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Journal Articles

Valemetostat for Relapsed or Refractory Peripheral T-Cell Lymphomas: Primary Results from a Phase 1 Trial

Eric Jacobsen, Dai Maruyama, Pierluigi Porcu, Kensei Tobinai, Pamela B. Allen, Kenji Ishitsuka, Kunihiro Tsukasaki, Shigeru Kusumoto, Francine M. Foss, Nobuhiko Yamauchi, Satoko Morishima, Yoshitaka Imaizumi, Koji Izutsu, Tatyana Feldman, Toyotaka Kawamata, Yasuyuki Kakurai, Hideyuki Yamauchi, Noha Biserna, Ai Inoue, Shinji Tsutsumi, Steven M. Horwitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 303.
https://doi.org/10.1182/blood-2023-172512
Published: 2023
Journal Articles

Impact of Mogamulizumab-Containing Chemotherapy on HBV Reactivation in Patients with T-Cell Lymphoma: A Multicenter Retrospective Observational Study (PROACTIVE-MOGA)

Kisato Nosaka, Shigeru Kusumoto, Yoshitaka Imaizumi, Hiroya Hashimoto, Junya Makiyama, Makoto Yoshimitsu, Takeharu Kato, Hidenori Sasaki, Youko Suehiro, Ki-Ryang Koh, Toyotaka Kawamata, Toshikazu Miyakawa, Yoshifusa Takatsuka, Takayuki Sato, Yuko Shirouchi, Koji Kato, Koji Izutsu, Tohru Murayama, Takehiro Higashi, Hiromi Iwasaki, Satoru Kosugi, Hitoji Uchiyama, Kunihiro Tsukasaki, Yusuke Yamashita, Fumiya Ogasawara, Emiko Sakaida, Takero Shindo, Kimikazu Yakushijin, Keiichi Akizuki, Ken-ichiro Etoh, Noriaki Kawano, Tetsuyuki Igarashi, Noriko Fukuhara, Nobuhiko Nakamura, Isao Yoshida, Nobuaki Nakano, Tomoharu Yoshizumi, Masashi Mizokami
Journal: Blood
Blood (2023) 142 (Supplement 1): 6192.
https://doi.org/10.1182/blood-2023-185878
Published: 2023
Journal Articles

Efficacy and Safety of Valemetostat Monotherapy in Patients with Relapsed or Refractory Peripheral T-Cell Lymphomas: Primary Results of the Phase 2 VALENTINE-PTCL01 Study

Steven M. Horwitz, Koji Izutsu, Neha Mehta-Shah, Raul Cordoba, Stefan K. Barta, Emmanuel Bachy, Giuseppe Gritti, Eric Jacobsen, Shigeru Kusumoto, Yann Guillermin, Anca Prica, Dok Hyun Yoon, Eva Domingo Domenech, Jie Wang, Jin Seok Kim, Kate Cwynarski, Marjolein van der Poel, Ai Inoue, Jin Jin, Sutan Wu, Keiko Nakajima, Pier Luigi Zinzani
Journal: Blood
Blood (2023) 142 (Supplement 1): 302.
https://doi.org/10.1182/blood-2023-179304
Published: 2023
Journal Articles

Valemetostat for Relapsed or Refractory B-Cell Lymphomas: Primary Results from a Phase 1 Trial

Koji Izutsu, Kenji Ishitsuka, Dai Maruyama, Kunihiro Tsukasaki, Shigeru Kusumoto, Yasuyuki Kakurai, Hideyuki Yamauchi, Ai Inoue, Masaya Tachibana, Shinji Tsutsumi, Kensei Tobinai
Journal: Blood
Blood (2023) 142 (Supplement 1): 1731.
https://doi.org/10.1182/blood-2023-179301
Published: 2023
Journal Articles

Whole Exome Sequencing Analysis of Diffuse Large B-Cell Lymphoma That Progressed to Central Nervous System

Tomotaka Suzuki, Rui Yokomori, Takaomi Sanda, Hiroki Yano, Takaki Kikuchi, Takashi Kanamori, Atsushi Inagaki, Takashi Yoshida, Satoshi Kayukawa, Yoshiko Oshima, Hirokazu Sasaki, Shiori Kinoshita, Tomoko Narita, Ayako Masaki, Masaki Ri, Shigeru Kusumoto, Hirokazu Komatsu, Hiroshi Inagaki, Shinsuke Iida
Journal: Blood
Blood (2023) 142 (Supplement 1): 1632.
https://doi.org/10.1182/blood-2023-174341
Published: 2023
Journal Articles

Recurrence of HBV Reactivation after Allogeneic Hematopoietic Transplantation in Recipients with Resolved HBV Infection: A Nation-Wide Multicenter Retrospective Study

Masahiro Onozawa, Shigeru Kusumoto, Yuho Najima, Hiroya Hashimoto, Kohei Okada, Masaharu Tamaki, Masatsugu Tanaka, Takayuki Sato, Tsutomu Takahashi, Kaoru Hatano, Koichi Onodera, Yukiyoshi Moriuchi, Kimikazu Yakushijin, Junya Kanda, Koji Nagafuji, Masao Ogata, Nobuaki Nakano, Akihiro Tamori, Masashi Mizokami
Journal: Blood
Blood (2023) 142 (Supplement 1): 3541.
https://doi.org/10.1182/blood-2023-173461
Published: 2023
Journal Articles

An open-label, single-arm phase 2 trial of valemetostat for relapsed or refractory adult T-cell leukemia/lymphoma

Clinical Trials & Observations
Koji Izutsu, Shinichi Makita, Kisato Nosaka, Makoto Yoshimitsu, Atae Utsunomiya, Shigeru Kusumoto, Satoko Morishima, Kunihiro Tsukasaki, Toyotaka Kawamata, Takaaki Ono, Shinya Rai, Hiroo Katsuya, Jun Ishikawa, Hironori Yamada, Kazunobu Kato, Masaya Tachibana, Yasuyuki Kakurai, Nobuaki Adachi, Kensei Tobinai, Kentaro Yonekura, Kenji Ishitsuka
Journal: Blood
Blood (2023) 141 (10): 1159–1168.
https://doi.org/10.1182/blood.2022016862
Published: 2023
Includes: Supplemental data
Journal Articles

Reduced-Intensity Conditioning with Fludarabine/Busulfan Versus Fludarabine/Low-Dose Melphalan in Patients with Non-Hodgkin Lymphoma Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Kimimori Kamijo, Yoshimitsu Shimomura, Sung-Won Kim, Takahide Ara, Jun Ishikawa, Tetsuya Eto, Nobuhiro Hiramoto, Ishikazu Mizuno, Shigeru Kusumoto, Yasunori Ueda, Ken-ichi Matsuoka, Makoto Onizuka, Takahiro Fukuda, Yoshiko Atsuta, Eisei Kondo
Journal: Blood
Blood (2022) 140 (Supplement 1): 2393–2394.
https://doi.org/10.1182/blood-2022-159411
Published: 2022
Journal Articles

Interim PET-Guided ABVD or ABVD/Escalated BEACOPP for Newly Diagnosed Advanced-Stage Classic Hodgkin Lymphoma (JCOG1305, INNOVATE-HL study)

Shigeru Kusumoto, Wataru Munakata, Ryunosuke Machida, Takashi Terauchi, Hiroaki Onaya, Masahiko Oguchi, Shinsuke Iida, Kisato Nosaka, Yasuhiro Suzuki, Yasuhiko Harada, Kana Miyazaki, Masaki Maruta, Noriko Fukuhara, Tomomi Toubai, Nobuko Kubota, Ken Ohmachi, Kazuhito Yamamoto, Takahiro Kumode, Ishikazu Mizuno, Takayuki Tabayashi, Hideki Tsujimura, Nobuyuki Takayama, Kohsuke Asagoe, Isao Yoshida, Yasushi Takamatsu, Suguru Fukuhara, Mai Takeuchi, Ukihide Tateishi, Dai Maruyama, Kunihiro Tsukasaki, Hirokazu Nagai
Journal: Blood
Blood (2022) 140 (Supplement 1): 3718–3720.
https://doi.org/10.1182/blood-2022-157006
Published: 2022
Journal Articles

Copy Number Alterations of Chromosome 9p24.1 in Elderly Patients with Advanced-Stage Classic Hodgkin Lymphoma Who Received ABVD: An Ancillary Analysis of Multi-Center Retrospective Study in Japan (HORIZON study)

Shinichi Makita, Shigeru Kusumoto, Jun-Ichi Tamaru, Hiroya Hashimoto, Akiko Miyagi Maeshima, Toshiki Uchida, Hideki Tsujimura, Eiichi Ohtsuka, Nobuyuki Takayama, Kayoko Murayama, Naoki Takahashi, Masahiro Yoshida, Hiroaki Morimoto, Yasuhiro Suzuki, Kazuyuki Shimada, Masanori Makita, Shuichi Ota, Hiroshi Gomyo, Hiroyuki Takahashi, Ritsuro Suzuki, Hiroo Katsuya, Hiro Tatetsu, Shuji Momose, Takahisa Yamashita, Kumiko Ohsawa, Naoko Asano, Dai Maruyama, Motoko Yamaguchi, Hirokazu Nagai
Journal: Blood
Blood (2022) 140 (Supplement 1): 11890–11892.
https://doi.org/10.1182/blood-2022-164977
Published: 2022
Journal Articles

Pivotal Phase 2 Study of the EZH1 and EZH2 Inhibitor Valemetostat Tosylate (DS-3201b) in Patients with Relapsed or Refractory Adult T-Cell Leukemia/Lymphoma

Makoto Yoshimitsu, Koji Izutsu, Shinichi Makita, Kisato Nosaka, Atae Utsunomiya, Shigeru Kusumoto, Satoko Morishima, Kunihiro Tsukasaki, Toyotaka Kawamata, Takaaki Ono, Shinya Rai, Hiroo Katsuya, Jun Ishikawa, Hironori Yamada, Kazunobu Kato, Masaya Tachibana, Yasuyuki Kakurai, Nobuaki Adachi, Kensei Tobinai, Kentaro Yonekura, Kenji Ishitsuka
Journal: Blood
Blood (2021) 138 (Supplement 1): 303.
https://doi.org/10.1182/blood-2021-146657
Published: 2021
Journal Articles

Clinical Outcomes of Elderly Patients with Advanced-Stage Classic Hodgkin Lymphoma Who Received an ABVD Regimen: A Multi-Center Retrospective Study in Japan (HORIZON study)

Shinichi Makita, Shigeru Kusumoto, Akiko Miyagi Maeshima, Hiroya Hashimoto, Hideki Tsujimura, Toshiki Uchida, Hiroaki Inoue, Eiichi Ohtsuka, Mitsutoshi Kurosawa, Nobuyuki Takayama, Eiju Negoro, Yasuhiro Suzuki, Junya Kuroda, Kayoko Murayama, Naoki Takahashi, Kazuyuki Shimada, Masataka Okamoto, Masanori Makita, Hiromi Iwasaki, Masahiro Yoshida, Naoko Asano, Jun-ichi Tamaru, Dai Maruyama, Motoko Yamaguchi, Hirokazu Nagai
Journal: Blood
Blood (2021) 138 (Supplement 1): 2451.
https://doi.org/10.1182/blood-2021-146340
Published: 2021
Journal Articles

Frequent genetic alterations in immune checkpoint–related genes in intravascular large B-cell lymphoma

Kazuyuki Shimada, Kenichi Yoshida, Yasuhiro Suzuki, Chisako Iriyama, Yoshikage Inoue, Masashi Sanada, Keisuke Kataoka, Masaaki Yuge, Yusuke Takagi, Shigeru Kusumoto, Yasufumi Masaki, Takahiko Ito, Yuichiro Inagaki, Akinao Okamoto, Yachiyo Kuwatsuka, Masahiro Nakatochi, Satoko Shimada, Hiroaki Miyoshi, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Yusuke Shiozawa, Yasuhito Nannya, Asako Okabe, Kei Kohno, Yoshiko Atsuta, Koichi Ohshima, Shigeo Nakamura, Seishi Ogawa, Akihiro Tomita, Hitoshi Kiyoi
Journal: Blood
Blood (2021) 137 (11): 1491–1502.
https://doi.org/10.1182/blood.2020007245
Published: 2021
Includes: Supplemental data
Journal Articles

Favorable Outcomes of Newly Diagnosed Intravascular Large B-Cell Lymphoma Patients Treated with R-CHOP Combined with High-Dose Methotrexate Plus Intrathecal Chemotherapy: Results from a Multicenter Phase 2 Trial (PRIMEUR-IVL)

Kazuyuki Shimada, MD, Motoko Yamaguchi, MD PhD, Yoshiko Atsuta, MD PhD, Kosei Matsue, MD PhD, Keijiro Sato, MD, Shigeru Kusumoto, MD PhD, Hirokazu Nagai, MD PhD, Jun Takizawa, MD PhD, Noriko Fukuhara, MD PhD, Koji Nagafuji, MD PhD, Kana Miyazaki, MD PhD, Eiichi Ohtsuka, MD, Masataka Okamoto, MD PhD, Yasumasa Sugita, MD PhD, Toshiki Uchida, MD PhD, Satoshi Kayukawa, MD, Atsushi Wake, MD PhD, Daisuke Ennishi, MD PhD, Yukio Kondo, MD, Tohru Izumi, MD, Yoshihiro Kin, MD, Kunihiro Tsukasaki, MD PhD, Daigo Hashimoto, Masaaki Yuge, MD PhD, Atsumi Yanagisawa, Yachiyo Kuwatsuka, MD PhD, Satoko Shimada, MD, Yasufumi Masaki, MD PhD, Nozomi Niitsu, MD PhD, Hitoshi Kiyoi, MD PhD, Ritsuro Suzuki, MD PhD, Takashi Tokunaga, MD PhD, Shigeo Nakamura, MD, Tomohiro Kinoshita, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 350.
https://doi.org/10.1182/blood-2019-126798
Published: 2019
Journal Articles

First-in-Human Study of the EZH1/2 Dual Inhibitor Valemetostat in Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) - Updated Results Focusing on Adult T-Cell Leukemia-Lymphoma (ATL)

Satoko Morishima, MD PhD, Kenji Ishitsuka, MD PhD, Koji Izutsu, MD PhD, Shigeru Kusumoto, MD PhD, Junya Makiyama, MD PhD, Atae Utsunomiya, MD, Kisato Nosaka, MD PhD, Takashi Ishida, MD PhD, Yoshitaka Imaizumi, MD PhD, Nobuhiko Yamauchi, MD, Kazushi Araki, DVM, PhD, Nobuaki Adachi, PhD, Tomonari Yamashita, Ryo Atsumi, PhD, Kunihiro Tsukasaki, MD PhD, Kensei Tobinai, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4025.
https://doi.org/10.1182/blood-2019-125507
Published: 2019
Journal Articles

Risk of HBV reactivation in patients with B-cell lymphomas receiving obinutuzumab or rituximab immunochemotherapy

Clinical Trials & Observations
Shigeru Kusumoto, Luca Arcaini, Xiaonan Hong, Jie Jin, Won Seog Kim, Yok Lam Kwong, Marion G. Peters, Yasuhito Tanaka, Andrew D. Zelenetz, Hiroshi Kuriki, Günter Fingerle-Rowson, Tina Nielsen, Eisuke Ueda, Hanna Piper-Lepoutre, Gila Sellam, Kensei Tobinai
Journal: Blood
Blood (2019) 133 (2): 137–146.
https://doi.org/10.1182/blood-2018-04-848044
Published: 2019
Includes: Supplemental data
Journal Articles

Impact of Prophylactic Antiviral Therapy on Clinical Outcomes of Hepatitis B Virus Surface Antigen Positive Patients with Diffuse Large B-Cell Lymphoma Treated with Rituximab-Containing Chemotherapy

Nobuhiko Yamauchi, Dai Maruyama, MD PhD, Ilseung Choi, MD PhD, Yoshiko Atsuta, MD PhD, Hirotaka Takasaki, MD PhD, Kazuho Miyashita, MD PhD, Yukiyoshi Moriuchi, MD, Hideki Tsujimura, MD PhD, Nobuko Kubota, MD PhD, Go Yamamoto, MD PhD, Tadahiko Igarashi, MD PhD, Koji Izutsu, MDPhD, Shinichiro Yoshida, MD PhD, Kensuke Kojima, MD PhD, Toshiki Uchida, MD PhD, Yoshiko Inoue, MD, Norifumi Tsukamoto, MD PhD, Eiichi Ohtsuka, MD PhD, Sachiko Suzuki, MD PhD, Yoko Inaguma, MD PhD, Satoshi Ichikawa, MD, Hiroshi Gomyo, MD, Yoko Ushijima, MD PhD, Kisato Nosaka, MD PhD, Mio Kurata, Yasuhito Tanaka, MD PhD, Ryuzo Ueda, MD PhD, Masashi Mizokami, MD PhD, Shigeru Kusumoto, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4209.
https://doi.org/10.1182/blood-2018-99-114850
Published: 2018
Journal Articles

DS-3201, a Potent EZH1/2 Dual Inhibitor, Demonstrates Antitumor Activity Against Non-Hodgkin Lymphoma (NHL) Regardless of EZH2 Mutation

Daisuke Honma, PhD, Emi Nosaka, Machiko Shiroishi, Yoshimi Takata, Yasuhiro Hama, Yuka Yamamoto, Nobuaki Adachi, PhD, Dai Maruyama, MD PhD, Kensei Tobinai, MD PhD, Takashi Ishida, MD PhD, Shigeru Kusumoto, MD, Kenji Ishitsuka, MD PhD, Yoshitaka Imaizumi, MD, PhD, Shogo Takeuchi, MD, Kunihiro Tsukasaki, MD PhD, Tomoyuki Fujioka, Jun Watanabe, Osamu Kanno, PhD, Eiji Kumazawa, PhD, Sumiaki Fujitani, MSc, Kazushi Araki, DVM, PhD, Kosaku Fujiwara, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2217.
https://doi.org/10.1182/blood-2018-99-113379
Published: 2018
Journal Articles

CCR4 mutations associated with superior outcome of adult T-cell leukemia/lymphoma under mogamulizumab treatment

Clinical Trials & Observations
Yuma Sakamoto, Takashi Ishida, Ayako Masaki, Takayuki Murase, Kentaro Yonekura, Yukie Tashiro, Masahito Tokunaga, Atae Utsunomiya, Asahi Ito, Shigeru Kusumoto, Shinsuke Iida, Ryuzo Ueda, Hiroshi Inagaki
Journal: Blood
Blood (2018) 132 (7): 758–761.
https://doi.org/10.1182/blood-2018-02-835991
Published: 2018
Includes: Supplemental data
Journal Articles

Phase 1/2 Study Evaluating the Safety, Pharmacokinetics, and Preliminary Efficacy of Venetoclax in Japanese Subjects with Chronic Lymphocytic Leukemia

Kiyohiko Hatake, MD PhD, Kazuhito Yamamoto, MDPhD, Noriko Fukuhara, MD PhD, Shigeru Kusumoto, MD, Koji Izutsu, MD, PhD, Ilseung Choi, MD, Hirokazu Nagai, MD PhD, Hideyuki Honda, BS, Junjiro Saeki, MS, Andrew W. Roberts, MS, Paulo Maciag, MD PhD, Suresh Agarwal, MS, PhD RPh, Ahmed Hamed Salem, PhD, Kevin J. Freise, PhD, Tsukasa Kiriyama, PharmD, BSc, Kensei Tobinai, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5352.
https://doi.org/10.1182/blood.V130.Suppl_1.5352.5352
Published: 2017