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Journal Articles

Class I PI3K Is Required for HSC Differentiation

Kristina Ames, PhD, Imit Kaur, PhD, Meng Tong, Shayda Hemmati, PhD, Ellen Tein, Shira Glushakow-Smith, Lindsay Gurska, Kira Gritsman, MD PhD

Blood (2019) 134 (Supplement_1): 2461.

https://doi.org/10.1182/blood-2019-123823

Published: 2019

Journal Articles

Analysis of Mechanisms Underlying Clonal Evolution of AML By a New Single-Cell Sequencing Platform

Ryosaku Inagaki, MSc, Masahiro Marshall Nakagawa, MD PhD, Yasuhito Nannya, MD PhD, Qi Xingxing, PhD, Lanying Zhao, MD, PhD, June Takeda, MD, Akinori Yoda, PhD, Ayana Kon, MD PhD, Hisashi Tsurumi, MD PhD, Hideki Makishima, MD PhD, Seishi Ogawa, MD PhD

Blood (2019) 134 (Supplement_1): 542.

https://doi.org/10.1182/blood-2019-126444

Published: 2019

Journal Articles

Analysis of a New Haematopoietic Stem/Progenitor Cells with Megakaryocyte Differentiation Potential

Mo Yang, MD, Shichao Chen, Liang Li, PhD, Hongwu Xin, Beng H Chong, MBBS, PhD, Liuming Yang

Blood (2019) 134 (Supplement_1): 4891.

https://doi.org/10.1182/blood-2019-127851

Published: 2019

Journal Articles

Suppression of CUL4B Induces G1 Cell Cycle Arrest through the Modulation of AKT Signaling Pathway

Ying Li, MD, Ya Zhang, MD, Xiangxiang Zhou, MD, Xin Wang, MDPhD

Blood (2018) 132 (Supplement 1): 5133.

https://doi.org/10.1182/blood-2018-99-118442

Published: 2018

Journal Articles

IGFBP7 As a Potential Therapeutic Target for AML

Yina Niu, PhD, Shuiyan Wu, MD, Shaoyan Hu, MD PhD

Blood (2018) 132 (Supplement 1): 5134.

https://doi.org/10.1182/blood-2018-99-119528

Published: 2018

Journal Articles

Safety and Efficacy of Long Term Suppression of PI3Kinase Pathway By Small Molecule PI3K-Delta Inhibitor, Leniolisib in Apds (Activated PI3Kδ Syndrome)

V. Koneti Rao, MD FRCPA, Sharon Webster, BSN, Virgil A.S.H. Dalm, MD, Anna Sediva, MD, P. Martin van Hagen, H. Michael Do, MD, Les Folio, MD, Maciej Cabanski, Marie-Anne Valentin, Stefan de Buck, Christoph Kalis, Anke Hasselberg, Christoph Burkhart, Klaus Kucher, MD, Birgitte Sloth, Gulbu Uzel, MD

Blood (2018) 132 (Supplement 1): 3706.

https://doi.org/10.1182/blood-2018-99-113426

Published: 2018

Journal Articles

Hematopoietic-Specific CSNK2B Loss in Mice Causes Impaired Erythropoiesis

Laura Quotti Tubi, PhD, Sara Canovas Nunes, PhD, Marilena Carrino, PhD, Ketty Gianesin, PhD, Sabrina Manni, PhD, Odile Filhol-Cochet, PhD, Brigitte Boldyreff, PhD, Livio Trentin, MD, Gianpietro Semenzato, MD, Francesco Piazza, MD

Blood (2017) 130 (Supplement 1): 82.

https://doi.org/10.1182/blood.V130.Suppl_1.82.82

Published: 2017

Journal Articles

NEDD4-1 Modulates the Resistance of Multiple Myeloma to Bortezomib Via PTEN/PI3K/Akt Signaling Pathway

Xi Huang, Zhang En Fan, Qingxiao Chen, MS, Haimeng Yan, Xu Ruyi, Xinling Liu, Huiyao Gu, Jingsong He, MD, He Huang, MD PhD, Qing Yi, MD PhD, Zhen Cai, MD PhD

Blood (2017) 130 (Supplement 1): 1787.

https://doi.org/10.1182/blood.V130.Suppl_1.1787.1787

Published: 2017

Journal Articles

Effective “activated PI3Kδ syndrome”–targeted therapy with the PI3Kδ inhibitor leniolisib

Blood (2017) 130 (21): 2307–2316.

https://doi.org/10.1182/blood-2017-08-801191

Published: 2017

Includes: Supplemental data

Journal Articles

Identification of CKMT1B As a New Target in EVI1-Positive AML

Alexandre Puissant, PhD, Nina Fenouille, PhD, Christopher F. Bassil, BA, Issam Ben-Sahra, PhD, Gabriela Alexe, PhD, Lina Benajiba, Azucena Ramos, Yana Pikman, MD, Michael R. Burgess, MD PhD, Ilene Galinsky, ANP, Daniel J. DeAngelo, MD PhD, Richard M. Stone, MD, Kevin Shannon, MD, Michael T. Hemann, PhD, Kimberly Stegmaier, MD

Blood (2015) 126 (23): 3674.

https://doi.org/10.1182/blood.V126.23.3674.3674

Published: 2015

Journal Articles

TLR2-PI3K/Akt Signaling Pathway Involved in Platelet Activation Induced By Group B Streptococci

Liping Ma, MD, Xiaoyan Liu, MD, Hongyun Liu, MD, Shuangfeng Xie, PhD, Yanmin Gao, MD, Ping Zhang, Zhang Guoyang

Blood (2015) 126 (23): 4635.

https://doi.org/10.1182/blood.V126.23.4635.4635

Published: 2015

Journal Articles

Manufacturing an Enhanced CAR T Cell Product By Inhibition of the PI3K/Akt Pathway During T Cell Expansion Results in Improved In Vivo Efficacy of Anti-BCMA CAR T Cells

Molly R. Perkins, D.Phil., Shannon Grande, PhD, Amanda Hamel, BS, Holly M. Horton, PhD, Tracy E. Garrett, BA, Sara M. Miller, Howard J. Latimer, IV, BS, Christopher J. Horvath, DVM, MS, DACVP, Michael Kuczewski, MS, Kevin M. Friedman, PhD, Richard A. Morgan, PhD

Blood (2015) 126 (23): 1893.

https://doi.org/10.1182/blood.V126.23.1893.1893

Published: 2015

Journal Articles

Novel Functional Roles for Ten-Eleven-Translocation 2 (Tet2) in Normal and Leukemic Growth of Mast Cells

Raghuveer Mali, PhD, Holly Rene Martin, PhD, Baskar Ramdas, PhD, Lakshmi Palam, PhD, Valeria Visconte, PhD, Tiu Ramon, MD, Helmut Hanenberg, MD, Mingjiang Xu, MD PhD, Reuben Kapur, PhD

Blood (2015) 126 (23): 775.

https://doi.org/10.1182/blood.V126.23.775.775

Published: 2015

Journal Articles

Novel target to kill CLL

Tadeusz Robak, Piotr Smolewski

Blood (2015) 125 (2): 211–212.

https://doi.org/10.1182/blood-2014-10-606582

Published: 2015

Journal Articles

Melatonin Protects Against Apoptosis of Megakaryocytes Via Its Receptors and Activation of PI3k/Akt Pathway

Su-yi Li, MD, Min Zhou, MD, Jie-yu Ye, MDPhD, Qi-zhou Lian, MDPhD, Fan-yi Meng, MD, Mo Yang, MDPhD

Blood (2014) 124 (21): 4201.

https://doi.org/10.1182/blood.V124.21.4201.4201

Published: 2014

Journal Articles

Synergistic Lethal Effects Between Gemcitabine and Arsenic Trioxide on Non-Hodgkin Lymphoma Cell Lines Is Associated with Modulation of PI3K/Akt Signaling Pathway

Mingwan Zhang, Xiaojun Xu, Yongbin Ye, Ziwen Guo, Xiaochun Bai, Jing Wang, Ruiqing Zhou, Dafa Qiu, Huiqing He, Xin He, Wenfang Yi, Guangyang Weng, Guo Kunyuan

Blood (2014) 124 (21): 5306.

https://doi.org/10.1182/blood.V124.21.5306.5306

Published: 2014

Journal Articles

Adipose-Derived Mesenchymal Stem Cells with Potential to Ameliorate Platelet Recovery and Enhance Megakaryopoiesis in a Mouse Model of Radiation-Induced Thrombocytopenia Via the PI3k/Akt Pathway

Xiao-Hui Zhang, MD, PhD, Jia-Min Zhang, Fei-Er Feng, Qian-Ming Wang, Xiao-Lu Zhu, Shi-Yuan Zhou, Yi Zhou, Hui-Sheng Ai, Xiao Jun Huang

Blood (2014) 124 (21): 2931.

https://doi.org/10.1182/blood.V124.21.2931.2931

Published: 2014

Journal Articles

BCR-ABL Tyrosine Kinase Inhibitors Interfere with the PI3K/Akt Signalling Pathway and Activate the Microphthalmia-Associated Transcription Factor (MITF) in Human Dendritic Cells

Daniela Doerfel, MD, Michael Gutknecht, Melanie Märklin, Lothar Kanz, MD, Helmut R. Salih, MD, Frank Gruenebach, Martin R Müller, MD PhD, Susanne M Rittig, MD

Blood (2014) 124 (21): 1416.

https://doi.org/10.1182/blood.V124.21.1416.1416

Published: 2014

Journal Articles

A key to the quest?

Xavier Leleu

Blood (2014) 124 (14): 2162–2163.

https://doi.org/10.1182/blood-2014-08-593822

Published: 2014

Journal Articles

PI3K/AKT Pathway Is Activated By MYD88 L265P and Use Of PI3K-Delta Inhibitors Induces Robust Tumor Cell Killing In Waldenstrom’s Macroglobulinemia

Guang Yang, PhD, Xia Liu, MD, Yangsheng Zhou, MD, Lian Xu, Yang Cao, MD, Robert Manning, Christopher Patterson, Christina K Tripsas, MA, Zachary Hunter, Sara Buhrlage, Ph.D, Nathanael S Gray, PhD, Steven Peter Treon, MD, MA, PhD

Blood (2013) 122 (21): 4255.

https://doi.org/10.1182/blood.V122.21.4255.4255

Published: 2013

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Class I PI3K Is Required for HSC Differentiation

Analysis of Mechanisms Underlying Clonal Evolution of AML By a New Single-Cell Sequencing Platform

Analysis of a New Haematopoietic Stem/Progenitor Cells with Megakaryocyte Differentiation Potential

Suppression of CUL4B Induces G1 Cell Cycle Arrest through the Modulation of AKT Signaling Pathway

IGFBP7 As a Potential Therapeutic Target for AML

Safety and Efficacy of Long Term Suppression of PI3Kinase Pathway By Small Molecule PI3K-Delta Inhibitor, Leniolisib in Apds (Activated PI3Kδ Syndrome)

Hematopoietic-Specific CSNK2B Loss in Mice Causes Impaired Erythropoiesis

NEDD4-1 Modulates the Resistance of Multiple Myeloma to Bortezomib Via PTEN/PI3K/Akt Signaling Pathway

Effective “activated PI3Kδ syndrome”–targeted therapy with the PI3Kδ inhibitor leniolisib

Identification of CKMT1B As a New Target in EVI1-Positive AML

TLR2-PI3K/Akt Signaling Pathway Involved in Platelet Activation Induced By Group B Streptococci

Manufacturing an Enhanced CAR T Cell Product By Inhibition of the PI3K/Akt Pathway During T Cell Expansion Results in Improved In Vivo Efficacy of Anti-BCMA CAR T Cells

Novel Functional Roles for Ten-Eleven-Translocation 2 (Tet2) in Normal and Leukemic Growth of Mast Cells

Novel target to kill CLL

Melatonin Protects Against Apoptosis of Megakaryocytes Via Its Receptors and Activation of PI3k/Akt Pathway

Synergistic Lethal Effects Between Gemcitabine and Arsenic Trioxide on Non-Hodgkin Lymphoma Cell Lines Is Associated with Modulation of PI3K/Akt Signaling Pathway

Adipose-Derived Mesenchymal Stem Cells with Potential to Ameliorate Platelet Recovery and Enhance Megakaryopoiesis in a Mouse Model of Radiation-Induced Thrombocytopenia Via the PI3k/Akt Pathway

BCR-ABL Tyrosine Kinase Inhibitors Interfere with the PI3K/Akt Signalling Pathway and Activate the Microphthalmia-Associated Transcription Factor (MITF) in Human Dendritic Cells

A key to the quest?

PI3K/AKT Pathway Is Activated By MYD88 L265P and Use Of PI3K-Delta Inhibitors Induces Robust Tumor Cell Killing In Waldenstrom’s Macroglobulinemia

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American Society of Hematology

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