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Journal Articles

Developing a Novel Anti-Bcma CAR-T for Relapsed or Refractory Multiple Myeloma

Xin Yao, PhD, Shigui Zhu, PhD, Jiaqi Huang, PhD, Xiaoyan Qu, MD PhD, Judy Zhu, MD, Yutian Wei, MS, Liping Lan, MS, Xiaoteng LV, MS, Junfeng Wu, PhD, Rirfei Wang, MS, Dingzhu Yang, Chengxiao Zheng, MD, DiJun Zhao, MS, Lei Fan, MD PhD, Fei Huang, Hua Lu, MD PhD, Chaocan Zhang, MS, Cheng Chen, PhD, Yanfeng Li, MS, Jiaqiang Ren, MD PhD, Li Zhang, MD, Michael Humphries, MD, Jianyong Li, MD, Yihong Yao, PhD
Blood (2019) 134 (Supplement_1): 50.
DOI: https://doi.org/10.1182/blood-2019-125372
Published: 2019
Journal Articles

Tisagenlecleucel Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed/Refractory Children and Young Adults with Acute Lymphoblastic Leukemia (ALL): Real World Experience from the Center for International Blood and Marrow Transplant Research (CIBMTR) and Cellular Therapy (CT) Registry

Stephan Grupp, MD PhD, Zhen-Huan Hu, MPH, Yiyun Zhang, PhD, Amy Keating, MD, Michael A. Pulsipher, MD, Christine Philips, Steven P. Margossian, MD PhD, Joseph Rosenthal, MD MS, Dana Salzberg, MD, Deborah E. Schiff, MD, Gregory Yanik, MD, Kevin J. Curran, MD, Andrew C. Harris, MD, Peiman Hematti, MD, Sarah Nikiforow, MD PhD, Patricia Steinert, PhD, Lan Yi, PhD, Raghav Chawla, MD PhD, Mary M. Horowitz, Eric Bleickardt, MD, Marcelo C. Pasquini, MDMS
Blood (2019) 134 (Supplement_1): 2619.
DOI: https://doi.org/10.1182/blood-2019-129279
Published: 2019
Journal Articles

Phase 1 Results of CNCT19: CD19 CAR Constructed of a New Anti-CD19 Chimeric Antigen Receptor in Relapsed or Refractory Acute Lymphoblastic Leukemia

Runxia Gu, Fang Liu, Dehui Zou, MD, Bingcheng Liu, Wei Liu, Xiaojuan Chen, MD, Kaiqi Liu, Ye Guo, MD, Xiaoyuan Gong, Rui Lv, Xia Chen, Chunlin Zhou, Mengjun Zhong, Yingxi Xu, Huijun Wang, Hui Wei, MD, Yingchang Mi, MD, Lugui Qiu, MD PhD, Lulu Lv, Min Wang, MD, Ying Wang, MD, Xiaofan Zhu, MD, Jianxiang Wang, MD
Blood (2019) 134 (Supplement_1): 2622.
DOI: https://doi.org/10.1182/blood-2019-125342
Published: 2019
Journal Articles

Local Manufacture of CD19 CAR-T Cells Using an Automated Closed-System: Robust Manufacturing and High Clinical Efficacy with Low Toxicities

Olga Molostova, MD, Larisa Shelikhova, MD, Dina Schneider, PhD, Rimma Khismatullina, MD, Yakov Muzalevsky, Alexey Kazachenok, Liane Preussner, Georg Rauser, Julia Abugova, Elena Kurnikova, Dmitriy Pershin, Viktoria Zubachenko, Alexander Popov, MD PhD, Olga Illarionova, MD, Natalia Miakova, MD PhD, Dmitry Litvinov, MD, Galina Novichkova, MD PhD, Alexey A. Maschan, MD, Rimas Orentas, PhD, Boro Dropulic, PhD, Michael Maschan, MDMSc
Blood (2019) 134 (Supplement_1): 2625.
DOI: https://doi.org/10.1182/blood-2019-130370
Published: 2019
Journal Articles

Preclinical Assessment of Non-Virally Engineered CD33.CAR Cytokine-Induced Killer (CIK) Cells in Chemoresistant AML Patient-Derived Xenografts

Maria Caterina Rotiroti, PhD, Chiara Buracchi, PhD, Silvia Arcangeli, PhD, Chiara F Magnani, PhD, Claudia Cappuzzello, PhD, Zsuzsanna Izsvak, PhD, Stefania Galimberti, PhD, Maria Grazia Valsecchi, PhD, Giuseppe Dastoli, MD, Marta Serafini, PhD, Ettore Biagi, MD, Andrea Biondi, MD, Sarah Tettamanti, PhD
Blood (2019) 134 (Supplement_1): 2665.
DOI: https://doi.org/10.1182/blood-2019-130399
Published: 2019
Journal Articles

UM171 Regulates the Hematopoietic Differentiation of Human Acquired Aplastic Anemia-Derived Induced Pluripotent Stem Cells

Tellechea Maria Florencia, MSc, Flavia S. Donaires, PhD, Tiago C. Silva, PhD, Lilian F. Moreira, PhD, Yordanka Armenteros, PhD, Rodrigo T. Calado, MD PhD
Blood (2019) 134 (Supplement_1): 2500.
DOI: https://doi.org/10.1182/blood-2019-127466
Published: 2019
Journal Articles

Detailed Multi-Method Analysis of Bone Marrow from Pediatric Pre-B-ALL Patients Prior to CD19-CAR-T Therapy Subsequently Evidencing Overt CAR-T Resistance

Katherine Elizabeth Masih, BS, Rebecca Gardner, MD, Berkley Gryder, PhD, Abdelmaksoud Abdallah, BS, Justin Lack, PhD, Benjamin Stanton, PhD, Ashley Wilson, PhD, Sivasish Sindiri, MS, Young Song, PhD, Zachary Rae, BS, Michael Kelly, PhD, Wang Chaoyu, MS, Xinyu Wen, MS, Adam Cheuk, PhD, Jun Wei, PhD, Michael C. Jensen, MD, Javed Khan, MD, Rimas Orentas, PhD
Blood (2019) 134 (Supplement_1): 2744.
DOI: https://doi.org/10.1182/blood-2019-130796
Published: 2019
Journal Articles

Efficient Ex Vivo Expansion of Highly Purified Human Umbilical Cord Blood-Derived Very Small CD34 + lin - CD45 - Stem Cells into Functional Endothelial Cells in Vitro in Chemically Identified, Feeder Layer-Free Medium Supplemented with Nicotinamide

Alison Domingues, MS, Kamila Bujko, MS, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc
Blood (2019) 134 (Supplement_1): 4882.
DOI: https://doi.org/10.1182/blood-2019-125819
Published: 2019
Journal Articles

Differential Alemtuzumab Dosage Effects in T-Cell Deplete Allogeneic Haematopoietic Stem Cell Transplants for Myeloid Malignancies- King's College Hospital London Experience

Varun Mehra, MBBS,MRCP,FRCPath, Daniele Avenoso, MD, Ximena Cabrera Castellano, Adrian Choy, Stefani Widya, Mili Shah, FRCPath, Shafqat Inam, MD, Shreyans Gandhi, MBBS,MDDNB,MRCP,FRCPath,MPhil, Austin Kulasekararaj, MD MRCP, FRCPath, Francesco Dazzi, PhD, Ghulam J. Mufti, MBBS, FRCP, FRCPath, DM, Antonio Pagliuca, MBBS, MA, FRCP, FRCPath, Hugues De Lavallade, Victoria Potter, MBBS, BSc, FRACP, FRCPA
Blood (2019) 134 (Supplement_1): 4622.
DOI: https://doi.org/10.1182/blood-2019-131239
Published: 2019
Journal Articles

Not All Patients with Mild Phenotype of Gaucher Disease (GD) Need Disease Specific Treatment As Reflected By Patients Reported Outcomes Measures

Shoshana Revel-Vilk, MD, Tama Dinur, PhD, Majdolen Istaiti, Dafna Frydman, DMV, Michal Becker-Cohen, MSc, Ari Zimran, MD
Blood (2019) 134 (Supplement_1): 4712.
DOI: https://doi.org/10.1182/blood-2019-123000
Published: 2019
Journal Articles

Bone Marrow Involvement in Patients with Type 1 Gaucher Disease Receiving Low-Dose Long Term Enzyme Replacement Therapy (median 18 years)

Shoshana Revel-Vilk, MD, Jeffrey Szer, MBBS, Michal Becker Cohen, Ari Zimran, MD
Blood (2019) 134 (Supplement_1): 4862.
DOI: https://doi.org/10.1182/blood-2019-131013
Published: 2019
Journal Articles

Economic Burden of Neurologic Toxicities Associated with Treating Relapsed Refractory Diffuse Large B-Cell Lymphoma in the United States

Michael S Broder, MD MSHS, Qiufei Ma, PhD, Tingjian Yan, PhD, Eunice Chang, PhD, Lamis K. Eldjerou, MD, Yanni Hao, PhD, David Kuzan, MD, Jie Zhang, PhD
Blood (2019) 134 (Supplement_1): 4719.
DOI: https://doi.org/10.1182/blood-2019-122587
Published: 2019
Journal Articles

Therapeutic Targeting of Monokine Production Is a Promising Strategy to Attenuate Cytokine-Release Syndrome in CAR-T Cell Therapy

Muneyoshi Futami, MD PhD, Keisuke Suzuki, MS, Satomi Kato, BS, Yoshio Tahara, MS, Yoichi Imai, MD PhD, Takayuki Mimura, PhD, Yoshihiro Watanabe, PhD, Arinobu Tojo, MD PhD
Blood (2019) 134 (Supplement_1): 2067.
DOI: https://doi.org/10.1182/blood-2019-129601
Published: 2019
Journal Articles

Combined Infusion of Anti-CD19 and Anti-Bcma CART Cells after Early or Later Transplantation in the Front Line Was Superior to Salvage Therapy for High Risk MM

Xiaolan Shi, Lingzhi Yan, Jingjing Shang, Liqing Kang, Song Jin, Huizhu Kang, Ruju Wang, Zhu Mingqing, Jiazi Zhou, Feiran Gong, Guanghua Chen, Jin Zhou, Huirong Chang, Weiqin Yao, Ying Yao, Yong Liu, Zhi Yan, Juanjuan Su, Depei Wu, MD PhD, Lei Yu, Fu Cheng Cheng, MD PhD
Blood (2019) 134 (Supplement_1): 1949.
DOI: https://doi.org/10.1182/blood-2019-131546
Published: 2019
Journal Articles

Incidence and Risk Factors of De Novo Skin Cancer in a Contemporary Cohort of Hematopoietic Cell Transplantation Survivors

Jennifer Berano Teh, Farah Abdulla, MD, Kelly Peng, Liezl Atencio, Alicia Gonzales, Meagan Echevarria, Alex Iukuridze, Alan Geller, Heeyoung Kim, Lennie Wong, PhD, Stephen J Forman, MD, Ryotaro Nakamura, MD, Badri Modi, MD, Saro H. Armenian, DO, MPH
Blood (2019) 134 (Supplement_1): 2011.
DOI: https://doi.org/10.1182/blood-2019-124993
Published: 2019
Journal Articles

Enabling Gene-Edited, Regulatory-like, T Cells (edTreg) for Treatment of IPEX and Other Autoimmune Disorders

Yuchi Honaker, PhD, Karen Sommer, PhD, Noelle Dahl, Yufei Xiang, MD, PhD, Christina Lopez, PhD, Samuel Scharffenberger, Michelle Christian, Troy R. Torgerson, MD PhD, Andrew M. Scharenberg, MD, David J. Rawlings, MD
Blood (2019) 134 (Supplement_1): 2071.
DOI: https://doi.org/10.1182/blood-2019-131946
Published: 2019
Journal Articles

Neurological Adverse Events Following CAR-T Cell Therapy: A Real-World Analysis of Adult Patients Treated with Axicabtagene Ciloleucel or Tisagenlecleucel

Ajeet Gajra, MD FACP, Marjorie E Zettler, PhD MPH, Eli G Phillips Jr., PharmD, JD, Andrew J Klink, PhD MPH, Jonathan K. Kish, PhD MPH, Sonam Mehta, Bruce Feinberg, DO
Blood (2019) 134 (Supplement_1): 1952.
DOI: https://doi.org/10.1182/blood-2019-129593
Published: 2019
Journal Articles

A Biophysically Defined MSC Subpopulation for Enhanced Homing and Immunosuppression

Zhiyong Poon, Xiubo Fan, PhD, Alice Cheung, PhD, Sudipto Bari, PhD, William YK Hwang, MBBS, FRCP
Blood (2019) 134 (Supplement_1): 2078.
DOI: https://doi.org/10.1182/blood-2019-126683
Published: 2019
Journal Articles

Results from CARTITUDE-1: A Phase 1b/2 Study of JNJ-4528, a CAR-T Cell Therapy Directed Against B-Cell Maturation Antigen (BCMA), in Patients with Relapsed and/or Refractory Multiple Myeloma (R/R MM)

Deepu Madduri, MD, Saad Z. Usmani, MD, Sundar Jagannath, Indrajeet Singh, PhD, Enrique Zudaire, PhD, Tzu-Min Yeh, Alicia J. Allred, PhD, Arnob Banerjee, MD, Jenna D. Goldberg, MD, Jordan M Schecter, MD, Sen Zhuang, Jeffrey R. Infante, MD, Syed Rizvi, Xiaohu (Frank) Fan, MD PhD, Andrzej Jakubowiak, MD PhD, Jesus G. Berdeja, MD
Blood (2019) 134 (Supplement_1): 577.
DOI: https://doi.org/10.1182/blood-2019-121731
Published: 2019
Journal Articles

Long-Term Follow-up of a Phase 1, First-in-Human Open-Label Study of LCAR-B38M, a Structurally Differentiated Chimeric Antigen Receptor T (CAR-T) Cell Therapy Targeting B-Cell Maturation Antigen (BCMA), in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM)

Bai-Yan Wang, MD PhD, Wan-Hong Zhao, MD PhD, Jie Liu, MD, Yin-Xia Chen, MD, Xing-Mei Cao, MD, Yun Yang, MD, Yi-Lin Zhang, MD, Fang-Xia Wang, MD PhD, Peng-Yu Zhang, MD PhD, Bo Lei, MD, Liu-Fang Gu, MD PhD, Jian-Li Wang, MD PhD, Jia-Jia Zhang, MD, Ru Zhang, MD, Hui Zhang, MD, Ying Shen, MD, Ju Bai, PhD, Yan Xu, MD, Xu-Geng Wang, MD PhD, Rui-Li Zhang, MD, Li-Li Wei, MD, Zong-Fang Li, MD PhD, Gai-Xia He, PhD, Yan Geng, MD PhD, Qian He, MD PhD, Qiu-Chuan Zhuang, Msc, Frank Xiao-Hu Fan, MD PhD, Wang-Gang Zhang, MD PhD, Ai-Li He, MD PhD
Blood (2019) 134 (Supplement_1): 579.
DOI: https://doi.org/10.1182/blood-2019-124953
Published: 2019