Hal E. Broxmeyer, PhD, Reuben Kapur, PhD

Blood (2018) 132 (Supplement 1): 3837.

https://doi.org/10.1182/blood-2018-99-117098

Published: 2018

Journal Articles

Suppression of CUL4B Induces G1 Cell Cycle Arrest through the Modulation of AKT Signaling Pathway

Ying Li, MD, Ya Zhang, MD, Xiangxiang Zhou, MD, Xin Wang, MDPhD

Blood (2018) 132 (Supplement 1): 5133.

https://doi.org/10.1182/blood-2018-99-118442

Published: 2018

Journal Articles

Selective Pressure from Chemotherapy Drives Convergent Evolution in Relapsing and Refractory AML across Age Groups

Timothy Junius Triche, Jr., PhD, Benjamin K. Johnson, PhD, Lyong Heo, MS, Yizhou Peter Huang, BS, Rhonda E. Ries, MA, Hamid Bolouri, PhD, Jason E. Farrar, MD, Soheil Meshinchi, MD PhD

Blood (2018) 132 (Supplement 1): 2609.

https://doi.org/10.1182/blood-2018-99-119323

Published: 2018

Journal Articles

Epigenetic silencing of miR-125b is required for normal B-cell development

Guideng Li, Alex Yick-Lun So, Reeshelle Sookram, Stephanie Wong, Jessica K. Wang, Yong Ouyang, Peng He, Yapeng Su, Rafael Casellas, David Baltimore

Blood (2018) 131 (17): 1920–1930.

https://doi.org/10.1182/blood-2018-01-824540

Published: 2018

Includes: Supplemental data

Journal Articles

Epigenetic Silencing of Catalase Induces Accumulation of Reactive Oxygen Species in Chronic Lymphocytic Leukemia B Cells Leading to Activation of Axl: An Escape Strategy?

Guru P Maiti, PhD MSc, Sutapa Sinha, PhD, Justin C Boysen, Neil E. Kay, MD, Asish K Ghosh, PhD

Blood (2016) 128 (22): 4363.

https://doi.org/10.1182/blood.V128.22.4363.4363

Published: 2016

Journal Articles

Histone Deacetylase Inhibitor SAHA Mediates Epigenetic Silencing of KIT D816V Mutated Systemic Mastocytosis Primary Mast Cells and Selective Apoptosis of Mutated Mast Cells

Hani Abdulkadir, Jennine Grootens, Matilda Kjellander, Eva Hellstrom Lindberg, MD PhD, Gunnar Nilsson, Professor, Johanna Ungerstedt, Associate Professor

Blood (2015) 126 (23): 2834.

https://doi.org/10.1182/blood.V126.23.2834.2834

Published: 2015

Journal Articles

Human Induced Pluripotent Stem Cells Incorporating Safe Harbor Loci Integrated Inducible Suicide Systems for Use in the Application of Cellular Therapeutics

Xiaosong Huang, PhD, Weijie Lan, PhD, Philippe Parone, PhD, Raedun Clarke, PhD, Ramzey Abujarour, PhD, Megan Robinson, BS, Miguel Meza, MS, Sarah Raynel, MS, Betsy Rezner, BS, David Robbins, BS, Tom Tong Lee, PhD, Daniel Shoemaker, PhD, Bahram Valamehr, PhD MBA

Blood (2015) 126 (23): 3237.

https://doi.org/10.1182/blood.V126.23.3237.3237

Published: 2015

Journal Articles

Polycomb-Dependent Epigenetic Landscape in Adult T Cell Leukemia (ATL); Providing Proof of Concept for Targeting EZH1/2 to Selectively Eliminate the HTLV-1 Infected Population

Makoto Yamagishi, PhD, Dai Fujikawa, Daisuke Honma, PhD, Nobuaki Adachi, PhD, Shota Nakagawa, Makoto Hori, Naoya Kurokawa, Ai Soejima, Kazumi Nakano, PhD, Tadanori Yamochi, PhD, Makoto Nakashima, Seiichiro Kobayashi, MD, PhD, Yuetsu Tanaka, MD, PhD, Masako Iwanaga, MD, PhD, Atae Utsunomiya, MD, PhD, Kaoru Uchimaru, MD, PhD, Kunihiro Tsukasaki, MD, PhD, Kazushi Araki, D.V.M., PhD, Toshiki Watanabe, MD, PhD

Blood (2015) 126 (23): 572.

https://doi.org/10.1182/blood.V126.23.572.572

Published: 2015

Journal Articles

Epigenetic Silencing of Mir-203 Contributes to IL2Rb Overexpression and Malignant Transformation in Cutaneous T-Cell Lymphoma

Ulrik Ralfkiaer, Martin Jansson, Katharina Kopp, Andreas Willerslev-Olsen, Fazila Asmar, Thorbjorn Krejsgaard, Peter de Nully Brown, Robert Gniadecki, Anders Woetman, Anders Lund, Niels Odum, Kirsten Groenbaek

Blood (2014) 124 (21): 3553.

https://doi.org/10.1182/blood.V124.21.3553.3553

Published: 2014

Journal Articles

Epigenetic Silencing of BRCA1 Is Linked to Homologous Recombination Repair Defects and Elevated Mir-155 Expression in Myeloid Neoplasms

Weijie Poh, BS, Alison R Moliterno, MD, Keith W. Pratz, MD, Ivana Gojo, MD, Michael A McDevitt, MD PhD, James G. Herman, MD

Blood (2014) 124 (21): 3525.

https://doi.org/10.1182/blood.V124.21.3525.3525

Published: 2014

Journal Articles

Histone Deacetylase 11 (HDAC11) As a Novel Transcriptional Regulator of C/EBP-β, in Immature Myeloid Cell to Myeloid Derived Suppressor Cell Transition

Jie Chen, MA, Eva Sahakian, PhD, John J. Powers, B.S., Maritza LienlafMoreno, BS, Limin Xing, PhD, Susan Deng, Allison Distler, Fengdong Cheng, MD, Alejandro Villagra, PhD, Pedro Horna, MD, Eduardo M. Sotomayor, MD, Javier Pinilla-Ibarz, MD PhD

Blood (2014) 124 (21): 225.

https://doi.org/10.1182/blood.V124.21.225.225

Published: 2014

Journal Articles

Methylation-Dependent Epigenetic Silencing Of Mir-152 and Mir-10b-5p Plays a Crucial Role In Modulating Tumor Progression In Multiple Myeloma

Wenjing Zhang, MD, Yu Zhang, MD, Yong Zhang, PhD, Yuji Mishima, PhD, Michaela Reagan, PhD, Siobhan Glavey, MD, Antonio Sacco, BS, Aldo M Roccaro, MD, PhD, Irene M Ghobrial, MD

Blood (2013) 122 (21): 3751.

https://doi.org/10.1182/blood.V122.21.3751.3751

Published: 2013

Journal Articles

A Novel Therapeutic Approach In Acute Myeloid Leukemia (AML): In Vivo Preclinical Pharmacokinetic (PK), Pharmacodynamic (PD) and Antileukemia Activities Of Synthetic 2’-O-Methylphosphorothioate Mir-29b

Hongyan Wang, PhD, Ramasamy Santhanam, Ph.D, Zhiliang Xie, MD, Xiaomeng Huang, Ming Chiu, Mitch A. Phelps, PhD, Alison R Walker, MD, Michael A. Caligiuri, MD, Ramiro Garzon, MD, James Lee, PhD, Natarajan Muthusamy, DVM, Ph.D, Kenneth K. Chan, Ph.D, Guido Marcucci, MD

Blood (2013) 122 (21): 3933.

https://doi.org/10.1182/blood.V122.21.3933.3933

Published: 2013

Journal Articles

Epigenetic Silencing Of Mir-137 Contributes To The Proliferation Of Multiple Myeloma By Targeting AURKA

Yu Qin, Fei Li, Gang An, Mu Hao, PhD., Meirong Zang, Lugui Qiu, MD

Blood (2013) 122 (21): 3144.

https://doi.org/10.1182/blood.V122.21.3144.3144

Published: 2013

Journal Articles

Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN /PI3K signal pathway

Yonghui Li, Li Gao, Xufeng Luo, Lili Wang, Xiaoning Gao, Wei Wang, Junzhong Sun, Liping Dou, Jingxin Li, Chengwang Xu, Lixin Wang, Minhang Zhou, Mengmeng Jiang, Jihao Zhou, Michael A. Caligiuri, Clara Nervi, Clara D. Bloomfield, Guido Marcucci, Li Yu

Blood (2013) 121 (3): 499–509.

https://doi.org/10.1182/blood-2012-07-444729

Published: 2013

Includes: Supplemental data

Journal Articles

Epigenetic Silencing of BCL2 , ETS1 , IL27RA and DICER1 in Low-Risk MDS Patients

Mónica del Rey, Kathleen O'Hagan, Margaret Dellett, Sara Aibar, Hilary A. A. Colyer, María Eugenia Alonso, María Diez-Campelo, Richard N. Armstrong, Daniel J. Sharpe, Norma C. Gutiérrez, Juan Luis García, Javier de las Rivas, Ken I Mills, PhD, Jesús M. Hernández-Rivas

Blood (2012) 120 (21): 1704.

https://doi.org/10.1182/blood.V120.21.1704.1704

Published: 2012

Journal Articles

HSC Aging Epigenome: Widespread Alterations in DNA Methylation and Transcription.

Mira Jeong, Ph.D., Min Luo, Ph.D., Deqiang Sun, Ph.D., Gretchen Darlington, Ph.D., Rebecca Hannah, Ph.D., Berthold Gottgens, Ph.D., Hui Wang, Ph.D., Rui Chen, Ph.D., Wei Li, Ph.D., Margaret A. Goodell, PhD

Blood (2012) 120 (21): 2329.

https://doi.org/10.1182/blood.V120.21.2329.2329

Published: 2012

Journal Articles

Regulation of Erythropoiesis by Histone Methyltransferase EZH2 Inhibitor 3-Deazaneplanocin A (DZNep)

Tohru Fujiwara, MD, PhD, Haruka Saitoh, Yoko Okitsu, MD, PhD, Noriko Fukuhara, MD, PhD, Yasushi Onishi, MD, PhD, Kenichi Ishizawa, MD, PhD, Ryo Ichinohasama, MD, PhD, Hideo Harigae, MD, PhD

Blood (2012) 120 (21): 982.

https://doi.org/10.1182/blood.V120.21.982.982

Published: 2012

Journal Articles

Targeting a Novel Epigenetic Silencing Mechanism to Efficiently Upregulate Fetal Globin Gene Expression

Fabiana Perna, MD, Ly P. Vu, Maria Themeli, MD, Ruben Hoya-Arias, PhD, Xinyang Zhao, PhD, Eirini P. Papapetrou, MD, PhD, Michel Sadelain, MD, PhD, Stephen D. Nimer, MD

Blood (2011) 118 (21): 352.

https://doi.org/10.1182/blood.V118.21.352.352

Published: 2011

NARROW

Loss of EZH2 Protein Expression in Myelodysplastic Syndrome Correlates with EZH2 Mutation and Portends a Worse Outcome

P38α/JNK Signaling Restrains Erythropoiesis By Suppressing Ezh2-Mediated Epigenetic Silencing of Bim

Suppression of CUL4B Induces G1 Cell Cycle Arrest through the Modulation of AKT Signaling Pathway

Selective Pressure from Chemotherapy Drives Convergent Evolution in Relapsing and Refractory AML across Age Groups

Epigenetic silencing of miR-125b is required for normal B-cell development

Epigenetic Silencing of Catalase Induces Accumulation of Reactive Oxygen Species in Chronic Lymphocytic Leukemia B Cells Leading to Activation of Axl: An Escape Strategy?

Histone Deacetylase Inhibitor SAHA Mediates Epigenetic Silencing of KIT D816V Mutated Systemic Mastocytosis Primary Mast Cells and Selective Apoptosis of Mutated Mast Cells

Human Induced Pluripotent Stem Cells Incorporating Safe Harbor Loci Integrated Inducible Suicide Systems for Use in the Application of Cellular Therapeutics

Polycomb-Dependent Epigenetic Landscape in Adult T Cell Leukemia (ATL); Providing Proof of Concept for Targeting EZH1/2 to Selectively Eliminate the HTLV-1 Infected Population

Epigenetic Silencing of Mir-203 Contributes to IL2Rb Overexpression and Malignant Transformation in Cutaneous T-Cell Lymphoma

Epigenetic Silencing of BRCA1 Is Linked to Homologous Recombination Repair Defects and Elevated Mir-155 Expression in Myeloid Neoplasms

Histone Deacetylase 11 (HDAC11) As a Novel Transcriptional Regulator of C/EBP-β, in Immature Myeloid Cell to Myeloid Derived Suppressor Cell Transition

Methylation-Dependent Epigenetic Silencing Of Mir-152 and Mir-10b-5p Plays a Crucial Role In Modulating Tumor Progression In Multiple Myeloma

A Novel Therapeutic Approach In Acute Myeloid Leukemia (AML): In Vivo Preclinical Pharmacokinetic (PK), Pharmacodynamic (PD) and Antileukemia Activities Of Synthetic 2’-O-Methylphosphorothioate Mir-29b

Epigenetic Silencing Of Mir-137 Contributes To The Proliferation Of Multiple Myeloma By Targeting AURKA

Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN /PI3K signal pathway

Epigenetic Silencing of BCL2 , ETS1 , IL27RA and DICER1 in Low-Risk MDS Patients

HSC Aging Epigenome: Widespread Alterations in DNA Methylation and Transcription.

Regulation of Erythropoiesis by Histone Methyltransferase EZH2 Inhibitor 3-Deazaneplanocin A (DZNep)

Targeting a Novel Epigenetic Silencing Mechanism to Efficiently Upregulate Fetal Globin Gene Expression

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American Society of Hematology

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American Society of Hematology

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