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Journal Articles

Dynamic CTCF binding directly mediates interactions among cis -regulatory elements essential for hematopoiesis

Qian Qi, Li Cheng, Xing Tang, Yanghua He, Yichao Li, Tiffany Yee, Dewan Shrestha, Ruopeng Feng, Peng Xu, Xin Zhou, Shondra Pruett-Miller, Ross C. Hardison, Mitchell J. Weiss, Yong Cheng

Blood (2021) 137 (10): 1327–1339.

DOI: https://doi.org/10.1182/blood.2020005780

Published: 2021

Includes: Supplemental data

Journal Articles

The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Peng Huang, Scott A. Peslak, Xianjiang Lan, Eugene Khandros, Jennifer A. Yano, Malini Sharma, Cheryl A. Keller, Belinda Giardine, Kunhua Qin, Osheiza Abdulmalik, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2020) 135 (24): 2121–2132.

DOI: https://doi.org/10.1182/blood.2020005301

Published: 2020

Includes: Supplemental data

Journal Articles

Site-specific methylation of 18S ribosomal RNA by SNORD42A is required for acute myeloid leukemia cell proliferation

Cornelius Pauli, Yi Liu, Christian Rohde, Chunhong Cui, Daria Fijalkowska, Dennis Gerloff, Carolin Walter, Jeroen Krijgsveld, Martin Dugas, Bayram Edemir, Caroline Pabst, Lutz P. Müller, Fengbiao Zhou, Carsten Müller-Tidow

Blood (2020) 135 (23): 2059–2070.

DOI: https://doi.org/10.1182/blood.2019004121

Published: 2020

Includes: Supplemental data

Journal Articles

Identification of ZNF217 As an Essential Oncogenic Gene in B-Cell Acute Lymphoblastic Leukemia By CRISPR/Cas9-Based Library Screening

Xi Qin, Rui Su, PhD, Lu Yang, PhD, Anthony K. N. Chan, PhD, Xiaolan Deng, Ying Qing, Lars Klemm, MS, Markus Müschen, MD PhD, Chun-Wei David Chen, PhD, Jianjun Chen, PhD

Blood (2019) 134 (Supplement_1): 1465.

DOI: https://doi.org/10.1182/blood-2019-129849

Published: 2019

Journal Articles

Paics, a De Novo Purine Synthetic Enzyme, Is a Novel Target for AML Therapy

Takuji Yamauchi, MD PhD, Kohta Miyawaki, MD, Yuichiro Semba, MD PhD, Fumihiko Nakao, MD, Takeshi Sugio, MD PhD, Kensuke Sasaki, MD, Jumpei Nogami, PhD, Matthew C. Canver, MD PhD, Simon Osborne, PhD, Luca Pinello, PhD, Deborah Taylor, PhD, Daniel E. Bauer, MD PhD, Koichi Akashi, MD PhD, Takahiro Maeda, MD PhD

Blood (2019) 134 (Supplement_1): 1390.

DOI: https://doi.org/10.1182/blood-2019-127047

Published: 2019

Journal Articles

Tudor Domain-Focused CRISPR Dropout Screen Identifies SGF29 As a Novel Essential Gene in MLL -Rearranged Leukemias

Anthony K. N. Chan, PhD, Christopher D. Delaney, Lu Yang, PhD, Wen-Han Chang, PhD, Kazuya Miyashita, PhD, Qiao Liu, MD, Sheela Pangeni Pokharel, MSc, Scott A. Armstrong, MD PhD, Chun-Wei David Chen, PhD

Blood (2019) 134 (Supplement_1): 530.

DOI: https://doi.org/10.1182/blood-2019-131467

Published: 2019

Journal Articles

Heterozygous Mutations of Clpb As a Newly Identified and Frequent Cause of Severe Congenital Neutropenia

Julia T Warren, MD PhD, Peeradol Wattanasirakul, David H Spencer, MD, Adam Locke, PhD, Vahagn Makaryan, MD, Audrey Anna Bolyard, RN, BS, Karl Welte, Julia Skokowa, MD PhD, David C. Dale, MD, Daniel C. Link, MD

Blood (2019) 134 (Supplement_1): 433.

DOI: https://doi.org/10.1182/blood-2019-129635

Published: 2019

Journal Articles

Pharmacological Inhibition of the RNA m 6 a Writer METTL3 As a Novel Therapeutic Strategy for Acute Myeloid Leukemia

Konstantinos Tzelepis, Etienne De Braekeleer, PhD MSc, Eliza Yankova, PhD, Justyna Rak, PhD, Demetrios Aspris, MSc, Ana Filipa Domingues, PhD, Richard Fosbeary, Alan Hendrick, PhD, Dan Leggate, PhD, Yaara Ofir-Rosenfeld, PhD, Alexandra Sapetschnig, PhD, Cristina Pina, MDDPhil, Mark Albertella, PhD, Wesley Blackaby, PhD, Oliver Rausch, PhD, George S. Vassiliou, FRCPath, MRCP, PhD, Tony Kouzarides, PhD

Blood (2019) 134 (Supplement_1): 403.

DOI: https://doi.org/10.1182/blood-2019-127962

Published: 2019

Journal Articles

Germline RUNX1 Variation and Predisposition to T-Cell Acute Lymphoblastic Leukemia in Children

Blood (2019) 134 (Supplement_1): 653.

DOI: https://doi.org/10.1182/blood-2019-125912

Published: 2019

Journal Articles

Hax1 Is Indispensable for Neutrophil Development in Zebrafish

Larissa Doll, Narges Aghaallaei, Karl Welte, Julia Skokowa, MD PhD, Baubak Bajoghli

Blood (2019) 134 (Supplement_1): 436.

DOI: https://doi.org/10.1182/blood-2019-130226

Published: 2019

Journal Articles

Non-Coding HOX Fusions in Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia

Fabienne R.S. Adriaanse, MSc, Sadie M. Sakurada, B.A., Shondra M. Pruett-Miller, PhD, Ronald W. Stam, PhD, Michel C Zwaan, MD PhD, Tanja A. Gruber, MD PhD

Blood (2019) 134 (Supplement_1): 533.

DOI: https://doi.org/10.1182/blood-2019-127014

Published: 2019

Journal Articles

Gata2 Expression and Function in PML-RARA- driven Preleukemia and APL

Casey D.S. Katerndahl, PhD, Timothy J Ley, MD, Michelle A Cai, Timothy P Rooney, Jr., Sai Mukund Ramakrishnan, MS, Sridhar Nonavinkere Srivatsan, MS, Christopher A Miller, PhD

Blood (2019) 134 (Supplement_1): 534.

DOI: https://doi.org/10.1182/blood-2019-131883

Published: 2019

Journal Articles

The Transmembrane Receptor Roundabout 1 (ROBO1) Is Necessary for Multiple Myeloma Proliferation and Homing to the Bone Marrow Niche

Giada Bianchi, MD, Peter G. Czarnecki, MD, Matthew Ho, PhD, Aldo M. Roccaro, MD PhD, Antonio Sacco, RN, Yawara Kawano, MD PhD, Anil Aktas Samur, PhD, Annamaria Gulla, MD, Tianzeng Chen, Kenneth Wen, Xinchen Wu, Yu-Tzu Tai, PhD, Gulden Camci-Unal, PhD, Irene M. Ghobrial, MD, Ruben D. Carrasco, MD PhD, Kenneth C. Anderson, MD

Blood (2019) 134 (Supplement_1): 507.

DOI: https://doi.org/10.1182/blood-2019-128778

Published: 2019

Journal Articles

Enasidenib Drives Maturation of Human Erythroid Precursors Independently of IDH2

Ritika Dutta, BS, Tian Y Zhang, MD PhD, Thomas Koehnke, MD, Daniel Thomas, MD PhD, Eric Gars, MD, Melissa Stafford, Yusuke Nakauchi, MD PhD, Satinder Kaur, BS, Raymond Yin, Anupama Narla, MD, Ravindra Majeti, MD PhD

Blood (2019) 134 (Supplement_1): 540.

DOI: https://doi.org/10.1182/blood-2019-124551

Published: 2019

Journal Articles

The Multidrug Transporter MRP4/ABCC4 Involved in the Leukemia Clinical Course Specifies the Novel PEL Human Blood Group System

Blood (2019) 134 (Supplement_1): 715.

DOI: https://doi.org/10.1182/blood-2019-124082

Published: 2019

Journal Articles

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Jaewoong Lee, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Lu Yang, PhD, Huimin Geng, PhD, John Chan, MD, Joo Y. Song, MD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 748.

DOI: https://doi.org/10.1182/blood-2019-127263

Published: 2019

Journal Articles

Recurrent Non-Coding Mutations in BCL7A May Have Significant Functional Consequence in Multiple Myeloma

Chandraditya Chakraborty, PhD, Eugenio Morelli, MD, María Linares, PhD, Kenneth C. Anderson, MD, Mehmet Kemal Samur, PhD, Mariateresa Fulciniti, PhD, Nikhil C. Munshi, MD

Blood (2019) 134 (Supplement_1): 857.

DOI: https://doi.org/10.1182/blood-2019-129155

Published: 2019

Journal Articles

Glutaminase Inhibition Overcomes Acquired Resistance to Mitochondrial Complex I in NOTCH1-Driven T-Cell Acute Lymphoblastic Leukemias (T-ALL) Via Block of Glutamine Driven Reductive Metabolism

Blood (2019) 134 (Supplement_1): 806.

DOI: https://doi.org/10.1182/blood-2019-128930

Published: 2019

Journal Articles

Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes

Grace A Ward, BS, Kathy McGraw, PhD, Amy F McLemore, M.S., Nghi B Lam, M.S., Hsin-An Hou, Benjamin S. Meyer, Alan F. List, MD

Blood (2019) 134 (Supplement_1): 774.

DOI: https://doi.org/10.1182/blood-2019-122358

Published: 2019

Journal Articles

GRK6 Regulates the Hemostatic Response to Injury through Its Rate-Limiting Effects on GPCR Signaling in Platelets

Xi Chen, PhD, Shuchi Gupta, Matthew Cooper, Daniel Dehelian, Xuefei Zhao, Lawrence F. Brass, MD PhD, Ulhas P. Naik, PhD, Meghna Ulhas Naik, MS, Jeffrey Benovic, Peisong Ma, PhD

Blood (2019) 134 (Supplement_1): 3611.

DOI: https://doi.org/10.1182/blood-2019-129175

Published: 2019

2 3 4 5

NARROW

Dynamic CTCF binding directly mediates interactions among cis -regulatory elements essential for hematopoiesis

The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Site-specific methylation of 18S ribosomal RNA by SNORD42A is required for acute myeloid leukemia cell proliferation

Identification of ZNF217 As an Essential Oncogenic Gene in B-Cell Acute Lymphoblastic Leukemia By CRISPR/Cas9-Based Library Screening

Paics, a De Novo Purine Synthetic Enzyme, Is a Novel Target for AML Therapy

Tudor Domain-Focused CRISPR Dropout Screen Identifies SGF29 As a Novel Essential Gene in MLL -Rearranged Leukemias

Heterozygous Mutations of Clpb As a Newly Identified and Frequent Cause of Severe Congenital Neutropenia

Pharmacological Inhibition of the RNA m 6 a Writer METTL3 As a Novel Therapeutic Strategy for Acute Myeloid Leukemia

Germline RUNX1 Variation and Predisposition to T-Cell Acute Lymphoblastic Leukemia in Children

Hax1 Is Indispensable for Neutrophil Development in Zebrafish

Non-Coding HOX Fusions in Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia

Gata2 Expression and Function in PML-RARA- driven Preleukemia and APL

The Transmembrane Receptor Roundabout 1 (ROBO1) Is Necessary for Multiple Myeloma Proliferation and Homing to the Bone Marrow Niche

Enasidenib Drives Maturation of Human Erythroid Precursors Independently of IDH2

The Multidrug Transporter MRP4/ABCC4 Involved in the Leukemia Clinical Course Specifies the Novel PEL Human Blood Group System

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Recurrent Non-Coding Mutations in BCL7A May Have Significant Functional Consequence in Multiple Myeloma

Glutaminase Inhibition Overcomes Acquired Resistance to Mitochondrial Complex I in NOTCH1-Driven T-Cell Acute Lymphoblastic Leukemias (T-ALL) Via Block of Glutamine Driven Reductive Metabolism

Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes

GRK6 Regulates the Hemostatic Response to Injury through Its Rate-Limiting Effects on GPCR Signaling in Platelets

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American Society of Hematology

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American Society of Hematology

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