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Journal Articles

Treg sensitivity to FasL and relative IL-2 deprivation drive idiopathic aplastic anemia immune dysfunction

Shok Ping Lim, Benedetta Costantini, Syed A. Mian, Pilar Perez Abellan, Shreyans Gandhi, Marc Martinez Llordella, Juan Jose Lozano, Rita Antunes dos Reis, Giovanni A. M. Povoleri, Thanos P. Mourikis, Ander Abarrategi, Linda Ariza-McNaughton, Susanne Heck, Jonathan M. Irish, Giovanna Lombardi, Judith C. W. Marsh, Dominique Bonnet, Shahram Kordasti, Ghulam J. Mufti

Blood (2020) 136 (7): 885–897.

https://doi.org/10.1182/blood.2019001347

Published: 2020

Includes: Supplemental data

Journal Articles

Phase I Clinical Trial of CK0801 (cord blood regulatory T cells) in Patients with Bone Marrow Failure Syndrome (BMF) Including Aplastic Anemia, Myelodysplasia and Myelofibrosis

Tapan M. Kadia, MD, Hongbing Ma, MD PhD, Ke Zeng, MD PhD, Mitsutaka Nishimoto, MD PhD, Mi-Ae Lyu, PhD, Meixian Huang, Musa Yilmaz, MD, Courtney D. DiNardo, MDMSc, Ghayas C. Issa, MD, Simrit Parmar, MBBS, Swami P. Iyer, MD, Parameswaran Hari, MBBS, MD, Naval G. Daver, MD, Elias Jabbour, MD, Gautam M. Borthakur, MD, Srdan Verstovsek, MD PhD

Blood (2019) 134 (Supplement_1): 1221.

https://doi.org/10.1182/blood-2019-127702

Published: 2019

Journal Articles

Telomeric Length to Characterize and Prognosticate Bone Marrow Failure, Risk of Clonal Evolution and Multi-System Complications in Aplastic Anemia and Other Hypocellular Cytopenic Disorders, Independent of Telomere Gene Complex Mutations

Shreyans Gandhi, MBBS,MDDNB,MRCP,FRCPath,MPhil, Jie Jiang, PhD, Simon Slade, BSc, Austin Kulasekararaj, MD MRCP, FRCPath, Victoria Potter, BSc, MBBS, FRCPA, Varun Mehra, MBBS,MRCP,FRCPath, Petra Muus, MD PhD, Andrea Da Silva, MBBS, Sudarshan Gurung, MBBS, MRCP, Alice Mason, B.Pharm, Aytug Kizilors, PhD, Nicholas Lea, PhD, Sahar Mansour, MD, Robin M. Ireland, MBBS, FRCP, FRCPath, Ghulam J. Mufti, MBBS, FRCP, FRCPath, DM, Judith Marsh, MD FRCPath

Blood (2019) 134 (Supplement_1): 3749.

https://doi.org/10.1182/blood-2019-130754

Published: 2019

Journal Articles

Allogeneic Hematopoietic Cell Transplantation for Severe Idiopathic Aplastic Anemia Older Than 40y

Hawk Kim, MD PhD, Yunsuk Choi, MD, Sung-Soo Yoon, MD PhD, Soo-Mee Bang, MD PhD, Hyeoung-Joon Kim, MD PhD, Sang Kyun Sohn, MD PhD, Yeung-Chul Mun, Young Rok Do, PhD MD, Yong Park, MD, Ji Hyun Lee, MD PhD, Sung Hwa Bae, MD, Ho Sup Lee, MD, Min Kyoung Kim, MD PhD, Won-Sik Lee, Jeong-Yeal Ahn, MD, Kyoo-Hyung Lee, MD PhD

Blood (2018) 132 (Supplement 1): 3876.

https://doi.org/10.1182/blood-2018-99-116190

Published: 2018

Journal Articles

Oligoclonal Expansion and T-Cells Subpopulations in Patients with Aplastic Anemia at Different Stages of the Disease

Anastasia V. Abramova, MD, Elena A. Mikhaylova, MD PhD Prof, Zalina T. Fidarova, MD PhD, Yuliya O. Davydova, Nikolay M. Kapranov, Tatiana I. Lobanova, MD, Anton V. Luchkin, MD, Alina E. Krasilnikova, Resident Physician, Roman V. Tivikov, MD, Vera V. Troitskaya, MD PhD, Irina V. Galtseva, PhD, Elena N. Parovichnikova, MD PhD, Valery G. Savchenko, MD PhD academician

Blood (2018) 132 (Supplement 1): 3864.

https://doi.org/10.1182/blood-2018-99-119414

Published: 2018

Journal Articles

Haploidentical Transplantation Using High Dose Post-Transplant Cyclophosphamide for Patients with Aplastic Anemia : The European Group for Blood and Marrow Transplantation Experience

Blood (2018) 132 (Supplement 1): 486.

https://doi.org/10.1182/blood-2018-99-114033

Published: 2018

Journal Articles

Selective Pharmacologic Inhibition of Paroxysmal Nocturnal Hemoglobinuria Clones

Amy C Graham, BS, MS, Alexey Efanov, PhD, Bartlomiej P. Przychodzen, Cassandra M. Hirsch, Vera Adema, PhD, Valeria Visconte, PhD, Jaroslaw P. Maciejewski

Blood (2018) 132 (Supplement 1): 1303.

https://doi.org/10.1182/blood-2018-99-114973

Published: 2018

Journal Articles

Heterozygous CTC1 Variants in Acquired Bone Marrow Failure

Wenyi Shen, MD, Cassandra M. Hirsch, Bartlomiej P. Przychodzen, Reda Z. Mahfouz, MD PhD, Tomas Radivoyevitch, Louis Williams, MD MBA, Mohammad Fahad B. Asad, Jaroslaw P. Maciejewski

Blood (2018) 132 (Supplement 1): 3866.

https://doi.org/10.1182/blood-2018-99-115193

Published: 2018

Journal Articles

Functional Characteristics of FAS-L Resistant and IL-2 Deprived Regulatory T Cells (Treg A) in Idiopathic Aplastic Anaemia

Benedetta Costantini, MD, Syed A Mian, PhD, Shok Ping Lim, PhD, Frederic Toulza, PhD, Stephen Orr, PhD, Pilar Perez-Abellan, MSc, Ander Abarrategi, PhD, Farzin Farzaneh, PhD, Dominique Bonnet, PhD, Judith Marsh, MD, Shahram Kordasti, MD PhD, Ghulam Mufti, DM, FRCP, FRCPath

Blood (2017) 130 (Supplement 1): 2450.

https://doi.org/10.1182/blood.V130.Suppl_1.2450.2450

Published: 2017

Journal Articles

Surveillance of the Immune Repertoire of Aplastic Anemia Patients Using Deep Sequencing

Cassandra M. Hirsch, BS, Michael J. Clemente, Valeria Visconte, PhD, Taha Bat, Bartlomiej P. Przychodzen, MSc, Tomas Radivoyevitch, PhD, Vera Adema, PhD, Yasunobu Nagata, MD PhD, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Babal K Jha, PhD, Sudipto Mukherjee, MD PhD MPH, Thomas Laframboise, PhD, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 2454.

https://doi.org/10.1182/blood.V130.Suppl_1.2454.2454

Published: 2017

Journal Articles

Effects of Immunosuppressive Therapy on Cell Mediated Immunity in Idiopathic Acquired Aplastic Anaemia

Gulab Fatima Rani, MBBS,MPhil,PhD, Muhammad Tariq Masood Khan, MBBS, PhD, Safia Jalal, MBBS,FCPS,MRCP, FRCPath, Yousaf Khan, MSc, BS MLT, Anisa Hussain, MBBS, FCPS, Shabir Khan, Ahmed Jawad, MBBS, PhD, Abid Sohail Taj, PhD MBBS, MRCPath

Blood (2017) 130 (Supplement 1): 4962.

https://doi.org/10.1182/blood.V130.Suppl_1.4962.4962

Published: 2017

Journal Articles

Efficacy of Low Dose Generic Antithymocyte Globulin and Cyclosporine in Idiopathic Aplastic Anemia

Aditya Jandial, MBBS, MD, Pankaj Malhotra, MD, Kundan Mishra, MD MBBS, MNAMS, Ram V Nampoothiri, MD MRCP, Deepesh P. Lad, MBBS, MD DM, Man Updesh Singh Sachdeva, Alka Khadwal, MD, Gaurav Prakash, Prashant Sharma, MD, Shano Naseem, MD MBBS, Reena Das, Neelam Varma, MBBS, MD, Subhash Varma, MBBS, MD

Blood (2017) 130 (Supplement 1): 4955.

https://doi.org/10.1182/blood.V130.Suppl_1.4955.4955

Published: 2017

Journal Articles

Two Distinct but Functionally Related Autoreactive T Cell Populations in Paroxysmal Nocturnal Hemoglobinuria and Idiopathic Aplastic Anemia: Glycosylphosphatidylinositol-Specific and IFNγ-Producing T Cells

Lucia Gargiulo, PhD, Michela Sica, PhD, Caterina Nannelli, BSc, Lucio Luzzatto, MD, Rosario Notaro, MD

Blood (2017) 130 (Supplement 1): 1166.

https://doi.org/10.1182/blood.V130.Suppl_1.1166.1166

Published: 2017

Journal Articles

Telomere Length Is Significantly Reduced in Patients with Aplastic Anemia and Is Not Influenced By Gender and Severity

Eunice Sindhuvi Edison, PhD, Aruna Barade, M.Tech, Anu Korula, MD DM, Nisham PN, MD DM, Anup Joseph Devasia, MD DM, Kavitha M Lakshmi, MSc, Kulkarni Uday Prakash, Aby Abraham, MD DM, Alok Srivastava, MD, Vikram Mathews, MD DM, Biju George, MDDM

Blood (2017) 130 (Supplement 1): 4964.

https://doi.org/10.1182/blood.V130.Suppl_1.4964.4964

Published: 2017

Journal Articles

Glycosylphosphatidylinositol-specific T cells, IFN-γ-producing T cells, and pathogenesis of idiopathic aplastic anemia

Lucia Gargiulo, Yoshitaka Zaimoku, Barbara Scappini, Hiroyuki Maruyama, Rie Ohumi, Lucio Luzzatto, Shinji Nakao, Rosario Notaro

Blood (2017) 129 (3): 388–392.

https://doi.org/10.1182/blood-2016-09-740845

Published: 2017

Journal Articles

Thrombin Generation in Paroxysmal Nocturnal Haemoglobinuria

Audrey Krüse Zeinad, MD PhD, Tania RFR Rocha, Pharmacist, Sandra Fatima Menosi Guallandro, MD PhD, Guilherme Henrique Hencklain Fonseca, MD, Paula Ribeiro Villaça, MD PhD, Erica Okazaki, MD, Vanderson Rocha, MD PhD, Elbio Antonio D'Amico, MD PhD

Blood (2016) 128 (22): 1426.

https://doi.org/10.1182/blood.V128.22.1426.1426

Published: 2016

Journal Articles

Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

Blood (2016) 128 (9): 1193–1205.

https://doi.org/10.1182/blood-2016-03-703702

Published: 2016

Includes: Supplemental data

Journal Articles

Telomere Length and Telomerase Assay Assist in Identifying Novel Telomere Gene Complex Mutations in a Cohort of Patients with Aplastic Anemia

Shreyans Gandhi, MBBS,MDDNB,MRCP,FRCPath, Jie Jiang, PhD, Nana Benson-Quarm, B.Sc, Dip (Nursing), Hanna Renshaw, MBBS, MA, Syed A Mian, BSc, M.Phil, Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Ghulam J Mufti, MBBS, DM, FRCP, FRCPath, Judith C. W. Marsh, MD FRCP, FRCPath

Blood (2015) 126 (23): 667.

https://doi.org/10.1182/blood.V126.23.667.667

Published: 2015

Journal Articles

Impact of Different In Vivo T Cell Depletion Strategies on Outcomes Following Hematopoietic Stem Cell Transplantation for Idiopathic Aplastic Anaemia: A Study on Behalf of the EBMT SAA Working Party

Sujith Samarasinghe, MD PhD, Simona Iacobelli, Cora Knol, Rose-Marie Hamladji, Gerard Socie, MD PhD, Mahmoud Aljurf, MD MPH, Mickey Koh, MD, Henrik Sengeloev, Jean-Hugues Dalle, PhD MD, Stephen Robinson, Andrea Bacigalupo, MD, Joan H Veelken, Dietrich Beelen, MD, Ghulam J Mufti, FRCP, FRCPath, John A Snowden, MD FRCP, FRCPath, Didier Blaise, MD PhD, Judith C.W. Marsh, MD, Carlo Dufour, MD, Antonio M Risitano, MD PhD

Blood (2015) 126 (23): 1210.

https://doi.org/10.1182/blood.V126.23.1210.1210

Published: 2015

Journal Articles

Auto-Reactive Glycosyl-Phosphatidyl-Inositol (GPI) Specific T Cells Are Present in Most Patients with Idiopathic Aplastic Anemia (IAA)

Lucia Gargiulo, PhD, Yoshitaka Zaimoku, MD, Barbara Scappini, MD, Hiroyuki Maruyama, MD, Rie Ohumi, Lucio Luzzatto, MD, Shinji Nakao, MD PhD, Rosario Notaro, MD

Blood (2015) 126 (23): 2409.

https://doi.org/10.1182/blood.V126.23.2409.2409

Published: 2015

NARROW

Treg sensitivity to FasL and relative IL-2 deprivation drive idiopathic aplastic anemia immune dysfunction

Phase I Clinical Trial of CK0801 (cord blood regulatory T cells) in Patients with Bone Marrow Failure Syndrome (BMF) Including Aplastic Anemia, Myelodysplasia and Myelofibrosis

Telomeric Length to Characterize and Prognosticate Bone Marrow Failure, Risk of Clonal Evolution and Multi-System Complications in Aplastic Anemia and Other Hypocellular Cytopenic Disorders, Independent of Telomere Gene Complex Mutations

Allogeneic Hematopoietic Cell Transplantation for Severe Idiopathic Aplastic Anemia Older Than 40y

Oligoclonal Expansion and T-Cells Subpopulations in Patients with Aplastic Anemia at Different Stages of the Disease

Haploidentical Transplantation Using High Dose Post-Transplant Cyclophosphamide for Patients with Aplastic Anemia : The European Group for Blood and Marrow Transplantation Experience

Selective Pharmacologic Inhibition of Paroxysmal Nocturnal Hemoglobinuria Clones

Heterozygous CTC1 Variants in Acquired Bone Marrow Failure

Functional Characteristics of FAS-L Resistant and IL-2 Deprived Regulatory T Cells (Treg A) in Idiopathic Aplastic Anaemia

Surveillance of the Immune Repertoire of Aplastic Anemia Patients Using Deep Sequencing

Effects of Immunosuppressive Therapy on Cell Mediated Immunity in Idiopathic Acquired Aplastic Anaemia

Efficacy of Low Dose Generic Antithymocyte Globulin and Cyclosporine in Idiopathic Aplastic Anemia

Two Distinct but Functionally Related Autoreactive T Cell Populations in Paroxysmal Nocturnal Hemoglobinuria and Idiopathic Aplastic Anemia: Glycosylphosphatidylinositol-Specific and IFNγ-Producing T Cells

Telomere Length Is Significantly Reduced in Patients with Aplastic Anemia and Is Not Influenced By Gender and Severity

Glycosylphosphatidylinositol-specific T cells, IFN-γ-producing T cells, and pathogenesis of idiopathic aplastic anemia

Thrombin Generation in Paroxysmal Nocturnal Haemoglobinuria

Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

Telomere Length and Telomerase Assay Assist in Identifying Novel Telomere Gene Complex Mutations in a Cohort of Patients with Aplastic Anemia

Impact of Different In Vivo T Cell Depletion Strategies on Outcomes Following Hematopoietic Stem Cell Transplantation for Idiopathic Aplastic Anaemia: A Study on Behalf of the EBMT SAA Working Party

Auto-Reactive Glycosyl-Phosphatidyl-Inositol (GPI) Specific T Cells Are Present in Most Patients with Idiopathic Aplastic Anemia (IAA)

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American Society of Hematology

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American Society of Hematology

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