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Journal Articles

A Phase 1 Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects with Stable Sickle Cell Disease: Trial in Progress

Anna Conrey, Dianna Lovins, Rivers Kimberly, Yuan Yee Lee, Kang Le, Britney Kruah, Xunde Wang, Belhu Metaferia, Philip S. Low, Neal Jeffries, William A Eaton, Swee Lay Thein

Blood (2024) 144 (Supplement 1): 1143.1.

https://doi.org/10.1182/blood-2024-193267

Published: 2024

Journal Articles

Mitapivat-Induced Improvements in RBC Deformability and Membrane Integrity in Patients with Sickle Cell Disease Are Sustained during Extended Therapy

Xunde Wang, Yechan Cho, Nancy Asomaning, Maureen Lundt, Anna Conrey, Britney Kruah, Amber M Yates, Megan Wind-Rotolo, Haiou Li, Kang Le, Swee Lay Thein

Blood (2024) 144 (Supplement 1): 2491.

https://doi.org/10.1182/blood-2024-206051

Published: 2024

Journal Articles

8-Oxoguanine DNA Glycosylase 1 Recruits Transcription Factor STAT1 to Promote the Inflammatory Responses in Sickle Cell Disease

Kang Le, Zenaide Quezado, Haiou Li, Sayuri Kamimura, Meghann L. Smith, Yuki Tahara, Yujeong Lee, Anna Conrey, Josie Schultz, Thorkell Andresson, Eric T Kool, Swee Lay Thein

Blood (2024) 144 (Supplement 1): 2490.

https://doi.org/10.1182/blood-2024-201619

Published: 2024

Journal Articles

The Amyloidogenic Transthyretin V122I Variant Increase Severity of Cardiac Phenotype and Mortality in Sickle Cell Disease

Haiou Li, Xunde Wang, Nancy Asomaning, Anna Conrey, Britney Kruah, Kylie Haymaker, Colin O. Wu, Vandana Sachdev, Swee Lay Thein

Blood (2024) 144 (Supplement 1): 800.

https://doi.org/10.1182/blood-2024-197909

Published: 2024

Journal Articles

Duffy Status and Hydroxyurea Dosing in Adult Patients with Sickle Cell Disease: A Potential for Iatrogenic Harm?

Eileen Ryan, Xunde Wang, Haiou Li, Anna Conrey, Swee Lay Thein

Blood (2024) 144 (Supplement 1): 2513.

https://doi.org/10.1182/blood-2024-203640

Published: 2024

Journal Articles

Acquired Mutations in the Mitochondrial Genome As Prognostic Markers in Sickle Cell Disease

Rudra Ray, Haiou Li, Nancy Asomaning, Kang Le, Xunde Wang, Justin Lack, Yuesheng Li, Sayuri Kamimura, Zenaide Quezado, Swee Lay Thein

Blood (2024) 144 (Supplement 1): 2485.

https://doi.org/10.1182/blood-2024-203373

Published: 2024

Journal Articles

A Machine Learning-Based Workflow for Predicting Transplant Outcome in Patients with Sickle Cell Disease

Haiou Li, Vandana Sachdev, Xin Tian, My-Le Nguyen, Matthew Hsieh, Courtney D. Fitzhugh, Emily Limerick, Wynona Coles, Nancy Asomaning, Anna Conrey, Colin O. Wu, Swee Lay Thein

Blood (2024) 144 (Supplement 1): 177.

https://doi.org/10.1182/blood-2024-194897

Published: 2024

Journal Articles

Recent developments in the use of pyruvate kinase activators as a new approach for treating sickle cell disease

Dina S. Parekh, William A. Eaton, Swee Lay Thein

Blood (2024) 143 (10): 866–871.

https://doi.org/10.1182/blood.2023021167

Published: 2024

Journal Articles

Exploring Near Infrared Spectroscopy As a Tool for Monitoring Tissue Hemodynamics for Patients with Sickle Cell Disease

Golnar Mostashari, Timothy Quang, Helen E Parker, Mai Hill, Dina Parekh, Andrew Keel, Anna Conrey, Swee Lay Thein, Bruce J Tromberg

Blood (2023) 142 (Supplement 1): 3862.

https://doi.org/10.1182/blood-2023-174241

Published: 2023

Journal Articles

Exploring Mitochondrial DNA Heteroplasmy in a Mouse Model of Sickle Cell Disease

Rudra Ray, John Hamre, Kang Le, Xunde Wang, Justin Lack, Yuesheng Li, Zenaide Quezado, Swee Lay Thein

Blood (2023) 142 (Supplement 1): 3858.

https://doi.org/10.1182/blood-2023-189660

Published: 2023

Journal Articles

A Phase 2/3, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study of Mitapivat in Patients with Sickle Cell Disease: RISE UP Phase 2 Results

Blood (2023) 142 (Supplement 1): 271.

https://doi.org/10.1182/blood-2023-187033

Published: 2023

Journal Articles

Long-Term Safety and Efficacy of Mitapivat, an Oral Pyruvate Kinase Activator, in Adults with Sickle Cell Disease: Extension of a Phase 1 Dose Escalation Study

Anna Conrey, Ingrid Frey, Nancy Asomaning, Ruth Pierre Charles, Dina Parekh, Julia Xu, Kang Le, Britney Kruah, Quan Li, Emily Dunkelberger, Troy Cellmer, Amber M Yates, Megan Wind-Rotolo, Neal Jeffries, William A Eaton, Swee Lay Thein

Blood (2023) 142 (Supplement 1): 273.

https://doi.org/10.1182/blood-2023-180165

Published: 2023

Journal Articles

Functional and Multi-Omics Signatures of Mitapivat Efficacy upon Activation of Pyruvate Kinase in Red Blood Cells from Patients with Sickle Cell Disease

Angelo D'Alessandro, Kang Le, Maureen Lundt, Quan Li, Emily Dunkelberger, Troy Cellmer, Andrew J Worth, Spurthi Patil, Chris Huston, Abby Grier, Monika monikA.dzieciatkow, Daniel Stephenson, William A Eaton, Swee Lay Thein

Blood (2023) 142 (Supplement 1): 2485.

https://doi.org/10.1182/blood-2023-181213

Published: 2023

Journal Articles

8-Oxoguanine DNA Glycosylase 1 Inhibition Suppresses Inflammatory Responses in Sickle Cell Disease

Kang Le, Zenaide Quezado, Sayuri Kamimura, Meghann L. Smith, Yuki Tahara, Yujeong Lee, Laxminath Tumburu, Anna Conrey, Eric T Kool, Swee Lay Thein

Blood (2023) 142 (Supplement 1): 2482.

https://doi.org/10.1182/blood-2023-182157

Published: 2023

Journal Articles

Evaluation of Red Cell Deformability in Sickle Cell Disease Patients, Sickle Cell Carriers, and Healthy Controls Using Lorrca-Derived Parameters

Nancy Asomaning, Xunde Wang, Maureen Lundt, Britney Kruah, Mai Hill, Anna Conrey, Ruth Pierre Charles, Ingrid Frey, Megan Wind-Rotolo, Chris Huston, Neal Jeffries, Swee Lay Thein

Blood (2023) 142 (Supplement 1): 5262.

https://doi.org/10.1182/blood-2023-184834

Published: 2023

Journal Articles

Longitudinal Characterization of Hemodynamic Changes with Multimodal Optical Techniques in Patients with Sickle Cell Disease Treated with Mitapivat

Timothy Quang, Ingrid Frey, Julia Xu, Golnar Mostashari, Anna Conrey, Dina S. Parekh, Ruth Pierre Charles, Brian Hill, Swee Lay Thein, Bruce J Tromberg

Blood (2023) 142 (Supplement 1): 2492.

https://doi.org/10.1182/blood-2023-174227

Published: 2023

Journal Articles

AG-946 Normalizes Glycolysis and Improves Red Cell Indices in a Humanized Sickle Cell Mouse Model

Rohitash Jamwal, Lily C. Wain, Christopher Copeland, Penelope A. Kosinski, Megan Wind-Rotolo, Ilya Gertsman, William Eaton, David M Bodine, Lenny Dang, Swee Lay Thein

Blood (2022) 140 (Supplement 1): 950–951.

https://doi.org/10.1182/blood-2022-156591

Published: 2022

Journal Articles

HBB rs334 , ABO R s8176703 and Plasmodium Falciparum Positivity at Enrollment Are Independently Associated with Lower Risk for Endemic Burkitt Lymphoma in Uganda, Tanzania, Kenya, and Malawi

Hyokyoung G Hong, Mateus H Gouveia, Martin Ogwang, Patrick Kerchan, Steven Reynolds, Constance N Tenge, Pamela A Were, Robert T Kuremu, Walter N Wekesa, Nestory Masalu, Esther Kawira, Tobias Kinyera, Xunde Wang, Jiefu Zhou, Isaac Otim, Ismail D Legason, Hadijah Nabalende, Herry Dhudha, Mediatrix Mumia, Francine G Baker, Temi Okusolubo, Leona W Ayers, Kishor Bhatia, James J Goedert, Joshua G Woo, Nathan Cole, Wen Luo, Belynda Hicks, Adebowale A Adeyemo, Ludmila Prokunina-Olsson, Daniel N. Shriner, Charles N Rotimi, George Chagaluka, W Thomas Johnston, Nora Mutalima, Eric Borgstein, George N Liomba, Steve Kamiza, Nyengo Mkandawire, Collins Mitambo, Collins Mitambo, Elizabeth Molyneux, Robert Newton, Michelle Manning, Joseph F Fraumeni, Jr., Ruth M Pfeiffer, Amy Hutchinson, Meredith Yeager, Swee Lay Thein, Stephen J. Chanock, Sam M. Mbulaiteye

Blood (2022) 140 (Supplement 1): 9314–9316.

https://doi.org/10.1182/blood-2022-170410

Published: 2022

Journal Articles

Pklr Variants Associated with Acute Pain in Sickle Cell Disease Influence ATP Concentrations in Red Blood Cells

Xunde Wang, Yi-Ping Fu, Quan Li, Emily B Dunkelberger, Mickias Tegegn, Penelope A. Kosinski, Heidi Mangus, John Hamre, Sam M. Mbulaiteye, Ludmila Prokunina-Olsson, Stephen J. Chanock, Nancy Asomaning, Neal Jeffries, William Eaton, Swee Lay Thein

Blood (2022) 140 (Supplement 1): 954–956.

https://doi.org/10.1182/blood-2022-167296

Published: 2022

Journal Articles

Feasibility of Near-Infrared Spectroscopy for Monitoring Hemodynamic Changes in Patients with Sickle Cell Disease Treated with Mitapivat

Timothy Quang, Julia Z Xu, Ingrid Frey, Kathryn Jaroszynski, Elise M. Berning, Anna Conrey, Ruth Pierre Charles, Brian Y Hill, Neal Jeffries, Swee Lay Thein, Bruce J. Tromberg

Blood (2022) 140 (Supplement 1): 2526–2527.

https://doi.org/10.1182/blood-2022-159559

Published: 2022

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A Phase 1 Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects with Stable Sickle Cell Disease: Trial in Progress

Mitapivat-Induced Improvements in RBC Deformability and Membrane Integrity in Patients with Sickle Cell Disease Are Sustained during Extended Therapy

8-Oxoguanine DNA Glycosylase 1 Recruits Transcription Factor STAT1 to Promote the Inflammatory Responses in Sickle Cell Disease

The Amyloidogenic Transthyretin V122I Variant Increase Severity of Cardiac Phenotype and Mortality in Sickle Cell Disease

Duffy Status and Hydroxyurea Dosing in Adult Patients with Sickle Cell Disease: A Potential for Iatrogenic Harm?

Acquired Mutations in the Mitochondrial Genome As Prognostic Markers in Sickle Cell Disease

A Machine Learning-Based Workflow for Predicting Transplant Outcome in Patients with Sickle Cell Disease

Recent developments in the use of pyruvate kinase activators as a new approach for treating sickle cell disease

Exploring Near Infrared Spectroscopy As a Tool for Monitoring Tissue Hemodynamics for Patients with Sickle Cell Disease

Exploring Mitochondrial DNA Heteroplasmy in a Mouse Model of Sickle Cell Disease

A Phase 2/3, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study of Mitapivat in Patients with Sickle Cell Disease: RISE UP Phase 2 Results

Long-Term Safety and Efficacy of Mitapivat, an Oral Pyruvate Kinase Activator, in Adults with Sickle Cell Disease: Extension of a Phase 1 Dose Escalation Study

Functional and Multi-Omics Signatures of Mitapivat Efficacy upon Activation of Pyruvate Kinase in Red Blood Cells from Patients with Sickle Cell Disease

8-Oxoguanine DNA Glycosylase 1 Inhibition Suppresses Inflammatory Responses in Sickle Cell Disease

Evaluation of Red Cell Deformability in Sickle Cell Disease Patients, Sickle Cell Carriers, and Healthy Controls Using Lorrca-Derived Parameters

Longitudinal Characterization of Hemodynamic Changes with Multimodal Optical Techniques in Patients with Sickle Cell Disease Treated with Mitapivat

AG-946 Normalizes Glycolysis and Improves Red Cell Indices in a Humanized Sickle Cell Mouse Model

HBB rs334 , ABO R s8176703 and Plasmodium Falciparum Positivity at Enrollment Are Independently Associated with Lower Risk for Endemic Burkitt Lymphoma in Uganda, Tanzania, Kenya, and Malawi

Pklr Variants Associated with Acute Pain in Sickle Cell Disease Influence ATP Concentrations in Red Blood Cells

Feasibility of Near-Infrared Spectroscopy for Monitoring Hemodynamic Changes in Patients with Sickle Cell Disease Treated with Mitapivat

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