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Journal Articles

A KLF4-DYRK2–mediated pathway regulating self-renewal in CML stem cells

Chun Shik Park, Andrew H. Lewis, Taylor J. Chen, Cory S. Bridges, Ye Shen, Koramit Suppipat, Monica Puppi, Julie A. Tomolonis, Paul D. Pang, Toni-Ann Mistretta, Leyuan Ma, Michael R. Green, Rachel Rau, H. Daniel Lacorazza
Blood (2019) 134 (22): 1960–1972.
DOI: https://doi.org/10.1182/blood.2018875922
Published: 2019
Includes: Supplemental data
Journal Articles

Dual Inhibition of MDM2 and XPO1 Synergizes to Induce Apoptosis in Acute Myeloid Leukemia Progenitor Cells with Wild-Type TP53 through Nuclear Accumulation of p53 and Suppression of c-Myc

Yuki Nishida, MD PhD, Jo Ishizawa, MD PhD, Vivian Ruvolo, MS, Kensuke Kojima, MD PhD, Rafael Heinz Montoya, Naval G. Daver, MD, Arnaud Lesegretain, Sharon Shacham, PhD MBA, Michael Andreeff, MD PhD
Blood (2019) 134 (Supplement_1): 2556.
DOI: https://doi.org/10.1182/blood-2019-126950
Published: 2019
Journal Articles

Anti-Tumor Effect of the EZH1/2 Dual Inhibitor Valemetostat Against Diffuse Large B-Cell Lymphoma Via Modulation of B-Cell Receptor Signaling and c-Myc Signaling Pathways

Yasuhiro Hama, PhD, Toshihiro Banjo, PhD, Daisuke Honma, PhD, Yoshimi Takata, Emi Nosaka, Machiko Shiroishi, Kenji Watanabe, Yuka Yamamoto, Tsuyoshi Hirata, Rika Nakano, Koichiro Inaki, PhD, Hiroki Goto, PhD, Yusuke Totoki, PhD, Miki Kataoka, Kyungtaek Lim, PhD, Chisa Wada, Eiji Kumazawa, PhD, Shinji Tsutsumi, PhD
Blood (2019) 134 (Supplement_1): 4642.
DOI: https://doi.org/10.1182/blood-2019-125436
Published: 2019
Journal Articles

Mechanistic Basis and Efficacy of Targeting β-Catenin-TCF7L2-JMJD6-MYC Axis to Overcome Resistance to BET Inhibitors

Christopher Peter Mill, PhD BA, Warren Fiskus, BSc,PhD, Dyana T. Saenz, PhD, Bernardo H Lara, Vrajesh Karkhanis, PhD, Taghi Manshouri, PhD, Isean Bhalla, Nancy Shao, James V Maher, Srdan Verstovsek, MD PhD, Kapil N. Bhalla, MD
Blood (2019) 134 (Supplement_1): 538.
DOI: https://doi.org/10.1182/blood-2019-125142
Published: 2019
Journal Articles

The Role of the BMP Pathway in Sustaining CML Stem Cells in the Bone Marrow Niche

Caroline Busch, BSc, MSc, Chloe Gulliver, BSc, MSc, Theresa Mulholland, BSc, Michele Zagnoni, BSc, MSc, PhD, Catherine C. Berry, BSc,PhD, Helen Wheadon, BSc, PhD
Blood (2019) 134 (Supplement_1): 3732.
DOI: https://doi.org/10.1182/blood-2019-123967
Published: 2019
Journal Articles

Targeting eIF4A Using MZ-735 Potently Induces Cell Death in Lymphoma Cells and Rapidly Represses mRNA Translation at the Global Level and in C-MYC and Other Oncogenes

Ipsita Pal, PhD, Yu Ri Kim, MD, Sohani Das Sharma, PhD, Prabhjot S. Mundi, MD, Andre M. Grilo, PhD, Luke E Berchowitz, PhD, Mingzhao Zhu, PhD, Hull G. Kenneth, PhD, Daniel Romo, PhD, Owen O'Connor, MD PhD, Marko Jovanovic, PhD, Changchun Deng, MD PhD
Blood (2019) 134 (Supplement_1): 4067.
DOI: https://doi.org/10.1182/blood-2019-131816
Published: 2019
Journal Articles

Low-Dose Triptolide Enhances Bromodomain Inhibitor JQ1-Induced Apoptosis of Acute Myeloid Leukemia Cells Via Down-Regulation of c-Myc Following RAS/MEK/ERK Inhibition

Bing Xu, Yuanfei Shi, Haijun Zhao, Yi Qiu, PhD
Blood (2019) 134 (Supplement_1): 5757.
DOI: https://doi.org/10.1182/blood-2019-123740
Published: 2019
Journal Articles

Proteostasis and Myeloid Stem Cell Production

Robert Signer, PhD
Blood (2019) 134 (Supplement_1): SCI-42.
DOI: https://doi.org/10.1182/blood-2019-121085
Published: 2019
Journal Articles

Ex vivo Engineering of Platelets

Koji Eto, MD
Blood (2019) 134 (Supplement_1): SCI-6.
DOI: https://doi.org/10.1182/blood-2019-121116
Published: 2019
Journal Articles

Gfi1 Upregulates c-Myc Expression and Promotes c-Myc-Driven Cell Proliferation

Yangyang Zhang, MD, Fan Dong, MD PhD
Blood (2019) 134 (Supplement_1): 3769.
DOI: https://doi.org/10.1182/blood-2019-124833
Published: 2019
Journal Articles

PP2A Activators Enhance Efficacy of FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells through AKT Inactivation-Dependent Pim-1 and c-Myc Proteasomal Degradation

Mario Scarpa, PhD, Prerna Singh, MS, Shivani Kapoor, MS, Jonelle K. Lee, MS, Sandrine Niyongere, MD, Goutham Narla, MD PhD, Danilo Perrotti, MD PhD, Maria R. Baer, MD
Blood (2019) 134 (Supplement_1): 1276.
DOI: https://doi.org/10.1182/blood-2019-129011
Published: 2019
Journal Articles

GFI1-Dependent SGPP1 Repression Promotes Growth and Survival of Myeloma Cells

Daniela Nicoleta Petrusca, PhD, Evgeny Berdyshev, PhD, Colin D. Crean, BS, Judith L Anderson, BS, G. David Roodman, MD PhD
Blood (2019) 134 (Supplement_1): 4387.
DOI: https://doi.org/10.1182/blood-2019-131106
Published: 2019
Journal Articles

Combined Targeting of Distinct c-Myc and JunB Transcriptional Programs for Multiple Myelioma Therapy

Judith Lind, PhD, Felix Czernilofsky, Sonia Vallet, MD, Fengjuan Fan, PhD, Martin Sattler, PhD, Latifa Bakiri, Erwin F Wagner, PhD, Martin Percherstorfer, MD, Klaus Podar, MD PhD
Blood (2019) 134 (Supplement_1): 4415.
DOI: https://doi.org/10.1182/blood-2019-125202
Published: 2019
Journal Articles

A Phase 1a/b Dose Escalation Study of Apto-253 in Patients with Relapsed or Refractory AML or High-Risk MDS

Stephen B Howell, MD, Hongying Zhang, MD PhD, William G Rice, PhD
Blood (2019) 134 (Supplement_1): 5148.
DOI: https://doi.org/10.1182/blood-2019-129685
Published: 2019
Journal Articles

P16, c-Myc, SOX11, P53, ki67 and CD71Protein Expression in Aggressive Morphological Variants of Mantle Cell Lymphomas Compared to Classical Morphological Mantle Cell Lymphomas in Multiple Clinical Trials

Barbara Burroni, Anne Moreau, MD, Mathieu Baldacini, MD, Antoine Martin, MD PhD, Steven Le Gouill, Vincent Ribrag, Rémy Gressin, MD, Chantal Brochet, Martin H. Dreyling, MD PhD, Samuel Griolet, Yannick Le Bris, PharmD, Morgane Cheminant, MD, Hanneke Kluin-Nelemans, MD, Olivier Hermine, MD PhD, Luc Mathieu Fornecker, MD PhD, Alexandra Traverse-Glehen, MD PhD, Danielle Canioni, MD
Blood (2019) 134 (Supplement_1): 2820.
DOI: https://doi.org/10.1182/blood-2019-129790
Published: 2019
Journal Articles

CRISPR Activation Screen for Drivers of MM Cell Proliferation

Huihui Tang, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Olga Dashevsky, PhD, Brian Glassner, PhD, Sondra L. Downey-Kopyscinski, PhD, Sara Gandolfi, MD, Michal Sheffer, PhD, Megan Bariteau, BSc, John G Doench, PhD, Constantine S. Mitsiades, MD PhD
Blood (2018) 132 (Supplement 1): 3197.
DOI: https://doi.org/10.1182/blood-2018-99-118712
Published: 2018
Journal Articles

The Novel Berbamine Derivative, Cbbm, Downregulates c-Myc to Block Diffuse Large B-Cell Lymphoma Cell Maintenance

Lei Zhang, MD, Rongzhen Xu, PhD, Ling Li, PhD, Xiaoying Zhao, MD, Jinwen Huang, MD
Blood (2018) 132 (Supplement 1): 212.
DOI: https://doi.org/10.1182/blood-2018-99-112006
Published: 2018
Journal Articles

CpG Oligodeoxynucleotide-Induced Apoptosis of B-Lineage Acute Lymphoblastic Leukemia Is through C-MYC/P53/BAX Signaling Pathway

Ling Bai, Wei Chen, MD PhD, Wei Li, MD, Lei Zhou, Chao Niu, Wei Han, Jiuwei Cui
Blood (2018) 132 (Supplement 1): 2216.
DOI: https://doi.org/10.1182/blood-2018-99-116556
Published: 2018
Journal Articles

Cooperative Repression of IRF4 and Induction of IRF7 By CDK4/6 Inhibition Sensitizes Mantle Cell Lymphoma Cells to IMiD-Mediated Apoptosis Independent of p16 Deletion or c-Myc Overexpression

Basel A Humos, Maurizio Di Liberto, PhD, Xiangao Huang, PhD, Olivier Elemento, PhD, Selina Chen-Kiang, PhD
Blood (2018) 132 (Supplement 1): 2864.
DOI: https://doi.org/10.1182/blood-2018-99-117487
Published: 2018
Journal Articles

Elucidation of the IMiDs-Resistant Mechanism and Development of the Overcoming Drugs Inducing CRBN Independent G2/M Cell Cycle Arrest in Myeloma Cells

Ryo Uozaki, Shuji Aida, Takasi Yamagughi, Tomofumi Yamamoto, BPharm, Sho Kashiwazaki, Hiroshi Yanagawa, Daiju Ichikawa, Maiko Matsushita, Yutaka Hattori
Blood (2018) 132 (Supplement 1): 4451.
DOI: https://doi.org/10.1182/blood-2018-99-115909
Published: 2018