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Journal Articles

A Phase 1 First in Human (FIH) Study of AMG 701, an Anti-B-Cell Maturation Antigen (BCMA) Half-Life Extended (HLE) BiTE ® (bispecific T-cell engager) Molecule, in Relapsed/Refractory (RR) Multiple Myeloma (MM)

Simon J Harrison, MBBS MRCP (UK) PhDFRCPath (UK) FRACP, Monique C. Minnema, MD PhD, Hans C. Lee, MD, Andrew Spencer, MBBS, FRACP, FRCPA, DM, Prashant Kapoor, MD, Deepu Madduri, MD, Jeremy Larsen, Sikander Ailawadhi, Jonathan L. Kaufman, MD, Marc S. Raab, MD, Parameswaran Hari, MD MRCP, Shinsuke Iida, MD PhD, Ravi Vij, MBBS, Faith E. Davies, Robin Lesley, PhD, Vijay V. Upreti, PhD, Zhao Yang, PhD, Anjali Sharma, MD, Alex Minella, MD, Suzanne Lentzsch, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
DOI: https://doi.org/10.1182/blood-2020-134063
Published: 2020
Journal Articles

Subcutaneous Daratumumab (DARA SC) Plus Standard-of-Care (SoC) Regimens in Multiple Myeloma (MM) across Lines of Therapy in the Phase 2 Pleiades Study: Initial Results of the Dara SC Plus Carfilzomib/Dexamethasone (D-Kd) Cohort, and Updated Results for the Dara SC Plus Bortezomib/Melphalan/Prednisone (D-VMP) and Dara SC Plus Lenalidomide/Dexamethasone (D-Rd) Cohorts

Philippe Moreau, MD, Ajai Chari, Mathias Haenel, MD, Albert Oriol, Paula Rodriguez-Otero, MD PhD, Helen McCarthy, PhD FRCPath, Kenshi Suzuki, MD PhD, Vania T. M. Hungria, MD PhD, Anna Sureda Balari, MD PhD, Lauriane Clement-Filliatre, MD, Cyrille Hulin, MD, Hila Magen, MD, Shinsuke Iida, MD PhD, Vladimir Maisnar, MD, Lionel Karlin, MD, Luděk Pour, MD, Cyrille Touzeau, Shiyi Yang, Michele Kosh, Maria Delioukina, Christoph Heuck, Hartmut Goldschmidt, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–30.
DOI: https://doi.org/10.1182/blood-2020-134935
Published: 2020
Journal Articles

Subcutaneous Daratumumab (DARA SC) + Bortezomib, Cyclophosphamide, and Dexamethasone (VCd) in Asian Patients with Newly Diagnosed Light Chain (AL) Amyloidosis: Subgroup Analysis from the Phase 3 Andromeda Study

Kenshi Suzuki, MD PhD, Ashutosh D. Wechalekar, Kihyun Kim, MD, Chihiro Shimazaki, MD PhD, Jin Seok Kim, MD PhD, Takayuki Ikezoe, MD PhD, Chang-Ki Min, MD, PhD, Fude Zhou, Shinsuke Iida, MD PhD, Nagaaki Katoh, Tomoaki Fujisaki, MD, Ho-Jin Shin, NamPhuong Tran, MD, Xiang Qin, MD PhD, Sandra Y. Vasey, MSc, Brenda Tromp, MSc, Brendan M. Weiss, MD, Jessica Vermeulen, MD PhD, Raymond L. Comenzo, MD, Efstathios Kastritis, MD, Jin Lu
Journal: Blood
Blood (2020) 136 (Supplement 1): 11.
DOI: https://doi.org/10.1182/blood-2020-136150
Published: 2020
Journal Articles

Feed-forward regulatory loop driven by IRF4 and NF-κB in adult T-cell leukemia/lymphoma

Regina Wan Ju Wong, Tze King Tan, Stella Amanda, Phuong Cao Thi Ngoc, Wei Zhong Leong, Shi Hao Tan, Kaori Asamitsu, Yurina Hibi, Ryuzo Ueda, Takashi Okamoto, Takashi Ishida, Shinsuke Iida, Takaomi Sanda
Journal: Blood
Blood (2020) 135 (12): 934–947.
DOI: https://doi.org/10.1182/blood.2019002639
Published: 2020
Includes: Supplemental data
Journal Articles

Randomized, Open-Label, Non-Inferiority, Phase 3 Study of Subcutaneous (SC) Versus Intravenous (IV) Daratumumab (DARA) Administration in Patients with Relapsed or Refractory Multiple Myeloma: Columba Update

Saad Z. Usmani, MD, Maria-Victoria Mateos, MD PhD, Hareth Nahi, MD PhD, Sebastian Grosicki, MD PhD, Vladimir I. Vorobyev, MD PhD, Ivan Spicka, MD PhD Prof, Vania T.M. Hungria, MD PhD, Sibirina Korenkova, Max Flogegard, Joan Bladé, MD PhD, Philippe Moreau, MD, Martin F. Kaiser, Shinsuke Iida, MD PhD, Jacob P. Laubach, MD, Tara Masterson, Kristen Anne Lantz, PhD, Lisa O'Rourke, MSN, RN, Christoph Heuck, Xiang Qin, Dolly A. Parasrampuria, PhD, Ming Qi, Nizar Bahlis, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1865.
DOI: https://doi.org/10.1182/blood-2019-122765
Published: 2019
Journal Articles

Randomized, Open-Label, Non-Inferiority, Phase 3 Study of Subcutaneous (SC) Versus Intravenous (IV) Daratumumab (DARA) Administration in Patients (Pts) with Relapsed or Refractory Multiple Myeloma (RRMM): Body Weight Subgroup Analysis of Columba

Maria-Victoria Mateos, MD PhD, Saad Z. Usmani, MD, Sebastian Grosicki, MD PhD, Vladimir I. Vorobyev, MD PhD, Ivan Spicka, MD PhD Prof, Vania T.M. Hungria, MD PhD, Sibirina Korenkova, Nizar Bahlis, MD, Max Flogegard, Joan Bladé, MD PhD, Philippe Moreau, MD, Martin F. Kaiser, Shinsuke Iida, MD PhD, Jacob P. Laubach, MD, Tara Masterson, Kristen Anne Lantz, PhD, Lisa O'Rourke, MSN, RN, Xiang Qin, Dolly A. Parasrampuria, PhD, Christoph Heuck, Ming Qi, MD PhD, Hareth Nahi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1906.
DOI: https://doi.org/10.1182/blood-2019-122501
Published: 2019
Journal Articles

Combined Inhibition of HDAC and AKT As a Strategy to Overcome Multi-Drug Resistance in Patients with Multiple Myeloma

Mitsuhito Hirano, MD, Yoichi Imai, MD PhD, Takahiko Murayama, PhD, Kota Sato, MD PhD, Junichi Yamamoto, PhD, Takumi Ito, PhD, Muneyoshi Futami, MD PhD, Masaki Ri, Hiroshi Yasui, MD PhD, Noriko Gotoh, MD, Shinsuke Iida, MD PhD, Tadao Ishida, MD PhD, Hiroshi Handa, MD PhD, Arinobu Tojo, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4325.
DOI: https://doi.org/10.1182/blood-2019-122662
Published: 2019
Journal Articles

Impact of Continuous and Maintenance Therapy on Survival Outcome in Patients with Newly Diagnosed Multiple Myeloma: A Multicenter Retrospective Collaborative Study of the Japanese Society of Myeloma

Shuji Ozaki, MD PhD, Hiroshi Handa, MD PhD, Takayuki Saitoh, MD PhD, Kazutaka Sunami, MD PhD, Tadao Ishida, MD PhD, Kenshi Suzuki, MD PhD, Tomoko Narita, MD, Shinsuke Iida, MD PhD, Yuichi Nakamura, MD PhD, Kazuhito Suzuki, MD, Noriko Nishimura, MD PhD, Hirokazu Murakami, MD PhD, Kazuyuki Shimizu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3085.
DOI: https://doi.org/10.1182/blood-2019-125390
Published: 2019
Journal Articles

Lipidomic Profiling of Plasma Samples in Patients with Newly Diagnosed Multiple Myeloma; A Biomarker Study for Predicting the Response and Toxicities of Melphalan, Prednisolone and Bortezomib (MPB) Regimen : An Ancillary Study of the JCOG1105 (JCOG1105A1)

Masaki Ri, Shinsuke Iida, MD PhD, Dai Maruyama, MD PhD, Kosuke Saito, Yoshiro Saito, Satoshi Osaga, Masahiro Tohkin, Naoki Miyata, Kensei Tobinai, MD PhD, Noriko Fukuhara, MD PhD, Kana Miyazaki, MD PhD, Yosuke Minami, MD PhD, Norifumi Tsukamoto, MD PhD, Hideki Tsujimura, MD PhD, Makoto Yoshimitsu, MD PhD, Kenichi Miyamoto, Kunihiro Tsukasaki, MD PhD, Hirokazu Nagai, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3156.
DOI: https://doi.org/10.1182/blood-2019-122218
Published: 2019
Journal Articles

Development of the First Transgenic Animal Model for IRF4-Induced Lymphoid Malignancy

Stella Amanda, MSc, BSc, Regina Wong, Tze King Tan, PhD, Muhammad Zulfaqar Ali, MSc, BSc, Yan Li, PhD, Zhi Yuan Gong, PhD, Shinsuke Iida, MD PhD, Takaomi Sanda, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1242.
DOI: https://doi.org/10.1182/blood-2019-129714
Published: 2019
Journal Articles

Phase 2 Study of Tirabrutinib (ONO/GS-4059), a Second-Generation Bruton's Tyrosine Kinase Inhibitor, Monotherapy in Patients with Treatment-Naïve or Relapsed/Refractory Waldenström Macroglobulinemia

Wataru Munakata, Naohiro Sekiguchi, MD PhD, Rai Shinya, MD,PhD, Kenshi Suzuki, MD PhD, Hiroshi Handa, MD PhD, Hirohiko Shibayama, MD PhD, Tomoyuki Endo, MD PhD, Yasuhito Terui, MD PhD, Noriko Iwaki, MD PhD, Noriko Fukuhara, MD PhD, Hiro Tatetsu, MD PhD, Shinsuke Iida, MD PhD, Takayuki Ishikawa, MD PhD, Ryota Shiibashi, Koji Izutsu, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 345.
DOI: https://doi.org/10.1182/blood-2019-124614
Published: 2019
Journal Articles

Subcutaneous Daratumumab Plus Standard Treatment Regimens in Patients with Multiple Myeloma across Lines of Therapy: Pleiades Study Update

Ajai Chari, MD, Jesús San-Miguel, Helen McCarthy, MBBS, PhD, Kenshi Suzuki, MD PhD, Vania T.M. Hungria, MD PhD, Anna Sureda, MD PhD, Aurore Perrot, MD PhD, Cyrille Hulin, MD, Hila Magen, MD, Shinsuke Iida, MD PhD, Vladimir Maisnar, MD PhD MBA, Lionel Karlin, MD, Ludek Pour, MD, Dolly A. Parasrampuria, PhD, Tara Masterson, Michele Kosh, RN, BSN, Shiyi Yang, Maria L. Delioukina, MD, Ming Qi, MD PhD, Robin Carson, MD BA, Cyrille Touzeau, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3152.
DOI: https://doi.org/10.1182/blood-2019-123560
Published: 2019
Journal Articles

Maintenance Therapy with the Oral Proteasome Inhibitor (PI) Ixazomib Significantly Prolongs Progression-Free Survival (PFS) Following Autologous Stem Cell Transplantation (ASCT) in Patients with Newly Diagnosed Multiple Myeloma (NDMM): Phase 3 Tourmaline-MM3 Trial

Meletios A Dimopoulos, MD, Francesca Gay, MDPhD, Fredrik H. Schjesvold, MDPhD, Meral Beksac, MD, Roman Hajek, Katja Weisel, MD, Hartmut Goldschmidt, MD, Vladimir Maisnar, MD, Philippe Moreau, Chang-Ki Min, MD PhD, Agnieszka Pluta, MD, Wee Joo Chng, MB ChB, PhD FRCP(UK), FRCPath, FAMS, Martin Kaiser, MD, Sonja Zweegman, MDPhD, Maria-Victoria Mateos, MD PhD, Andrew Spencer, MBBS, FRACP, FRCPA, DM, Shinsuke Iida, MDPhD, Gareth Morgan, MD, Zhaoyang Teng, PhD, Kaveri Suryanarayan, MD, Tomas Skacel, MD PhD, Ajeeta B Dash, PhD, Richard Labotka, MD, S. Vincent Rajkumar, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 301.
DOI: https://doi.org/10.1182/blood-2018-99-112079
Published: 2018
Journal Articles

Evaluation of Sustained Minimal Residual Disease (MRD) Negativity in Relapsed/Refractory Multiple Myeloma (RRMM) Patients (Pts) Treated with Daratumumab in Combination with Lenalidomide Plus Dexamethasone (D-Rd) or Bortezomib Plus Dexamethasone (D-Vd): Analysis of Pollux and Castor

Hervé Avet-Loiseau, MD PhD, Jesus F San-Miguel, MD PhD, Tineke Casneuf, PhD, Shinsuke Iida, MD PhD, Sagar Lonial, MD, Saad Z. Usmani, MD, Andrew Spencer, MBBS, FRACP, FRCPA, DM, Philippe Moreau, Torben Plesner, MD DSc, Katja Weisel, MD, Jon Ukropec, PhD, Linda Okonkwo, Sonali Trivedi, Christopher Joseph Velas, BS, Xiang Qin, Ming Qi, MD PhD, Christopher Chiu, PhD, Nizar Bahlis, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3272.
DOI: https://doi.org/10.1182/blood-2018-99-113177
Published: 2018
Journal Articles

Efficacy and Safety of Autologous Stem Cell Transplantation in Elderly Patients with Multiple Myeloma in the Era of Novel Agents

Shohei Mizuno, MD PhD, Koji Kawamura, MD PhD, Ichiro Hanamura, MD PhD, Kazutaka Sunami, MD PhD, Takehiko Mori, MD PhD, Fumihiko Nakamura, Shinsuke Iida, MD PhD, Hideyuki Nakazawa, PhD MD, Masanori Makita, Shinichi Kako, MD, Masashi Sawa, MD PhD, Yasunori Ueda, MD PhD, Hiroyuki Takahashi, MD PhD, Yoshinobu Kanda, MD PhD, Tatsuo Ichinohe, MD PhD, Yoshiko Atsuta, MD PhD, Hiroyuki Takamatsu, MD PhD, Akiyoshi Takami, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3437.
DOI: https://doi.org/10.1182/blood-2018-99-109905
Published: 2018
Journal Articles

Randomized Phase II/III Study of Standard R-CHOP Versus CHOP Combined with Dose-Dense Weekly Rituximab (RW-CHOP) for Previously Untreated DLBCL: JCOG0601

Ken Ohmachi, MD, Tomohiro Kinoshita, MD PhD, Kensei Tobinai, MD PhD, Gakuto Ogawa, MD PhD, Tomonori Mizutani, MD PhD, Nobuhiko Yamauchi, MD, Noriko Fukuhara, MD PhD, Toshiki Uchida, MD PhD, Kazuhito Yamamoto, MD PhD, Kana Miyazaki, MD PhD, Norifumi Tsukamoto, MD PhD, Shinsuke Iida, MD PhD, Takahiko Utsumi, MD PhD, Isao Yoshida, MD PhD, Yoshitaka Imaizumi, MD, PhD, Takashi Tokunaga, MD PhD, Shinichiro Yoshida, MD PhD, Yasufumi Masaki, MD PhD, Tohru Murayama, MD PhD, Yoshihiro Yakushijin, MD PhD, Youko Suehiro, MD PhD, Kisato Nosaka, MD PhD, Nobuaki Dobashi, MD, Junya Kuroda, MD PhD, Yasushi Takamatsu, MD PhD, Dai Maruyama, MD PhD, Kiyoshi Ando, MD PhD, Kenichi Ishizawa, MD PhD, Michinori Ogura, MD PhD, Tadashi Yoshino, MD PhD, Tomomitsu Hotta, MD PhD, Kunihiro Tsukasaki, MD PhD, Hirokazu Nagai, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4194.
DOI: https://doi.org/10.1182/blood-2018-99-110201
Published: 2018
Journal Articles

CCR4 mutations associated with superior outcome of adult T-cell leukemia/lymphoma under mogamulizumab treatment

Clinical Trials & Observations
Yuma Sakamoto, Takashi Ishida, Ayako Masaki, Takayuki Murase, Kentaro Yonekura, Yukie Tashiro, Masahito Tokunaga, Atae Utsunomiya, Asahi Ito, Shigeru Kusumoto, Shinsuke Iida, Ryuzo Ueda, Hiroshi Inagaki
Journal: Blood
Blood (2018) 132 (7): 758–761.
DOI: https://doi.org/10.1182/blood-2018-02-835991
Published: 2018
Includes: Supplemental data
Journal Articles

Daratumumab, Lenalidomide, and Dexamethasone (DRd) Versus Lenalidomide and Dexamethasone (Rd) in Relapsed or Refractory Multiple Myeloma (RRMM) Based on Prior Treatment History, Renal Function, and Cytogenetic Risk: Subgroup Analyses of Pollux

Philippe Moreau, MDPhD, Albert Oriol, MD, Jonathan L. Kaufman, MD, Heather Sutherland, MD, Marc Lalancette, MD FRCP, Hila Magen, MD, Shinsuke Iida, MD PhD, Jin Seok Kim, MD PhD, Miles Prince, MD FRACP, FRCPA, Tara Cochrane, Lisa O'Rourke, MSN, RN, Kaida Wu, Jordan M. Schecter, Nizar J. Bahlis, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1883.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1883.1883
Published: 2017
Journal Articles

Enhancer profiling identifies critical cancer genes and characterizes cell identity in adult T-cell leukemia

Regina Wan Ju Wong, Phuong Cao Thi Ngoc, Wei Zhong Leong, Alice Wei Yee Yam, Tinghu Zhang, Kaori Asamitsu, Shinsuke Iida, Takashi Okamoto, Ryuzo Ueda, Nathanael S. Gray, Takashi Ishida, Takaomi Sanda
Journal: Blood
Blood (2017) 130 (21): 2326–2338.
DOI: https://doi.org/10.1182/blood-2017-06-792184
Published: 2017
Includes: Supplemental data
Journal Articles

Cyclin-dependent kinase 9 is a novel specific molecular target in adult T-cell leukemia/lymphoma

Tomoko Narita, Takashi Ishida, Asahi Ito, Ayako Masaki, Shiori Kinoshita, Susumu Suzuki, Hisashi Takino, Takashi Yoshida, Masaki Ri, Shigeru Kusumoto, Hirokazu Komatsu, Kazunori Imada, Yuetsu Tanaka, Akifumi Takaori-Kondo, Hiroshi Inagaki, Arne Scholz, Philip Lienau, Taruho Kuroda, Ryuzo Ueda, Shinsuke Iida
Journal: Blood
Blood (2017) 130 (9): 1114–1124.
DOI: https://doi.org/10.1182/blood-2016-09-741983
Published: 2017
Includes: Supplemental data