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Journal Articles

Ex Vivo Expansion with E478 Increases the Rate of CRISPR-Mediated Homology Directed Repair of the Beta-Globin Gene in Human Hematopoietic Stem Cells By >10-Fold and Improves In Vivo Engraftment By >120-Fold

Kevin A. Goncalves, PhD, Megan D. Hoban, PhD, Sharon L. Hyzy, MS, Katia S. George, BA, Anthony E. Boitano, PhD, Michael P. Cooke, PhD

Blood (2019) 134 (Supplement_1): 4634.

DOI: https://doi.org/10.1182/blood-2019-131157

Published: 2019

Journal Articles

Evaluation of Pulmonary Function in Patient with Transfusion Dependent Beta Thalassemia with Severe Iron Overload

Mohamed A Yassin, MBBS, MSc, Mushtaq Ahmad, MD, Shehab Mohamed, MD, Khadra S Yassin, BSC, Abdulqadir Jeprel Nashwan, BSN, MSN, Vincenzo Desanctis, MD PhD, Ashraf Tawfiq Soliman, MD PhD

Blood (2019) 134 (Supplement_1): 4818.

DOI: https://doi.org/10.1182/blood-2019-121828

Published: 2019

Journal Articles

Targeting B-Cell Maturation Antigen (BCMA) with CC-93269, a 2+1 T Cell Engager, Elicits Significant Apoptosis in Diffuse Large B-Cell Lymphoma Preclinical Models

Patrick R. Hagner, PhD, Michelle Waldman, MS, Falon D. Gray, DVM, DACVP, Renee Yura, PhD, Sarah Hersey, MS, MBA, Henry Chan, PhD, Mingjun Zhang, PhD, Isaac Boss, Anita K Gandhi

Blood (2019) 134 (Supplement_1): 1580.

DOI: https://doi.org/10.1182/blood-2019-126115

Published: 2019

Journal Articles

First Description of B Cell Maturation Antigen Expression in Light Chain Amyloidosis

Susan Bal, MDMBBS, Allison Sigler, Alexander Chan, MD, David J. Chung, MD PhD, Ahmet Dogan, MD PhD, Sergio A Giralt, MD, Hani Hassoun, MD, Heather J Landau, MD

Blood (2019) 134 (Supplement_1): 5452.

DOI: https://doi.org/10.1182/blood-2019-127332

Published: 2019

Journal Articles

Non-Coding HOX Fusions in Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia

Fabienne R.S. Adriaanse, MSc, Sadie M. Sakurada, B.A., Shondra M. Pruett-Miller, PhD, Ronald W. Stam, PhD, Michel C Zwaan, MD PhD, Tanja A. Gruber, MD PhD

Blood (2019) 134 (Supplement_1): 533.

DOI: https://doi.org/10.1182/blood-2019-127014

Published: 2019

Journal Articles

Pulsation Activates Mechanosensitive Piezo1 to Form Long-Term Hematopoietic Stem Cells

Giorgia Scapin, PhD, Dhvanit I Shah, PhDPharmD

Blood (2019) 134 (Supplement_1): 445.

DOI: https://doi.org/10.1182/blood-2019-121948

Published: 2019

Journal Articles

No Evidence for Hematopoietic Stem Cell Self-Renewal in-Vivo Following Inflammatory Challenge

Blood (2019) 134 (Supplement_1): 456.

DOI: https://doi.org/10.1182/blood-2019-125744

Published: 2019

Journal Articles

Longitudinal Tracking of Acute Myeloid Leukemia Stem Cells in Xenografts and Patients By microRNA Reporters and Single Cell RNA Sequencing

Matteo Maria Naldini, Gabriele Casirati, MD, Matteo Barcella, PhD, Stefano Beretta, PhD, Ivan Merelli, PhD, Carolina Caserta, Giacomo Desantis, PhD, Francesca Pavesi, MD, Fabio Ciceri, MD, Bernhard Gentner, MD

Blood (2019) 134 (Supplement_1): 916.

DOI: https://doi.org/10.1182/blood-2019-131167

Published: 2019

Journal Articles

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Jaewoong Lee, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Lu Yang, PhD, Huimin Geng, PhD, John Chan, MD, Joo Y. Song, MD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 748.

DOI: https://doi.org/10.1182/blood-2019-127263

Published: 2019

Journal Articles

Lysosomal Activation Is Required for Priming of Quiescent Hematopoietic Stem Cells

Tasleem Arif, PhD, Raymond Liang, PhD, Maio Lin, Msc, Svetlana Kalmikova, Msc, Artem Kasianov, PhD, Dmitri Papatsenko, PhD, Saghi Ghaffari, PhD MD

Blood (2019) 134 (Supplement_1): 722.

DOI: https://doi.org/10.1182/blood-2019-131934

Published: 2019

Journal Articles

Splenic CD24 low Red Pulp Macrophages Provide an Alternate Niche for Chronic Myeloid Leukemia Stem Cells

Michael A Amrein, MD PhD, Elias D Bührer, MD PhD, Stefan Forster, MD, Stephan Isringhausen, Christian M Schürch, MD PhD, Salil S. Bhate, MMath, Mohamad Al Sayed, PhD, Cesar Nombela Arrieta, PhD, Ramin Radpour, PhD, Carsten Riether, PhD, Adrian F Ochsenbein, MD

Blood (2019) 134 (Supplement_1): 1634.

DOI: https://doi.org/10.1182/blood-2019-126593

Published: 2019

Journal Articles

Molecular Characterization and Novel Therapeutic Strategy for X-Linked Sideroblastic Anemia Associated with ALAS2 Missense Variants

Koya Ono, MD, Tohru Fujiwara, MD PhD, Kei Saito, MD PhD, Chie Suzuki, Noriyuki Takahashi, Koichi Onodera, MD PhD, Satoshi Ichikawa, MD PhD, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Hisayuki Yokoyama, MD PhD, Yukio Nakamura, MD PhD, Hideo Harigae, MD PhD

Blood (2019) 134 (Supplement_1): 3530.

DOI: https://doi.org/10.1182/blood-2019-124810

Published: 2019

Journal Articles

The Genetic Architecture of Myeloproliferative Neoplasms-Blast Phase (MPN-BP) Stem Cells

Xiaoli Wang, MD PhD, Raajit K. Rampal, MD PhD, Cing Siang Hu, Noushin Farnoud, PhD, Christopher Famulare, MS, Minal A Patel, MPH, Erin McGovern, BA, Ronald Hoffman, MD

Blood (2019) 134 (Supplement_1): 1677.

DOI: https://doi.org/10.1182/blood-2019-128836

Published: 2019

Journal Articles

Redefining "Gold Standard": Ultra-Sensitive Characterization of Commercial DNA Standards with Duplex Sequencing

Jacob Higgins, PhD, Gabriel Pratt, PhD, Charles C. Valentine, MS, Lindsey N. Williams, PhD, Jesse J. Salk, MD PhD

Blood (2019) 134 (Supplement_1): 2093.

DOI: https://doi.org/10.1182/blood-2019-131428

Published: 2019

Journal Articles

Activation of the Receptor Tyrosine Kinase (RET) By GDNF/GFRα1 Improves Cord Blood-Derived HSC in Vitro expansion and In Vivo engraftment

William Grey, PhD MSc, Rakhee Chauhan, PhD, Manuel Garcia-Albornoz, Hector Huerga Encabo, Neil McDonald, PhD, Dominique Bonnet, PhD

Blood (2019) 134 (Supplement_1): 1924.

DOI: https://doi.org/10.1182/blood-2019-121331

Published: 2019

Journal Articles

Modified Anti-FXa Assays for Measuring the Residual Activity of Apixaban and Rivaroxaban in Andexanet Alfa-Containing Samples on the ACL TOP Family ® Coagulation Analyzers

Anuja Khan, PhD, Krisjela Shishko, BS, Sam Arcidiacono, BS, Khanh Bui, BS, Genmin Lu, Pamela B. Conley, PhD, Anne Winkler, MD

Blood (2019) 134 (Supplement_1): 1153.

DOI: https://doi.org/10.1182/blood-2019-126254

Published: 2019

Journal Articles

Stringent Small Molecule Dose Requirements for the Optimal Expansion of Hematopoietic Stem Cells Revealed By Predictive Analytics and Xenotransplants

Javed K Manesia, PhD, Sakhar Almoflehi, Roya Pasha, Suria Jahan, MSc, John Blake, PhD, Julie Audet, PhD, Nicolas Pineault, PhD

Blood (2019) 134 (Supplement_1): 1185.

DOI: https://doi.org/10.1182/blood-2019-128692

Published: 2019

Journal Articles

Andexanet Alpha Differentially Neutralizes the Anticoagulant, Antiprotease and Thrombin Generation Inhibitory Effects of Unfractionated Heparin, Enoxaparin and Fondaparinux

Fakiha Siddiqui, Alfonso J Tafur, MD MS, Debra Hoppensteadt, PhD, Jeanine Walenga, PhD, Walter Jeske, PhD, Emily Bontekoe, Ahmed Kouta, Jawed Fareed, PhD

Blood (2019) 134 (Supplement_1): 1158.

DOI: https://doi.org/10.1182/blood-2019-127072

Published: 2019

Journal Articles

Both Arid1b and Arid2 Are Tumor Suppressors in MLL-AF9 Leukemogenesis

Theresa Bluemn, Jesse Schmitz, Yongwei Zheng, PhD, Nan Zhu, PhD

Blood (2019) 134 (Supplement_1): 1248.

DOI: https://doi.org/10.1182/blood-2019-127123

Published: 2019

Journal Articles

Genomic Analysis of Cellular Hierarchy in Acute Myeloid Leukemia Using Ultrasensitive LC-FACS-Seq

Caner Saygin, MD, Arletta Lozanski, Tzyy-Jye Doong, Shelley Orwick, BS, Deedra Nicolet, MS, Jadwiga Labanowska, Nyla A. Heerema, PhD, Rosa Lapalombella, PhD, Gregory K. Behbehani, MD PhD, John C. Byrd, MD, Gerard Lozanski, MD, James S. Blachly, MD

Blood (2019) 134 (Supplement_1): 186.

DOI: https://doi.org/10.1182/blood-2019-125285

Published: 2019

NARROW

Ex Vivo Expansion with E478 Increases the Rate of CRISPR-Mediated Homology Directed Repair of the Beta-Globin Gene in Human Hematopoietic Stem Cells By >10-Fold and Improves In Vivo Engraftment By >120-Fold

Evaluation of Pulmonary Function in Patient with Transfusion Dependent Beta Thalassemia with Severe Iron Overload

Targeting B-Cell Maturation Antigen (BCMA) with CC-93269, a 2+1 T Cell Engager, Elicits Significant Apoptosis in Diffuse Large B-Cell Lymphoma Preclinical Models

First Description of B Cell Maturation Antigen Expression in Light Chain Amyloidosis

Non-Coding HOX Fusions in Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia

Pulsation Activates Mechanosensitive Piezo1 to Form Long-Term Hematopoietic Stem Cells

No Evidence for Hematopoietic Stem Cell Self-Renewal in-Vivo Following Inflammatory Challenge

Longitudinal Tracking of Acute Myeloid Leukemia Stem Cells in Xenografts and Patients By microRNA Reporters and Single Cell RNA Sequencing

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Lysosomal Activation Is Required for Priming of Quiescent Hematopoietic Stem Cells

Splenic CD24 low Red Pulp Macrophages Provide an Alternate Niche for Chronic Myeloid Leukemia Stem Cells

Molecular Characterization and Novel Therapeutic Strategy for X-Linked Sideroblastic Anemia Associated with ALAS2 Missense Variants

The Genetic Architecture of Myeloproliferative Neoplasms-Blast Phase (MPN-BP) Stem Cells

Redefining "Gold Standard": Ultra-Sensitive Characterization of Commercial DNA Standards with Duplex Sequencing

Activation of the Receptor Tyrosine Kinase (RET) By GDNF/GFRα1 Improves Cord Blood-Derived HSC in Vitro expansion and In Vivo engraftment

Modified Anti-FXa Assays for Measuring the Residual Activity of Apixaban and Rivaroxaban in Andexanet Alfa-Containing Samples on the ACL TOP Family ® Coagulation Analyzers

Stringent Small Molecule Dose Requirements for the Optimal Expansion of Hematopoietic Stem Cells Revealed By Predictive Analytics and Xenotransplants

Andexanet Alpha Differentially Neutralizes the Anticoagulant, Antiprotease and Thrombin Generation Inhibitory Effects of Unfractionated Heparin, Enoxaparin and Fondaparinux

Both Arid1b and Arid2 Are Tumor Suppressors in MLL-AF9 Leukemogenesis

Genomic Analysis of Cellular Hierarchy in Acute Myeloid Leukemia Using Ultrasensitive LC-FACS-Seq

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American Society of Hematology

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American Society of Hematology

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