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Journal Articles

Immunogenomic identification and characterization of granulocytic myeloid-derived suppressor cells in multiple myeloma

Cristina Perez, Cirino Botta, Aintzane Zabaleta, Noemi Puig, Maria-Teresa Cedena, Ibai Goicoechea, Daniel Alameda, Edurne San José-Eneriz, Juana Merino, Paula Rodríguez-Otero, Catarina Maia, Diego Alignani, Patricia Maiso, Irene Manrique, David Lara-Astiaso, Amaia Vilas-Zornoza, Sarai Sarvide, Caterina Riillo, Marco Rossi, Laura Rosiñol, Albert Oriol, María-Jesús Blanchard, Rafael Rios, Anna Sureda, Jesus Martin, Rafael Martinez, Joan Bargay, Javier de la Rubia, Miguel-Teodoro Hernandez, Joaquin Martinez-Lopez, Alberto Orfao, Xabier Agirre, Felipe Prosper, Maria-Victoria Mateos, Juan-José Lahuerta, Joan Blade, Jesús F. San-Miguel, Bruno Paiva
Journal: Blood
Blood (2020) 136 (2): 199–209.
DOI: https://doi.org/10.1182/blood.2019004537
Published: 2020
Includes: Supplemental data
Journal Articles

Defining the Differentiation States of Multiple Myeloma at Single Cell Resolution Reveals Opportunities for Immunotherapy

Julia Frede, PhD MPhil, Praveen Anand, PhD, Andrew J. Yee, MD, Tushara Vijaykumar, Monica S. Nair, Johannes M. Waldschmidt, MD, Sayalee V. Potdar, Jake A. Kloeber, Antonis Kokkalis, PhD MSc, Guangwu Guo, PhD, Samantha J. Shapiro, Mason L. Mann, Robb S Friedman, MD, Brea C. Lipe, MD, Erica L. Campagnaro, MD, Craig E. Cole, MD, Elizabeth K. O'Donnell, MD, Thomas Guerrero, MD, Omar Nadeem, MD, Jacob P. Laubach, MD, Nikhil C. Munshi, MD, Paul G. Richardson, MD, Kenneth C. Anderson, MD, Noopur Raje, MD, Birgit Knoechel, MD PhD, Jens G. Lohr, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3091.
DOI: https://doi.org/10.1182/blood-2019-130247
Published: 2019
Journal Articles

Development and Performance of Risk Stratification Models for AML Patients Utilizing ELN-2017 Guidelines and Additional Prognostic Factors: A SWOG Report

Era L Pogosova-Agadjanyan, BS, Anna Moseley, M.S., Megan Othus, PhD, Frederick R. Appelbaum, MD, Thomas R. Chauncey, MD PhD, I-Ming L. Chen, DVM, MS, Harry P. Erba, MD PhD, John E. Godwin, MD, Isaac C. Jenkins, MS, Min Fang, MD PhD, Mike Huynh, Kenneth J Kopecky, Alan F. List, MD, Jasmine Naru, PhD, Jerald P. Radich, MD, Emily Stevens, MD PhD, Brooke E Willborg, BS, Cheryl L. Willman, MD, Brent L Wood, MD PhD, Qing Zhang, Soheil Meshinchi, MD PhD, Derek Stirewalt, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2691.
DOI: https://doi.org/10.1182/blood-2019-124529
Published: 2019
Journal Articles

Somatic Mutations and Loss of Heterozygosity of HLA Genes Are Frequently Occurred and Tightly Associated with Poor Prognosis in Adult T Cell Leukemia-Lymphoma

Keita Tamaki, MD, Satoko Morishima, MD PhD, Shingo Suzuki, PhD, Atsuko Shigenari, Ikumi Nomura, Yutaro Yokota, Kazuho Morichika, MD, Yukiko Nishi, MD PhD, Sawako Nakachi, MD PhD, Shiki Okamoto, PhD, Kennosuke Karube, MD PhD, Takuya Fukushima, MD PhD, Takashi Shiina, PhD, Hiroaki Masuzaki, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2785.
DOI: https://doi.org/10.1182/blood-2019-128070
Published: 2019
Journal Articles

A CRISPR/Cas9 Library Screen in Patients' Leukemia Cells In Vivo

Ehsan Bahrami, PhD, Martin Becker, PhD, Anna-Katharina Wirth, MSc, Jan Phillip Schmid, MSc, Tobias Herold, MD, Rupert Öllinger, PhD, Roland Rad, Irmela Jeremias, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3945.
DOI: https://doi.org/10.1182/blood-2019-124288
Published: 2019
Journal Articles

Acute Myeloid Leukemia Export Mitochondria in Extracellular Vesicles Which Induces Pro-Tumoral Changes in Bone Marrow Macrophages

Jamie A Moore, BSc, MSc, Jayna J Mistry, BSc, Rebecca H Horton, Charlotte Hellmich, MBBChir, Adam Pattinson, MSc, BSc, Adam Morfakis, BSc, Yu Sun, BSc, MSc, PhD, Matthew Lawes, MD, Christopher J Morris, PhD, Anna Haestier, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1427.
DOI: https://doi.org/10.1182/blood-2019-128447
Published: 2019
Journal Articles

Leukemic Stem Cell Phenotype Is Associated with Mutational Profile in Acute Myeloid Leukemia

Ja Min Byun, MD, Dong-Yeop Shin, MD PhD, Youngil Koh, Sung-Soo Yoon, MD PhD, Junshik Hong, MD, Inho Kim, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3852.
DOI: https://doi.org/10.1182/blood-2019-126373
Published: 2019
Journal Articles

Free Fatty Acid Uptake By Hematopoietic Stem and Progenitor Cells Drives Immune Cell Expansion in Response to Salmonella Typhimurium infection

Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Christopher R Marlein, PhD, Naiara Beraza, PhD, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1197.
DOI: https://doi.org/10.1182/blood-2019-128237
Published: 2019
Journal Articles

Ibrutinib Treatment in CLL Patients Improves T Cell Function and Blinatumomab Redirected Cytotoxicity

Meixiao Long, MD, Erich Williams, Clara Berard, Carolyn Cheney, BS, Eileen Hu, BS, Seema A. Bhat, MD, Kerry A. Rogers, MD, Jennifer Woyach, MD, Natarajan Muthusamy, DVM,PhD, John C. Byrd, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1049.
DOI: https://doi.org/10.1182/blood-2019-125417
Published: 2019
Journal Articles

Repurposing Clofazimine As a Novel Drug for the Treatment of PI-Resistant Stem Cell-like Subclones in Myeloma

Harish Kumar, PhD, Ujjal Kumar Mukherjee, PhD, Suman Mazumder, PhD, Sabyasachi Sanyal, PhD, Brian G. Van Ness, PhD, Amit Kumar Mitra, PhD MSc, BSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 4418.
DOI: https://doi.org/10.1182/blood-2019-131596
Published: 2019
Journal Articles

RNA Sequencing of Hodgkin Lymphoma Reed-Sternberg Cells Uncovers a Plasma Cell Signature and Escape from NK Cell Recognition

Ethel Cesarman, MD PhD, Mikhail Roshal, MD PhD, Jonathan Reichel, PhD, Wagner Florian, PhD, Bhavneet Binder, Sakellarios Zairis, Jouliana Sadek, PhD, Joshua Brody, MD, Raul Rabadan, PhD, Sandeep Dave, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 549.
DOI: https://doi.org/10.1182/blood-2019-131163
Published: 2019
Journal Articles

Efficient Ex Vivo Expansion of Highly Purified Human Umbilical Cord Blood-Derived Very Small CD34 + lin - CD45 - Stem Cells into Functional Endothelial Cells in Vitro in Chemically Identified, Feeder Layer-Free Medium Supplemented with Nicotinamide

Alison Domingues, MS, Kamila Bujko, MS, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 4882.
DOI: https://doi.org/10.1182/blood-2019-125819
Published: 2019
Journal Articles

CD38 Knockout Primary NK Cells to Prevent "Fratricide" and Boost Daratumumab Activity

Yuya Nagai, MD, Meisam Naeimi Kararoudi, PhD DVM, Ezgi Elmas, MS, Marcelo Pereira, Syed Abbas Ali, MD, Philip Hollingsworth Imus, MD, Dean Anthony Lee, MD PhD, Gabriel Ghiaur, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 870.
DOI: https://doi.org/10.1182/blood-2019-129456
Published: 2019
Journal Articles

Activation of JAK2/STAT5 Pathway Reduces Expression Level of DNMT3a in MPN Cell Line

Jie Zhou, Aibin Liang, PhD, Shaoguang Li, Wenjun Zhang, Jianfei FU, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5394.
DOI: https://doi.org/10.1182/blood-2019-125434
Published: 2019
Journal Articles

Myeloma Derived Extracellular Vesicles Containing Endoplasmic Reticulum Remodel the Bone Marrow Microenvironment Towards a Pro-Tumoral Senescent Phenotype

Yu Sun, BSc, MSc, PhD, Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Christopher R Marlein, PhD, Anna Haestier, Cesar A. Gomez, MD PhD FRCPath, Christopher J Morris, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 689.
DOI: https://doi.org/10.1182/blood-2019-128268
Published: 2019
Journal Articles

Single-Cell Analysis Based Dissection of Clonality in Myelofibrosis

Elena Mylonas, Kenichi Yoshida, MD PhD, Mareike Frick, Kaja Hoyer, Friederike Christen, Jaspal Kaeda, PhD FRCPath, Matthias Obenaus, Daniel Nörenberg, MD, Cornelius Hennch, Willy Chan, Yotaro Ochi, MD, Yuichi Shiraishi, Yusuke Shiozawa, MD PhD, Thorsten Zenz, MD, Christopher C. Oakes, PhD, Birgit Sawitzki, Michaela Schwarz, MD, Lars Bullinger, Philipp Le Coutre, MD, Matthew John Jerome Rose-Zerilli, Seishi Ogawa, MD PhD, Frederik Damm, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 469.
DOI: https://doi.org/10.1182/blood-2019-123367
Published: 2019
Journal Articles

Single Cell Transcriptomic Analysis of the Multiple Myeloma Bone Marrow Identifies a Unique Inflammatory Stromal Cell Population Associated with TNF Signaling

Madelon M.E. de Jong, MD, Zoltan Kellermayer, MD PhD, Natalie Papazian, M Duin, Annemiek Broyl, MD PhD, Pieter Sonneveld, Tom Cupedo
Journal: Blood
Blood (2019) 134 (Supplement_1): 690.
DOI: https://doi.org/10.1182/blood-2019-123012
Published: 2019
Journal Articles

KIFC1 Mediates Centrosome Clustering Prior to Proplatelet Formation from Megakaryocytes

Adrian R. Wilkie, PhD, Leila J. Noetzli, PhD, Genevieve Couldwell, Anthony R. Sciaudone, Anjana Ray, PhD, Kellie R. Machlus, PhD, Joseph E. Italiano, Jr., BS, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 721.
DOI: https://doi.org/10.1182/blood-2019-130803
Published: 2019
Journal Articles

Chromatin Accessibility Mapping of Primary Erythroid Cell Populations Leads to Identification and Validation of Nuclear Factor I X (NFIX) As a Novel Fetal Hemoglobin (HbF) Repressor

Mudit Chaand, PhD, Chris Fiore, PhD, Brian T Johnston, MS, Diane H Moon, PhD, John P Carulli, PhD, Jeffrey R Shearstone, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 812.
DOI: https://doi.org/10.1182/blood-2019-124337
Published: 2019
Journal Articles

YAP and TAZ in Fibroblastic Reticular Cells Support Hematopoiesis and Retention of Lymphocytes in Lymph Nodes

Hyunsoo Cho, MD PhD, Yu Ri Kim, MD, Jieun Jang, MD, Haerim Chung, MD, Soo-Jeong Kim, Sung Yong Choi, Bae Hosung, Ralf Adams, Burkhard Ludewig, PhD, Jin Seok Kim, MD PhD, June-Won Cheong, MD PhD, Yoo Hong Min, MD PhD, Gou Young Koh
Journal: Blood
Blood (2019) 134 (Supplement_1): 3595.
DOI: https://doi.org/10.1182/blood-2019-124625
Published: 2019