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Complement Activation in a Murine Model of Sickle Cell Disease: Inhibition of Vaso-Occlusion By Blocking C5 Activation
Terry Robert Schaid, Jr., BA, Julia Nguyen, BS, Chunsheng Chen, PhD, Fuad Abdulla, DVM, Trevor Killeen, Hao Nguyen, Joseph Edmund, MBBS, Margaret A Lindorfer, PhD, Ronald P Taylor, PhD, Agustin P Dalmasso, MD, John D Belcher, PhD, Gregory M Vercellotti, MD
Blood (2016) 128 (22): 158.
Deficiency of Either Carboxypeptidase B2 or Carboxypeptidase N Exacerbated Disease Activity in a Mouse Model of Hemolytic Uremic Syndrome
Lawrence L. Leung, MD, Zhifei Shao, MD PhD, Toshihiko Nishimura, PhD, Qin Zhou, PhD, Laura Gigliello, Peter Castro, John Higgins, John Morser, PhD
Blood (2016) 128 (22): 3758.
Complement C5 Inhibition Blocks the Cytokine Storm and Consumptive Coagulopathy By Decreasing Lipopolysaccharide (LPS) Release in E. coli Sepsis
Ravi Shankar Keshari, PhD, Robert Silasi-Mansat, PhD, Narcis I. Popescu, PhD, Marybeth Langer, PhD, Hala Chaaban, MD, Cristina Lupu, PhD, Mark K. Coggeshall, Steven DeMarco, PhD, Florea Lupu, PhD
Blood (2015) 126 (23): 765.
Hung Nguyen, PhD, Jessica Lauren Heinrichs, BS, MS, Jianing Fu, PhD, Yongxia Wu, MD PhD, David Bastian, Steven Schutt, Anusara Daenthanasanmak, PhD, Mohammmed Dany, Chen Liu, MD PhD, David Fairlie, PhD, Stephen Tomlinson, PhD, Xue-Zhong Yu, MD MS
Blood (2015) 126 (23): 3076.
Jae Wha Kim, PhD, Yong-Jae Kim, Young-Jun Kim, PhD, Sun Young Yoon, PhD, Jinseon Jeong, Young-Eun Ko, Su-Hyun Shin, Nina Yoo, Myung-Hwan Kim, MD PhD, Cheolwon Suh, MD PhD, Ki-Young Sohn, Heung-Jae Kim, PhD, Yong-Hae Han, PhD, Saeho Chong, PhD
Blood (2015) 126 (23): 2210.
A Novel C5 Complement Inhibitor Protects Against Sepsis-Induced Activation of Complement, Coagulation and Inflammation and Provides Survival Benefit in E. coli Sepsis
Ravi Keshari, PhD, Robert Silasi-Mansat, PhD, Narcis I. Popescu, PhD, Hala Chaaban, MD, Cristina Lupu, PhD, Steven J DeMarco, PhD, Florea Lupu, PhD
Blood (2014) 124 (21): 112.
Switching from IgG1 to IgG3 Isotype to Boost Complement-Activating Capacities of Therapeutic Antibodies – Impact of CD55 Expression on the Mode of Action
Blood (2014) 124 (21): 3506.
TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins
Ju Shi, Eileen L. Rose, Andrew Singh, Sami Hussain, Nancy E. Stagliano, Graham C. Parry, Sandip Panicker
Blood (2014) 123 (26): 4015–4022.
Includes: Supplemental data
Debra Hoppensteadt, Ph.D., Kazuhisa Tsuruta, Ph.D., Joe Hirman, Ph.D., Inder Kaul, MD, MPH, Yutaka Osawa, M Pharm, Jawed Fareed, Ph.D.
Blood (2013) 122 (21): 3577.
TNT009, a Classical Complement Pathway Specific Inhibitor, Prevents Complement Dependent Hemolysis Induced By Cold Agglutinin Disease Patient Autoantibodies
Sandip Panicker, Ph.D., Ju Shi, Ph.D., Eileen Rose, Sami Hussain, Susan Tom, William Strober, Steven R. Sloan, M.D., Ph.D., Graham Parry, Ph.D., Nancy Stagliano, Ph.D.
Blood (2013) 122 (21): 42.
Blood (2013) 122 (21): 1105.
Dysregulation of Inflammatory and Hemostatic Markers in Sepsis Associated Disseminated Intravascular Coagulation.
Jawed Fareed, PhD, Debra Hoppensteadt, Josephine Cunanan, MD, Michael Mosier, MD, Yutaka Osawa, Inder Kaul
Blood (2012) 120 (21): 2223.
Melisa Soland, PhD, Mariana Bego, PhD, Evan Colletti, PhD, Christopher D Porada, PhD, Esmail Zanjani, PhD, Stephen St. Jeor, PhD, Graca Almeida-Porada, MD, PhD
Blood (2012) 120 (21): 1253.
Studies in C4b-Deficient Mice Provide Further Evidence That Complement Cascade Orchestrates the Mobilization of Hematopoietic Stem/Progenitor Cells.
Anna Janowska-Wieczorek, MD, PhD, Leah A. Marquez-Curtis, PhD, Danila Leontyev, PhD, Donald R. Branch, PhD, Janina Ratajczak, MD, PhD, Mariusz Z Ratajczak, MD, PhD
Blood (2012) 120 (21): 2316.
Exon Skipping and Alternative Splicing of CPB2 mRNA in Multiple Cell Types Results in Variants of TAFI That Are Inactive and Not Secretable
Joellen H. H. Lin, M.Sc., Mathieu Garand, Ph.D., Branislava Zagorac, B.Sc., Anastassia Filipieva, B.Sc., Marlys L Koschinsky, Ph.D., Michael B Boffa, Ph.D.
Blood (2011) 118 (21): 1189.
Debra Hoppensteadt, Ph.D., Josephine Cunanan, MD, Nasiredin Sadeghi, MS, Inder Kaul, MD, Jawed Fareed, PhD
Blood (2010) 116 (21): 3656.
Clinical Trials & Observations
Ioannis Kourtzelis, Maciej M. Markiewski, Michael Doumas, Stavros Rafail, Konstantinos Kambas, Ioannis Mitroulis, Stelios Panagoutsos, Ploumis Passadakis, Vasilios Vargemezis, Paola Magotti, Hongchang Qu, Tom Eirik Mollnes, Konstantinos Ritis, John D. Lambris
Blood (2010) 116 (4): 631–639.
Includes: Supplemental data
Granulocyte-Derived Cationic Peptides (GDCPs) Present in Leucophoresis Products Enhance Homing of Hematopoietic Stem Cells (HSCs) to SDF-1 Gradient; Potential Implications for Accelerated Recovery of Hematopoiesis After Transplantation of Mobilized Peripheral Blood Stem Cells (PBSC).
HakMo Lee, PhD, Wan Wu, Marcin Wysoczynski, Magdalena Kucia, Ph.D., Mary J. Laughlin, MD, Janina Ratajczak, M.D., Ph.D., Mariusz Z Ratajczak, MD, PhD
Blood (2009) 114 (22): 371.
Mobilization Studies in Complement-Deficient Mice Reveal That AMD3100 Mobilization Depends On Complement Cascade Activation and Suggest Involvement of “Membrane Attack Complex - MAC” in Egress of Hematopoietic Stem/Progenitor Cells.
Marcin Wysoczynski, PhD, HakMo Lee, PhD, Rui Liu, M.D., Wan Wu, Janina Ratajczak,, M.D., Ph.D., Mariusz Z Ratajczak, MD, PhD
Blood (2009) 114 (22): 367.
Higher Prevalence of Heparin-Induced Thrombocytopenia Antibodies in Asian Indian Population: Is This Due to Contaminated Heparin?
Blood (2009) 114 (22): 4182.