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Journal Articles

Topoisomerase I-DNA Covalent Complexes in Myeloid Malignancies: A Potential Biomarker for Topoisomerase I Inhibitor Sensitivity

Mira A. Kohorst, MD, Karen S. Flatten, Kevin L. Peterson, Paula A. Schneider, Cristina Correia, Keith W. Pratz, MD, B. Douglas Smith, MD, Scott H. Kaufmann, MD PhD

Blood (2018) 132 (Supplement 1): 5146.

https://doi.org/10.1182/blood-2018-99-115667

Published: 2018

Journal Articles

Inhibiting SOX11-DNA Interaction in Mantle Cell Lymphoma

Stephanie Christie, Shashidhar Jatiani, PhD, Pei-Yu Kuo, MS, Violetta Leshchenko, PhD, Abhijeet Kapoor, PhD, Paola Bisignano, PhD, Aneel Aggarwal, PhD, Marta Filizola, PhD, Samir Parekh, MD

Blood (2016) 128 (22): 1840.

https://doi.org/10.1182/blood.V128.22.1840.1840

Published: 2016

Journal Articles

Concomitant Acute Promyelocytic Leukemia and Chronic Lymphocytic Leukemia: Molecularly Two Distinct Diseases

Jingdong Su, MD, Hazem E. El-Osta, MD, Reinhold Munker, MD, Glenn M. Mills, MD, Srinivas S. Devarakonda, MD

Blood (2015) 126 (23): 4904.

https://doi.org/10.1182/blood.V126.23.4904.4904

Published: 2015

Journal Articles

The Poison Oligonucleotide F10 Is Efficiently Taken Up By, and Highly Effective Against, Acute Lymphoblastic Leukemia While Sparing Normal Hematopoietic Cells

Timothy Pardee, MD, PhD, Jamie Jennings-Gee, PhD, Kristin Stadelman, MS, David L. Caudell, DVM, PhD, William Gmeiner, PhD

Blood (2013) 122 (21): 2674.

https://doi.org/10.1182/blood.V122.21.2674.2674

Published: 2013

Journal Articles

Profiling Of Polycyclic Aromatic Hydrocarbons-Induced Genotoxicity In Peripheral Blood Stem Cells and Bone Marrow Mesenchymal Stem Cells

Hwan-Young Kim, Hye-Ran Kim, PhD, Trang Nguyen Thi Dai, Hee-Jo Baek, MD, PhD, Jae-Dong Moon, MD, PhD, Jong-Hee Shin, MD, PhD, Soon-Pal Suh, MD, PhD, Hoon Kook, MD, PhD, Dong-Wook Ryang, MD, PhD, Myung-Geun Shin, MD, PhD

Blood (2013) 122 (21): 1221.

https://doi.org/10.1182/blood.V122.21.1221.1221

Published: 2013

Journal Articles

Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4

Yonghwan Kim, Gabriella S. Spitz, Uma Veturi, Francis P. Lach, Arleen D. Auerbach, Agata Smogorzewska

Blood (2013) 121 (1): 54–63.

https://doi.org/10.1182/blood-2012-07-441212

Published: 2013

Includes: Supplemental data

Journal Articles

Protein Profiling of Hematopoietic Progenitor Cells and Leukemia Cells Identifies Novel Biomarkers Associated with Exposure of Polycyclic Aromatic Hydrocarbons

Hwan-Young Kim, Hye-Ran Kim, PhD, Stephanie J. Won, Hee-Jo Baek, MD, PhD, Jae-Dong Moon, MD, PhD, Jong-Hee Shin, MD, PhD, Soon-Pal Suh, MD, PhD, Hoon Kook, MD, PhD, Dong-Wook Ryang, MD, PhD, Myung-Geun Shin, MD, PhD

Blood (2012) 120 (21): 4690.

https://doi.org/10.1182/blood.V120.21.4690.4690

Published: 2012

Journal Articles

Unique Dual Targeting of Thymidylate Synthase and Topoisomerase1 by FdUMP[10] Results in High Efficacy Against AML and Low Toxicity

Timothy Pardee, MD, PhD, Evan Gomes, PhD, Jamie Jennings-Gee, PhD, David L. Caudell, DVM, PhD, William Gmeiner, PhD

Blood (2011) 118 (21): 2584.

https://doi.org/10.1182/blood.V118.21.2584.2584

Published: 2011

Journal Articles

AR-67, a DNA Topo-Isomerase I Inhibitor, Demonstrates Acceptable Tolerability and Preliminary Activity in a Phase II Trial of Patients with Myelodysplastic Syndrome (MDS) and Chronic Myelomonocytic Leukemia (CMML),

Naval Daver, MD, Hagop M. Kantarjian, MD, Guillermo Garcia-Manero, Gautam Borthakur, Farhad Ravandi, MD, Tapan Kadia, Zeev Estrov, Marina Konopleva, M.D., Ph.D., Stefan Faderl, MD, Jorge E. Cortes

Blood (2011) 118 (21): 3820.

https://doi.org/10.1182/blood.V118.21.3820.3820

Published: 2011

Journal Articles

Is Standard Treatment (DA 3+7) Is Still Recommended As Front Line Therapy for Adult Patients with De Novo AML? the Role of Etoposide

Firas Al Sabty, MD, PhD, Eva Demeckova, Ladislav Sopko, Eva Weismanova, Martin Mistrik, MD, PhD

Blood (2011) 118 (21): 4272.

https://doi.org/10.1182/blood.V118.21.4272.4272

Published: 2011

Journal Articles

The Effect of Tyrosine Kinase Inhibitor Resistant to CML Cells Which Was Transfected with HO-1 Lentiviral Vector

Jishi Wang, Cheng Chen, Yuan Yang, Qin Fang

Blood (2011) 118 (21): 4716.

https://doi.org/10.1182/blood.V118.21.4716.4716

Published: 2011

Journal Articles

A Role for Splicing Factors and R-Loop Formation in the Pathophysiology of Fanconi Anemia.

Allison M Green, M.Phil., Natalie Collins, M.D., PhD, Simonne Longerich, PhD, Patrick Sung, PhD, Gary M Kupfer, M.D.

Blood (2010) 116 (21): 3371.

https://doi.org/10.1182/blood.V116.21.3371.3371

Published: 2010

Journal Articles

The Novel Fluoropyrimidine FdUMP[10] Is Highly Active Against Acute Myeloid Leukemia

Timothy Pardee, MD, PhD, Evan Gomes, PhD, Jamie Jennings-Gee, PhD, David L. Caudell, DVM, PhD, William Gmeiner, PhD

Blood (2010) 116 (21): 3302.

https://doi.org/10.1182/blood.V116.21.3302.3302

Published: 2010

Journal Articles

Phase I Study Results of Gimatecan In the Treatment of Myelodysplastic Syndrome (MDS)

Naveen Pemmaraju, MD, Hagop Kantarjian, MD, Guillermo Garcia-Manero, MD, Stefan Faderl, MD, Alessandra Ferrajoli, MD, Gautam Borthakur, MD, Tapan Kadia, MD, Jorge E. Cortes, MD

Blood (2010) 116 (21): 1883.

https://doi.org/10.1182/blood.V116.21.1883.1883

Published: 2010

Journal Articles

Evidence for Reduced Angiogenesis in Bone Marrow of Systemic Sclerosis Patients Immunohistochemetry and Computerized Imagine Analysis.

Valentina Carrai, Renato Alterini, Riccardo Saccardi, Irene Miniati, Luigi Rigacci, Gloria Capaccioli, Irene Donnini, Giada Rotunno, Alberto Bosi, Marco Matucci Cerinic

Blood (2009) 114 (22): 5126.

https://doi.org/10.1182/blood.V114.22.5126.5126

Published: 2009

Journal Articles

Modified Topotecan Combination with Cyclophosphamide and Ara-C (CAT) for Patients with Refractory/Relapsed Leukemia.

Sui-jing Wu, MD, Xin Du, MD, PhD, Wei Lin, MD, Zi-lun Huang, MD, Xiao-li Zhou, MD, Jian-yu Weng, MD, Li-ye Zhong, MD, Ze-sheng Lu, MD

Blood (2007) 110 (11): 4357.

https://doi.org/10.1182/blood.V110.11.4357.4357

Published: 2007

Journal Articles

Preclinical Results of the Camptothecin-Polymer Conjugate IT-101 in Multiple Human Lymphoma Xenografts.

Tontanai Numbenjapon, MD, Jianyi Wang, MD, David Colcher, PhD, Thomas Schluep, ScD, Mark E. Davis, PhD, Julienne Duringer, BS, Stephen J. Forman, MD, Andrew Raubitschek, MD

Blood (2007) 110 (11): 1376.

https://doi.org/10.1182/blood.V110.11.1376.1376

Published: 2007

Journal Articles

Phase I/II Trial of High-Dose Melphalan (M) and Topotecan (T) Followed by Autologous Stem Cell Rescue in Patients ≤ 60 and > 60 Years of Age with Multiple Myeloma (MM).

Daniel Sullivan, MD, Melissa Alsina, MD, Claudio Anasetti, MD, Teresa Field, MD, PhD, Mohamed Kharfan-Dabaja, MD, Hugo Fernandez, MD, William Dalton, PhD, MD, Ernesto Ayala, MD, Jyoti Raychaudhuri, MD, Lia Perez, MD, Janelle Perkins, PharmD, Michael Schell, PhD, Christine McIsaac, RN, Beth Maddox, RN, Jana Gump, BS, Richard Lush, PhD, Tony Frudakis, PhD

Blood (2007) 110 (11): 943.

https://doi.org/10.1182/blood.V110.11.943.943

Published: 2007

Journal Articles

Assessing DNA Damage Ex Vivo Induced by Chemotherapy Targeting Topoisomerase Inhibitors in Acute Leukemias.

Dorota H. Halicka, MD, PhD, Fevzi M. Ozkaynak, M.D., Karen Seiter, M.D., Malgorzata A. Kajstura, M.S., Delong Liu, M.D., Toshiki Tanaka, M.D., Frank Traganos, Ph.D., Zbigniew Darzynkiewicz, M.D.,Ph.D.

Blood (2006) 108 (11): 4372.

https://doi.org/10.1182/blood.V108.11.4372.4372

Published: 2006

Journal Articles

Human Tissue Transglutaminase Activity Is Inhibited by Protein Kinase Inhibitors: Potential Therapeutic Implication for Hematological Disorders.

Thung-S. Lai, PhD, Yusha Liu, Ho Young Lee, Eric Toone, Ph.D., Charles S. Greenberg, M.D.

Blood (2006) 108 (11): 1614.

https://doi.org/10.1182/blood.V108.11.1614.1614

Published: 2006

NARROW

Topoisomerase I-DNA Covalent Complexes in Myeloid Malignancies: A Potential Biomarker for Topoisomerase I Inhibitor Sensitivity

Inhibiting SOX11-DNA Interaction in Mantle Cell Lymphoma

Concomitant Acute Promyelocytic Leukemia and Chronic Lymphocytic Leukemia: Molecularly Two Distinct Diseases

The Poison Oligonucleotide F10 Is Efficiently Taken Up By, and Highly Effective Against, Acute Lymphoblastic Leukemia While Sparing Normal Hematopoietic Cells

Profiling Of Polycyclic Aromatic Hydrocarbons-Induced Genotoxicity In Peripheral Blood Stem Cells and Bone Marrow Mesenchymal Stem Cells

Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4

Protein Profiling of Hematopoietic Progenitor Cells and Leukemia Cells Identifies Novel Biomarkers Associated with Exposure of Polycyclic Aromatic Hydrocarbons

Unique Dual Targeting of Thymidylate Synthase and Topoisomerase1 by FdUMP[10] Results in High Efficacy Against AML and Low Toxicity

AR-67, a DNA Topo-Isomerase I Inhibitor, Demonstrates Acceptable Tolerability and Preliminary Activity in a Phase II Trial of Patients with Myelodysplastic Syndrome (MDS) and Chronic Myelomonocytic Leukemia (CMML),

Is Standard Treatment (DA 3+7) Is Still Recommended As Front Line Therapy for Adult Patients with De Novo AML? the Role of Etoposide

The Effect of Tyrosine Kinase Inhibitor Resistant to CML Cells Which Was Transfected with HO-1 Lentiviral Vector

A Role for Splicing Factors and R-Loop Formation in the Pathophysiology of Fanconi Anemia.

The Novel Fluoropyrimidine FdUMP[10] Is Highly Active Against Acute Myeloid Leukemia

Phase I Study Results of Gimatecan In the Treatment of Myelodysplastic Syndrome (MDS)

Evidence for Reduced Angiogenesis in Bone Marrow of Systemic Sclerosis Patients Immunohistochemetry and Computerized Imagine Analysis.

Modified Topotecan Combination with Cyclophosphamide and Ara-C (CAT) for Patients with Refractory/Relapsed Leukemia.

Preclinical Results of the Camptothecin-Polymer Conjugate IT-101 in Multiple Human Lymphoma Xenografts.

Phase I/II Trial of High-Dose Melphalan (M) and Topotecan (T) Followed by Autologous Stem Cell Rescue in Patients ≤ 60 and > 60 Years of Age with Multiple Myeloma (MM).

Assessing DNA Damage Ex Vivo Induced by Chemotherapy Targeting Topoisomerase Inhibitors in Acute Leukemias.

Human Tissue Transglutaminase Activity Is Inhibited by Protein Kinase Inhibitors: Potential Therapeutic Implication for Hematological Disorders.

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American Society of Hematology

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American Society of Hematology

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