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Journal Articles

BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells

Kimihito C. Kawabata, Hongliang Zong, Cem Meydan, Sarah Wyman, Bas J. Wouters, Mayumi Sugita, Srinjoy Goswami, Michael Albert, Winnie Yip, Gail J. Roboz, Zhengming Chen, Ruud Delwel, Martin Carroll, Christopher E. Mason, Ari Melnick, Monica L. Guzman
Journal: Blood
Blood (2021) 137 (6): 812–825.
https://doi.org/10.1182/blood.2019001745
Published: 2021
Includes: Supplemental data
Journal Articles

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Jaewoong Lee, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Lu Yang, PhD, Huimin Geng, PhD, John Chan, MD, Joo Y. Song, MD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus MĂĽschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 748.
https://doi.org/10.1182/blood-2019-127263
Published: 2019
Journal Articles

Unique Regulatory Pathways Dictate the Translational Program in Hematopoietic Stem and Progenitor Cells

Harold K. Elias, MD, Christina Spevak, PhD, Lavanya Kannan, PhD, Mohamed A.E. Ali, MD PhD, Gaelle H Martin, PhD, Shanmugapriya Selvaraj, MS, William S Eng, Guangjie Zhao, BS, Amanda Ernlund, PhD, Vinagolu Rajasekhar, PhD, Carolien M Woolthuis, MD PhD, Robert J Schneider, PhD, Christopher Y. Park, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1180.
https://doi.org/10.1182/blood-2019-131333
Published: 2019
Journal Articles

GATA2 -Dependent Developmental and Regenerative Networks

Alexandra Soukup, PhD, Kirby D Johnson, PhD, Daniel J Conn, PhD, Evgenia Shishkova, PhD, Koichi Ricardo Katsumura, MD PhD, Peng Liu, PhD, Erik A. Ranheim, MD PhD, Katherine R. Calvo, MD PhD, Amy P. Hsu, Steven M. Holland, MD, Joshua J Coon, PhD, Sunduz Keles, PhD, Emery H Bresnick, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1182.
https://doi.org/10.1182/blood-2019-126875
Published: 2019
Journal Articles

A Test to Quantify NOTCH Pathway Activity in T Cell Acute Lymphoblastic Leukemia Patients

Kirsten Canté-Barrett, PhD, Laurent Holtzer, PhD, Henk van Ooijen, PhD, Rico Hagelaar, Valentina Cordo', MSc, Wim Verhaegh, PhD, Anja van de Stolpe, MD PhD, Jules P.P. Meijerink, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4661.
https://doi.org/10.1182/blood-2019-122856
Published: 2019
Journal Articles

Proteomic Analysis of Mitochondrial Membrane Protein FAM210B in Erythroid Cells

Chie Suzuki, Tohru Fujiwara, MD PhD, Hiroki Shima, Koya Ono, MD, Kei Saito, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Hisayuki Yokoyama, MD PhD, Shinichi Fujimaki, Yukio Nakamura, MD PhD, Hideo Harigae, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3523.
https://doi.org/10.1182/blood-2019-122618
Published: 2019
Journal Articles

Involvement of RUNX1 Pathway Is a Common Event in the Leukemic Transformation of Chronic Myeloproliferative Neoplasms (MPNs)

Paola Guglielmelli, MD PhD, Niccolò Bartalucci, PhDBSc, Elisa Contini, PhD, Giada Rotunno, PhD, Annalisa Pacilli, PhD, Simone Romagnoli, BSc, Lara Mannelli, MD, Francesco Mannelli, MD, Giacomo Coltro, MD, Alessandro Pancrazzi, PhD, Valentina Ariu, BSci, Sara Fiaccabrino, Roberto Semeraro, Alberto Magi, PhD, Carmela Mannarelli, PhD, Francesca Gesullo, BSci, Chiara Paoli, PhD, Alessandro M. Vannucchi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2968.
https://doi.org/10.1182/blood-2019-129094
Published: 2019
Journal Articles

gata2 is Required for the runx1 -Independent Hematopoiesis in Zebrafish

Erica Bresciani, PhD, Blake Carrington, Erika M Kwon Kim, PhD, Kai Yu, PhD, Kevin Bishop, Stefania Dell'Orso, PhD, Vittorio Sartorelli, PhD, Raman B. Sood, PhD, Paul P. Liu, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2463.
https://doi.org/10.1182/blood-2019-127334
Published: 2019
Journal Articles

Single Cell Sequencing Reveals Heterogeneity of Gene Expression in KMT2A Rearranged Infant ALL at Relapse Compared to Diagnosis

Erin Guest, MD, Byunggil Yoo, MS, Rumen Kostadinov, PhD, Midhat S. Farooqi, MD PhD, Emily Farrow, PhD CGC, Margaret Gibson, Neil Miller, Karina Shah, Tomi Pastinen, MD PhD, Patrick A. Brown, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2756.
https://doi.org/10.1182/blood-2019-131999
Published: 2019
Journal Articles

EGFL7 Antagonizes NOTCH Signaling and Represents a Novel Therapeutic Target in Acute Myeloid Leukemia (AML)

Marius Bill, MD PhD, Aparna Pathmanathan, Malith Karunasiri, Changxian Shen, Matthew Burke, Parvathi Ranganathan, PhD, Dimitrios Papaioannou, MD, Nina C. Zitzer, DVM, Katiri Snyder, Allison LaRocco, Allison Walker, Zachary Brannan, Ansel P. Nalin, Aharon G. Freud, MD PhD, Mikhail Dikov, Xiaoli Zhang, PhD, Clara D. Bloomfield, MD, Ramiro Garzon, MD, Adrienne M. Dorrance, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2546.
https://doi.org/10.1182/blood-2019-131856
Published: 2019
Journal Articles

PRMT5 Inhibition Modulates E2F1 Methylation and Gene Regulatory Networks Leading to Therapeutic Efficacy in JAK2VF Mutant MPN

Friederike Pastore, MD, Neha Bhagwat, PhDBS, Aishwarya Krishnan, Alessandro Pastore, Bing Li, MD, Robert L Bowman, PhD, Wenbin Xiao, MD PhD, Aaron D Viny, MDMS, Abdul Karzai, Anouar Zouak, Young C Park, Keith Cordner, Stephanie Braunstein, Alexander Grego, Jaanvi Mehta, Benjamin H Durham, MD, Richard P. Koche, PhD, Jesper Maag, Peggy Scherle, PhD, Kris Vaddi, PhD, Ross L. Levine, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 473.
https://doi.org/10.1182/blood-2019-127122
Published: 2019
Journal Articles

SETDB1 Mediated H3K9 Methylation Suppresses MLL-Fusion Target Expression and Leukemic Transformation

Andrew G. Muntean, PhD, James Ropa, Nirmalya SAHA, PhD MSc, BSc, Hsiang-Yu Hu, BS, Justin Serio, Lili Zhao, Venkatesha Basrur, Alexei Nesvizhskii, Ivan Maillard, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 110.
https://doi.org/10.1182/blood-2019-122610
Published: 2019
Journal Articles

The Relationships between Target Gene Transduction, Engraftment of HSCs and RBC Physiology in Sickle Cell Disease Gene Therapy

Melissa Bonner, PhD, Julie Kanter, MD, Elizabeth Macari, PhD, Ricky Lane, Gretchen Lewis, BMBS, Paige Coles, Sarah Kassenaar, Sai Mynampati, MS, Robert Schulze, Madison Hebert, Mark C. Walters, MD, Alexis A. Thompson, MD MPH, Mohammed Asmal, MD PhD, John F. Tisdale, MD, Francis J. Pierciey, Jr.
Journal: Blood
Blood (2019) 134 (Supplement_1): 206.
https://doi.org/10.1182/blood-2019-129124
Published: 2019
Journal Articles

Hottip Lncrna Reinforces CTCF Defined Chromatin Boundaries and Drives Wnt Target Gene Expression in AML Leukemogenesis

Huacheng Luo, Ganqian Zhu, PhD, Tsz Kan Fung, Yi Qiu, PhD, Mingjiang Xu, MD PhD, Chi Wai Eric So, Suming Huang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 277.
https://doi.org/10.1182/blood-2019-127323
Published: 2019
Journal Articles

Inhibition of the MiR-185-PAK6-Mediated Survival and Metabolic Pathways Selectively Targets Drug-Resistant CML Stem/Progenitor Cells

Andrew Wu, BSc, Katharina Rothe, PhD, Min Chen, PhD, Hanyang Lin, PhD, Artem Babaian, PhD, Ryan Yen, BSc, Donna L. Forrest, MD, Xiaoyan Jiang, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4138.
https://doi.org/10.1182/blood-2019-127826
Published: 2019
Journal Articles

Gfi1 Upregulates c-Myc Expression and Promotes c-Myc-Driven Cell Proliferation

Yangyang Zhang, MD, Fan Dong, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3769.
https://doi.org/10.1182/blood-2019-124833
Published: 2019
Journal Articles

Variant Pcgf-PRC1 Regulates Susceptibility of PRC2 Mediated H3K27me3 to Safeguard B Cell Fate of Hematopoietic Stem/Progenitor Cells

Junichiro Takano, MD, Yaeko Nakajima-Takagi, PhD, Shinsuke Ito, PhD, Haruhiko Koseki, MD PhD, Atsushi Iwama, MD PhD, Tomokatsu Ikawa, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3717.
https://doi.org/10.1182/blood-2019-129518
Published: 2019
Journal Articles

A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance Via Blocking Receptor Auto-Induction and BIM/Bmf Expression in ALL

Jianping Li, MD, Catalina Troche, PhD, Julia Hlavka Zhang, BS, Jonathan Shrimp, PhD, Jacob S. Roth, PhD, Duohui Jing, PhD, Alok Swaroop, PhD, Marta Kulis, Jon Oyer, PhD, Christine Will, MS, Daphne Dupere-Richer, PhD, Alberto Riva, PhD, Crissandra Pipe, LATG, Amin Sobn, PhD, Sharon Norton, MS, Richard Lynn Bennett, PhD, Min Shen, PhD, Matthew D. Hall, PhD, Richard B. Lock, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3758.
https://doi.org/10.1182/blood-2019-126910
Published: 2019
Journal Articles

Role of IGF2BP1 and Target Genes in ETV6-RUNX1 Positive B-Acute Lymphoblastic Leukemia

Jayanth Kumar Palanichamy, MD, Gunjan Sharma, MSc, Thakur Nidhi, MBBS, Anita Chopra, MD DM, Sameer Bakhshi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3818.
https://doi.org/10.1182/blood-2019-128019
Published: 2019
Journal Articles

Combined Targeting of Distinct c-Myc and JunB Transcriptional Programs for Multiple Myelioma Therapy

Judith Lind, PhD, Felix Czernilofsky, Sonia Vallet, MD, Fengjuan Fan, PhD, Martin Sattler, PhD, Latifa Bakiri, Erwin F Wagner, PhD, Martin Percherstorfer, MD, Klaus Podar, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4415.
https://doi.org/10.1182/blood-2019-125202
Published: 2019