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Seth E. Karol
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Journal Articles

ITCC-101/APAL2020D: A Randomized Phase 3 Trial of Fludarabine/Cytarabine/Gemtuzumab Ozogamycin with or without Venetoclax in Children with Relapsed Acute Myeloid Leukemia

Sae Ishimaru, Gwenaëlle Gueguen, Seth E. Karol, Francisco J. Bautista Sirvent, Valeria Ceolin, Bianca F. Goemans, Marlous Bakker, Laura Di Laurenzio, Jennifer Lukin, Harm Van Tinteren, Gauri B. Sunkersett, Maika Onishi, Kristina Unnebrink, Dirk Reinhardt, Gwen L Nichols, E. Anders Kolb, C. Michel Zwaan
Journal: Blood
Blood (2022) 140 (Supplement 1): 3369–3370.
https://doi.org/10.1182/blood-2022-168818
Published: 2022
Journal Articles

Pharmacotypes across the Genomic Landscape of Pediatric Acute Lymphoblastic Leukemia and Impact on Treatment Response

Shawn Lee, Wenjian Yang, Yoshihiro Gocho, August John, Lauren Rowland, Brandon Smart, Hannah Williams, Dylan Maxwell, Jeremy Hunt, Wentao Yang, Kristine R. Crews, Kathryn G Roberts, Sima Jeha, Cheng Cheng, Seth E. Karol, Mary V. Relling, Gary Rosner, Hiroto Inaba, Charles G. Mullighan, Ching-Hon Pui, William E. Evans, Jun J. Yang
Journal: Blood
Blood (2022) 140 (Supplement 1): 1730–1731.
https://doi.org/10.1182/blood-2022-156699
Published: 2022
Journal Articles

Genetics of osteonecrosis in pediatric acute lymphoblastic leukemia and general populations

Wenjian Yang, Meenakshi Devidas, Yiwei Liu, Colton Smith, Yunfeng Dai, Naomi Winick, Stephen P. Hunger, Mignon L. Loh, Elizabeth A. Raetz, Eric C. Larsen, William L. Carroll, Stuart S. Winter, Kimberly P. Dunsmore, Leonard A. Mattano, Jr, Mary V. Relling, Seth E. Karol
Journal: Blood
Blood (2021) 137 (11): 1550–1552.
https://doi.org/10.1182/blood.2020008471
Published: 2021
Includes: Supplemental data
Journal Articles

Dosing-related saturation of toxicity and accelerated drug clearance with pegaspargase treatment

Clinical Trials & Observations
Yiwei Liu, John C. Panetta, Wenjian Yang, Seth E. Karol, Cheng Cheng, Jun J. Yang, William E. Evans, Hiroto Inaba, Ching-Hon Pui, Sima Jeha, Mary V. Relling
Journal: Blood
Blood (2020) 136 (25): 2955–2958.
https://doi.org/10.1182/blood.2020006214
Published: 2020
Includes: Supplemental data
Journal Articles

Allogeneic Hematopoietic Cell Transplantation Is Critical to Maintain Remissions after CD19-CAR T-Cell Therapy for Pediatric ALL: A Single Center Experience

Aimee C Talleur, MD, Renee M. Madden, MS, MD, Amr Qudeimat, MD, Ewelina Mamcarz, MD, Akshay Sharma, MBBS, Ashok Srinivasan, MD, Ali Y Suliman, MD, Mireya Paulina Velasquez, MD, Timothy Lockey, PhD, Alisha Gaboriault, Seth E. Karol, MD, Hiroto Inaba, MD PhD, Ying Li, MD PhD, Pam Young, Guolian Kang, PhD, Cheng Cheng, PhD, Wenting Zheng, PhD, Sheng Zhou, PhD, Salem M. Akel, PhD, Terrence L Geiger, MD PhD, Michael M Meagher, PhD, Ching-Hon Pui, MD, Brandon M Triplett, MD, Stephen Gottschalk, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
https://doi.org/10.1182/blood-2020-138528
Published: 2020
Journal Articles

Clinical Benefit and Tolerability of Crenolanib in Children with Relapsed Acute Myeloid Leukemia Harboring Treatment Resistant FLT3 ITD and Variant FLT3 TKD Mutations Treated on Compassionate Access

Katherine Tarlock, MD, Soheil Meshinchi, MDPhD, Jeffrey E. Rubnitz, MD, Seth E. Karol, MD, Barbara Spitzer, MD, Amit J. Sabnis, MD, Asif Pathan, PhD RPh, Boo Messahel, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 23–24.
https://doi.org/10.1182/blood-2020-140399
Published: 2020
Journal Articles

Venetoclax Alone or in Combination with Chemotherapy: Responses in Pediatric Patients with Relapsed/Refractory Acute Myeloid Leukemia with Heterogeneous Genomic Profiles

Seth E. Karol, MD, Henrique Bittencourt, MD PhD, Daniel A. Morgenstern, MD, Margaret E. Macy, MD, Seong Lin Khaw, MD, Todd M. Cooper, DO, Arnaud Petit, MD PhD, Giridharan Ramsingh, MD, Bo Tong, PhD, Kristina Unnebrink, PhD, Deeksha Vishwamitra, PhD, Fengjiao Dunbar, PhD, Betty A. Prine, BS, Tammy L. Palenski, PhD, Andrew E. Place, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-136999
Published: 2020
Journal Articles

Proposed Scheme for Dosing Venetoclax in Pediatric Patients with Relapsed/Refractory Acute Myeloid Leukemia: Analysis of Developmental Pharmacokinetics and Exposure-Response Relationships

Mohamed A Badawi, PhD, Sathej Gopalakrishnan, PhD, Benjamin Engelhardt, PhD, Tammy L. Palenski, PhD, Su Young Kim, Seth E. Karol, MD, Jeffrey E. Rubnitz, MD, Rajeev Menon, PhD, Ahmed Hamed Salem, PhD FCP
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
https://doi.org/10.1182/blood-2020-139593
Published: 2020
Journal Articles

Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia Harboring Heterogeneous Genomic Profiles Respond to Venetoclax in Combination with Chemotherapy

Andrew E. Place, MDPhD, Seth E. Karol, MD, Christopher J. Forlenza, MD, Marion Gambart, MD, Todd M. Cooper, DO, Christopher Fraser, MBBS, Gunnar Cario, MD PhD, Maureen M O'Brien, MD, Nicolas U. Gerber, MD, Phillip Barnette, MD, Dirk Reinhardt, MDPhD, Giridharan Ramsingh, MD, Bo Tong, PhD, Kristina Unnebrink, PhD, Deeksha Vishwamitra, PhD, Fengjiao Dunbar, PhD, Betty A. Prine, BS, Tammy L. Palenski, PhD, Mignon L. Loh, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-137376
Published: 2020
Journal Articles

Predicting success of desensitization after pegaspargase allergy

Clinical Trials & Observations
Hope D. Swanson, John C. Panetta, Patricia J. Barker, Yiwei Liu, Hiroto Inaba, Mary V. Relling, Ching-Hon Pui, Seth E. Karol
Journal: Blood
Blood (2020) 135 (1): 71–75.
https://doi.org/10.1182/blood.2019003407
Published: 2020
Includes: Supplemental data
Journal Articles

Venetoclax in Combination with High-Dose Chemotherapy Is Active and Well-Tolerated in Children with Relapsed or Refractory Acute Myeloid Leukemia

Seth E Karol, MD, Thomas Alexander, MDMPH, Amit Budraja, PhD, Stanley Pounds, PhD, Kristin E Canavera, PhD, Lei Wang, MS, Joshua Wolf, MBBS, PhD, Jeffery M. Klco, MD PhD, Ahmed Hamed Salem, PhD FCP, Tammy Palenski, PhD, Norman J. Lacayo, MD, Ching-Hon Pui, MD, Joseph T. Opferman, PhD, Jeffrey Rubnitz, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 178.
https://doi.org/10.1182/blood-2019-127716
Published: 2019
Journal Articles

Safety, Efficacy, and PK of the BCL2 Inhibitor Venetoclax in Combination with Chemotherapy in Pediatric and Young Adult Patients with Relapsed/Refractory Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia: Phase 1 Study

Seth E Karol, MD, Todd M Cooper, DO, Henrique Bittencourt, Lia Gore, MD, Maureen M O'Brien, MD, Christopher Fraser, MD, Marion Gambart, MD, Gunnar Cario, MD PhD, Christian Michel Zwaan, MD PhD, Jean-Pierre Bourquin, MD PhD, Mignon L. Loh, MD, Hubert Caron, MD PhD, Betty Prine, Ahmed Hamed Salem, PhD FCP, Kristina Unnebrink, Bo Tong, PhD, Tammy Palenski, PhD, Andrew E. Place, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2649.
https://doi.org/10.1182/blood-2019-129805
Published: 2019
Journal Articles

Hypertension is a modifiable risk factor for osteonecrosis in acute lymphoblastic leukemia

Laura J. Janke, Sara L. Van Driest, Mary V. Portera, Ravi V. Atreya, Joshua C. Denny, Deqing Pei, Cheng Cheng, Sue C. Kaste, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Mary V. Relling, Seth E. Karol
Journal: Blood
Blood (2019) 134 (12): 983–986.
https://doi.org/10.1182/blood.2019000006
Published: 2019
Includes: Supplemental data
Journal Articles

Pegaspargase Allergic Reactions Are Related to Anti-Pegaspargase Antibodies and to Intensity of Intrathecal Therapy

Yiwei Liu, PhD, Colton A Smith, PhD, Wenjian Yang, PhD, Lauren Thompson, Anisha Dash, Jacob Counts, May Chung, Alejandro R Molinelli, PhD, Deqing Pei, MS, Nancy M Kornegay, Erik A Springer, John C Panetta, PhD, Kristine R Crews, PharmD, Hope Swanson, PharmD, Cheng Cheng, PhD, Seth E Karol, MD, William E. Evans, PharmD, Hiroto Inaba, MD, Ching-Hon Pui, MD, Sima Jeha, MD, Mary V Relling, PharmD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2697.
https://doi.org/10.1182/blood-2018-99-110141
Published: 2018
Journal Articles

The Effect of Asparaginase on Serum Triglycerides during Therapy for Acute Lymphoblastic Leukemia

Emily R Finch, PhD, Colton A Smith, PhD, Wenjian Yang, PhD, Nancy M Kornegay, John C Panetta, PhD, Kristine R Crews, PharmD, Alejandro R Molinelli, PhD, Cheng Cheng, PhD, Deqing Pei, MS, Laura B. Ramsey, PhD, Seth E Karol, MD, Hiroto Inaba, MD, John T. Sandlund, MD, Monika Metzger, MD, William E. Evans, PharmD, Sima Jeha, MD, Ching-Hon Pui, MD, Mary V Relling, PharmD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2665.
https://doi.org/10.1182/blood-2018-99-117093
Published: 2018
Journal Articles

Zoledronic Acid Reduces Osteonecrosis and Anti-Leukemic Efficacy in Murine Models of Acute Lymphoblastic Leukemia Therapy

Laura Janke, DVM, PhD, Jieun Kim, PhD, David Jenkins, BS, Monique A Payton, BS, Mary V Relling, PharmD, Seth E Karol, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4029.
https://doi.org/10.1182/blood-2018-99-112941
Published: 2018
Journal Articles

Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia

Clinical Trials & Observations
Seth E. Karol, Leonard A. Mattano, Jr, Wenjian Yang, Kelly W. Maloney, Colton Smith, ChengCheng Liu, Laura B. Ramsey, Christian A. Fernandez, Tamara Y. Chang, Geoffrey Neale, Cheng Cheng, Elaine Mardis, Robert Fulton, Paul Scheet, F. Anthony San Lucas, Eric C. Larsen, Mignon L. Loh, Elizabeth A. Raetz, Stephen P. Hunger, Meenakshi Devidas, Mary V. Relling
Journal: Blood
Blood (2016) 127 (5): 558–564.
https://doi.org/10.1182/blood-2015-10-673848
Published: 2016
Includes: Supplemental data
Journal Articles

Genetic Risk Factors for the Development of Osteonecrosis in Children Under Age 10 Treated for Acute Lymphoblastic Leukemia

Seth E. Karol, MD, Wenjian Yang, PhD, Leonard A. Mattano, Jr., MD, Kelly W. Maloney, MD, Colton Smith, PhD, Chengcheng Liu, B.S, Laura B. Ramsey, PhD, Christian A. Fernandez, PhD, Tamara Y. Chang, MD, Geoffrey A. Neale, PhD, Cheng Cheng, PhD, Elaine R Mardis, PhD, Robert S. Fulton, PhD, Paul Scheet, PhD, Eric C. Larsen, MD, Mignon L. Loh, MD, Elizabeth Raetz, MD, Stephen P Hunger, MD, Meenakshi Devidas, PhD, Mary V. Relling, PharmD
Journal: Blood
Blood (2015) 126 (23): 250.
https://doi.org/10.1182/blood.V126.23.250.250
Published: 2015
Journal Articles

Genome-Wide Association Study Identifies PNPLA3 I148M Variant Associated with Elevated Transaminase Levels after Induction Therapy in Pediatric ALL Patients

Christian A. Fernandez, PhD, Colton Smith, PhD, Wenjian Yang, PhD, Chengcheng Liu, B.S, Laura B. Ramsey, PhD, Seth E. Karol, MD, Ching-Hon Pui, MD, William E. Evans, PharmD, Sima Jeha, MD, Mary V. Relling, PharmD
Journal: Blood
Blood (2015) 126 (23): 3714.
https://doi.org/10.1182/blood.V126.23.3714.3714
Published: 2015
Journal Articles

Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia

Clinical Trials & Observations
Seth E. Karol, Wenjian Yang, Sara L. Van Driest, Tamara Y. Chang, Sue Kaste, Erica Bowton, Melissa Basford, Lisa Bastarache, Dan M. Roden, Joshua C. Denny, Eric Larsen, Naomi Winick, William L. Carroll, Cheng Cheng, Deqing Pei, Christian A. Fernandez, Chengcheng Liu, Colton Smith, Mignon L. Loh, Elizabeth A. Raetz, Stephen P. Hunger, Paul Scheet, Sima Jeha, Ching-Hon Pui, William E. Evans, Meenakshi Devidas, Leonard A. Mattano, Jr, Mary V. Relling
Journal: Blood
Blood (2015) 126 (15): 1770–1776.
https://doi.org/10.1182/blood-2015-05-643601
Published: 2015
Includes: Supplemental data