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Journal Articles

The SF3b Splicing Complex Regulates DNA Damage Response in Acute Lymphoblastic Leukemia

Shalini Sankar, Miriam Guillen Navarro, Frida Ponthan, PhD, Simon Bomken, MD, Sirintra Nakjang, Vasily Grinev, PhD, Hesta McNeill, Michel C Zwaan, MD PhD, Josef Vormoor, MD PhD, Ronald W. Stam, PhD, Olaf Heidenreich

Blood (2019) 134 (Supplement_1): 1237.

https://doi.org/10.1182/blood-2019-124787

Published: 2019

Journal Articles

Accumulation of Endogenous DNA Damage Sustain Malignant Progression and Increase Therapy Resistance in Multiple Myeloma

Maria Gkotzamanidou, MD PhD, Evangelos Terpos, MD PhD, Nikhil C. Munshi, MD, Vassilis L. Souliotis, PhD, Meletios A. Dimopoulos, MD

Blood (2019) 134 (Supplement_1): 1788.

https://doi.org/10.1182/blood-2019-123502

Published: 2019

Journal Articles

Macrophages Promote DNA Repair of Double Strand Break in Multiple Myeloma Cells By Non-Homologous End Joining(NHEJ), Nevertheless Decrease Its Accuracy

Mengmeng Dong, Enfan Zhang, Haimeng Yan, MD, Ruyi Xu, He Huang, Anyong Xie, Zhen Cai, MD PhD

Blood (2019) 134 (Supplement_1): 3087.

https://doi.org/10.1182/blood-2019-126753

Published: 2019

Journal Articles

Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML)

Liana E Gynn, BSc, Elizabeth Anderson, PhD, Gareth M Robinson, PhD, Sarah Anne Wexler, MBBS, MRCP, FRCPath, Gillian Upstill-Goddard, Christine Cox, Rhys Gareth Morgan, PhD, Jennifer E May, PhD BSc

Blood (2019) 134 (Supplement_1): 2492.

https://doi.org/10.1182/blood-2019-122891

Published: 2019

Journal Articles

DNMT3A with Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks

Kartika Venugopal, MS, Daniil E Shabashvili, PhD, Jianping Li, MD, Luisa M Posada, Richard Lynn Bennett, PhD, Yang Feng, MS, Daphne Dupere Richer, PhD, Alberto Riva, PhD, Santhi Pondugula, PhD, Jonathan E. Bird, PhD, Jonathan D. Licht, MD, Olga A Guryanova, MD PhD

Blood (2019) 134 (Supplement_1): 535.

https://doi.org/10.1182/blood-2019-128213

Published: 2019

Journal Articles

Replication Stress Response and CDKN1A Engagement Constrain Fetal Hematopoietic Stem Cell Pool Size in Fanconi Anemia

Makiko Mochizuki-Kashio, PhD, Young Me Yoon, Theresa N Menna, BS, Markus Grompe, MD, Peter Kurre, MD

Blood (2019) 134 (Supplement_1): 107.

https://doi.org/10.1182/blood-2019-125669

Published: 2019

Journal Articles

Ongoing Spontaneous DNA Damage Creates Synthetic Lethality Targeted By Novel RAD51 Inhibitors in Multiple Myeloma

Subodh Kumar, PhD, Maria Gkotzamanidou, MD PhD, Srikanth Talluri, PhD, Melinda Day, PhD, Mychell Neptune, Lakshmi B. Potluri, Chandraditya Chakraborty, PhD, Kevin Mills, PhD, Masood A. Shammas, PhD, Nikhil C. Munshi, MD

Blood (2019) 134 (Supplement_1): 4378.

https://doi.org/10.1182/blood-2019-129121

Published: 2019

Journal Articles

Targeting DNA Damage and Repair in Acute Myeloid Leukemia Carrying Internal Tandem Duplication of Fms-like Tyrosine Kinase 3 (FLT3-ITD) - a Mechanistic Study

Ka Lam Nelson Ng, PhD, Claire Lynn, Thomas Wing Yan Leung, Eric Chi Wai So, PhD, Anskar Yu Hung Leung, MD PhD

Blood (2019) 134 (Supplement_1): 1261.

https://doi.org/10.1182/blood-2019-129472

Published: 2019

Journal Articles

PIG-a Gene Expression Deficiency Association with Reduced DNA Damage Checkpoint Response and Activation

Jeffrey J Pu, MD PhD, Shasha Lu, MD PhD, Matthew Nemesure, Emmanuel Kwame Teye, PhD, Emily Schleicher, George-Lucian Moldovan, PhD, Robert A. Brodsky, MD, Fangyuan Chen, MD PhD

Blood (2018) 132 (Supplement 1): 3875.

https://doi.org/10.1182/blood-2018-99-119177

Published: 2018

Journal Articles

Inhibition of ATR Potentiates Acute Myeloid Leukemia Cells to the RNA Pol I Transcription Inhibitor CX-5461

Margaret Shatara, MD, Tingting Wang, Xinyu Li, Holly Edwards, BS, Jeffrey W. Taub, MD, Hai Lin, MD, Yubin Ge, PhD

Blood (2018) 132 (Supplement 1): 5224.

https://doi.org/10.1182/blood-2018-99-113937

Published: 2018

Journal Articles

Cells with DNMT3A Mutations Are More Sensitive to Cytarabine-Induced DNA Damage

Kartika Venugopal, MS, Jianping Li, MD, Daniil E Shabashvili, PhD, Luisa M Posada, Yang Feng, MS, Daphne Dupere-Richer, PhD, Aditya Bele, PhD, Jonathan D. Licht, MD, Olga A Guryanova, MD PhD

Blood (2018) 132 (Supplement 1): 2643.

https://doi.org/10.1182/blood-2018-99-118708

Published: 2018

Journal Articles

Attempt to Prove the Existence of Abnormal B Lymphocyte As Myeloma-Initiating Cells from B Cell-Derived Induced Pluripotent Stem Cells

Aki Yanagi, MS, Naohiro Tsuyama, PhD, Yukari Yanai, MS, Yu Abe, PhD, Misaki Sugai, BS, Akinobu Ota, PhD, Karnan Sivasundaram, PhD, Tomonari Shigemura, MD PhD, Megumi Sasatani, PhD, Kenji Kamiya, MD PhD, Ichiro Hanamura, MD PhD, Takayuki Ikezoe, MD PhD, Masafumi Onodera, MD PhD, Akira Sakai, MD PhD

Blood (2018) 132 (Supplement 1): 1896.

https://doi.org/10.1182/blood-2018-99-112759

Published: 2018

Journal Articles

Epidermal Growth Factor Receptor - Mediated DNA Repair Regulates Hematopoietic Stem Cell Regeneration

Tiancheng Fang, Heather A Himburg, PhD, Martina M Roos, PhDPharmD, Yurun Zhang, Jenny Kan, BS, Liman Zhao, John P Chute, MD

Blood (2018) 132 (Supplement 1): 638.

https://doi.org/10.1182/blood-2018-99-115526

Published: 2018

Journal Articles

CRISPR/Cas9-Generated Models Uncover Therapeutic Vulnerabilities of Del(11q) Chronic Lymphocytic Leukemia Cells to Dual BCR and PARP Inhibition

Miguel Quijada Álamo, BSc, MSc, María Hernández-Sánchez, PhD, José Luis Ordóñez, PhD, Verónica Alonso Pérez, PhD, Ana E. Rodriguez, PhD, Ignacio García-Tuñón, PhD, Ana B Herrero, PhD, Laura San-Segundo, Michaela Gruber, MD PhD, Juan Luis García, PhD, Rocio Benito, PhD, Catherine J. Wu, MD, Jesús-María Hernández-Rivas, MD PhD

Blood (2018) 132 (Supplement 1): 948.

https://doi.org/10.1182/blood-2018-99-116080

Published: 2018

Journal Articles

AURKA Regulates the Mechanism of ATR Mediated DNA Damage Response about Drug Resistance in Multiple Myeloma

Zhang Shuaishuai, MD, Yu Qin, An Gang, MD, Mu Hao, PhD, Yan Xu, MD, Shuhui Deng, Tengteng Yu, Wen Zhou, Lugui Qiu, MD

Blood (2017) 130 (Supplement 1): 5354.

https://doi.org/10.1182/blood.V130.Suppl_1.5354.5354

Published: 2017

Journal Articles

Functional and Biological Implications of CUX1 Mutations and Deletions in Myeloid Neoplasms

Mai Aly, MD, Zubaidah M Ramdzan', PhD, Yasunobu Nagata, MD PhD, Suresh K. Balasubramanian, MD, Naoko Hosono, MD,PhD, Hideki Makishima, MD,PhD,FACP., Valeria Visconte, PhD, Bartlomiej P. Przychodzen, MSc, Cassandra M. Hirsch, BS, Mikkael A. Sekeres, MD MS, Alain Nepveu", PhD, Jaroslaw Maciejewski", MD,PhD,FACP.

Blood (2017) 130 (Supplement 1): 120.

https://doi.org/10.1182/blood.V130.Suppl_1.120.120

Published: 2017

Journal Articles

Exportin-1 Connects Dynamic Transcription and Translation of Genotoxic Stress Genes in Diffuse Large B-Cell Lymphoma Patients

Rossella Marullo, MD PhD, Maria Revuelta, PhD, Nahuel Zamponi, PhD, Biljana Culjkovic, PhD, Shao Ning Yang, Haelee Ahn, Giorgio Inghirami, MD, Katherine L. B. Borden, PhD, Leandro Cerchietti, MD

Blood (2017) 130 (Supplement 1): 312.

https://doi.org/10.1182/blood.V130.Suppl_1.312.312

Published: 2017

Journal Articles

Synthetic Lethal Interaction between Apto-253 and Impaired BRCA1/2 Function

Cheng-Yu Tsai, PhD, Si Sun, MD, Hongying Zhang, MD, Andrea Local, PhD, Khalid Benbatoul, BS, Peter Folger, BS, Susan Sheng, PhD, William Rice, PhD, Stephen Howell, MD

Blood (2017) 130 (Supplement 1): 5000.

https://doi.org/10.1182/blood.V130.Suppl_1.5000.5000

Published: 2017

Journal Articles

B Cell-Derived Induced Pluripotent Stem Cells Are Useful for Determining the Cellular Origin of Abnormal B Cells in Multiple Myeloma

Aki Yanagi, Fumihiko Kawamura, MS, Makoto Inaki, PhD, Atsushi Katafuchi, PhD, Yukari Yanai, MS, Yu Abe, MD, Naohiro Tsuyama, PhD, Misaki Sugai, BS, Mitsunori Higuchi, MD PhD, Satoshi Muto, MD PhD, Takumi Yamaura, MD, Hiroyuki Suzuki, MD PhD, Hideyoshi Noji, MD PhD, Shinichi Suzuki, MD PhD, Yoshida A Mitsuaki, PhD, Megumi Sasatani, PhD, Kenji Kamiya, MD PhD, Masafumi Onodera, MD PhD, Akira Sakai, MDPhD

Blood (2017) 130 (Supplement 1): 1808.

https://doi.org/10.1182/blood.V130.Suppl_1.1808.1808

Published: 2017

Journal Articles

APTO-253 Interaction with G-Quadruplex DNA Is Linked to Inhibition of c-Myc Expression, Induction of DNA Damage, and Generation of Synthetic Lethality in Cells with BRCA1/2 Impairment

Andrea Local, PhD, Hongying Zhang, MD, Khalid Benbatoul, BS, Peter Folger, BS, Susan Sheng, PhD, Cheng-Yu Tsai, PhD, Stephen Howell, MD, William Rice, PhD

Blood (2017) 130 (Supplement 1): 5094.

https://doi.org/10.1182/blood.V130.Suppl_1.5094.5094

Published: 2017

NARROW

The SF3b Splicing Complex Regulates DNA Damage Response in Acute Lymphoblastic Leukemia

Accumulation of Endogenous DNA Damage Sustain Malignant Progression and Increase Therapy Resistance in Multiple Myeloma

Macrophages Promote DNA Repair of Double Strand Break in Multiple Myeloma Cells By Non-Homologous End Joining(NHEJ), Nevertheless Decrease Its Accuracy

Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML)

DNMT3A with Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks

Replication Stress Response and CDKN1A Engagement Constrain Fetal Hematopoietic Stem Cell Pool Size in Fanconi Anemia

Ongoing Spontaneous DNA Damage Creates Synthetic Lethality Targeted By Novel RAD51 Inhibitors in Multiple Myeloma

Targeting DNA Damage and Repair in Acute Myeloid Leukemia Carrying Internal Tandem Duplication of Fms-like Tyrosine Kinase 3 (FLT3-ITD) - a Mechanistic Study

PIG-a Gene Expression Deficiency Association with Reduced DNA Damage Checkpoint Response and Activation

Inhibition of ATR Potentiates Acute Myeloid Leukemia Cells to the RNA Pol I Transcription Inhibitor CX-5461

Cells with DNMT3A Mutations Are More Sensitive to Cytarabine-Induced DNA Damage

Attempt to Prove the Existence of Abnormal B Lymphocyte As Myeloma-Initiating Cells from B Cell-Derived Induced Pluripotent Stem Cells

Epidermal Growth Factor Receptor - Mediated DNA Repair Regulates Hematopoietic Stem Cell Regeneration

CRISPR/Cas9-Generated Models Uncover Therapeutic Vulnerabilities of Del(11q) Chronic Lymphocytic Leukemia Cells to Dual BCR and PARP Inhibition

AURKA Regulates the Mechanism of ATR Mediated DNA Damage Response about Drug Resistance in Multiple Myeloma

Functional and Biological Implications of CUX1 Mutations and Deletions in Myeloid Neoplasms

Exportin-1 Connects Dynamic Transcription and Translation of Genotoxic Stress Genes in Diffuse Large B-Cell Lymphoma Patients

Synthetic Lethal Interaction between Apto-253 and Impaired BRCA1/2 Function

B Cell-Derived Induced Pluripotent Stem Cells Are Useful for Determining the Cellular Origin of Abnormal B Cells in Multiple Myeloma

APTO-253 Interaction with G-Quadruplex DNA Is Linked to Inhibition of c-Myc Expression, Induction of DNA Damage, and Generation of Synthetic Lethality in Cells with BRCA1/2 Impairment

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American Society of Hematology

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ASH Publications

American Society of Hematology

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