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Journal Articles

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

Blood (2022) 139 (7): 1080–1097.

DOI: https://doi.org/10.1182/blood.2021012778

Published: 2022

Includes: Supplemental data

Journal Articles

Targeting Control of Cell Cycle Enhances the Activity of Conventional Chemotherapy in Chemotherapy-Resistant Acute Myeloid Leukemia

Victoria Y Ling, Sebastien Jacquelin, Jasmin Straube, Rohit Haldar, Yashaswini Janardhanan, Leanne T Cooper, Claudia Bruedigam, Emily Cooper, William Godfrey, Siok-Keen Tey, Lars Bullinger, Marco J Herold, Jonathan Baell, Megan Bywater, Steven W Lane

Blood (2021) 138 (Supplement 1): 2241.

DOI: https://doi.org/10.1182/blood-2021-148379

Published: 2021

Journal Articles

A Phase-Ib/II Clinical Evaluation of Ponatinib in Combination with Azacitidine in FLT3 -ITD and CBL -Mutant Acute Myeloid Leukemia (PON-AZA study)

David Kipp, Sun Loo, Andrew Charles Perkins, Steven W Lane, Emily Blyth, Anoop Kumar Enjeti, Ashish Bajel, John Reynolds, Andrew H. Wei

Blood (2021) 138 (Supplement 1): 2350.

DOI: https://doi.org/10.1182/blood-2021-154247

Published: 2021

Journal Articles

A Phase 2 Study of the LSD1 Inhibitor Img-7289 (bomedemstat) for the Treatment of Essential Thrombocythemia (ET)

Blood (2021) 138 (Supplement 1): 386.

DOI: https://doi.org/10.1182/blood-2021-148210

Published: 2021

Journal Articles

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease

Blood (2021) 138 (8): 722–737.

DOI: https://doi.org/10.1182/blood.2020006375

Published: 2021

Includes: Supplemental data

Journal Articles

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Blood (2021) 137 (20): 2721–2735.

DOI: https://doi.org/10.1182/blood.2020010167

Published: 2021

Includes: Supplemental data

Journal Articles

Inflammation in del(20q): a MST opportunity?

Steven W. Lane

Blood (2019) 134 (20): 1685–1686.

DOI: https://doi.org/10.1182/blood.2019003028

Published: 2019

Journal Articles

Loss of Phospholipase C Gamma 1 (PLCG1) Impairs AML1-ETO Induced Leukemia Stem Cell Self-Renewal

Blood (2019) 134 (Supplement_1): 531.

DOI: https://doi.org/10.1182/blood-2019-121996

Published: 2019

Journal Articles

Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation

Blood (2018) 132 (26): 2707–2721.

DOI: https://doi.org/10.1182/blood-2018-04-846220

Published: 2018

Includes: Supplemental data

Journal Articles

Small-Molecule Inhibition of PRMT5 Induces Translational Stress and p53 in JAK2V617F Mutant Myeloproliferative Neoplasms

Stefan Sonderegger, PhD MSc, Loretta Cerruti, BSc, Cedric Tremblay, PhD, Emma Toulmin, PhD, Jesslyn Saw, BSc, Tom Nebl, PhD, Katherine M Hannan, PhD, Steven W. Lane, MD PhD, Hendrik Falk, PhD, Ashwin Unnikrishnan, PhD, Paul Stupple, PhD, Ian Street, PhD, Stephen Jane, MDPhD, Rachel Altura, PhD, Benjamin Nicholson, PhD, David J. Curtis, MBBS,PhD

Blood (2018) 132 (Supplement 1): 53.

DOI: https://doi.org/10.1182/blood-2018-99-118406

Published: 2018

Journal Articles

Oncogenic-Drivers Dictate Immune Responses to Control Disease Progression in Acute Myeloid Leukaemia

Rebecca Austin, BSc, Megan Bywater, PhD, Jasmin Straube, PhD, Leanne T Cooper, Madeleine Headlam, PhD, Keyur Dave, PhD, Matthias Braun, PhD, Tobias Bald, PhD, Fernando Guimaraes, PhD, Sebastien Jacquelin, PhD, Matthew Witkowski, PhD, Iannis Aifantis, PhD, Geoffrey R Hill, MD PhD, Mark J Smyth, PhD, Steven W. Lane, MD PhD

Blood (2018) 132 (Supplement 1): 904.

DOI: https://doi.org/10.1182/blood-2018-99-112009

Published: 2018

Journal Articles

Identification of Genetic Pathways Controlling Resistance to Standard Combination Chemotherapy in Acute Myeloid Leukemia

Victoria Y Ling, MBBS, William Godfrey, Sebastien Jacquelin, PhD, Jasmin Straube, PhD, Leanne T Cooper, Claudia Bruedigam, PhD, Siok-Keen Tey, MBBS PhDFRACP FRCPA, Lars Bullinger, MD, Marco J Herold, Megan Bywater, PhD, Steven W. Lane, MD PhD

Blood (2018) 132 (Supplement 1): 2771.

DOI: https://doi.org/10.1182/blood-2018-99-115729

Published: 2018

Journal Articles

The impact of age, NPM1 mut , and FLT3 ITD allelic ratio in patients with acute myeloid leukemia

Jasmin Straube, Victoria Y. Ling, Geoffrey R. Hill, Steven W. Lane

Blood (2018) 131 (10): 1148–1153.

DOI: https://doi.org/10.1182/blood-2017-09-807438

Published: 2018

Includes: Supplemental data

Journal Articles

Integrated Molecular Analysis Identifies Replicative Stress As Sensitizer to Imetelstat Therapy in AML

Claudia Bruedigam, Amy H Porter, Brad Wackrow, Jasmin Straube, PhD, Leanne T Cooper, Axia Song, Stanley Chun-Wei Lee, PhD, Omar Abdel-Wahab, MD, Geoffrey R Hill, MD, Steven W. Lane, MD PhD

Blood (2017) 130 (Suppl_1): 798.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.798.798

Published: 2017

Journal Articles

In Vivo Expansion of Recipient DC Leads to Deletion of Donor Alloreactive CD8 + T Cells and Is an Alternative to Post-Transplant Cyclophosphamide for the Prevention of Graft-Versus-Host Disease after BMT

Kate A Markey, MBBS, PhD, Rachel D Kuns, BSc, Daniel J Browne, BSc, Kate H Gartlan, PhD, Renee J Robb, PhD, J Paulo Martins, BSc, Andrea S Henden, MBBS, Simone A Minnie, BSc, Melody Cheong, PhD, Motoko Koyama, MD PhD, Mark J Smyth, PhD, Gabrielle T Belz, PhD, Thomas Brocker, PhD, Mariapia Degli-Esposti, PhD, Steven W. Lane, MD PhD, Geoff R Hill, MD

Blood (2017) 130 (Supplement 1): 4443.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.4443.4443

Published: 2017

Journal Articles

Hacking the stem cell niche

Steven W. Lane, Florian H. Heidel

Blood (2017) 129 (22): 2951–2952.

DOI: https://doi.org/10.1182/blood-2017-04-777789

Published: 2017

Journal Articles

Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress

Blood (2017) 129 (18): 2479–2492.

DOI: https://doi.org/10.1182/blood-2016-06-725093

Published: 2017

Includes: Supplemental data

Journal Articles

GVHD prevents NK-cell–dependent leukemia and virus-specific innate immunity

Mark D. Bunting, Antiopi Varelias, Fernando Souza-Fonseca-Guimaraes, Iona S. Schuster, Katie E. Lineburg, Rachel D. Kuns, Peter Fleming, Kelly R. Locke, Nicholas D. Huntington, Bruce R. Blazar, Steven W. Lane, Siok-Keen Tey, Kelli P. A. MacDonald, Mark J. Smyth, Mariapia A. Degli-Esposti, Geoffrey R. Hill

Blood (2017) 129 (5): 630–642.

DOI: https://doi.org/10.1182/blood-2016-08-734020

Published: 2017

Includes: Supplemental data

Journal Articles

The Preclinical Efficacy of a Novel Telomerase Inhibitor, Imetelstat, in AML - a Randomized Trial in Patient-Derived Xenografts

Claudia Bruedigam, PhD, Brad Wackrow, Axia Song, Amy H Porter, Stanley Chun-Wei Lee, PhD, Andrew S. Moore, MBBS FRACP PhD, Omar Abdel-Wahab, MD, Steven W Lane, PhD

Blood (2016) 128 (22): 578.

DOI: https://doi.org/10.1182/blood.V128.22.578.578

Published: 2016

Journal Articles

Crispr-Cas9 Mediated Disruption of Dnmt3a in JakV617F Hematopoietic Stem Cells Accelerates Disease Phenotype and Induces Lethal Myelofibrosis

Sebastien Jacquelin, PhD, Emma Dishington, Therese Vu, Axia Song, Matthew Heidecker, Solene Guignes, Claudia Bruedigam, PhD, Joanne Sutton, Geoffrey R Hill, MD PhD, Nicole Cloonan, PhD, Dirk Heckl, PhD, Steven W Lane, PhD

Blood (2016) 128 (22): 794.

DOI: https://doi.org/10.1182/blood.V128.22.794.794

Published: 2016

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NARROW

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

Targeting Control of Cell Cycle Enhances the Activity of Conventional Chemotherapy in Chemotherapy-Resistant Acute Myeloid Leukemia

A Phase-Ib/II Clinical Evaluation of Ponatinib in Combination with Azacitidine in FLT3 -ITD and CBL -Mutant Acute Myeloid Leukemia (PON-AZA study)

A Phase 2 Study of the LSD1 Inhibitor Img-7289 (bomedemstat) for the Treatment of Essential Thrombocythemia (ET)

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Inflammation in del(20q): a MST opportunity?

Loss of Phospholipase C Gamma 1 (PLCG1) Impairs AML1-ETO Induced Leukemia Stem Cell Self-Renewal

Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation

Small-Molecule Inhibition of PRMT5 Induces Translational Stress and p53 in JAK2V617F Mutant Myeloproliferative Neoplasms

Oncogenic-Drivers Dictate Immune Responses to Control Disease Progression in Acute Myeloid Leukaemia

Identification of Genetic Pathways Controlling Resistance to Standard Combination Chemotherapy in Acute Myeloid Leukemia

The impact of age, NPM1 mut , and FLT3 ITD allelic ratio in patients with acute myeloid leukemia

Integrated Molecular Analysis Identifies Replicative Stress As Sensitizer to Imetelstat Therapy in AML

In Vivo Expansion of Recipient DC Leads to Deletion of Donor Alloreactive CD8 + T Cells and Is an Alternative to Post-Transplant Cyclophosphamide for the Prevention of Graft-Versus-Host Disease after BMT

Hacking the stem cell niche

Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress

GVHD prevents NK-cell–dependent leukemia and virus-specific innate immunity

The Preclinical Efficacy of a Novel Telomerase Inhibitor, Imetelstat, in AML - a Randomized Trial in Patient-Derived Xenografts

Crispr-Cas9 Mediated Disruption of Dnmt3a in JakV617F Hematopoietic Stem Cells Accelerates Disease Phenotype and Induces Lethal Myelofibrosis

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ASH Publications

American Society of Hematology

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ASH Publications

American Society of Hematology

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