1-20 of 784
chief complaint
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Targeting cereblon in AML

Steven Grant
Journal: Blood
Blood (2021) 137 (5): 584–586.
https://doi.org/10.1182/blood.2020009827
Published: 2021
Journal Articles

CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells

Christine Surka, Liqing Jin, Nathan Mbong, Chin-Chun Lu, In Sock Jang, Emily Rychak, Derek Mendy, Thomas Clayton, Elizabeth Tindall, Christy Hsu, Celia Fontanillo, Eileen Tran, Adrian Contreras, Stanley W. K. Ng, Mary Matyskiela, Kai Wang, Philip Chamberlain, Brian Cathers, James Carmichael, Joshua Hansen, Jean C. Y. Wang, Mark D. Minden, Jinhong Fan, Daniel W. Pierce, Michael Pourdehnad, Mark Rolfe, Antonia Lopez-Girona, John E. Dick, Gang Lu
Journal: Blood
Blood (2021) 137 (5): 661–677.
https://doi.org/10.1182/blood.2020008676
Published: 2021
Includes: Supplemental data
Journal Articles

The QUAZAR AML-001 Maintenance Trial: Results of a Phase III International, Randomized, Double-Blind, Placebo-Controlled Study of CC-486 (Oral Formulation of Azacitidine) in Patients with Acute Myeloid Leukemia (AML) in First Remission

Andrew H. Wei, MBBS, FRACP, FRCPA, PhD, Hartmut Döhner, MD, Christopher Pocock, MBBS, Pau Montesinos, MD PhD, Boris Afanasyev, MD DSci, Hervé Dombret, MD, Farhad Ravandi, MD, Hamid Sayar, MD MSc, Jun Ho Jang, MD PhD, Kimmo Porkka, MD, Dominik Selleslag, MD, Irwindeep Sandhu, MD, Mehmet Turgut, MD, Valentina Giai, MD, Yishai Ofran, MD, Merih Kizil Cakar, MD, Aida Botelho de Sousa, MD, Justyna Rybka, MD PhD, Chiara Frairia, MD, Lorenza Borin, MD, Germana Beltrami, MD, Jaroslav Cermak, MD PhD, Gert J. Ossenkoppele, MD PhD, Ignazia La Torre, MD, Barry Skikne, MD, Keshava Kumar, PhD, Qian Dong, DrPH, CL Beach, PharmD, Gail J. Roboz, MD
Journal: Blood
Blood (2019) 134 (Supplement_2): LBA-3.
https://doi.org/10.1182/blood-2019-132405
Published: 2019
Journal Articles

Can Monosomy 7 be Targeted By Next Generation Cereblon-Modulating Agents?

Vera Adema, PhD, Cassandra M Kerr, MS, Wencke Walter, PhD, Stephan Hutter, PhD, Yasunobu Nagata, MD PhD, Hassan Awada, MD, Sunisa Kongkiatkamon, Christina A. Snider, BA, Milo Co, Rainey Magdalena, Arda Durmaz, Manja Meggendorfer, PhD, Aziz Nazha, MD, Jacob Scott, MD, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Francesc Sole, PhD, Torsten Haferlach, MD, Valeria Visconte, PhD, Jaroslaw P. Maciejewski, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1270.
https://doi.org/10.1182/blood-2019-128967
Published: 2019
Journal Articles

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Angela Su, Frank Ling, Camille Vaganay, Bryann Pardieu, Lina Benajiba, MD/PhD, Gaetano Sodaro, Justine Pasanisi, Kevin H Lin, BS, Justine Rutter, PhD, Christopher F. Bassil, Iléana Antony-Debre, PhD, Gabriela Alexe, PhD, Jean-François Benoist, MD, Yana Pikman, MD, Jun Qi, PhD, Herve Dombret, MD PhD, Claude Preudhomme, PharmD, PhD, Nina Fenouille, Hava M. Golan, Kimberly Stegmaier, MD, Camille Lobry, Kris C Wood, PhD, Raphael Itzykson, Alexandre Puissant, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 877.
https://doi.org/10.1182/blood-2019-131255
Published: 2019
Journal Articles

The Effects of Utilization of Individualized Pain Plans in Treatment of Vaso-Occlusive Crises in the Emergency Department

Sherraine Griffin, MD, Payal Desai, MD, Eric Adkins, MD MSc, Michael G (MD) Purcell, MD, Luca Delatore, MD, Ying Huang, MS, MA, Melanie Heinlein, BSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 4682.
https://doi.org/10.1182/blood-2019-126991
Published: 2019
Journal Articles

Gene Polymorphisms and Vincristine-Induced Neuropathy in Patients Who Received R-CHOP Chemotherapy

Akihiko Sawaki, MD, Kana Miyazaki, MD PhD, Toshifumi Takeuchi, MD PhD, Kyoko Kobayashi, MD PhD, Hiroshi Imai, MD PhD, Isao Tawara, MD PhD, Ryoichi Ono, MD PhD, Tetsuya Nosaka, MD PhD, Motoko Yamaguchi, MD PhD, Naoyuki Katayama, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1624.
https://doi.org/10.1182/blood-2019-122796
Published: 2019
Journal Articles

Multidimensional Single Cell Analysis Shows Increased T/NK Cell Subsets in Both Blood and Bone Marrow of Iberdomide (CC-220) Treated Relapsed/Refractory Multiple Myeloma Patients

Michael Amatangelo, Oliver Van Oekelen, MD MSc, Adeeb H Rahman, PhD, Alessandro Lagana, PhD, Sarah Gooding, FRCPath,MRCP,MBBChir, Hervé Avet-Loiseau, MD PhD, Udo Oppermann, PhD, William E Pierceall, PhD, Anjan Thakurta, Samir Parekh, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1775.
https://doi.org/10.1182/blood-2019-126146
Published: 2019
Journal Articles

CC-92480 Is a Novel Cereblon E3 Ligase Modulator with Enhanced Tumoricidal and Immunomodulatory Activity Against Sensitive and Resistant Multiple Myeloma Cells

Antonia Lopez-Girona, Courtney G. Havens, Gang Lu, Emily Rychak, Derek Mendy, Bonny Gaffney, Christine Surka, Chin-Chun Lu, Mary Matyskiela, Gody Khambatta, Lilly Wong, Joshua Hansen, Daniel W. Pierce, Brian E. Cathers, James Carmichael
Journal: Blood
Blood (2019) 134 (Supplement_1): 1812.
https://doi.org/10.1182/blood-2019-124338
Published: 2019
Journal Articles

CC-92480, a Novel Cereblon E3 Ligase Modulator, Is Synergistic with Dexamethasone, Bortezomib, and Daratumumab in Multiple Myeloma

Lilly Wong, Rama Krishna Narla, Jim Leisten, Daniel Bauer, Matthew Groza, Bonny Gaffney, Courtney G. Havens, Justin Choi, Jack Houston, Antonia Lopez-Girona, Joshua Hansen, Brian E. Cathers, James Carmichael, Daniel W. Pierce
Journal: Blood
Blood (2019) 134 (Supplement_1): 1815.
https://doi.org/10.1182/blood-2019-124345
Published: 2019
Journal Articles

Chemically Induced Degradation of MALT1 to Treat B-Cell Lymphomas

Lorena Fontan, PhD, John Hatcher, PhD, David Scott, Qi Qiao, Ilkay Us, Guangyan Du, Matthew Durant, Jimmy Wilson, Hao Wu, PhD, Nathanael Gray, Ari Melnick, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2073.
https://doi.org/10.1182/blood-2019-130666
Published: 2019
Journal Articles

Late Effects Are Important Considerations in Initial Hodgkin Lymphoma Treatment Decision-Making According to Survivors

Anita J Kumar, MDMS, Rachel Murphy-Banks, MA, Ruth Ann Weidner, MBA, MRP, Susan K Parsons, MD MRP
Journal: Blood
Blood (2019) 134 (Supplement_1): 2137.
https://doi.org/10.1182/blood-2019-124481
Published: 2019
Journal Articles

The Role of SOD2 in Maintaining Endothelial Cell Function in SCD

Atinuke Dosunmu-Ogunbi, Yingze Zhang, PhD, Seyed Mehdi Nouraie, PhD MD, Adam Straub, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3563.
https://doi.org/10.1182/blood-2019-131238
Published: 2019
Journal Articles

An Institutional Retrospective Study on Recognizing the Delay in Multiple Myeloma Diagnosis

Nima Ghalehsari, MD, Pragnan Kancharla, MD MBBS, Neil S Nimkar, MD, Anita Mazloom, MD, Farah Ashraf, DO, Angelica Singh, MD, Mendel Goldfinger, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3430.
https://doi.org/10.1182/blood-2019-127625
Published: 2019
Journal Articles

Implication of Inherited Genetic Variants Associated with Follicular Lymphoma Susceptibility in the Prognosis of Patients Treated By Immunochemotherapy in PRIMA Study

Herve Ghesquieres, MD PhD, Youenn Drouet, PhD, Sarah Huet, PharmD PhD, Guillaume Cartron, Marie-Helene Delfau, MD PhD, Fritz Offner, MD, Pauline Brice, Luc Xerri, MD PhD, Reda Bouabdallah, Gilles A. Salles, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2780.
https://doi.org/10.1182/blood-2019-130357
Published: 2019
Journal Articles

Pharmacodynamic Responses to CC-90009, a Novel Cereblon E3 Ligase Modulator, in a Phase I Dose-Escalation Study in Relapsed or Refractory Acute Myeloid Leukemia (R/R AML)

Jinhong Fan, Hongbin Wang, Suzana Couto, Tsun-Wen Sheena Yao, Geoffrey L. Uy, MD, Amer M. Zeidan, MBBS, MHS, Mark D. Minden, Pau Montesinos, Daniel J. DeAngelo, Jessica K. Altman, Jamie Koprivnikar, MD, Paresh Vyas, MD PhD, Yngvar Fløisand, María Belén Vidriales, Bjørn Tore Gjertsen, Tonia J. Buchholz, Michael Pourdehnad, Daniel W. Pierce
Journal: Blood
Blood (2019) 134 (Supplement_1): 2547.
https://doi.org/10.1182/blood-2019-124291
Published: 2019
Journal Articles

Elucidating the Mechanism of Action of CC-90009, a Novel Cereblon E3 Ligase Modulator, in AML Via Genome-Wide CRISPR Screen

Gang Lu, Christine Surka, Chin-Chun Lu, In Sock Jang, PhD, Kai Wang, PhD, Mark Rolfe, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 405.
https://doi.org/10.1182/blood-2019-125492
Published: 2019
Journal Articles

MANIFEST, a Phase 2 Study of CPI-0610, a Bromodomain and Extraterminal Domain Inhibitor (BETi), As Monotherapy or "Add-on" to Ruxolitinib, in Patients with Refractory or Intolerant Advanced Myelofibrosis

John Mascarenhas, MD, Marina Kremyanskaya, Ronald Hoffman, MD, Prithviraj Bose, MD, Moshe Talpaz, MD, Claire N Harrison, Professor, Vikas Gupta, MD FRCP, FRCPath, Brian Leber, MD, Shireen Sirhan, MD, Sujan Kabir, MD, Adrian Senderowicz, MD, James Shao, MS, Jennifer Mertz, PhD, Patrick Trojer, PhD, Srdan Verstovsek, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 670.
https://doi.org/10.1182/blood-2019-127119
Published: 2019
Journal Articles

Clinical Activity of CC-90009, a Cereblon E3 Ligase Modulator and First-in-Class GSPT1 Degrader, As a Single Agent in Patients with Relapsed or Refractory Acute Myeloid Leukemia (R/R AML): First Results from a Phase I Dose-Finding Study

Geoffrey L. Uy, MD, Mark D. Minden, Pau Montesinos, Daniel J. DeAngelo, Jessica K. Altman, Jamie Koprivnikar, MD, Paresh Vyas, MD PhD, Yngvar Fløisand, María Belén Vidriales, Bjørn Tore Gjertsen, Jordi Esteve, Tonia J. Buchholz, Suzana Couto, Jinhong Fan, Bishoy Hanna, Li Li, Daniel W. Pierce, Kristen Hege, Michael Pourdehnad, Amer M. Zeidan, MBBS, MHS
Journal: Blood
Blood (2019) 134 (Supplement_1): 232.
https://doi.org/10.1182/blood-2019-123966
Published: 2019
Journal Articles

First Clinical Study of the B-Cell Maturation Antigen (BCMA) 2+1 T Cell Engager (TCE) CC-93269 in Patients (Pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Interim Results of a Phase 1 Multicenter Trial

Luciano J. Costa, MD PhD, Sandy W. Wong, Arancha Bermúdez, Javier de la Rubia, María-Victoria Mateos, Enrique M. Ocio, Paula Rodríguez-Otero, Jesús San-Miguel, Shaoyi Li, Rafael Sarmiento, Pilar Lardelli, Allison Gaudy, Isaac Boss, Lisa M. Kelly, Michael R. Burgess, Kristen Hege, William I. Bensinger
Journal: Blood
Blood (2019) 134 (Supplement_1): 143.
https://doi.org/10.1182/blood-2019-122895
Published: 2019