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Sarah K. Tasian
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Journal Articles

Non-Canonical Exon Usage in Pediatric Leukemia: Implications for Chemoresistance

Manuel Torres-Diz, Andrei Thomas-Tikhonenko, Clara Reglero, Adolfo Ferrando, Catherine D Falkenstein, Sarah K Tasian, Priyanka Sehgal, Zhiwei Ang, Yoseph Barash, Caleb Radens
Journal: Blood
Blood (2022) 140 (Supplement 1): 3264–3265.
DOI: https://doi.org/10.1182/blood-2022-167006
Published: 2022
Journal Articles

Transcriptional Rewiring and Therapeutic Resistance in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia

Yang Y Ding, Joseph Patrick Loftus, Benjamin Mathier, Wenbao Yu, David Hottman Allen, Bing He, Catherine D Falkenstein, Sarah K Tasian, Kai Tan
Journal: Blood
Blood (2022) 140 (Supplement 1): 354–355.
DOI: https://doi.org/10.1182/blood-2022-169341
Published: 2022
Journal Articles

Preclinical In Vivo Activity of the Menin Inhibitor Ziftomenib (KO-539) in Pediatric KMT2A -Rearranged Acute Lymphoblastic Leukemia

Catherine D Falkenstein, Lisa M Niswander, Linda Kessler, Blake Tomkinson, Francis Burrows, Sarah K Tasian
Journal: Blood
Blood (2022) 140 (Supplement 1): 3491–3492.
DOI: https://doi.org/10.1182/blood-2022-157225
Published: 2022
Journal Articles

Targeting CD38 in T-ALL Upregulates the Targetable Polyamine Metabolism Pathway

Caroline Diorio, Tiffaney L. Vincent, Tori Fuller, Rawan Shraim, Tina Glisovic-Aplenc, Theresa Ryan, Kimberly Veliz, Haley Newman, Gerald Wertheim, Hamid Bassiri, Annette Vu, Michael Hogarty, Carl H June, Stephan A. Grupp, Sarah K Tasian, Richard Aplenc, Saar Gill, David T. Teachey
Journal: Blood
Blood (2022) 140 (Supplement 1): 10285–10286.
DOI: https://doi.org/10.1182/blood-2022-167893
Published: 2022
Journal Articles

A Phase 2 Study of Ruxolitinib with Chemotherapy in Children with Philadelphia Chromosome-like Acute Lymphoblastic Leukemia (AALL1521/INCB18424-269): Biologic Characteristics and Minimal Residual Disease Response of Patients with Non- CRLF2 -Rearranged JAK Pathway Alterations

Sarah K Tasian, Deborah S Hunter, I-Ming L Chen, Richard C Harvey, Andrew J. Carroll, Elizabeth Wagner, Shalini C Reshmi, Michael J Borowitz, Brent L. Wood, Jeannie Daniel, Meenakshi Devidas, Elizabeth A. Raetz, Stephen P. Hunger, Albert Assad, Mignon L. Loh
Journal: Blood
Blood (2022) 140 (Supplement 1): 6117–6118.
DOI: https://doi.org/10.1182/blood-2022-164699
Published: 2022
Journal Articles

Pharmacologic Inhibition of DYRK1A Results in Hyperactivation and Hyperphosphorylation of MYC and ERK Rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

V. S. S. Abhinav Ayyadevara, Gerald Wertheim, John Chukinas, Joseph Patrick Loftus, Sung June Lee, Anil Kumar, Rahul S. Bhansali, Srividya Swaminathan, Thierry Besson, Junwei Shi, John D. Crispino, Sarah K Tasian, Martin P. Carroll, Christian Hurtz
Journal: Blood
Blood (2022) 140 (Supplement 1): 3486–3488.
DOI: https://doi.org/10.1182/blood-2022-162782
Published: 2022
Journal Articles

Safety and Activity of Flotetuzumab in Pediatric and Young Adult Patients with Relapsed/Refractory Acute Myeloid Leukemia: Results from the COG PEPN1812 Phase 1 Trial

Adam J. Lamble, Xiaowei Liu, Charles Minard, Olga Militano, Melanie Brooke Bernhardt, Todd M. Cooper, Edward A. Kolb, Erin H. Breese, Elizabeth Fox, Sarah K Tasian, Brenda J. Weigel
Journal: Blood
Blood (2022) 140 (Supplement 1): 6209–6210.
DOI: https://doi.org/10.1182/blood-2022-158029
Published: 2022
Journal Articles

Clinical Experience with Azacitidine and Venetoclax +/- Gemtuzumab in Pediatric Patients with Relapsed or Refractory Acute Leukemias: A Report from the Children's Hospital of Philadelphia

Lisa M Niswander, Perry Chung, Caroline Diorio, Sarah K Tasian
Journal: Blood
Blood (2022) 140 (Supplement 1): 6173–6174.
DOI: https://doi.org/10.1182/blood-2022-166232
Published: 2022
Journal Articles

Cytosine base editing enables quadruple-edited allogeneic CART cells for T-ALL

Caroline Diorio, Ryan Murray, Mark Naniong, Luis Barrera, Adam Camblin, John Chukinas, Lindsey Coholan, Aaron Edwards, Tori Fuller, Claudia Gonzales, Stephan A. Grupp, Alden Ladd, Melissa Le, Angelica Messana, Faith Musenge, Haley Newman, Yeh-Chuin Poh, Henry Poulin, Theresa Ryan, Rawan Shraim, Sarah K. Tasian, Tiffaney Vincent, Lauren Young, Yingying Zhang, Giuseppe Ciaramella, Jason Gehrke, David T. Teachey
Journal: Blood
Blood (2022) 140 (6): 619–629.
DOI: https://doi.org/10.1182/blood.2022015825
Published: 2022
Includes: Supplemental data
Journal Articles

Transcriptomic Features of Immune Exhaustion and Senescence Predict Outcomes and Define Checkpoint Blockade-Unresponsive Microenvironments in Acute Myeloid Leukemia

Sergio Rutella, Jayakumar Vadakekolathu, Francesco Mazziotta, Stephen Reeder, Tung On Yau, Rupkatha Mukhopadhyay, Heidi Altmann, Michael Kramer, Hanna A. Knaus, Joshua F. Zeidner, Vedran Radojcic, Andrea Arruda, Mark D. Minden, Sarah K Tasian, Martin Bornhäuser, Ivana Gojo, Leo Luznik
Journal: Blood
Blood (2021) 138 (Supplement 1): 223.
DOI: https://doi.org/10.1182/blood-2021-145854
Published: 2021
Journal Articles

Pharmacologic Inhibition of DYRK1A Results in Hyperactivation and Hyperphosphorylation of MYC and ERK Rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

Christian Hurtz, Gerald Wertheim, John Chukinas, Joseph Patrick Loftus, Sung June Lee, Anil Kumar, Rahul S. Bhansali, Srividya Swaminathan, Thierry Besson, Junwei Shi, John D. Crispino, Sarah K Tasian, Martin P. Carroll
Journal: Blood
Blood (2021) 138 (Supplement 1): 506.
DOI: https://doi.org/10.1182/blood-2021-144476
Published: 2021
Journal Articles

Alisertib Synergistically Strengthens the Anti-Leukemia Activity of Venetoclax in TCF3-Hlf B-ALL

Asen Bagashev, Joseph Patrick Loftus, Colin Wakefield, Gerald Wertheim, Christian Hurtz, Martin P. Carroll, Kimberly Stegmaier, Yana Pikman, Sarah K Tasian
Journal: Blood
Blood (2021) 138 (Supplement 1): 705.
DOI: https://doi.org/10.1182/blood-2021-148671
Published: 2021
Journal Articles

Precision Co-Targeting of the Thymic Stromal Lymphopoietin Receptor in Childhood CRLF2 -Rearranged Acute Lymphoblastic Leukemia

Asen Bagashev, Joseph Patrick Loftus, Savannah Ross, Lisa M Niswander, Haiying Qin, Terry J. Fry, Sarah K Tasian
Journal: Blood
Blood (2021) 138 (Supplement 1): 1705.
DOI: https://doi.org/10.1182/blood-2021-148602
Published: 2021
Journal Articles

Multi-Modal Targeting of FLT3 with Chimeric Antigen Receptor T Cell Immunotherapy and Tyrosine Kinase Inhibition in High-Risk Pediatric Leukemias

Lisa M Niswander, Zachary Graff, Asen Bagashev, Lillie Leach, Terry J. Fry, Sarah K Tasian
Journal: Blood
Blood (2021) 138 (Supplement 1): 404.
DOI: https://doi.org/10.1182/blood-2021-147321
Published: 2021
Journal Articles

Activated natural killer cells predict poor clinical prognosis in high-risk B- and T-cell acute lymphoblastic leukemia

Caroline Duault, Anil Kumar, Adeleh Taghi Khani, Sung June Lee, Lu Yang, Min Huang, Christian Hurtz, Bryan Manning, Lucy Ghoda, Tinisha McDonald, Norman J. Lacayo, Kathleen M. Sakamoto, Martin Carroll, Sarah K. Tasian, Guido Marcucci, Jianhua Yu, Michael A. Caligiuri, Holden T. Maecker, Srividya Swaminathan
Journal: Blood
Blood (2021) 138 (16): 1465–1480.
DOI: https://doi.org/10.1182/blood.2020009871
Published: 2021
Includes: Supplemental data
Journal Articles

An Immune Senescence and Exhaustion-Related RNA Profile Predicts Clinical Outcomes in Acute Myeloid Leukemia

Jayakumar Vadakekolathu, PhD, Tung On Yau, Heidi Altmann, PhD, Sarah E. Church, PhD, Hanna A Knaus, MD, Mark D. Minden, Jan K Davidson-Moncada, MDPhD, Sarah K Tasian, MD, Martin Bornhäuser, MD, Ivana Gojo, MD, Leo Luznik, MD, Sergio Rutella, MDPhDFRCPath
Journal: Blood
Blood (2020) 136 (Supplement 1): 26–27.
DOI: https://doi.org/10.1182/blood-2020-134779
Published: 2020
Journal Articles

DYRK1A Is Required to Alleviate Replication Stress in KMT2A -Rearranged Acute Lymphoblastic Leukemia

Christian Hurtz, PhD, Martin P. Carroll, MD, Sarah K Tasian, MD, Gerald Wertheim, MD, PhD, Rahul S. Bhansali, MDPhD, Sung June Lee, BA, Anil Kumar, PhD, Anne Lehman, Joseph Patrick Loftus, BS, Grace Jeschke, PhD, John D. Crispino, PhD, Thierry Besson, PhD, Junwei Shi, PhD, Srividya Swaminathan, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
DOI: https://doi.org/10.1182/blood-2020-141258
Published: 2020
Journal Articles

Outcomes of Patients with Down Syndrome and CRLF2 -Overexpressing Acute Lymphoblastic Leukemia (ALL): A Report from the Children's Oncology Group (COG)

Karen R Rabin, MDPhD, Meenakshi Devidas, PhD, Zhiguo Chen, Yunfeng Dai, PhD, Sarah K Tasian, MD, Johann K Hitzler, MD, Kathryn G Roberts, PhD, Andrew J Carroll, PhD, Nyla A Heerema, PhD, Michael J Borowitz, MD PhD, Brent L Wood, MD PhD, Charles G Mullighan, MBBS, MD, Richard C Harvey, PhD, I-Ming L Chen, Cheryl L Willman, MD, Shalini C Reshmi, PhD, Julie M Gastier-Foster, PhD, Kelly W Maloney, MD, Eric C Larsen, MD, Reuven J Schore, MD, Michael J Burke, MD, Wanda L Salzer, MD, Naomi J Winick, MD, William L. Carroll, MD, Elizabeth A. Raetz, MD, Anne Angiolillo, MD, Mignon L. Loh, MD, Stephen P Hunger, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 44–45.
DOI: https://doi.org/10.1182/blood-2020-143165
Published: 2020
Journal Articles

Outcomes of Patients with CRLF2 -Overexpressing Acute Lymphoblastic Leukemia without Down Syndrome: A Report from the Children's Oncology Group

Sarah K Tasian, MD, Yunfeng Dai, PhD, Meenakshi Devidas, PhD, Kathryn G Roberts, PhD, Richard C Harvey, PhD, I-Ming L Chen, DVM, MS, Andrew J Carroll, PhD, Nyla A Heerema, PhD, Shalini C Reshmi, PhD, Julie M Gastier-Foster, PhD, Michael J Borowitz, MD PhD, Brent L Wood, MD PhD, Charles G Mullighan, MBBS, MD, Cheryl L Willman, MD, Kelly W Maloney, MD, Eric C Larsen, MD, Anne L Angiolillo, MD, Reuven J Schore, MD, Michael J Burke, MD, Wanda L Salzer, MD, Naomi J Winick, MD, William L. Carroll, MD, Stephen P Hunger, MD, Elizabeth A. Raetz, MD, Karen R Rabin, MDPhD, Mignon L. Loh, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 45–46.
DOI: https://doi.org/10.1182/blood-2020-134327
Published: 2020
Journal Articles

Reducing Dependence on General Anesthesia for Pediatric Oncology Outpatients Undergoing Repeated Lumbar Punctures

Esther R. Berko, MD, Yahui Wei, Emily Stiglich, Derek Klingman, Julie Vardaro, Sarah K Tasian, MD, Sara McDonough, CRNP, Katelyn Oranges, CRNP, Kelly Meyers, CRNP, Eileen Aber, CRNP, Miriam Kolb, CRNP, Lindsay Borel, Nicholas Evageliou, MD, Rebecca Citrin, MD, Jane Minturn, MD PhD, Anne Reilly, MD, Susan R. Rheingold, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 9–10.
DOI: https://doi.org/10.1182/blood-2020-143153
Published: 2020