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Journal Articles

NOTCH1 signaling during CD4+ T-cell activation alters transcription factor networks and enhances antigen responsiveness

Alec B Wilkens, Elena Fulton, Margot J Pont, Gabriel O Cole, Isabel Leung, Sylvia M Stull, Matthew R Hart, Irwin D Bernstein, Scott N Furlan, Stanley R Riddell

Blood blood.2021015144.

DOI: https://doi.org/10.1182/blood.2021015144

Published: 2022

Includes: Supplemental data

Journal Articles

Functional Consequence and Therapeutic Targeting of Cryptic ALK Fusions (ALK fus ) in Monosomy7 AML

Makia K. Manselle, Tiffany A. Hylkema, Amanda R. Leonti, Rhonda E. Ries, Quy Le, Scott N Furlan, Soheil Meshinchi

Blood (2021) 138 (Supplement 1): 2357.

DOI: https://doi.org/10.1182/blood-2021-148179

Published: 2021

Journal Articles

Single-Cell Transcriptomics for Residual Disease Detection in Acute Myelogenous Leukemia Post Allogeneic Hematopoietic Cell Transplantation

Sami B Kanaan, Shruti Bhise, Todd M. Cooper, Soheil Meshinchi, Scott N Furlan

Blood (2021) 138 (Supplement 1): 518.

DOI: https://doi.org/10.1182/blood-2021-151504

Published: 2021

Journal Articles

EZH2-Mediated MHC Class II Silencing Drives Immune Evasion in AML with t(16;21) ( FUS-ERG)

Nate J Buteyn, Connor G Burke, Jenny L. Smith, Rhonda E. Ries, Amanda R. Leonti, Timothy I. Shaw, Benjamin J. Huang, Todd A. Alonzo, Scott N. Furlan, Jason E Farrar, Soheil Meshinchi, Timothy Junius Triche, Jr.

Blood (2021) 138 (Supplement 1): 374.

DOI: https://doi.org/10.1182/blood-2021-153256

Published: 2021

Journal Articles

Integrated Transcriptomics and Proteomics Identifies Therapeutic Targets in Pediatric Acute Myeloid Leukemia

Benjamin J. Huang, Jenny L. Smith, Timothy I. Shaw, Scott N Furlan, Rhonda E. Ries, Amanda R. Leonti, Erin Lynn Crowgey, Lisa Wei, Jason E Farrar, Tim Triche, Xiaotu Ma, Quy Le, Soheil Meshinchi

Blood (2021) 138 (Supplement 1): 1296.

DOI: https://doi.org/10.1182/blood-2021-153970

Published: 2021

Journal Articles

Repurposing a novel anti-cancer RXR agonist to attenuate murine acute GVHD and maintain graft-versus-leukemia responses

Blood (2021) 137 (8): 1090–1103.

DOI: https://doi.org/10.1182/blood.2020005628

Published: 2021

Includes: Supplemental data

Journal Articles

Integrated Stem Cell Signature and Cytomolecular Risk Determination in Pediatric Acute Myeloid Leukemia

Benjamin J. Huang, MD, Jenny L. Smith, MSc, MD, Rhonda E. Ries, MA, Amanda R. Leonti, MS, Erin Lynn Crowgey, PhD, Scott N. Furlan, MD, Timothy Shaw, PhD, Lisa Wei, BS, Yi-Cheng Wang, MS, Robert B. Gerbing, MA, Todd A. Alonzo, PhD, Todd M. Cooper, DO, Edward A. Kolb, MD, Xiaotu Ma, PhD, Jason E. Farrar, MD, Timothy Junius Triche, Jr., PhD, Soheil Meshinchi, MDPhD

Blood (2020) 136 (Supplement 1): 28–29.

DOI: https://doi.org/10.1182/blood-2020-142638

Published: 2020

Journal Articles

The Transcriptomic Landscape of NUP98-Rearranged Pediatric Acute Myeloid Leukemia

Jenny L. Smith, MSc, MD, Eline J.M. Bertrums, Rhonda E. Ries, MA, Fabiana Ostronoff, MD, Amanda R. Leonti, MS, Scott N. Furlan, MD, Bianca F. Goemans, MD PhD, Soheil Meshinchi, MDPhD

Blood (2020) 136 (Supplement 1): 36–37.

DOI: https://doi.org/10.1182/blood-2020-138935

Published: 2020

Journal Articles

Integrative Analysis of Single-Cell RNA-Seq and ATAC-Seq Data across Treatment Time Points in Pediatric AML

Lisa Wei, BS, Diane Trinh, Rhonda E. Ries, MA, Dan Jin, PhD, Richard D. Corbett, Jenny L. Smith, MSc, MD, Scott N. Furlan, MD, Soheil Meshinchi, MDPhD, Marco A. Marra, PhD

Blood (2020) 136 (Supplement 1): 29.

DOI: https://doi.org/10.1182/blood-2020-140473

Published: 2020

Journal Articles

IL2 and Rapamycin Enhance Persistence of Adoptively-Transferred Ex-Vivo Expanded T Regulatory Cells

Scott N Furlan, MD, Christina Lopez, PhD, Victor Tkachev, PhD, Kayla Betz, Daniel J Hunt, James Hibbard, PhD, Bruce R. Blazar, MD, Cole Trapnell, PhD, Leslie Kean, MD PhD

Blood (2018) 132 (Supplement 1): 2049.

DOI: https://doi.org/10.1182/blood-2018-99-120254

Published: 2018

Journal Articles

Uncovering the Molecular Signature of Pathogenic Tissue-Infiltrating T Cells during Acute Graft-Versus-Host Disease

Victor Tkachev, PhD, Scott N Furlan, MD, E. Lake Potter, Hengqi Zheng, MD, Daniel J Hunt, Lucrezia Colonna, PhD, Agne Taraseviciute, MD PhD, Judith M Carlson, BS, Kayla Betz, Alison Yu, PhD, Michelle Hoffman, MS, Audrey Baldessari, DVM, Sarah Herrin, Joe Olvera, Chad Littlewood, Christopher English, Bruce R. Blazar, MD, Mario Roederer, PhD, Leslie Kean, MD PhD

Blood (2018) 132 (Supplement 1): 805.

DOI: https://doi.org/10.1182/blood-2018-99-113652

Published: 2018

Journal Articles

Pharmacologic Blockade of Notch/Delta-like Ligand 4 Signaling Protects from Gastrointestinal Acute Graft-Versus-Host Disease in Non-Human Primates

Victor Tkachev, PhD, Frank Kuhnert, PhD, Scott N Furlan, MD, Hengqi Zheng, MD, Daniel J Hunt, Lucrezia Colonna, PhD, Judith M Carlson, BS, Agne Taraseviciute, MD PhD, Angela Panoskaltsis-Mortari, PhD, Virginia Hoglund, Kayla Betz, Alison Yu, PhD, Bruce R. Blazar, MD, Steve Carpenter, MD PhD, Olivier Harari, MD PhD, Gavin Thurston, PhD, Ivan Maillard, MD PhD, Leslie Kean, MD PhD

Blood (2018) 132 (Supplement 1): 2027.

DOI: https://doi.org/10.1182/blood-2018-99-110030

Published: 2018

Journal Articles

Modeling and Understanding the Biology of Transplant-Mediated HIV Cure in a Non-Human Primate Model

Blood (2017) 130 (Suppl_1): 694.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.694.694

Published: 2017

Journal Articles

Striking Clinical, Molecular and Immunological Outcomes in Non-Human Primate Hematopoietic Stem Cell Transplantation Using a Novel OX40L Blockade Agent, KY1005, Combined with Rapamycin

Victor Tkachev, PhD, Scott N. Furlan, MD, Ben Watkins, MD, Betty Zheng, MD, Daniel Hunt, Angela Panoskaltsis-Mortari, PhD, Kayla Betz, Melanie Brown, Katie Zeleski, Alison Yu, PhD, Bruce R. Blazar, MD, Duncan Casson, Ian Kirby, Phil Bland-Ward, Leslie Kean, MD PhD

Blood (2016) 128 (22): 3341.

DOI: https://doi.org/10.1182/blood.V128.22.3341.3341

Published: 2016

Journal Articles

Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells

Scott N. Furlan, Benjamin Watkins, Victor Tkachev, Sarah Cooley, Angela Panoskaltsis-Mortari, Kayla Betz, Melanie Brown, Daniel J. Hunt, John B. Schell, Katie Zeleski, Alison Yu, Cynthia R. Giver, Edmund K. Waller, Jeffrey S. Miller, Bruce R. Blazar, Leslie S. Kean

Blood (2016) 128 (21): 2568–2579.

DOI: https://doi.org/10.1182/blood-2016-07-726547

Published: 2016

Includes: Supplemental data

Journal Articles

Th17/Th22 Cells Mediate Breakthrough Graft-Versus-Host-Disease

Scott N. Furlan, MD, Victor Tkachev, PhD, Ben Watkins, MD, Kayla Betz, Angela Panoskaltsis-Mortari, PhD, Bruce R. Blazar, MD, Leslie Kean, MD PhD

Blood (2015) 126 (23): 1878.

DOI: https://doi.org/10.1182/blood.V126.23.1878.1878

Published: 2015

Journal Articles

T Stem Cell Memory Dynamics during Acute Graft-Versus-Host Disease

Victor Tkachev, PhD, Scott N. Furlan, MD, Ben Watkins, MD, Angela Panoskaltsis-Mortari, PhD, Bruce R. Blazar, MD, Leslie Kean, MD PhD

Blood (2015) 126 (23): 3079.

DOI: https://doi.org/10.1182/blood.V126.23.3079.3079

Published: 2015

Journal Articles

Loss of Programmed Death Ligand-1 Expression on Donor T Cells Lessens Acute Graft-Versus-Host Disease Lethality

Blood (2015) 126 (23): 147.

DOI: https://doi.org/10.1182/blood.V126.23.147.147

Published: 2015

Journal Articles

T-Cell Transcriptome Analysis Reveals the Mechanisms Controlling Synergy Between Costimulation Blockade and mTOR Inhibition during Graft Versus Host Disease Prevention

Scott N. Furlan, MD, Benjamin Watkins, MD, Kelly Hanby, Aneesah P. Garrett, Angela Panoskaltsis-Mortari, PhD, Bruce R. Blazar, MD, Leslie S. Kean

Blood (2014) 124 (21): 3824.

DOI: https://doi.org/10.1182/blood.V124.21.3824.3824

Published: 2014

Journal Articles

Preventing Primate GvHD Using a Novel Antagonistic Anti-CD28 Antibody Plus Rapamycin: Downregulation of CD8 Activation and Preservation of the Naïve Cell Phenotype Predicts GvHD-Free Survival

Benjamin Watkins, MD, Aneesah P. Garrett, Jingyang Chen, Scott N. Furlan, MD, Kelly Hamby, Bernard Vanhove, PhD, Leslie S. Kean, MD PhD

Blood (2014) 124 (21): 2425.

DOI: https://doi.org/10.1182/blood.V124.21.2425.2425

Published: 2014

NARROW

NOTCH1 signaling during CD4+ T-cell activation alters transcription factor networks and enhances antigen responsiveness

Functional Consequence and Therapeutic Targeting of Cryptic ALK Fusions (ALK fus ) in Monosomy7 AML

Single-Cell Transcriptomics for Residual Disease Detection in Acute Myelogenous Leukemia Post Allogeneic Hematopoietic Cell Transplantation

EZH2-Mediated MHC Class II Silencing Drives Immune Evasion in AML with t(16;21) ( FUS-ERG)

Integrated Transcriptomics and Proteomics Identifies Therapeutic Targets in Pediatric Acute Myeloid Leukemia

Repurposing a novel anti-cancer RXR agonist to attenuate murine acute GVHD and maintain graft-versus-leukemia responses

Integrated Stem Cell Signature and Cytomolecular Risk Determination in Pediatric Acute Myeloid Leukemia

The Transcriptomic Landscape of NUP98-Rearranged Pediatric Acute Myeloid Leukemia

Integrative Analysis of Single-Cell RNA-Seq and ATAC-Seq Data across Treatment Time Points in Pediatric AML

IL2 and Rapamycin Enhance Persistence of Adoptively-Transferred Ex-Vivo Expanded T Regulatory Cells

Uncovering the Molecular Signature of Pathogenic Tissue-Infiltrating T Cells during Acute Graft-Versus-Host Disease

Pharmacologic Blockade of Notch/Delta-like Ligand 4 Signaling Protects from Gastrointestinal Acute Graft-Versus-Host Disease in Non-Human Primates

Modeling and Understanding the Biology of Transplant-Mediated HIV Cure in a Non-Human Primate Model

Striking Clinical, Molecular and Immunological Outcomes in Non-Human Primate Hematopoietic Stem Cell Transplantation Using a Novel OX40L Blockade Agent, KY1005, Combined with Rapamycin

Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells

Th17/Th22 Cells Mediate Breakthrough Graft-Versus-Host-Disease

T Stem Cell Memory Dynamics during Acute Graft-Versus-Host Disease

Loss of Programmed Death Ligand-1 Expression on Donor T Cells Lessens Acute Graft-Versus-Host Disease Lethality

T-Cell Transcriptome Analysis Reveals the Mechanisms Controlling Synergy Between Costimulation Blockade and mTOR Inhibition during Graft Versus Host Disease Prevention

Preventing Primate GvHD Using a Novel Antagonistic Anti-CD28 Antibody Plus Rapamycin: Downregulation of CD8 Activation and Preservation of the Naïve Cell Phenotype Predicts GvHD-Free Survival

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American Society of Hematology

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ASH Publications

American Society of Hematology

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