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Journal Articles

Deciphering the Somatic and Germline Structural Variation Landscape in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia By Whole Genome Optical Mapping

Danielle Brandes, Triantafyllia Brozou, Karin Nebral, Anke K. Bergmann, Oskar A. Haas, Stefan Köhrer, Martin Stanulla, Ute Fischer, Arndt Borkhardt, Rabea Wagener

Blood (2022) 140 (Supplement 1): 9203–9204.

DOI: https://doi.org/10.1182/blood-2022-163110

Published: 2022

Journal Articles

A Human iPSC Model Reveals Specific Upregulation of Linker Histone H1-0 in ETV6::RUNX1 + Preleukemia and B Cell Precursor Acute Lymphoblastic Leukemia

Vera H Jepsen, Daniel Hein, Daniel Picard, Tobias Lautwein, Rabea Wagener, Nan Qin, Annika Filip, Merja Heinäniemi, Arndt Borkhardt, Ute Fischer

Blood (2022) 140 (Supplement 1): 3469–3470.

DOI: https://doi.org/10.1182/blood-2022-163564

Published: 2022

Journal Articles

The Role of Adult Cancer Predisposition Genes in Hematological Malignancies of Childhood

Triantafyllia Brozou, Rabea Wagener, Danielle Brandes, Ute Fischer, Arndt Borkhardt

Blood (2022) 140 (Supplement 1): 8750–8751.

DOI: https://doi.org/10.1182/blood-2022-159655

Published: 2022

Journal Articles

Toward prevention of childhood ALL by early-life immune training

Julia Hauer, Ute Fischer, Arndt Borkhardt

Blood (2021) 138 (16): 1412–1428.

DOI: https://doi.org/10.1182/blood.2020009895

Published: 2021

Journal Articles

An intact gut microbiome protects genetically predisposed mice against leukemia

Blood (2020) 136 (18): 2003–2017.

DOI: https://doi.org/10.1182/blood.2019004381

Published: 2020

Includes: Supplemental data

Journal Articles

Investigation of New Therapeutic Compounds for Juvenile Myelomonocytic Leukemia Using Induced Pluripotent Stem Cells with Stably Activated Ras Pathway

Lisa Maria Kuhn, Cyrill Schipp, PhD, Daniel Hein, PhD, Bianca Killing, Nan Qin, PhD, Vera H Jepsen, M.Sc., Heinz Ahlert, MSc, BSc, Jasmin Bartl, PhD, Viktoria Marquardt, M.Sc., David Pauck, Kai Völtzke, M.Sc., Jonathan Lim, PhD, Gabriel Leprivier, PhD, Marc Remke, MD, Sanil Bhatia, PhD, Thorsten Rosenbaum, MD, Arndt Borkhardt, MD, Ute Fischer, PhD

Blood (2019) 134 (Supplement_1): 4651.

DOI: https://doi.org/10.1182/blood-2019-131406

Published: 2019

Journal Articles

Family Trio-Based Whole Genome Optical Mapping Identifies Candidate Structural Variations Predisposing Children to Acute Lymphoblastic Leukemia

Ute Fischer, PhD, Layal Yasin, PhD, Julia Täubner, PhD, Triantafyllia Brozou, MD, Arndt Borkhardt, MD

Blood (2019) 134 (Supplement_1): 5201.

DOI: https://doi.org/10.1182/blood-2019-130014

Published: 2019

Journal Articles

Therapeutic Stratification of PTEN-MYC Axis Appears to be Promising for Molecular Targeted Therapies in Refractory and Relapsed T-Cell Acute Lymphoblastic Leukemia

Heinz Ahlert, MSc, BSc, Sanil Bhatia, PhD, Marc Remke, MD, Melf Sönnichsen, M.Sc., Niklas Dienstbier, M.Sc., Ute Fischer, PhD, Julia Hauer, MD, Arndt Borkhardt, MD

Blood (2019) 134 (Supplement_1): 3883.

DOI: https://doi.org/10.1182/blood-2019-128136

Published: 2019

Journal Articles

The preleukemic TCF3 -PBX1 gene fusion can be generated in utero and is present in ≈0.6% of healthy newborns

Daniel Hein, Karin Dreisig, Markus Metzler, Shai Izraeli, Kjeld Schmiegelow, Arndt Borkhardt, Ute Fischer

Blood (2019) 134 (16): 1355–1358.

DOI: https://doi.org/10.1182/blood.2019002215

Published: 2019

Includes: Supplemental data

Journal Articles

Activation of CRLF2/IL7RA Signaling in Normal Human Cord Blood Hematopoietic Progenitors Induces Philadelphia-like B-Cell Precursor Pre-Leukemia and Leukemia In Vivo

Ifat Geron, PhD, Angela Maria Savino, PhD, Noa Tal, MD PhD, John Brown, PhD, Virginia A Turati, DPhil, Yu Nee Lee, PhD, Chela James, PhD, Avigail Rein Gil, MD, Yehudit Birger, PhD, Inna Muler, Michal Hameiri, PhD, Victoria Marcu-Malina, PhD, Ute Fischer, PhD, Arndt Borkhardt, MD, Ilan M. Kirsch, MD, Arnon Nagler, MD, Tariq Enver, PhD, Shai Izraeli, MD

Blood (2018) 132 (Supplement 1): 566.

DOI: https://doi.org/10.1182/blood-2018-99-115913

Published: 2018

Journal Articles

Determination of the Origin of the t(1;19) TCF3-PBX1 Fusion By Genomic Inverse PCR for Exploration of Ligated Breakpoints (GIPFEL)

Daniel Hein, PhD, Karin Dreisig, PhD, Shai Izraeli, MD, Kjeld Schmiegelow, MD, Arndt Borkhardt, MD, Ute Fischer, PhD

Blood (2018) 132 (Supplement 1): 4093.

DOI: https://doi.org/10.1182/blood-2018-99-110521

Published: 2018

Journal Articles

Five percent of healthy newborns have an ETV6-RUNX1 fusion as revealed by DNA-based GIPFEL screening

Daniel Schäfer, Marianne Olsen, David Lähnemann, Martin Stanulla, Robert Slany, Kjeld Schmiegelow, Arndt Borkhardt, Ute Fischer

Blood (2018) 131 (7): 821–826.

DOI: https://doi.org/10.1182/blood-2017-09-808402

Published: 2018

Includes: Supplemental data

Journal Articles

The Landscape of Circular RNAs in Drug Resistant TCF3 -Rearranged Childhood Leukemia

Cai Chen, Daniel Picard, M.Sc., Nan Qin, PhD, Cyrill Schipp, MSc, Michael Gombert, PhD, Sebastian Ginzel, M.Sc., Jianda Hu, Prof MDPhD, Arndt Borkhardt, Prof MD, Marc Remke, Ute Fischer, PhD

Blood (2017) 130 (Supplement 1): 1432.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1432.1432

Published: 2017

Journal Articles

Identifying Possible Candidate Factors Influencing the Penetrance of Heterozygous NFKB1 Loss of Function Mutations By Whole Exome Sequencing

Cyrill Schipp, MSc, Arndt Borkhardt, MD, Polina Stepensky, MD, Ute Fischer, PhD

Blood (2016) 128 (22): 3706.

DOI: https://doi.org/10.1182/blood.V128.22.3706.3706

Published: 2016

Journal Articles

Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia Relapsing after Allogeneic Stem Cell Transplantation

Jessica I Hoell, MD, Sebastian Ginzel, MSc, Cornelia Eckert, PhD, Michael Gombert, PhD, Ute Fischer, PhD, Martin Stanulla, MD, Martin Schrappe, MD PhD, Udo zur Stadt, PhD, Peter Bader, MD, Brigitte Strahm, MD, Julia Alten, Anja Moericke, MD, Gabriele Escherich, MD, Arend Stackelberg, MD, Christina Peters, MD, Arndt Borkhardt, MD, Roland Meisel, MD

Blood (2016) 128 (22): 601.

DOI: https://doi.org/10.1182/blood.V128.22.601.601

Published: 2016

Journal Articles

2% of Healthy Newborns Reveal ETV6-RUNX1 Fusion By Genomic Inverse PCR for Exploration of Ligated Breakpoints (GIPFEL)

Daniel Schaefer, MSc, Marianne Olsen, MD, Ulrik Lausten-Thomsen, MD PhD, Cyrill Schipp, MSc, Martin Stanulla, MD, Robert K. Slany, PhD, Kjeld Schmiegelow, MD DMSc, Arndt Borkhardt, MD, Ute Fischer, PhD

Blood (2016) 128 (22): 4082.

DOI: https://doi.org/10.1182/blood.V128.22.4082.4082

Published: 2016

Journal Articles

Activating Mutation of STAT3 Protects Lymphocytes from Apoptosis and Leads to a Clinical Phenotype Resembling the Autoimmune Lymphoproliferative Syndrome

Schafiq Nabhani, PhD, Hagit Miskin, MD, Cyrill Schipp, MSc, Dan Harlev, Shoshana Revel-Vilk, MD MSc, Michael Gombert, PhD, Sebastian Ginzel, MSc, Arndt Borkhardt, MD, Polina Stepensky, MD, Ute Fischer, PhD

Blood (2015) 126 (23): 2218.

DOI: https://doi.org/10.1182/blood.V126.23.2218.2218

Published: 2015

Journal Articles

A New ETV6-RUNX1 In Vivo Model Produces a Phenocopy of the Human Pb-ALL

Blood (2015) 126 (23): 3658.

DOI: https://doi.org/10.1182/blood.V126.23.3658.3658

Published: 2015

Journal Articles

Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency

Blood (2015) 125 (5): 753–761.

DOI: https://doi.org/10.1182/blood-2014-08-593202

Published: 2015

Includes: Supplemental data

Journal Articles

Dysregulation of IL12 Signaling As a Novel Cause of an Autoimmune Lymphoproliferative like Syndrome

Schafiq Nabhani, MSc, Sebastian Ginzel, MSc, Hagit Miskin, MD, Shoshana Revel-Vilk, MD MSc, Dan Harlev, MD, Bernhard Fleckenstein, MD Prof, Andrea Höhnscheid, PhD, Prasad T. Oommen, MD, Michaela Kuhlen, MD, Ralf Thiele, PhD Prof, Hans-Jürgen Laws, MD, Arndt Borkhardt, Polina Stepensky, MD, Ute Fischer, PhD

Blood (2014) 124 (21): 1420.

DOI: https://doi.org/10.1182/blood.V124.21.1420.1420

Published: 2014

NARROW

Deciphering the Somatic and Germline Structural Variation Landscape in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia By Whole Genome Optical Mapping

A Human iPSC Model Reveals Specific Upregulation of Linker Histone H1-0 in ETV6::RUNX1 + Preleukemia and B Cell Precursor Acute Lymphoblastic Leukemia

The Role of Adult Cancer Predisposition Genes in Hematological Malignancies of Childhood

Toward prevention of childhood ALL by early-life immune training

An intact gut microbiome protects genetically predisposed mice against leukemia

Investigation of New Therapeutic Compounds for Juvenile Myelomonocytic Leukemia Using Induced Pluripotent Stem Cells with Stably Activated Ras Pathway

Family Trio-Based Whole Genome Optical Mapping Identifies Candidate Structural Variations Predisposing Children to Acute Lymphoblastic Leukemia

Therapeutic Stratification of PTEN-MYC Axis Appears to be Promising for Molecular Targeted Therapies in Refractory and Relapsed T-Cell Acute Lymphoblastic Leukemia

The preleukemic TCF3 -PBX1 gene fusion can be generated in utero and is present in ≈0.6% of healthy newborns

Activation of CRLF2/IL7RA Signaling in Normal Human Cord Blood Hematopoietic Progenitors Induces Philadelphia-like B-Cell Precursor Pre-Leukemia and Leukemia In Vivo

Determination of the Origin of the t(1;19) TCF3-PBX1 Fusion By Genomic Inverse PCR for Exploration of Ligated Breakpoints (GIPFEL)

Five percent of healthy newborns have an ETV6-RUNX1 fusion as revealed by DNA-based GIPFEL screening

The Landscape of Circular RNAs in Drug Resistant TCF3 -Rearranged Childhood Leukemia

Identifying Possible Candidate Factors Influencing the Penetrance of Heterozygous NFKB1 Loss of Function Mutations By Whole Exome Sequencing

Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia Relapsing after Allogeneic Stem Cell Transplantation

2% of Healthy Newborns Reveal ETV6-RUNX1 Fusion By Genomic Inverse PCR for Exploration of Ligated Breakpoints (GIPFEL)

Activating Mutation of STAT3 Protects Lymphocytes from Apoptosis and Leads to a Clinical Phenotype Resembling the Autoimmune Lymphoproliferative Syndrome

A New ETV6-RUNX1 In Vivo Model Produces a Phenocopy of the Human Pb-ALL

Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency

Dysregulation of IL12 Signaling As a Novel Cause of an Autoimmune Lymphoproliferative like Syndrome

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American Society of Hematology

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American Society of Hematology

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