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Journal Articles

The whole-genome landscape of Burkitt lymphoma subtypes

Razvan I. Panea, Cassandra L. Love, Jennifer R. Shingleton, Anupama Reddy, Jeffrey A. Bailey, Ann M. Moormann, Juliana A. Otieno, John Michael Ong’echa, Cliff I. Oduor, Kristin M. S. Schroeder, Nestory Masalu, Nelson J. Chao, Megan Agajanian, Michael B. Major, Yuri Fedoriw, Kristy L. Richards, Grzegorz Rymkiewicz, Rodney R. Miles, Bachir Alobeid, Govind Bhagat, Christopher R. Flowers, Sarah L. Ondrejka, Eric D. Hsi, William W. L. Choi, Rex K. H. Au-Yeung, Wolfgang Hartmann, Georg Lenz, Howard Meyerson, Yen-Yu Lin, Yuan Zhuang, Micah A. Luftig, Alexander Waldrop, Tushar Dave, Devang Thakkar, Harshit Sahay, Guojie Li, Brooke C. Palus, Vidya Seshadri, So Young Kim, Randy D. Gascoyne, Shawn Levy, Minerva Mukhopadyay, David B. Dunson, Sandeep S. Dave
Blood (2019) 134 (19): 1598–1607.
DOI: https://doi.org/10.1182/blood.2019001880
Published: 2019
Includes: Supplemental data
Journal Articles

The whole-genome landscape of Burkitt lymphoma subtypes

Razvan I. Panea, Cassandra L. Love, Jennifer R. Shingleton, Anupama Reddy, Jeffrey A. Bailey, Ann M. Moormann, Juliana A. Otieno, John Michael Ong’echa, Cliff I. Oduor, Kristin M. S. Schroeder, Nestory Masalu, Nelson J. Chao, Megan Agajanian, Michael B. Major, Yuri Fedoriw, Kristy L. Richards, Grzegorz Rymkiewicz, Rodney R. Miles, Bachir Alobeid, Govind Bhagat, Christopher R. Flowers, Sarah L. Ondrejka, Eric D. Hsi, William W. L. Choi, Rex K. H. Au-Yeung, Wolfgang Hartmann, Georg Lenz, Howard Meyerson, Yen-Yu Lin, Yuan Zhuang, Micah A. Luftig, Alexander Waldrop, Tushar Dave, Devang Thakkar, Harshit Sahay, Guojie Li, Brooke C. Palus, Vidya Seshadri, So Young Kim, Randy D. Gascoyne, Shawn Levy, Minerva Mukhopadyay, David B. Dunson, Sandeep S. Dave
Blood (2019) 134 (19): 1598–1607.
DOI: https://doi.org/10.1182/blood.2019001880
Published: 2019
Includes: Supplemental data
Journal Articles

PRDM16s transforms megakaryocyte-erythroid progenitors into myeloid leukemia–initiating cells

Tianyuan Hu, Kiyomi Morita, Matthew C. Hill, Yajian Jiang, Ayumi Kitano, Yusuke Saito, Feng Wang, Xizeng Mao, Kevin A. Hoegenauer, Kazuhiro Morishita, James F. Martin, P. Andrew Futreal, Koichi Takahashi, Daisuke Nakada
Blood (2019) 134 (7): 614–625.
DOI: https://doi.org/10.1182/blood.2018888255
Published: 2019
Journal Articles

A novel model of controlling PD-L1 expression in ALK + anaplastic large cell lymphoma revealed by CRISPR screening

Jing-Ping Zhang, Zhihui Song, Hong-Bo Wang, Lang Lang, Yuan-Zhong Yang, Wenming Xiao, Daniel E. Webster, Wei Wei, Stefan K. Barta, Marshall E. Kadin, Louis M. Staudt, Masao Nakagawa, Yibin Yang
Blood (2019) 134 (2): 171–185.
DOI: https://doi.org/10.1182/blood.2019001043
Published: 2019
Journal Articles

RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1

Christopher P. Mill, Warren Fiskus, Courtney D. DiNardo, Yimin Qian, Kanak Raina, Kimal Rajapakshe, Dimuthu Perera, Cristian Coarfa, Tapan M. Kadia, Joseph D. Khoury, Dyana T. Saenz, David N. Saenz, Anuradha Illendula, Koichi Takahashi, Steven M. Kornblau, Michael R. Green, Andrew P. Futreal, John H. Bushweller, Craig M. Crews, Kapil N. Bhalla
Blood (2019) 134 (1): 59–73.
DOI: https://doi.org/10.1182/blood.2018893982
Published: 2019
Journal Articles

Gene editing in hemophilia: a “CRISPR” choice?

Steven W. Pipe, Sundar R. Selvaraj
Blood (2019) 133 (26): 2733–2734.
DOI: https://doi.org/10.1182/blood.2019001180
Published: 2019
Journal Articles

CRISPR/Cas9-mediated in vivo gene targeting corrects hemostasis in newborn and adult factor IX–knockout mice

Lili Wang, Yang Yang, Camilo Ayala Breton, John White, Jia Zhang, Yan Che, Alexei Saveliev, Deirdre McMenamin, Zhenning He, Caitlin Latshaw, Mingyao Li, James M. Wilson
Blood (2019) 133 (26): 2745–2752.
DOI: https://doi.org/10.1182/blood.2019000790
Published: 2019
Journal Articles

Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background

Brief Report
Mianmian Yin, Yang Jo Chung, R. Coleman Lindsley, Robert L. Walker, Yuelin J. Zhu, Benjamin L. Ebert, Paul S. Meltzer, Peter D. Aplan
Blood (2019) 133 (24): 2610–2614.
DOI: https://doi.org/10.1182/blood.2018864173
Published: 2019
Journal Articles

CRISPR/Cas9 PIG -A gene editing in nonhuman primate model demonstrates no intrinsic clonal expansion of PNH HSPCs

Tae-Hoon Shin, Eun Jung Baek, Marcus A. F. Corat, Shirley Chen, Jean-Yves Metais, Aisha A. AlJanahi, Yifan Zhou, Robert E. Donahue, Kyung-Rok Yu, Cynthia E. Dunbar
Blood (2019) 133 (23): 2542–2545.
DOI: https://doi.org/10.1182/blood.2019000800
Published: 2019
Journal Articles

Loss-of-function mutations in PTPRJ cause a new form of inherited thrombocytopenia

Caterina Marconi, Christian A. Di Buduo, Kellie LeVine, Serena Barozzi, Michela Faleschini, Valeria Bozzi, Flavia Palombo, Spencer McKinstry, Giuseppe Lassandro, Paola Giordano, Patrizia Noris, Carlo L. Balduini, Anna Savoia, Alessandra Balduini, Tommaso Pippucci, Marco Seri, Nicholas Katsanis, Alessandro Pecci
Blood (2019) 133 (12): 1346–1357.
DOI: https://doi.org/10.1182/blood-2018-07-859496
Published: 2019
Journal Articles

A Single -195 C < G HBG1 Promoter Mediated By CRISPR/Cas9 Genome Editing Induces Fetal Hemoglobin Synthesis in Hudep-2

Priscila Keiko Matsumoto Martin, PhD, Dulcinéia Martins de Albuquerque, PhD, Carolina Lanaro, PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Fernando F. Costa, MD, PhD
Blood (2018) 132 (Supplement 1): 3481.
DOI: https://doi.org/10.1182/blood-2018-99-118534
Published: 2018
Journal Articles

Targeting Burkitt Lymphoma By CAR-Extracellular Vesicles: A Tropism-Delivery Platform for CRISPR/Cas9 System

Qian Xu, Zheng Zhang, MD, Lei Zhao, MD, Yun Qin, Yicheng Zhang, MD PhD, Jue Wang, MD PhD, Jianfeng Zhou, MD PhD
Blood (2018) 132 (Supplement 1): 3487.
DOI: https://doi.org/10.1182/blood-2018-99-115003
Published: 2018
Journal Articles

Conversion of T-Effector Cells to Immunosuppressive T-Regulatory-like Cells By CRISPR/Cas9-Mediated Integration of a FOXP3 Transgene

Yuchi Honaker, PhD, Yufei Xiang, MD, PhD, Logan Fisher, B.S., Karen Sommer, PhD, Troy R. Torgerson, MD PhD, Andrew M. Scharenberg, MD, David J. Rawlings, MD
Blood (2018) 132 (Supplement 1): 3490.
DOI: https://doi.org/10.1182/blood-2018-99-117456
Published: 2018
Journal Articles

CRISPR/Cas9 Knock-in HL60 Cells Closely Simulate Cellular and Functional Abnormalities of ELANE associated Neutropenia; Phenotype Rescue with MK-0339 Neutrophil Elastase Inhibitor

Vahagn Makaryan, MD, Breanna Fletcher, BSc, Merideth L. Kelley, MSc, Masoud Nasri, Julia Skokowa, MD PhD, Karl Welte, David C Dale, MD
Blood (2018) 132 (Supplement 1): 3683.
DOI: https://doi.org/10.1182/blood-2018-99-113054
Published: 2018
Journal Articles

Glucocorticoid Resistance in IKZF1-Deleted BCP-ALL: It Is PTEN Again

Laurens Van Der Meer, PhD, Rene Marke, MSc, Miriam Butler, MSc, Dorette van Ingen Schenau, MSc, Blanca Scheijen, PhD, Frank van Leeuwen, PhD
Blood (2018) 132 (Supplement 1): 4088.
DOI: https://doi.org/10.1182/blood-2018-99-112888
Published: 2018
Journal Articles

BET Inhibitors Potentiate Activation of p53 and Killing of AML By MDM2 Inhibitors — a Candidate Combination Therapy

Peter D Adams, Anne Louise Latif, Ashley Newcombe, Neil Robertson, Maria Terradas, Helen Stewart, Claire Reid, Loveena Rishi Delori, Timothy Chevassut, Xu Huang, BSc, PhD, Karen Keeshan, Karen Blyth, Mhairi Copland
Blood (2018) 132 (Supplement 1): 3912.
DOI: https://doi.org/10.1182/blood-2018-99-115509
Published: 2018
Journal Articles

CRISPR Activation Screen for HDAC Inhibitor Resistance

Huihui Tang, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Olga Dashevsky, PhD, Brian Glassner, PhD, Sondra L. Downey-Kopyscinski, PhD, Sara Gandolfi, MD, Michal Sheffer, PhD, Megan Bariteau, BSc, John G Doench, PhD, Constantine S. Mitsiades, MD PhD
Blood (2018) 132 (Supplement 1): 3958.
DOI: https://doi.org/10.1182/blood-2018-99-119044
Published: 2018
Journal Articles

A Genome-Wide CRISPR Screen Implicates MYC Dysregulation in TCF3 - PBX1 B-ALL

Ruth E Cranston, BSc, Paul B Sinclair, PhD, Matthew Bashton, PhD, Matthew P Selby, PhD, Christine J Harrison, PhD FRCPath
Blood (2018) 132 (Supplement 1): 3915.
DOI: https://doi.org/10.1182/blood-2018-99-110015
Published: 2018
Journal Articles

Hematopoietic Phf6 Deletion in Mice Causes HSC Depletion and Expansion of Myeloid Progenitors

Roman Verner, Gabrielle Ochoco, Patrick Somers, Cristian Taborda, Vikram R Paralkar, MD
Blood (2018) 132 (Supplement 1): 3829.
DOI: https://doi.org/10.1182/blood-2018-99-120041
Published: 2018
Journal Articles

Modeling Human Paroxysmal Nocturnal Hemoglobinuria Via CRISPR/Cas9 HSPC Gene Editing in Non-Human Primate

Taehoon Shin, PhD, Eun Jung Baek, MD, Marcus A.F. Corat, PhD, Shirley Chen, BS, Robert E. Donahue, VMD, Kyung-Rok Yu, PhD, Cynthia E. Dunbar, MD
Blood (2018) 132 (Supplement 1): 1309.
DOI: https://doi.org/10.1182/blood-2018-99-111984
Published: 2018