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Journal Articles

Synergistic efficacy of dual PI3K-d/g inhibitor Duvelisib with Bcl2 inhibitor Venetoclax in Richter's Syndrome PDX models

Andrea Iannello, Nicoletta Vitale, Silvia Coma, Francesca Arruga, Amy Chadburn, Arianna Di Napoli, Carlo Laudanna, John Allan, Richard R. Furman, Jonathan A. Pachter, Silvia Deaglio, Tiziana Vaisitti
Journal: Blood
Blood blood.2020010187.
DOI: https://doi.org/10.1182/blood.2020010187
Published: 2021
Includes: Supplemental data
Journal Articles

ROR1 targeting with the antibody drug-conjugate VLS-101 is effective in Richter syndrome patient-derived xenograft mouse models

Tiziana Vaisitti, Francesca Arruga, Nicoletta Vitale, Thanh-Trang Thi Lee, Mira Ko, Amy Chadburn, Esteban Braggio, Arianna Di Napoli, Andrea Iannello, John Allan, Langdon L Miller, Brian J Lannutti, Richard R. Furman, Katti Jessen, Silvia Deaglio
Journal: Blood
Blood blood.2020008404.
DOI: https://doi.org/10.1182/blood.2020008404
Published: 2021
Includes: Supplemental data
Journal Articles

Combined Genetic Lesions in TP53 and CDKN2A/CDKN2B Drive B Cell Receptor-Dependent/Costimulatory Signal-Independent Proliferation in Richter Syndrome

Supriya Chakraborty, PhD, Claudio Martines, MS, Fabiola Porro, MS, Ilaria Fortunati, BS, Alice Bonato, BA, Marija Dimishkovska, PhD, Brijesh Yadav, PhD, Idanna Innocenti, MDPhD, Rosa Fazio, BA, Tizianna Vaisitti, PhD, Silvia Deaglio, MD, Alberto Zamò, MD PhD, Aleksandar Dimovski, MD PhD, Luca Laurenti, MD, Dimitar G Efremov, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
DOI: https://doi.org/10.1182/blood-2020-136668
Published: 2020
Journal Articles

CD79b Expression in Richter's Transformation

John N. Allan, MD, Erica B Bhavsar, BS, Tiziana Vaisitti, PhD, Vincent Sarno, Yifang Liu, Francesca Arruga, PhD, Maureen Joyce, Mathias Schulz, MD MBA, Silvia Deaglio, MD PhD, Richard R. Furman, MD, Amy Chadburn, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4279.
DOI: https://doi.org/10.1182/blood-2019-128305
Published: 2019
Journal Articles

Expression of the Tigit/CD226/CD155 Receptors/Ligand System in Chronic Lymphocytic Leukemia

Francesca Arruga, PhD, Giulia Guerra, Denis Baev, PhD, Catherine Hoofd, PhD, Marta Coscia, MD PhD, Giovanni Francesco D'Arena, MD, Gianluca Gaidano, MD PhD, Richard R. Furman, MD, Silvia Deaglio, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5454.
DOI: https://doi.org/10.1182/blood-2019-128308
Published: 2019
Journal Articles

Vls-101 Is a Novel Therapeutic Antibody-Drug Conjugate (ADC) Targeting Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) in Richter's Syndrome (RS)

Tiziana Vaisitti, PhD, Katti Jessen, PhD, Thanh-Trang Vo, PhD, Mira Ko, Francesca Arruga, PhD, Nicoletta Vitale, PhD, Esteban Braggio, PhD, Arianna Di Napoli, Amy Chadburn, MD, John N. Allan, MD, Richard R. Furman, MD, Langdon L. Miller, Brian J Lanutti, PhD, Silvia Deaglio, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2856.
DOI: https://doi.org/10.1182/blood-2019-126827
Published: 2019
Journal Articles

The Dual PI3K-δ/γ Inhibitor Duvelisib in Combination with the Bcl-2 Inhibitor Venetoclax Shows Promising Responses in Richter Syndrome-PDX Models

Andrea Iannello, PhD, Francesca Arruga, PhD, Nicoletta Vitale, PhD, Elisa Marchi, Richard R. Furman, MD, John N. Allan, MD, Silvia Coma, PhD, Jonathan A. Pachter, PhD, Silvia Deaglio, MD PhD, Tiziana Vaisitti, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2862.
DOI: https://doi.org/10.1182/blood-2019-125754
Published: 2019
Journal Articles

IDH2 inhibition enhances proteasome inhibitor responsiveness in hematological malignancies

Elisa Bergaggio, Chiara Riganti, Giulia Garaffo, Nicoletta Vitale, Elisabetta Mereu, Cecilia Bandini, Elisa Pellegrino, Verdiana Pullano, Paola Omedè, Katia Todoerti, Luciano Cascione, Valentina Audrito, Anna Riccio, Antonio Rossi, Francesco Bertoni, Silvia Deaglio, Antonino Neri, Antonio Palumbo, Roberto Piva
Journal: Blood
Blood (2019) 133 (2): 156–167.
DOI: https://doi.org/10.1182/blood-2018-05-850826
Published: 2019
Includes: Supplemental data
Journal Articles

Targeting the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Novel Therapeutic Opportunities

Andrea Papait, PhD, Tiziana Vaisitti, PhD, Sara Serra, PhD, Valentina Audrito, PhD, Francesco Tito, Giulia Guerra, Dimitar G Efremov, MDPhD, Silvia Deaglio, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 240.
DOI: https://doi.org/10.1182/blood-2018-99-118057
Published: 2018
Journal Articles

NOTCH1 Stabilization By PEST Mutations Enhances IgM-Mediated Activity in Chronic Lymphocytic Leukemia

Francesca Arruga, PhD, Valeria Bracciamà, Alison Yeomans, PhD, Annalisa D'Avola, PhD, Marta Coscia, MD, Giovanni Francesco D'Arena, MD, Gianluca Gaidano, MD PhD, John N. Allan, MD, Richard R. Furman, MD, Graham Packham, PhD, Silvia Deaglio, MD PhD, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2018) 132 (Supplement 1): 1832.
DOI: https://doi.org/10.1182/blood-2018-99-118064
Published: 2018
Journal Articles

Hyper-Activation of the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Therapeutic Opportunities

Tiziana Vaisitti, PhD, Sara Serra, PhD, Cinzia Bologna, PhD, Nicoletta Vitale, PhD, Stefania Gobessi, PhD BS, Dimitar G Efremov, MD PhD, Silvia Deaglio, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1721.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1721.1721
Published: 2017
Journal Articles

Genetic and Molecular Characterization of Novel Richter Syndrome Patient-Derived Xenograft Models

Tiziana Vaisitti, PhD, John N. Allan, MD, Esteban Braggio, PhD, Francesca Arruga, PhD, Amy Chadburn, MD, Richard R. Furman, MD, Silvia Deaglio, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4297.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.4297.4297
Published: 2017
Journal Articles

Targeting Cellular Metabolism and Survival in Chronic Lymphocytic Leukemia and Richter Syndrome Cells By a Novel NF-Kb Inhibitor

Tiziana Vaisitti, PhD, Federica Gaudino, Samedy Ouk, Sara Serra, PhD, Johannes L. Zakrzewski, MD, Erica B. Bhavsar, John N. Allan, MD, Hsiou-Chi Liou, PhD, Richard R. Furman, Silvia Deaglio, MD PhD
Journal: Blood
Blood (2016) 128 (22): 304.
DOI: https://doi.org/10.1182/blood.V128.22.304.304
Published: 2016
Journal Articles

Characterization and Prognostic Relevance of Circulating Microvesicles in Chronic Lymphocytic Leukemia

Luciana De Luca, Giovanni D'Arena, MD, Vittorio Simeon, PhD, Stefania Trino, PhD, Ilaria Laurenzana, PhD, Antonella Caivano, Francesco La Rocca, Oreste Villani, MD, Giovanna Mansueto, MD, Silvia Deaglio, MD PhD, Idanna Innocenti, MD, Luca Laurenti, Stefano Molica, MD, Giuseppe Pietrantuono, MD, Angelo De Stradis, Luigi Del Vecchio, MD, Pellegrino Musto, MD
Journal: Blood
Blood (2016) 128 (22): 4375.
DOI: https://doi.org/10.1182/blood.V128.22.4375.4375
Published: 2016
Journal Articles

Mutations in NOTCH1 PEST Domain Orchestrate CCL19-Driven Homing of Chronic Lymphocytic Leukemia (CLL) Cells By Modulating the Tumor Suppressor Gene DUSP22

Francesca Arruga, PhD, Branimir Gizdic, Cinzia Bologna, Simona Cignetto, Roberta Buonincontri, PhD, Sara Serra, PhD, Tiziana Vaisitti, PhD, Nicoletta Vitale, Giulia Garaffo, Elisabetta Mereu, Fary Diop, Francesco Neri, Marta Coscia, MD PhD, John N. Allan, MD, Roberto Piva, Salvatore Oliviero, Richard R. Furman, MD, Davide Rossi, Gianluca Gaidano, MD PhD, Silvia Deaglio, MD PhD
Journal: Blood
Blood (2016) 128 (22): 969.
DOI: https://doi.org/10.1182/blood.V128.22.969.969
Published: 2016
Journal Articles

The genetics of nodal marginal zone lymphoma

Valeria Spina, Hossein Khiabanian, Monica Messina, Sara Monti, Luciano Cascione, Alessio Bruscaggin, Elisa Spaccarotella, Antony B. Holmes, Luca Arcaini, Marco Lucioni, Fabrizio Tabbò, Sakellarios Zairis, Fary Diop, Michaela Cerri, Sabina Chiaretti, Roberto Marasca, Maurilio Ponzoni, Silvia Deaglio, Antonio Ramponi, Enrico Tiacci, Laura Pasqualucci, Marco Paulli, Brunangelo Falini, Giorgio Inghirami, Francesco Bertoni, Robin Foà, Raul Rabadan, Gianluca Gaidano, Davide Rossi
Journal: Blood
Blood (2016) 128 (10): 1362–1373.
DOI: https://doi.org/10.1182/blood-2016-02-696757
Published: 2016
Includes: Supplemental data
Journal Articles

Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts

Irene Scarfò, Elisa Pellegrino, Elisabetta Mereu, Ivo Kwee, Luca Agnelli, Elisa Bergaggio, Giulia Garaffo, Nicoletta Vitale, Manuel Caputo, Rodolfo Machiorlatti, Paola Circosta, Francesco Abate, Antonella Barreca, Domenico Novero, Susan Mathew, Andrea Rinaldi, Enrico Tiacci, Sara Serra, Silvia Deaglio, Antonino Neri, Brunangelo Falini, Raul Rabadan, Francesco Bertoni, Giorgio Inghirami, Roberto Piva, the European T-Cell Lymphoma Study Group
Journal: Blood
Blood (2016) 127 (2): 221–232.
DOI: https://doi.org/10.1182/blood-2014-12-614503
Published: 2016
Includes: Supplemental data
Journal Articles

Adenosine Signaling Mediates Hypoxic Responses in the Chronic Lymphocytic Leukemia Microenvironment

Sara Serra, PhD, Davide Brusa, PhD, Tiziana Vaisitti, PhD, Roberta Buonincontri, PhD, Valentina Audrito, PhD, Marta Coscia, MD PhD, Davide Rossi, MD PhD, Erica B. Bhavsar, Richard R. Furman, MD, Gianluca Gaidano, MD PhD, Silvia Deaglio, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4145.
DOI: https://doi.org/10.1182/blood.V126.23.4145.4145
Published: 2015
Journal Articles

Ibrutinib Targets Nurse-like Cells Supporting an Immunosuppressive Phenotype in Chronic Lymphocytic Leukemia

Stefania Fiorcari, PhD, Rossana Maffei, PhD, Valentina Audrito, PhD, Silvia Martinelli, PhD, Elisa Ten Hacken, PhD, Giulia Grisendi, PhD, Patrizia Zucchini, Chiara Quadrelli, PhD, Mario Luppi, MD, PhD, Jan A. Burger, MD, PhD, Silvia Deaglio, Roberto Marasca, MD
Journal: Blood
Blood (2015) 126 (23): 613.
DOI: https://doi.org/10.1182/blood.V126.23.613.613
Published: 2015
Journal Articles

SLAMF1/CD150 Activates Autophagy in Chronic Lymphocytic Leukemia Cells, Modulating Chemotaxis and Responses to Therapy

Cinzia Bologna, Roberta Buonincontri, PhD, Sara Serra, PhD, Tiziana Vaisitti, PhD, Valentina Audrito, PhD, Davide Brusa, PhD, Andrea Pagnani, Marta Coscia, Giovanni D'Arena, Erica B. Bhavsar, Richard R. Furman, Davide Rossi, MD PhD, Gianluca Gaidano, Cox Terhorst, Silvia Deaglio
Journal: Blood
Blood (2015) 126 (23): 1728.
DOI: https://doi.org/10.1182/blood.V126.23.1728.1728
Published: 2015