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Journal Articles

Feasibility of Near-Infrared Spectroscopy for Monitoring Hemodynamic Changes in Patients with Sickle Cell Disease Treated with Mitapivat

Timothy Quang, Julia Z Xu, Ingrid Frey, Kathryn Jaroszynski, Elise M. Berning, Anna Conrey, Ruth Pierre Charles, Brian Y Hill, Neal Jeffries, Swee Lay Thein, Bruce J. Tromberg

Blood (2022) 140 (Supplement 1): 2526–2527.

https://doi.org/10.1182/blood-2022-159559

Published: 2022

Journal Articles

The Pyruvate Kinase Activator Mitapivat Improves Red Blood Cell Deformability and Sickling Kinetics in Adult Patients with Sickle Cell Disease

Maureen Lundt, Nancy Asomaning, Ingrid Frey, Xunde Wang, Anna Conrey, Julia Z Xu, Quan Li, Emily B Dunkelberger, Neal Jeffries, William Eaton, Swee Lay Thein

Blood (2022) 140 (Supplement 1): 2508–2509.

https://doi.org/10.1182/blood-2022-170010

Published: 2022

Journal Articles

HBB rs334 , ABO R s8176703 and Plasmodium Falciparum Positivity at Enrollment Are Independently Associated with Lower Risk for Endemic Burkitt Lymphoma in Uganda, Tanzania, Kenya, and Malawi

Hyokyoung G Hong, Mateus H Gouveia, Martin Ogwang, Patrick Kerchan, Steven Reynolds, Constance N Tenge, Pamela A Were, Robert T Kuremu, Walter N Wekesa, Nestory Masalu, Esther Kawira, Tobias Kinyera, Xunde Wang, Jiefu Zhou, Isaac Otim, Ismail D Legason, Hadijah Nabalende, Herry Dhudha, Mediatrix Mumia, Francine G Baker, Temi Okusolubo, Leona W Ayers, Kishor Bhatia, James J Goedert, Joshua G Woo, Nathan Cole, Wen Luo, Belynda Hicks, Adebowale A Adeyemo, Ludmila Prokunina-Olsson, Daniel N. Shriner, Charles N Rotimi, George Chagaluka, W Thomas Johnston, Nora Mutalima, Eric Borgstein, George N Liomba, Steve Kamiza, Nyengo Mkandawire, Collins Mitambo, Collins Mitambo, Elizabeth Molyneux, Robert Newton, Michelle Manning, Joseph F Fraumeni, Jr., Ruth M Pfeiffer, Amy Hutchinson, Meredith Yeager, Swee Lay Thein, Stephen J. Chanock, Sam M. Mbulaiteye

Blood (2022) 140 (Supplement 1): 9314–9316.

https://doi.org/10.1182/blood-2022-170410

Published: 2022

Journal Articles

Pklr Variants Associated with Acute Pain in Sickle Cell Disease Influence ATP Concentrations in Red Blood Cells

Xunde Wang, Yi-Ping Fu, Quan Li, Emily B Dunkelberger, Mickias Tegegn, Penelope A. Kosinski, Heidi Mangus, John Hamre, Sam M. Mbulaiteye, Ludmila Prokunina-Olsson, Stephen J. Chanock, Nancy Asomaning, Neal Jeffries, William Eaton, Swee Lay Thein

Blood (2022) 140 (Supplement 1): 954–956.

https://doi.org/10.1182/blood-2022-167296

Published: 2022

Journal Articles

Phenotypic Screening of the Reframe Drug Repurposing Library to Discover New Drugs for Treating Sickle Cell Disease

William A. Eaton, Belhu Metaferia, Troy Cellmer, Emily B. Dunkelberger, Quan Li, Eric R. Henry, James Hofrichter, Dwayne Staton, Matthew M. Hsieh, Anna Conrey, John Tisdale, Arnab K. Chatterjee, Swee Lay Thein

Blood (2022) 140 (Supplement 1): 11089–11090.

https://doi.org/10.1182/blood-2022-159634

Published: 2022

Journal Articles

AG-946 Normalizes Glycolysis and Improves Red Cell Indices in a Humanized Sickle Cell Mouse Model

Rohitash Jamwal, Lily C. Wain, Christopher Copeland, Penelope A. Kosinski, Megan Wind-Rotolo, Ilya Gertsman, William Eaton, David M Bodine, Lenny Dang, Swee Lay Thein

Blood (2022) 140 (Supplement 1): 950–951.

https://doi.org/10.1182/blood-2022-156591

Published: 2022

Journal Articles

Activating Pyruvate Kinase Improves Red Blood Cell Integrity By Reducing Band3 Tyrosine Phosphorylation

Kang Le, Xunde Wang, Maureen Lundt, Anna Conrey, Ingrid Frey, Silvia Giannini, Penelope A. Kosinski, John A. Hausman, Philip S. Low, Neal Jeffries, Swee Lay Thein

Blood (2022) 140 (Supplement 1): 5395–5396.

https://doi.org/10.1182/blood-2022-160378

Published: 2022

Journal Articles

A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease

Blood (2022) 140 (19): 2053–2062.

https://doi.org/10.1182/blood.2022015403

Published: 2022

Includes: Supplemental data

Journal Articles

Diffuse myocardial fibrosis as an SCD biomarker

Swee Lay Thein, Vandana Sachdev

Blood (2022) 140 (11): 1191–1192.

https://doi.org/10.1182/blood.2022017725

Published: 2022

Journal Articles

Revisiting anemia in sickle cell disease and finding the balance with therapeutic approaches

Julia Zhe Xu, Swee Lay Thein

Blood (2022) 139 (20): 3030–3039.

https://doi.org/10.1182/blood.2021013873

Published: 2022

Journal Articles

Iron Status Is Inversely Correlated with Circulating Red Cells in Patients with Sickle Cell Anemia

Nermi Parrow, Anna Conrey, Swee Lay Thein, Robert E Fleming

Blood (2021) 138 (Supplement 1): 3115.

https://doi.org/10.1182/blood-2021-154078

Published: 2021

Journal Articles

Individuals with Sickle Cell Disease Have a Higher Burden of Mitochondrial DNA Heteroplasmy

Laxminath Tumburu, Maliha Maryam Ahmad, Chunyu Liu, Clifton L. Dalgard, Mehdi Pirooznia, Swee Lay Thein

Blood (2021) 138 (Supplement 1): 954.

https://doi.org/10.1182/blood-2021-153000

Published: 2021

Journal Articles

Pklr Is a Genetic Modifier of Sickle Cell Disease

Xunde Wang, Mickias Tegegn, Fayaz Seifuddin, Stephan Menzel, Hamel Patel, Yi-Ping Fu, Neal Jeffries, Mehdi Pirooznia, Kate Gardner, Swee Lay Thein

Blood (2021) 138 (Supplement 1): 953.

https://doi.org/10.1182/blood-2021-151842

Published: 2021

Journal Articles

Mitapivat (AG-348) Demonstrates Safety, Tolerability, and Improvements in Anemia, Hemolysis, Oxygen Affinity, and Hemoglobin S Polymerization Kinetics in Adults with Sickle Cell Disease: A Phase 1 Dose Escalation Study

Julia Z. Xu, Anna Conrey, Ingrid Frey, Eveline Gwaabe, Laurel A Menapace, Laxminath Tumburu, Maureen Lundt, Quan Li, Kristen Glass, Varsha Iyer, Heidi Mangus, Charles Kung, Lenny Dang, Penelope A. Kosinski, Peter Hawkins, Neal Jeffries, William Eaton, Swee Lay Thein

Blood (2021) 138 (Supplement 1): 10.

https://doi.org/10.1182/blood-2021-145398

Published: 2021

Journal Articles

Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin

Eric R. Henry, Belhu Metaferia, Quan Li, Julia Harper, Robert B. Best, Kristen E. Glass, Troy Cellmer, Emily B. Dunkelberger, Anna Conrey, Swee Lay Thein, H. Franklin Bunn, William A. Eaton

Blood (2021) 138 (13): 1172–1181.

https://doi.org/10.1182/blood.2021012070

Published: 2021

Includes: Supplemental data

Journal Articles

Circulating mitochondrial DNA is a proinflammatory DAMP in sickle cell disease

Blood (2021) 137 (22): 3116–3126.

https://doi.org/10.1182/blood.2020009063

Published: 2021

Includes: Multimedia, Supplemental data

Journal Articles

Dietary iron restriction improves markers of disease severity in murine sickle cell anemia

Nermi L. Parrow, Pierre-Christian Violet, Nisha Ajit George, Faris Ali, Shivam Bhanvadia, Ryan Wong, John F. Tisdale, Courtney Fitzhugh, Mark Levine, Swee Lay Thein, Robert E. Fleming

Blood (2021) 137 (11): 1553–1555.

https://doi.org/10.1182/blood.2020006919

Published: 2021

Includes: Supplemental data

Journal Articles

Mitochondrial DNA Variation in Individuals with Sickle Cell Disease

Maliha Maryam Ahmad, BS, Laxminath Tumburu, PhD, Chunyu Liu, PhD, Mehdi Pirooznia, MD PhD, Swee Lay Thein, DSc, FRCP, MBBS, MRCP

Blood (2020) 136 (Supplement 1): 11.

https://doi.org/10.1182/blood-2020-138518

Published: 2020

Journal Articles

RNA Seq Profiles and Bioinformatics Validation in a Large Sample of Sickle Cell Disease Patients

Jen Judy, PhDMS, Xunde Wang, PhD, Fayaz Seifuddin, PhD, Laxminath Tumburu, PhD, Mehdi Pirooznia, MD PhD, Swee Lay Thein, DSc, FRCP, MBBS, MRCP

Blood (2020) 136 (Supplement 1): 13–14.

https://doi.org/10.1182/blood-2020-139382

Published: 2020

Journal Articles

Cfcloud: A Cloud-Based Workflow for Cell-Free DNA Data Analysis

Ilker Tunc, PhD, Sean Agbor-Enoh, MD PhD, Hannah Valantine, MD, M.R.C.P, Swee Lay Thein, DSc,FRCP,FRCPath,MBBS,MRCPath,MRCP, Mehdi Pirooznia, MD PhD

Blood (2020) 136 (Supplement 1): 31–32.

https://doi.org/10.1182/blood-2020-138785

Published: 2020

NARROW

Feasibility of Near-Infrared Spectroscopy for Monitoring Hemodynamic Changes in Patients with Sickle Cell Disease Treated with Mitapivat

The Pyruvate Kinase Activator Mitapivat Improves Red Blood Cell Deformability and Sickling Kinetics in Adult Patients with Sickle Cell Disease

HBB rs334 , ABO R s8176703 and Plasmodium Falciparum Positivity at Enrollment Are Independently Associated with Lower Risk for Endemic Burkitt Lymphoma in Uganda, Tanzania, Kenya, and Malawi

Pklr Variants Associated with Acute Pain in Sickle Cell Disease Influence ATP Concentrations in Red Blood Cells

Phenotypic Screening of the Reframe Drug Repurposing Library to Discover New Drugs for Treating Sickle Cell Disease

AG-946 Normalizes Glycolysis and Improves Red Cell Indices in a Humanized Sickle Cell Mouse Model

Activating Pyruvate Kinase Improves Red Blood Cell Integrity By Reducing Band3 Tyrosine Phosphorylation

A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease

Diffuse myocardial fibrosis as an SCD biomarker

Revisiting anemia in sickle cell disease and finding the balance with therapeutic approaches

Iron Status Is Inversely Correlated with Circulating Red Cells in Patients with Sickle Cell Anemia

Individuals with Sickle Cell Disease Have a Higher Burden of Mitochondrial DNA Heteroplasmy

Pklr Is a Genetic Modifier of Sickle Cell Disease

Mitapivat (AG-348) Demonstrates Safety, Tolerability, and Improvements in Anemia, Hemolysis, Oxygen Affinity, and Hemoglobin S Polymerization Kinetics in Adults with Sickle Cell Disease: A Phase 1 Dose Escalation Study

Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin

Circulating mitochondrial DNA is a proinflammatory DAMP in sickle cell disease

Dietary iron restriction improves markers of disease severity in murine sickle cell anemia

Mitochondrial DNA Variation in Individuals with Sickle Cell Disease

RNA Seq Profiles and Bioinformatics Validation in a Large Sample of Sickle Cell Disease Patients

Cfcloud: A Cloud-Based Workflow for Cell-Free DNA Data Analysis

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American Society of Hematology

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ASH Publications

American Society of Hematology

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