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Journal Articles

Immunodeficiency and bone marrow failure with mosaic and germline TLR8 gain of function

Jahnavi Aluri, Alicia Bach, Saara Kaviany, Luana Chiquetto Paracatu, Maleewan Kitcharoensakkul, Magdalena A. Walkiewicz, Christopher D. Putnam, Marwan Shinawi, Nermina Saucier, Elise M. Rizzi, Michael T. Harmon, Molly P. Keppel, Michelle Ritter, Morgan Similuk, Elaine Kulm, Michael Joyce, Adriana A. de Jesus, Raphaela Goldbach-Mansky, Yi-Shan Lee, Marina Cella, Peggy L. Kendall, Mary C. Dinauer, Jeffrey J. Bednarski, Christina Bemrich-Stolz, Scott W. Canna, Shirley M. Abraham, Matthew M. Demczko, Jonathan Powell, Stacie M. Jones, Amy M. Scurlock, Suk See De Ravin, Jack J. Bleesing, James A. Connelly, V. Koneti Rao, Laura G. Schuettpelz, Megan A. Cooper
Journal: Blood
Blood (2021) 137 (18): 2450–2462.
https://doi.org/10.1182/blood.2020009620
Published: 2021
Includes: Supplemental data
Journal Articles

CRISPR/Cas9 Genome Editing to Treat Sickle Cell Disease and B-Thalassemia: Re-Creating Genetic Variants to Upregulate Fetal Hemoglobin Appear Well-Tolerated, Effective and Durable.

Michelle I. Lin, PhD, Elizabeth Paik, PhD, Bibhu Mishra, PhD, David Burkhardt, Andrew Kernytsky, PhD, Michael Pettiglio, Yi-Shan Chen, Kaleigh Tomkinson, Amanda Woo, Mauricio Cortes, PhD, Siyuan Tan, PhD, Todd D Borland, BS, Lawrence Klein, PhD, Angela Yen, PhD, Sudipta Mahajan, Eric Chan, PhD, Brenda Eustace, PhD, Matthew Porteus, MD PhD, Tirtha Chakraborty, PhD, Chad Cowan, Rodger Novak, MD, Ante Lundberg, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 284.
https://doi.org/10.1182/blood.V130.Suppl_1.284.284
Published: 2017
Journal Articles

Targeting chronic myeloid leukemia stem cells with the hypoxia-inducible factor inhibitor acriflavine

Giulia Cheloni, Michele Tanturli, Ignazia Tusa, Ngoc Ho DeSouza, Yi Shan, Antonella Gozzini, Fréderic Mazurier, Elisabetta Rovida, Shaoguang Li, Persio Dello Sbarba
Journal: Blood
Blood (2017) 130 (5): 655–665.
https://doi.org/10.1182/blood-2016-10-745588
Published: 2017
Includes: Supplemental data
Journal Articles

Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy

Clinical Trials & Observations
Eric J. Duncavage, Geoffrey L. Uy, Allegra A. Petti, Christopher A. Miller, Yi-Shan Lee, Bevan Tandon, Feng Gao, Catrina C. Fronick, Michelle O’Laughlin, Robert S. Fulton, Richard K. Wilson, Meagan A. Jacoby, Amanda F. Cashen, Lukas D. Wartman, Matthew J. Walter, Peter Westervelt, Daniel C. Link, John F. DiPersio, Timothy J. Ley, John S. Welch
Journal: Blood
Blood (2017) 129 (10): 1397–1401.
https://doi.org/10.1182/blood-2016-10-745273
Published: 2017
Includes: Supplemental data
Journal Articles

PFKFB3 Is a Crucial Target in the Treatment of Tyrosine Kinase Inhibitor Resistant Chronic Myelogenous Leukemia

Yu Zhu, Jianyong Li, Chun Qiao, Yi Shan, MD, Sixuan Qian, Yaoyu Chen, Ming Hong, Huihui Zhao, Huapeng LI, Xuejun Zhu, Yang Zhongfa
Journal: Blood
Blood (2016) 128 (22): 3936.
https://doi.org/10.1182/blood.V128.22.3936.3936
Published: 2016
Journal Articles

Targeting Chronic Myeloid Leukemia Stem Cells through Pharmacological Inhibition of HIF-1α

Giulia Cheloni, PhD, Michele Tanturli, PhD, DeSouza Ho Ngoc, Yi Shan, MD, Ignazia Tusa, PhD, Elisabetta Rovida, PhD, Shaoguang Li, MD PhD, Persio Dello Sbarba, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4235.
https://doi.org/10.1182/blood.V128.22.4235.4235
Published: 2016
Journal Articles

Exome Sequencing of Hodgkin's and Non-Hodgkin Composite Lymphomas Identifies Shared Somatic Mutations Indicative of Common Founding Precursors

Felicia Gomez, PhD, Matthew Matlock, BA, Kilannin Krysiak, PhD, Yi-Shan Lee, MD, Eric J. Duncavage, MD, Michelle O'Laughlin, BS, Malachi Griffith, PhD, Todd A Fehniger, MD PhD, Lukas D. Wartman, MD, Obi L. Griffith, PhD
Journal: Blood
Blood (2016) 128 (22): 5285.
https://doi.org/10.1182/blood.V128.22.5285.5285
Published: 2016
Journal Articles

Inhibition of CML Stem Cells with an Alkaloid That Reduces β-Catenin

Shawnya J. Michaels, MS,MBA, Ngoc DeSouza, PhDCandidate, Yi Shan, MD, Shaoguang Li, MD PhD, Saira Bates, MBA
Journal: Blood
Blood (2016) 128 (22): 1882.
https://doi.org/10.1182/blood.V128.22.1882.1882
Published: 2016
Journal Articles

PKC Pathways Mediate BCR-ABL-Independent Imatinib Resistance in Chronic Myeloid Leukemia

Leyuan Ma, Yi Shan, Robert Bai, Liting Xue, Christopher A. Eide, Jianhong Ou, Lihua J. Zhu, Lloyd Hutchinson, PhD, Jan Cerny, MD PhD, H. Jean Khoury, MD, Zhi Sheng, Brian J. Druker, Shaoguang Li, MD PhD, Michael Green
Journal: Blood
Blood (2014) 124 (21): 1790.
https://doi.org/10.1182/blood.V124.21.1790.1790
Published: 2014
Journal Articles

Genetic and Pharmacologic Targeting Of Alox5 Attenuates JAK2V617F Induced PV In Mice

Yaoyu Chen, MD, PhD, Yi Shan, Zhiru Guo, PhD, Aibin Liang, MD, PhD, Shaoguang Li, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 112.
https://doi.org/10.1182/blood.V122.21.112.112
Published: 2013
Journal Articles

Nfkb1 Plays a Tumor-Suppressing Role in BCR-ABL-Induced Leukemias

Con Sullivan, Yaoyu Chen, Zhiru Guo, Yi Shan, Cong Peng, Haojian Zhang, Jason Bubier, Thomas Sproule, Derry Roopenian, Shaoguang Li, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1666.
https://doi.org/10.1182/blood.V120.21.1666.1666
Published: 2012
Journal Articles

A tumor suppressor function of the Msr1 gene in leukemia stem cells of chronic myeloid leukemia

Yaoyu Chen, Con Sullivan, Cong Peng, Yi Shan, Yiguo Hu, Dongguang Li, Shaoguang Li
Journal: Blood
Blood (2011) 118 (2): 390–400.
https://doi.org/10.1182/blood-2010-11-316760
Published: 2011
Includes: Supplemental data