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Journal Articles

Complement Activation in a Murine Model of Sickle Cell Disease: Inhibition of Vaso-Occlusion By Blocking C5 Activation

Terry Robert Schaid, Jr., BA, Julia Nguyen, BS, Chunsheng Chen, PhD, Fuad Abdulla, DVM, Trevor Killeen, Hao Nguyen, Joseph Edmund, MBBS, Margaret A Lindorfer, PhD, Ronald P Taylor, PhD, Agustin P Dalmasso, MD, John D Belcher, PhD, Gregory M Vercellotti, MD

Blood (2016) 128 (22): 158.

https://doi.org/10.1182/blood.V128.22.158.158

Published: 2016

Journal Articles

Deficiency of Either Carboxypeptidase B2 or Carboxypeptidase N Exacerbated Disease Activity in a Mouse Model of Hemolytic Uremic Syndrome

Lawrence L. Leung, MD, Zhifei Shao, MD PhD, Toshihiko Nishimura, PhD, Qin Zhou, PhD, Laura Gigliello, Peter Castro, John Higgins, John Morser, PhD

Blood (2016) 128 (22): 3758.

https://doi.org/10.1182/blood.V128.22.3758.3758

Published: 2016

Journal Articles

Control of Neutrophil Endothelial Transmigration By EC-18 in Chemotherapy Induced Neutropenia

Jae Wha Kim, PhD, Yong-Jae Kim, Young-Jun Kim, PhD, Sun Young Yoon, PhD, Jinseon Jeong, Young-Eun Ko, Su-Hyun Shin, Nina Yoo, Myung-Hwan Kim, MD PhD, Cheolwon Suh, MD PhD, Ki-Young Sohn, Heung-Jae Kim, PhD, Yong-Hae Han, PhD, Saeho Chong, PhD

Blood (2015) 126 (23): 2210.

https://doi.org/10.1182/blood.V126.23.2210.2210

Published: 2015

Journal Articles

Complement C5 Inhibition Blocks the Cytokine Storm and Consumptive Coagulopathy By Decreasing Lipopolysaccharide (LPS) Release in E. coli Sepsis

Ravi Shankar Keshari, PhD, Robert Silasi-Mansat, PhD, Narcis I. Popescu, PhD, Marybeth Langer, PhD, Hala Chaaban, MD, Cristina Lupu, PhD, Mark K. Coggeshall, Steven DeMarco, PhD, Florea Lupu, PhD

Blood (2015) 126 (23): 765.

https://doi.org/10.1182/blood.V126.23.765.765

Published: 2015

Journal Articles

Targeting Host Complement C3a/C5a Receptors to Control of Acute Graft-Versus-Host Disease in Mice

Hung Nguyen, PhD, Jessica Lauren Heinrichs, BS, MS, Jianing Fu, PhD, Yongxia Wu, MD PhD, David Bastian, Steven Schutt, Anusara Daenthanasanmak, PhD, Mohammmed Dany, Chen Liu, MD PhD, David Fairlie, PhD, Stephen Tomlinson, PhD, Xue-Zhong Yu, MD MS

Blood (2015) 126 (23): 3076.

https://doi.org/10.1182/blood.V126.23.3076.3076

Published: 2015

Journal Articles

A Novel C5 Complement Inhibitor Protects Against Sepsis-Induced Activation of Complement, Coagulation and Inflammation and Provides Survival Benefit in E. coli Sepsis

Ravi Keshari, PhD, Robert Silasi-Mansat, PhD, Narcis I. Popescu, PhD, Hala Chaaban, MD, Cristina Lupu, PhD, Steven J DeMarco, PhD, Florea Lupu, PhD

Blood (2014) 124 (21): 112.

https://doi.org/10.1182/blood.V124.21.112.112

Published: 2014

Journal Articles

Switching from IgG1 to IgG3 Isotype to Boost Complement-Activating Capacities of Therapeutic Antibodies – Impact of CD55 Expression on the Mode of Action

Stefanie Derer, PhD, Thies Rösner, Stefan Lohse, PhD, Matthias Peipp, PhD, Thomas Valerius, MD

Blood (2014) 124 (21): 3506.

https://doi.org/10.1182/blood.V124.21.3506.3506

Published: 2014

Journal Articles

TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins

Ju Shi, Eileen L. Rose, Andrew Singh, Sami Hussain, Nancy E. Stagliano, Graham C. Parry, Sandip Panicker

Blood (2014) 123 (26): 4015–4022.

https://doi.org/10.1182/blood-2014-02-556027

Published: 2014

Includes: Supplemental data

Journal Articles

Plasmin Cleaves Complement iC3b, Preventing CR3/4 Mediated Phagocytosis By Macrophages

Erica A. Peterson, MD, Jonathan H Foley, PhD, Michael J Krisinger, Edward Conway

Blood (2013) 122 (21): 1105.

https://doi.org/10.1182/blood.V122.21.1105.1105

Published: 2013

Journal Articles

A Comparison Of Hemostatic and Inflammatory Markers In Overt and Non-Overt DIC

Debra Hoppensteadt, Ph.D., Kazuhisa Tsuruta, Ph.D., Joe Hirman, Ph.D., Inder Kaul, MD, MPH, Yutaka Osawa, M Pharm, Jawed Fareed, Ph.D.

Blood (2013) 122 (21): 3577.

https://doi.org/10.1182/blood.V122.21.3577.3577

Published: 2013

Journal Articles

TNT009, a Classical Complement Pathway Specific Inhibitor, Prevents Complement Dependent Hemolysis Induced By Cold Agglutinin Disease Patient Autoantibodies

Sandip Panicker, Ph.D., Ju Shi, Ph.D., Eileen Rose, Sami Hussain, Susan Tom, William Strober, Steven R. Sloan, M.D., Ph.D., Graham Parry, Ph.D., Nancy Stagliano, Ph.D.

Blood (2013) 122 (21): 42.

https://doi.org/10.1182/blood.V122.21.42.42

Published: 2013

Journal Articles

Mesenchymal Stem Cells Engineered to Inhibit Complement-Mediated Damage

Melisa Soland, PhD, Mariana Bego, PhD, Evan Colletti, PhD, Christopher D Porada, PhD, Esmail Zanjani, PhD, Stephen St. Jeor, PhD, Graca Almeida-Porada, MD, PhD

Blood (2012) 120 (21): 1253.

https://doi.org/10.1182/blood.V120.21.1253.1253

Published: 2012

Journal Articles

Dysregulation of Inflammatory and Hemostatic Markers in Sepsis Associated Disseminated Intravascular Coagulation.

Jawed Fareed, PhD, Debra Hoppensteadt, Josephine Cunanan, MD, Michael Mosier, MD, Yutaka Osawa, Inder Kaul

Blood (2012) 120 (21): 2223.

https://doi.org/10.1182/blood.V120.21.2223.2223

Published: 2012

Journal Articles

Studies in C4b-Deficient Mice Provide Further Evidence That Complement Cascade Orchestrates the Mobilization of Hematopoietic Stem/Progenitor Cells.

Anna Janowska-Wieczorek, MD, PhD, Leah A. Marquez-Curtis, PhD, Danila Leontyev, PhD, Donald R. Branch, PhD, Janina Ratajczak, MD, PhD, Mariusz Z Ratajczak, MD, PhD

Blood (2012) 120 (21): 2316.

https://doi.org/10.1182/blood.V120.21.2316.2316

Published: 2012

Journal Articles

Exon Skipping and Alternative Splicing of CPB2 mRNA in Multiple Cell Types Results in Variants of TAFI That Are Inactive and Not Secretable

Joellen H. H. Lin, M.Sc., Mathieu Garand, Ph.D., Branislava Zagorac, B.Sc., Anastassia Filipieva, B.Sc., Marlys L Koschinsky, Ph.D., Michael B Boffa, Ph.D.

Blood (2011) 118 (21): 1189.

https://doi.org/10.1182/blood.V118.21.1189.1189

Published: 2011

Journal Articles

Dysregulation of Inflammatory and Hemostatic Markers In Disseminated Intravascular Coagulation.

Debra Hoppensteadt, Ph.D., Josephine Cunanan, MD, Nasiredin Sadeghi, MS, Inder Kaul, MD, Jawed Fareed, PhD

Blood (2010) 116 (21): 3656.

https://doi.org/10.1182/blood.V116.21.3656.3656

Published: 2010

Journal Articles

Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis

Ioannis Kourtzelis, Maciej M. Markiewski, Michael Doumas, Stavros Rafail, Konstantinos Kambas, Ioannis Mitroulis, Stelios Panagoutsos, Ploumis Passadakis, Vasilios Vargemezis, Paola Magotti, Hongchang Qu, Tom Eirik Mollnes, Konstantinos Ritis, John D. Lambris

Blood (2010) 116 (4): 631–639.

https://doi.org/10.1182/blood-2010-01-264051

Published: 2010

Includes: Supplemental data

Journal Articles

Human Mesenchymal Stem Cells Elicit Complement Activation in Human Blood.

Katarina Le Blanc, MD, PhD, Guido Moll, Ida Rasmusson, Kristina Nilsson Ekdahl, Graciela Elgue, Berit Sundberg, Bo Nilsson

Blood (2009) 114 (22): 4580.

https://doi.org/10.1182/blood.V114.22.4580.4580

Published: 2009

Journal Articles

Granulocyte-Derived Cationic Peptides (GDCPs) Present in Leucophoresis Products Enhance Homing of Hematopoietic Stem Cells (HSCs) to SDF-1 Gradient; Potential Implications for Accelerated Recovery of Hematopoiesis After Transplantation of Mobilized Peripheral Blood Stem Cells (PBSC).

HakMo Lee, PhD, Wan Wu, Marcin Wysoczynski, Magdalena Kucia, Ph.D., Mary J. Laughlin, MD, Janina Ratajczak, M.D., Ph.D., Mariusz Z Ratajczak, MD, PhD

Blood (2009) 114 (22): 371.

https://doi.org/10.1182/blood.V114.22.371.371

Published: 2009

Journal Articles

Mobilization Studies in Complement-Deficient Mice Reveal That AMD3100 Mobilization Depends On Complement Cascade Activation and Suggest Involvement of “Membrane Attack Complex - MAC” in Egress of Hematopoietic Stem/Progenitor Cells.

Marcin Wysoczynski, PhD, HakMo Lee, PhD, Rui Liu, M.D., Wan Wu, Janina Ratajczak,, M.D., Ph.D., Mariusz Z Ratajczak, MD, PhD

Blood (2009) 114 (22): 367.

https://doi.org/10.1182/blood.V114.22.367.367

Published: 2009

NARROW

Complement Activation in a Murine Model of Sickle Cell Disease: Inhibition of Vaso-Occlusion By Blocking C5 Activation

Deficiency of Either Carboxypeptidase B2 or Carboxypeptidase N Exacerbated Disease Activity in a Mouse Model of Hemolytic Uremic Syndrome

Control of Neutrophil Endothelial Transmigration By EC-18 in Chemotherapy Induced Neutropenia

Complement C5 Inhibition Blocks the Cytokine Storm and Consumptive Coagulopathy By Decreasing Lipopolysaccharide (LPS) Release in E. coli Sepsis

Targeting Host Complement C3a/C5a Receptors to Control of Acute Graft-Versus-Host Disease in Mice

A Novel C5 Complement Inhibitor Protects Against Sepsis-Induced Activation of Complement, Coagulation and Inflammation and Provides Survival Benefit in E. coli Sepsis

Switching from IgG1 to IgG3 Isotype to Boost Complement-Activating Capacities of Therapeutic Antibodies – Impact of CD55 Expression on the Mode of Action

TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins

Plasmin Cleaves Complement iC3b, Preventing CR3/4 Mediated Phagocytosis By Macrophages

A Comparison Of Hemostatic and Inflammatory Markers In Overt and Non-Overt DIC

TNT009, a Classical Complement Pathway Specific Inhibitor, Prevents Complement Dependent Hemolysis Induced By Cold Agglutinin Disease Patient Autoantibodies

Mesenchymal Stem Cells Engineered to Inhibit Complement-Mediated Damage

Dysregulation of Inflammatory and Hemostatic Markers in Sepsis Associated Disseminated Intravascular Coagulation.

Studies in C4b-Deficient Mice Provide Further Evidence That Complement Cascade Orchestrates the Mobilization of Hematopoietic Stem/Progenitor Cells.

Exon Skipping and Alternative Splicing of CPB2 mRNA in Multiple Cell Types Results in Variants of TAFI That Are Inactive and Not Secretable

Dysregulation of Inflammatory and Hemostatic Markers In Disseminated Intravascular Coagulation.

Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis

Human Mesenchymal Stem Cells Elicit Complement Activation in Human Blood.

Granulocyte-Derived Cationic Peptides (GDCPs) Present in Leucophoresis Products Enhance Homing of Hematopoietic Stem Cells (HSCs) to SDF-1 Gradient; Potential Implications for Accelerated Recovery of Hematopoiesis After Transplantation of Mobilized Peripheral Blood Stem Cells (PBSC).

Mobilization Studies in Complement-Deficient Mice Reveal That AMD3100 Mobilization Depends On Complement Cascade Activation and Suggest Involvement of “Membrane Attack Complex - MAC” in Egress of Hematopoietic Stem/Progenitor Cells.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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