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Journal Articles

Molecular and cellular features of CTLA-4 blockade for relapsed myeloid malignancies after transplantation

Clinical Trials & Observations

Blood blood.2021010867.

DOI: https://doi.org/10.1182/blood.2021010867

Published: 2021

Includes: Supplemental data

Journal Articles

Architecture of Sample Preparation and Data Governance of Immuno-Genomic Data Collected from Bone Marrow and Peripheral Blood Samples Obtained from Multiple Myeloma Patients

Shaadi Mehr, PhD, Daniel Auclair, Mark Hamilton, PhD, Leon Rozenblit, Hearn Jay Cho, MD PhD, Lijun Yao, MS, Reyka G Jayasinghe, PhD, Manoj Bhasin, PhD, Steven E. Labkoff, MD, Taxiarchis Kourelis, MD, Madhav V. Dhodapkar, MD, Deon Doxie, Sacha Gnjatic, Cassandra Dewitt, Sergey Miron

Blood (2020) 136 (Supplement 1): 17–18.

DOI: https://doi.org/10.1182/blood-2020-142882

Published: 2020

Journal Articles

Characterization of Plasma and Immune Cells Molecular Landscape That Play a Role in Rapid Progression of Multiple Myeloma Using Cross Center Scrna-Seq Study

Manoj Bhasin, PhD, Beena E Thomas, Reyka G Jayasinghe, PhD, Nicolas Fernandez, PhD, Swati S Bhasin, PhD, Taxiarchis Kourelis, MD, Madhav V. Dhodapkar, MD, Ravi Vij, Shaji K. Kumar, MD, Shaadi Mehr, PhD, Mark Hamilton, PhD, Hearn Jay Cho, MD PhD, Daniel Auclair, Sacha Gnjatic, Li Ding, PhD, David E. Avigan, MD

Blood (2020) 136 (Supplement 1): 6–8.

DOI: https://doi.org/10.1182/blood-2020-143350

Published: 2020

Journal Articles

Integrated Cytof, Scrna-Seq and Cite-Seq Analysis of Bone Marrow Immune Microenvironment in the Mmrf Commpass Study

Lijun Yao, MS, Reyka G Jayasinghe, PhD, Beena E Thomas, Swati S Bhasin, PhD, Nicolas Fernandez, PhD, Taxiarchis Kourelis, MD, Deon Doxie, David E. Avigan, MD, Madhav V. Dhodapkar, MD, Shaji K. Kumar, MD, Ravi Vij, MBBS, Shaadi Mehr, PhD, Mark Hamilton, PhD, Hearn Jay Cho, MD PhD, Daniel Auclair, Sacha Gnjatic, PhD, Manoj Bhasin, PhD, Li Ding, PhD

Blood (2020) 136 (Supplement 1): 28–29.

DOI: https://doi.org/10.1182/blood-2020-142534

Published: 2020

Journal Articles

Identification and Validation of CD138- Multiple Myeloma Immune and Tumor Subpopulations Using Cross Center Scrna-Seq Data

Reyka G Jayasinghe, PhD, Lijun Yao, MS, Beena Thomas, Swati S Bhasin, PhD, Nicolas Fernandez, PhD, David E. Avigan, MD, Taxiarchis Kourelis, MD, Madhav V. Dhodapkar, MD, Ravi Vij, MD MBA, Shaadi Mehr, PhD, Mark Hamilton, PhD, Hearn Jay Cho, MD PhD, Daniel Auclair, Sacha Gnjatic, Li Ding, PhD

Blood (2020) 136 (Supplement 1): 15.

DOI: https://doi.org/10.1182/blood-2020-143256

Published: 2020

Journal Articles

Reduced Antigen Presentation May Contribute to Immunomodulatory Drug Resistance in Multiple Myeloma

David G. Coffey, MD, Ola Landgren, MD PhD, Yuexin Xu, PhD, Dickran Kazandjian, MD, Trevor J. Pugh, PhD, Sacha Gnjatic, PhD, Edus H. Warren, MD PhD, Damian J. Green, MD

Blood (2019) 134 (Supplement_1): 4367.

DOI: https://doi.org/10.1182/blood-2019-126222

Published: 2019

Journal Articles

High Dimensional Immune Profiling in Smoldering Multiple Myeloma Identifies Novel Organizing Features of the Tumor Microenvironment

Hearn Jay Cho, MD PhD, Deepak Perumal, PhD, Adeeb H Rahman, PhD, Seunghee Kim-Schultze, PhD, Jennifer Yesil, Daniel Auclair, Tineke Casneuf, PhD, Homer Adams, III, PhD, Samir Parekh, MD, Sacha Gnjatic, PhD, Nicolas Fernandez, PhD

Blood (2019) 134 (Supplement_1): 4384.

DOI: https://doi.org/10.1182/blood-2019-130554

Published: 2019

Journal Articles

Genomic and Immunologic Analysis of Cmaf and Hypermutated Multiple Myeloma: Implications for Immunologic Therapy

Hearn Jay Cho, MD PhD, Deepak Perumal, PhD, Adeeb H Rahman, PhD, Donald Jackson, PhD, Michael Robbins, PhD, Seunghee Kim-Schultze, PhD, Sacha Gnjatic, PhD, Samir Parekh, MD, Jonathan J Keats, PhD, Daniel Auclair

Blood (2019) 134 (Supplement_1): 3093.

DOI: https://doi.org/10.1182/blood-2019-131274

Published: 2019

Journal Articles

Phase 1 Study of Elotuzumab and Peripheral Blood Mononuclear Cell Reconstitution in Combination with Autologous Stem Cell Transplantation and Lenalidomide Maintenance for Multiple Myeloma

Keren Osman, MD, Ajai Chari, Samir Parekh, MD, Adolfo Aleman, Jessica Caro, MD, Gillian Morgan, RN, Erika Florendo, NP, Elaine Chan, Gina Strumolo, Katarzyna Zarychta, Lisa La, BS, MS, John Mandeli, PhD, Seunghee Kim-Schultze, PhD, Sacha Gnjatic, PhD, Sundar Jagannath, MD, Hearn Jay Cho, MD PhD

Blood (2017) 130 (Supplement 1): 3282.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.3282.3282

Published: 2017

Journal Articles

Recombinant (rec) MAGE-A3 Protein Immunotherapy and Peripheral Blood Lymphocyte (PBL) Reconstitution Induce Strong Antigen-Specific Humoral and Cellular Immune Responses in Patients Undergoing Autologous Stem Cell Transplantation (ASCT) for Consolidation of Multiple Myeloma (MM)

Adam D. Cohen, MD, Nikoletta Lendvai, MDPhD, Sacha Gnjatic, PhD, Achim A Jungbluth, MD, Stephane Bertolini, Linda Pan, Pharm.D., Ralph Venhaus, Ioanna Tsakos, Katarzyna Garcia, MS, Linda Thibodeau, RN, Katherine Alpaugh, PhD, Nailah Cummings, Rafik Fellague-Chebra, MD, Olivier Gruselle, Hearn J. Cho, MD PhD

Blood (2014) 124 (21): 1184.

DOI: https://doi.org/10.1182/blood.V124.21.1184.1184

Published: 2014

Journal Articles

MAGE-A3 Recombinant Protein (recMAGE-A3) Immunotherapy and Autologous Peripheral Blood Lymphocyte (PBL) Infusion Is Safe and Induces Robust Humoral Immune Responses In Multiple Myeloma (MM) Patients Undergoing Autologous Stem Cell Transplantation (autoSCT)

Adam D Cohen, MD, Nikoletta Lendvai, MD PhD, Sacha Gnjatic, Ph.D., Achim A Jungbluth, MD, Stephane Bertolini, Linda Pan, Pharm.D., Ralph Venhaus, Ioanna Tsakos, Katarzyna Garcia, MS, Linda Thibodeau, RN, Katherine Alpaugh, PhD, Nailah Cummings, Rafik Fellague-Chebra, MD, Olivier Gruselle, Hearn J. Cho, MD, PhD

Blood (2013) 122 (21): 154.

DOI: https://doi.org/10.1182/blood.V122.21.154.154

Published: 2013

Journal Articles

Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma

Hiroyoshi Nishikawa, Yuka Maeda, Takashi Ishida, Sacha Gnjatic, Eiichi Sato, Fumiko Mori, Daisuke Sugiyama, Asahi Ito, Yasuo Fukumori, Atae Utsunomiya, Hiroshi Inagaki, Lloyd J. Old, Ryuzo Ueda, Shimon Sakaguchi

Blood (2012) 119 (13): 3097–3104.

DOI: https://doi.org/10.1182/blood-2011-09-379982

Published: 2012

Includes: Supplemental data

Journal Articles

Analysis of Spontaneous Vs. Vaccine-Induced Antibody Responses Against Cancer-Testis Antigen MAGE-A3 in Cancer Patients

Yanran Cao, M.D., Sacha Gnjatic, Ph.D., Vincent G. Brichard, M.D. Ph.D., Tim Luetkens, M.D., Sebastian Kobold, M.D., Katrin Bartels, Nasser Altorki, M.D., Friedrich Haag, M.D., Gerd Ritter, M.D., Carsten Bokemeyer, M.D., Lloyd J Old, M.D., Nicolaus Kroeger, M.D., Djordje Atanackovic, M.D.

Blood (2011) 118 (21): 5087.

DOI: https://doi.org/10.1182/blood.V118.21.5087.5087

Published: 2011

Journal Articles

MAGE-A3 or NY-ESO1 Expression and Spontaneous Antibody Responses to NY-ESO1 in Newly Diagnosed Multiple Myeloma Patients Are Associated with Worse Overall Survival

Adam D Cohen, Ping Lu, Sacha Gnjatic, James Hoffman, Erika Ritter, Ping Zhou, Julie Teruya-Feldstein, Jodie Tassello, Nicole Hanson, Denise Frosina, Achim Jungbluth, Guenther Koehne, Hani Hassoun, Suresh Jhanwar, Heather Landau, Stephen Nimer, Raymond L. Comenzo

Blood (2008) 112 (11): 5110.

DOI: https://doi.org/10.1182/blood.V112.11.5110.5110

Published: 2008

Journal Articles

RHAMM-R3 peptide vaccination in patients with acute myeloid leukemia, myelodysplastic syndrome, and multiple myeloma elicits immunologic and clinical responses

Blood (2008) 111 (3): 1357–1365.

DOI: https://doi.org/10.1182/blood-2007-07-099366

Published: 2008

Journal Articles

Induction of regulatory T cell–resistant helper CD4 + T cells by bacterial vector

Hiroyoshi Nishikawa, Takemasa Tsuji, Elke Jäger, Gabriel Briones, Gerd Ritter, Lloyd J. Old, Jorge E. Galán, Hiroshi Shiku, Sacha Gnjatic

Blood (2008) 111 (3): 1404–1412.

DOI: https://doi.org/10.1182/blood-2007-09-113761

Published: 2008

Includes: Supplemental data

Journal Articles

Host Immune Responses Against CT Antigens in Multiple Myeloma Patients.

Nikoletta Lendvai, MD, PhD, Sacha Gnjatic, PhD, Erika Ritter, Yao-Tseng Chen, MD, PhD, Christina Coughlin, MD, PhD, Robert H. Vonderheide, MD, DPhil, Ruben Niesvizky, MD, Nina Bhardwaj, MD, PhD, Selina Chen-Kiang, PhD, Lloyd J. Old, MD, Hearn J. Cho, MD, PhD

Blood (2006) 108 (11): 3492.

DOI: https://doi.org/10.1182/blood.V108.11.3492.3492

Published: 2006

Journal Articles

Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation

Djordje Atanackovic, Julia Arfsten, Yanran Cao, Sacha Gnjatic, Frank Schnieders, Katrin Bartels, Georgia Schilling, Christiane Faltz, Christine Wolschke, Judith Dierlamm, Gerd Ritter, Thomas Eiermann, Dieter Kurt Hossfeld, Axel R. Zander, Achim A. Jungbluth, Lloyd J. Old, Carsten Bokemeyer, Nicolaus Kröger

Blood (2006) 109 (3): 1103–1112.

DOI: https://doi.org/10.1182/blood-2006-04-014480

Published: 2006

Includes: Supplemental data

Journal Articles

Vaccination with MAGE-3 Protein Can Induce a Potent Immune Response in a Healthy Donor Which Can Be Adoptively Transferred Via Stem Cell Transplant (Tx) to a Multiple Myeloma (MM) Patient.

Sacha Gnjatic, PhD, Susann Szmania, BS, Amberly Moreno, BS, M. Cottler-Fox, MD, John Shaughnessy, MD, Bart Barlogie, MD, PhD, Lloyd Old, PhD, Guido Tricot, MD, PhD, Frits van Rhee, MD, PhD

Blood (2005) 106 (11): 2197.

DOI: https://doi.org/10.1182/blood.V106.11.2197.2197

Published: 2005

Journal Articles

CD4 + CD25 + regulatory T cells control the induction of antigen-specific CD4 + helper T cell responses in cancer patients

Clinical Trials & Observations Brief Report

Hiroyoshi Nishikawa, Elke Jäger, Gerd Ritter, Lloyd J. Old, Sacha Gnjatic

Blood (2005) 106 (3): 1008–1011.

DOI: https://doi.org/10.1182/blood-2005-02-0607

Published: 2005

Includes: Supplemental data

NARROW

Molecular and cellular features of CTLA-4 blockade for relapsed myeloid malignancies after transplantation

Architecture of Sample Preparation and Data Governance of Immuno-Genomic Data Collected from Bone Marrow and Peripheral Blood Samples Obtained from Multiple Myeloma Patients

Characterization of Plasma and Immune Cells Molecular Landscape That Play a Role in Rapid Progression of Multiple Myeloma Using Cross Center Scrna-Seq Study

Integrated Cytof, Scrna-Seq and Cite-Seq Analysis of Bone Marrow Immune Microenvironment in the Mmrf Commpass Study

Identification and Validation of CD138- Multiple Myeloma Immune and Tumor Subpopulations Using Cross Center Scrna-Seq Data

Reduced Antigen Presentation May Contribute to Immunomodulatory Drug Resistance in Multiple Myeloma

High Dimensional Immune Profiling in Smoldering Multiple Myeloma Identifies Novel Organizing Features of the Tumor Microenvironment

Genomic and Immunologic Analysis of Cmaf and Hypermutated Multiple Myeloma: Implications for Immunologic Therapy

Phase 1 Study of Elotuzumab and Peripheral Blood Mononuclear Cell Reconstitution in Combination with Autologous Stem Cell Transplantation and Lenalidomide Maintenance for Multiple Myeloma

Recombinant (rec) MAGE-A3 Protein Immunotherapy and Peripheral Blood Lymphocyte (PBL) Reconstitution Induce Strong Antigen-Specific Humoral and Cellular Immune Responses in Patients Undergoing Autologous Stem Cell Transplantation (ASCT) for Consolidation of Multiple Myeloma (MM)

MAGE-A3 Recombinant Protein (recMAGE-A3) Immunotherapy and Autologous Peripheral Blood Lymphocyte (PBL) Infusion Is Safe and Induces Robust Humoral Immune Responses In Multiple Myeloma (MM) Patients Undergoing Autologous Stem Cell Transplantation (autoSCT)

Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma

Analysis of Spontaneous Vs. Vaccine-Induced Antibody Responses Against Cancer-Testis Antigen MAGE-A3 in Cancer Patients

MAGE-A3 or NY-ESO1 Expression and Spontaneous Antibody Responses to NY-ESO1 in Newly Diagnosed Multiple Myeloma Patients Are Associated with Worse Overall Survival

RHAMM-R3 peptide vaccination in patients with acute myeloid leukemia, myelodysplastic syndrome, and multiple myeloma elicits immunologic and clinical responses

Induction of regulatory T cell–resistant helper CD4 + T cells by bacterial vector

Host Immune Responses Against CT Antigens in Multiple Myeloma Patients.

Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation

Vaccination with MAGE-3 Protein Can Induce a Potent Immune Response in a Healthy Donor Which Can Be Adoptively Transferred Via Stem Cell Transplant (Tx) to a Multiple Myeloma (MM) Patient.

CD4 + CD25 + regulatory T cells control the induction of antigen-specific CD4 + helper T cell responses in cancer patients

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American Society of Hematology

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American Society of Hematology

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