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Journal Articles

Dietary iron restriction improves markers of disease severity in murine sickle cell anemia

Nermi L. Parrow, Pierre-Christian Violet, Nisha Ajit George, Faris Ali, Shivam Bhanvadia, Ryan Wong, John F. Tisdale, Courtney Fitzhugh, Mark Levine, Swee Lay Thein, Robert E. Fleming
Journal: Blood
Blood (2021) 137 (11): 1553–1555.
DOI: https://doi.org/10.1182/blood.2020006919
Published: 2021
Includes: Supplemental data
Journal Articles

Circulating mitochondrial DNA is a pro-inflammatory DAMP in sickle cell disease

Laxminath Tumburu, Shohini Ghosh-Choudhary, Fayaz Seifuddin, Emilia A Barbu, Simon Yang, Maliha M Ahmad, Lauren H.W. Wilkins, Ilker Tunc, Ishwarya Sivakumar, James S Nichols, Pradeep K Dagur, Shutong Yang, Luis E.F Almeida, Zenaide M Quezado, Christian Combs, Eric J Lindberg, Christopher K. E. Bleck, Jun Zhu, Arun S Shet, Jay H. Chung, Mehdi Pirooznia, Swee Lay Thein
Journal: Blood
Blood blood.2020009063.
DOI: https://doi.org/10.1182/blood.2020009063
Published: 2021
Includes: Multimedia, Supplemental data
Journal Articles

Phase 1 Multiple Ascending Dose Study of Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of Mitapivat (AG-348) in Subjects with Sickle Cell Disease

Julia Z. Xu, MDMS, Anna Conrey, NP, Ingrid Frey, RN, BSN, MS, James Nichols, RN, Laurel A Menapace, MD, Laxminath Tumburu, PhD, Timothy Lequang, MSc, Quan Li, PhD, Emily Dunkelberger, PhD, Eric Henry, PhD, Troy Cellmer, PhD, Varsha Iyer, Heidi Mangus, BS, Charles Kung, PhD, Lenny Dang, PhD, Penelope A. Kosinski, MS, Peter Hawkins, PhD, Neal Jeffries, PhD, William Eaton, MD, Swee Lay Thein, DSc, FRCP, MBBS, MRCP
Journal: Blood
Blood (2020) 136 (Supplement 1): 21–22.
DOI: https://doi.org/10.1182/blood-2020-137716
Published: 2020
Journal Articles

Mitochondrial DNA Variation in Individuals with Sickle Cell Disease

Maliha Maryam Ahmad, BS, Laxminath Tumburu, PhD, Chunyu Liu, PhD, Mehdi Pirooznia, MD PhD, Swee Lay Thein, DSc, FRCP, MBBS, MRCP
Journal: Blood
Blood (2020) 136 (Supplement 1): 11.
DOI: https://doi.org/10.1182/blood-2020-138518
Published: 2020
Journal Articles

RNA Seq Profiles and Bioinformatics Validation in a Large Sample of Sickle Cell Disease Patients

Jen Judy, PhDMS, Xunde Wang, PhD, Fayaz Seifuddin, PhD, Laxminath Tumburu, PhD, Mehdi Pirooznia, MD PhD, Swee Lay Thein, DSc, FRCP, MBBS, MRCP
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–14.
DOI: https://doi.org/10.1182/blood-2020-139382
Published: 2020
Journal Articles

Cfcloud: A Cloud-Based Workflow for Cell-Free DNA Data Analysis

Ilker Tunc, PhD, Sean Agbor-Enoh, MD PhD, Hannah Valantine, MD, M.R.C.P, Swee Lay Thein, DSc,FRCP,FRCPath,MBBS,MRCPath,MRCP, Mehdi Pirooznia, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 31–32.
DOI: https://doi.org/10.1182/blood-2020-138785
Published: 2020
Journal Articles

Platelet Phenotype Prediction from Whole Genome Sequencing in 621 Sickle Cell Disease Patients

Celina Montemayor Garcia, MD PhD, Julie K. Weisman, MD, Xunde Wang, PhD, Divya Gandla, James Owen Long, MD, Clifton L. Dalgard, PhD, Mehdi Pirooznia, MD PhD, Harvey Klein, MD, Swee Lay Thein, DSc, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2295.
DOI: https://doi.org/10.1182/blood-2019-131640
Published: 2019
Journal Articles

Hydroxyurea Reverses Dysfunctional Ubiquitin-Proteasomal System in Sickle CELL Disease and Suppresses Posttranslational Alterations in Hemoglobin and CELL Membranes

Swee Lay Thein, DSc, MBBS, Arun S Shet, MD, Michael Brad Strader, PhD, Fanato Meng, PhD, Michael Heaven, PhD, Jana Sirsendu, PhD, Abdu Alayash, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4822.
DOI: https://doi.org/10.1182/blood-2019-122840
Published: 2019
Journal Articles

A Machine Learning Algorithm to Improve Risk Assessment for Patients with Sickle Cell Disease

Vandana Sachdev, MD, Yuan Gu, PhD, James Nichols, RN, Wen Li, RCS, Stanislav Sidenko, RCS, Darlene Allen, MT(ASCP), Colin Wu, PhD, Swee Lay Thein, DSc, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 893.
DOI: https://doi.org/10.1182/blood-2019-125846
Published: 2019
Journal Articles

Neutrophil Extracellular Traps Are an Intrinsic Feature in Sickle Cell Disease

Emilia Alina Barbu, Venina Marcela Dominical, PhD, Laurel Mendelsohn, BS, James Nichols, RN, Darlene Allen, MT(ASCP), Swee Lay Thein, DSc,FRCP,FRCPath,MBBS,MRCPath,MRCP
Journal: Blood
Blood (2018) 132 (Supplement 1): 3651.
DOI: https://doi.org/10.1182/blood-2018-99-118723
Published: 2018
Journal Articles

Red Blood Cell and Platelet Phenotype Prediction from Whole Genome Sequencing in 621 Sickle Cell Disease Patients: Correlation with Alloimmunization History, Serology and Other Genotyping Methods

Celina Montemayor Garcia, MD PhD, Julie K. Weisman, MD, Divya Gandla, James Owen Long, MD, Clifton Lee Dalgard, PhD CLS, Mehdi Pirooznia, MD PhD, Harvey Klein, MD, Swee Lay Thein, DSc, FRCP, FRCPath, MBBS, MRCPath, MRCP
Journal: Blood
Blood (2018) 132 (Supplement 1): 2388.
DOI: https://doi.org/10.1182/blood-2018-99-115008
Published: 2018
Journal Articles

Cell-Free Mitochondrial DNA Is Elevated in Sickle Cell Disease Patients, and Serve As a Potential Proinflammatory DAMP

Laxminath Tumburu, PhD, Shohini Ghosh-Choudhary, Emilia Alina Barbu, Simon Yang, Lauren D Harrison Ware, Ilker Tunc, PhD, Fayaz Tasaduck Seifuddin, Mehdi Pirooznia, MD PhD, Jun Zhu, PhD, Swee Lay Thein, DSc,FRCP,FRCPath,MBBS,MRCPath,MRCP
Journal: Blood
Blood (2018) 132 (Supplement 1): 1068.
DOI: https://doi.org/10.1182/blood-2018-99-118440
Published: 2018
Journal Articles

How I treat the older adult with sickle cell disease

Clinical Trials & Observations
Swee Lay Thein, Jo Howard
Journal: Blood
Blood (2018) 132 (17): 1750–1760.
DOI: https://doi.org/10.1182/blood-2018-03-818161
Published: 2018
Journal Articles

Prevention of Morbidity in Sickle Cell Disease Phase II (Improvement of Cognition in children with Sickle Cell Disease with Auto-adjusting Continuous Positive Airways Pressure: Phase II) (POMS 2b paediatric cohort)

April E Slee, Jamie M Kawadler, PhD, Melanie Koelbel, MSc, Hanne Stotesbury, MSc, David C Rees, MD, Maria Pelidis, MD, Jo Howard, MBBCh, Swee Lay Thein, DSc,FRCP,FRCPath,MBBS,MRCPath,MRCP, Simon Skene, PhD, Sahota Sati, BSc, Carol Nwosu, BSc, Maureen Gwam, BSc, Dawn Saunders, MD, Johanna C Gavlak, PhD, Gupta Atul, MD, Simrat Sarkaria, Christina Liossi, PhD, Fenella J Kirkham, MD, Baba Inusa, MD MRCP
Journal: Blood
Blood (2017) 130 (Supplement 1): 3556.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.3556.3556
Published: 2017
Journal Articles

Prevention of Morbidity in Sickle Cell Disease Phase II (Improvement of Pain and Quality of Life in Children with Sickle Cell Disease with Auto-adjusting Continuous Positive Airways Pressure: Phase II) (POMS 2b pediatric cohort)

Baba Inusa, MD MRCP, Jo Howard, MBBCh, Subarna Chakravorty, MBBS, PhD FRCPath, MRCP, Maria Pelidis, MD, Swee Lay Thein, DSc,FRCP,FRCPath,MBBS,MRCPath,MRCP, Fenella J Kirkham, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3537.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.3537.3537
Published: 2017
Journal Articles

Common Fetal Hemoglobin Variants Modify Hematological Phenotypes in MDS/MPN/Myeloma Patients Receiving Cytotoxic Drugs

Norris E. Igbineweka, MBBS, BSc (Hons), MRCP, Adam Pilarski, MBBS, BA (Hons), MRCS, Helen Rooks, BSc, Amandine Breton, PhD BS, MSc, Hannah Hall, BMBS, Dilan D. Joshi, MSc, BMBS, Daveena Meeks, MBBS BSc, Stephan Menzel, MD PhD, Timothy Chevassut, BMBCh MA, MPH, PhD, Swee Lay Thein, DSc,FRCP,FRCPath,MBBS,MRCPath,MRCP
Journal: Blood
Blood (2017) 130 (Supplement 1): 1202.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1202.1202
Published: 2017
Journal Articles

Ventilation-Perfusion Scan Is Superior to CT Pulmonary Angiography in Detection of Chronic Thromboembolic Pulmonary Hypertension in SCD Adults

Alem Mehari, MD MS, Norris E. Igbineweka, MBBS, BSc (Hons), MRCP, Darlene Allen, MT(ASCP), James Nichols, RN, Swee Lay Thein, DSc,FRCP,FRCPath,MBBS,MRCPath,MRCP, Nargues Weir, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2248.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.2248.2248
Published: 2017
Journal Articles

The NLRP3 Inflammasome in Platelets Is Upregulated in Sickle Cell Disease and Promotes Platelet Aggregation and In Vitro Thrombosis

Sebastian Vogel, MD PhD, Taruna Arora, MD, Xunde Wang, PhD, Luis E. Almeida, MD PhD, Zenaide Quezado, MD, Swee Lay Thein, DSc,FRCP,FRCPath,MBBS,MRCPath,MRCP
Journal: Blood
Blood (2017) 130 (Supplement 1): 2234.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.2234.2234
Published: 2017
Journal Articles

Pain and Opioid Use after Reversal of Sickle Cell Disease Following Hematopoietic Stem Cell Transplant

Deepika S. Darbari, MD, Jaquette Liljencrantz, MD, Austin Ikechi, Staci Martin, PhD, Roderick Marie Claire, Courtney D. Fitzhugh, MD, John F Tisdale, MD, Swee Lay Thein, DSc,FRCP,FRCPath,MBBS,MRCPath,MRCP, Matthew Hsieh, MD
Journal: Blood
Blood (2017) 130 (Suppl_1): 970.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.970.970
Published: 2017
Journal Articles

Reversible binding of hemoglobin to band 3 constitutes the molecular switch that mediates O 2 regulation of erythrocyte properties

Haiyan Chu, Mary M. McKenna, Nathan A. Krump, Suilan Zheng, Laurel Mendelsohn, Swee Lay Thein, Lisa J. Garrett, David M. Bodine, Philip S. Low
Journal: Blood
Blood (2016) 128 (23): 2708–2716.
DOI: https://doi.org/10.1182/blood-2016-01-692079
Published: 2016
Includes: Supplemental data