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Yvonne Suessmuth
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Journal Articles

Higher abatacept exposure after transplant decreases acute GVHD risk without increasing adverse events

Clinical Trials & Observations
Takuto Takahashi, Mahmoud Al-Kofahi, Mutaz Jaber, Brandi Bratrude, Kayla Betz, Yvonne Suessmuth, Alison Yu, Donna S. Neuberg, Sung W. Choi, Jeffrey Davis, Christine Duncan, Roger Giller, Michael Grimley, Andrew C. Harris, David Jacobsohn, Nahal Lalefar, Nosha Farhadfar, Michael A. Pulsipher, Shalini Shenoy, Aleksandra Petrovic, Kirk R. Schultz, Gregory A. Yanik, Bruce R. Blazar, John T. Horan, Benjamin Watkins, Amelia Langston, Muna Qayed, Leslie S. Kean
Journal: Blood
Blood (2023) 142 (8): 700–710.
https://doi.org/10.1182/blood.2023020035
Published: 2023
Includes: Supplemental data
Journal Articles

Early Breakthrough T Cell Proliferation Despite CNI/MTX Prophylaxis Is a Harbinger of Acute Gvhd (AGVHD) and Is Controlled By Abatacept: Mechanism of Success of the ABA2 Agvhd Prevention Trial

Alexandre Albanese, Alal Eran, Yvonne Suessmuth, Kayla Betz, Brandi Bratrude, Paula Keskula, Lorenzo Cagnin, Amelia Langston, Muna Qayed, John T. Horan, Bruce R. Blazar, Benjamin Watkins, Leslie S. Kean
Journal: Blood
Blood (2022) 140 (Supplement 1): 274–275.
https://doi.org/10.1182/blood-2022-170693
Published: 2022
Journal Articles

Single-Cell RNA-Seq Reveals an Interferon-Driven Inflammatory CD4 Naïve T Cell Subpopulation at Day 100 in Hematopoietic Stem Cell Transplant Patients That Ultimately Develop Chronic Gvhd

Alexandre Albanese, Edward Chen, Jillian Zavistaski, Kayla Betz, Yvonne Suessmuth, Lorenzo Cagnin, Paula Keskula, Kyle Kimler, James Kaminski, Bruce R. Blazar, Benjamin Watkins, Leslie S. Kean
Journal: Blood
Blood (2022) 140 (Supplement 1): 270–271.
https://doi.org/10.1182/blood-2022-170214
Published: 2022
Journal Articles

Abatacept for the Prevention of Gvhd in Pediatric and Adult Patients Receiving 7/8 HLA-Mismatched Unrelated Transplant for Hematologic Malignancies: A Real-World Analysis

Sharmila Raghunandan, Lev Gorfinkel, Michael Graiser, Brandi Bratrude, Kayla Betz, Yvonne Suessmuth, Scott Gillespie, Adrianna Lynn Westbrook, Kirsten M. Williams, Michelle Schoettler, Amelia Langston, Leslie Kean, Muna Qayed, John T. Horan, Benjamin Watkins
Journal: Blood
Blood (2022) 140 (Supplement 1): 7653–7655.
https://doi.org/10.1182/blood-2022-163627
Published: 2022
Journal Articles

Potent Interaction between CMV Reactivation and Gvhd: Immunologic Evidence for Blunting of CMV-Driven Immune Reconstitution in the Setting of Gvhd

Yvonne Suessmuth, PhD, Kayla Betz, BS, Alison Yu, PhD, Brandi Bratrude, Benjamin Watkins, MD, Muna Qayed, MDMSc, John T. Horan, MDMPH, Leslie Kean, MD PhD, Amelia Langston, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 50.
https://doi.org/10.1182/blood-2020-141856
Published: 2020
Journal Articles

Predicting Immune Pathology after Hematopoietic Stem Cell Transplant with Transcriptomics: Naïve CD4 T Cell Expansion at Day 100 Predicts Patients with De Novo Chronic Gvhd

Ben Watkins, MD, James Kaminski, Muna Qayed, MDMSc, Kayla Betz, BS, Yvonne Suessmuth, PhD, Brandi Bratrude, Alison Yu, PhD, Victor Tkachev, PhD, Kathryn Pellegrini, Steven Bosinger, PhD, Bruce R. Blazar, MD, John T. Horan, MDMPH, Amelia Langston, MD, Leslie Kean, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 38–39.
https://doi.org/10.1182/blood-2020-139488
Published: 2020
Journal Articles

Transcriptomic Analysis of CD4+ T Cell Dysfunction during Gvhd: Evidence for Profound Reprograming of T Cell Signaling during Acute Gvhd That Is Controlled during CD28:CD80/86 Costimulation Blockade with Abatacept

Benjamin Watkins, Yvonne Suessmuth, Kayla Betz, BS, Alison Yu, PhD, Brandi Bratrude, Muna Qayed, MD MSc, Kathryn Pellegrini, Steven Bosinger, Amelia Langston, MD, John T. Horan, MDMPH, Bruce R. Blazar, MD, Leslie Kean, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 596.
https://doi.org/10.1182/blood-2019-131955
Published: 2019
Journal Articles

T Cell Costimulation Blockade with Abatacept Nearly Eliminates Early Severe Acute Graft Versus Host Disease after HLA-Mismatched (7/8 HLA Matched) Unrelated Donor Transplant, with a Favorable Impact on Disease-Free and Overall Survival

Ben Watkins, MD, Muna Qayed, MDMSc, Brandi Bratrude, Kayla Betz, Melanie Brown, BS, James Rhodes, Shauna Sinclair, Yvonne Suessmuth, Alison Yu, PhD, Kyle Hebert, Marcelo C. Pasquini, MDMS, Sung W. Choi, MD MS, Jeffrey Davis, Christine Duncan, MD MSc, Roger Giller, MD, Michael Grimley, MD, Andrew C Harris, MD, David A. Jacobsohn, MD, Nahal Lalefar, Maxim Norkin, MD, Michael A Pulsipher, MD, Shalini Shenoy, MD, Bruce Blazar, MD, Amelia Langston, MD, John T Horan, MD, Leslie Kean, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 212.
https://doi.org/10.1182/blood.V130.Suppl_1.212.212
Published: 2017
Journal Articles

CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire

Yvonne Suessmuth, Rithun Mukherjee, Benjamin Watkins, Divya T. Koura, Knut Finstermeier, Cindy Desmarais, Linda Stempora, John T. Horan, Amelia Langston, Muna Qayed, Hanna J. Khoury, Audrey Grizzle, Jennifer A. Cheeseman, Jason A. Conger, Jennifer Robertson, Aneesah Garrett, Allan D. Kirk, Edmund K. Waller, Bruce R. Blazar, Aneesh K. Mehta, Harlan S. Robins, Leslie S. Kean
Journal: Blood
Blood (2015) 125 (25): 3835–3850.
https://doi.org/10.1182/blood-2015-03-631853
Published: 2015
Includes: Supplemental data
Journal Articles

The myeloproliferative disorder–associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3

Michelle B. Hookham, Joanne Elliott, Yvonne Suessmuth, Judith Staerk, Alister C. Ward, William Vainchenker, Melanie J. Percy, Mary Frances McMullin, Stefan N. Constantinescu, James A. Johnston
Journal: Blood
Blood (2007) 109 (11): 4924–4929.
https://doi.org/10.1182/blood-2006-08-039735
Published: 2007
Includes: Supplemental data