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Journal Articles

A Phase II Study of Mini-Hyper-CVD Plus Venetoclax in Patients with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia

Sangeetha Venugopal, Hagop Kantarjian, Nicholas J. Short, Philip A. Thompson, Naveen Pemmaraju, Nitin Jain, William G. Wierda, Gautam Borthakur, Guillermo Montalban-Bravo, Farhad Ravandi, Guillermo Garcia-Manero, Tapan M. Kadia, Maro Ohanian, Kelly S. Chien, Jennifer Thankachan, Benjamin Nwakanme, Rebecca Garris, Elias J. Jabbour
Journal: Blood
Blood (2021) 138 (Supplement 1): 1239.
DOI: https://doi.org/10.1182/blood-2021-153826
Published: 2021
Journal Articles

A Phase II Study of CPX-351 Plus Venetoclax in Patients with Relapsed/Refractory (R/R) or Newly Diagnosed Acute Myeloid Leukemia (AML)

Kunhwa Kim, Hagop Kantarjian, Gautam Borthakur, Koichi Takahashi, Nicholas J. Short, Courtney D. DiNardo, Elias J. Jabbour, Kelly S. Chien, Naval Daver, Naveen Pemmaraju, Nitin Jain, Lade Adewale, Guillermo Montalban-Bravo, William G. Wierda, Srdan Verstovsek, Marina Konopleva, Farhad Ravandi, Tapan M. Kadia
Journal: Blood
Blood (2021) 138 (Supplement 1): 1275.
DOI: https://doi.org/10.1182/blood-2021-154148
Published: 2021
Journal Articles

Characteristics and Outcomes of Adolescent and Young Adult (AYA) Patients with Myelodysplastic Syndrome (MDS) and Chronic Myelomonocytic Leukemia (CMML): A Single-Center Retrospective Analysis

Shehab Fareed Mohamed, Tareq Abuasba, Kelly S. Chien, Guillermo Montalban-Bravo, Faezeh Darbaniyan, Sherry A. Pierce, Kelly A. Soltysiak, Fadi Haddad, David McCall, Branko Cuglievan, Elias J. Jabbour, Naval Daver, Tapan M. Kadia, Naveen Pemmaraju, Hagop Kantarjian, Guillermo Garcia-Manero
Journal: Blood
Blood (2021) 138 (Supplement 1): 3687.
DOI: https://doi.org/10.1182/blood-2021-149018
Published: 2021
Journal Articles

A Phase I Study of the Combination of Venetoclax and Azacitidine in Relapse/Refractory Higher Risk Myelodysplastic Syndrome (MDS)

Sai Prasad Prasad Desikan, Guillermo Montalban-Bravo, Maro Ohanian, Naval Daver, Musa Yilmaz, Marina Konopleva, Tapan M. Kadia, Sangeetha Venugopal, Heather Schneider, Kelly S. Chien, Rashmi Kanagal-Shamanna, Hagop Kantarjian, Guillermo Garcia-Manero
Journal: Blood
Blood (2021) 138 (Supplement 1): 3704.
DOI: https://doi.org/10.1182/blood-2021-153170
Published: 2021
Journal Articles

Inhibition of MDM2 Improves the Therapeutic Effect of Hypomethylating Agents in Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML)

Yue Wei, Hong Zheng, Pamela Lockyer, Naran Bao, Faezeh Darbaniyan, Ziyi Li, Rashmi Kanagal-Shamanna, Kelly A. Soltysiak, Hui Yang, Irene Ganan-Gomez, Kim-Anh Do, Simona Colla, Kelly S. Chien, Guillermo Montalban-Bravo, Naval Daver, Guillermo Garcia-Manero
Journal: Blood
Blood (2021) 138 (Supplement 1): 3664.
DOI: https://doi.org/10.1182/blood-2021-150811
Published: 2021
Journal Articles

Updated Results of a Phase 1/2 Study of Lower Dose CPX-351 for Patients with Int-2 or High Risk IPSS Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia after Failure to Hypomethylating Agents

Guillermo Montalban-Bravo, Elias J. Jabbour, Zeev E. Estrov, Tapan M. Kadia, Farhad Ravandi, Kelly S. Chien, Graciela M. Nogueras González, Xiao Qin Dong, Stefan Faderl, Heather Schneider, Rosmy B. John, Meghan Anne Meyer, Hagop Kantarjian, Guillermo Garcia-Manero
Journal: Blood
Blood (2021) 138 (Supplement 1): 3674.
DOI: https://doi.org/10.1182/blood-2021-151493
Published: 2021
Journal Articles

Initial Results of Phase I/II Study of Azacitidine in Combination with Quizartinib for Patients with Myelodysplastic Syndrome and Myelodysplastic/Myeloproliferative Neoplasm with FLT3 or CBL Mutations

Tareq Abuasab, Elias J. Jabbour, Nicholas J. Short, Marina Konopleva, Kelly S. Chien, Shehab Fareed Mohamed, Naval Daver, Rashmi Kanagal-Shamanna, Hagop Kantarjian, Guillermo Garcia-Manero, Guillermo Montalban-Bravo
Journal: Blood
Blood (2021) 138 (Supplement 1): 1536.
DOI: https://doi.org/10.1182/blood-2021-153189
Published: 2021
Journal Articles

Impact of Frontline Treatment Approach in Patients with Secondary AML and Prior Hypomethylating Agent Exposure: A Retrospective Analysis of 562 Patients with Treated Secondary AML

Sangeetha Venugopal, Tapan M. Kadia, Farhad Ravandi, Courtney D. DiNardo, Naval Daver, Gautam Borthakur, Marina Konopleva, Guillermo Garcia-Manero, Guillermo Montalban-Bravo, Abhishek Maiti, Musa Yilmaz, Ghayas C. Issa, Kelly S. Chien, Sherry A. Pierce, Hagop Kantarjian, Nicholas J. Short
Journal: Blood
Blood (2021) 138 (Supplement 1): 794.
DOI: https://doi.org/10.1182/blood-2021-153960
Published: 2021
Journal Articles

A Triplet Combination of Azacitidine, Venetoclax and Gilteritinib for Patients with FLT3 -Mutated Acute Myeloid Leukemia: Results from a Phase I/II Study

Nicholas J. Short, Courtney D. DiNardo, Naval Daver, Daniel Nguyen, Musa Yilmaz, Tapan M. Kadia, Guillermo Garcia-Manero, Ghayas C. Issa, Xuelin Huang, Wei Qiao, Koji Sasaki, Guillermo Montalban-Bravo, Kelly S. Chien, Gautam Borthakur, Ricardo Delumpa, Anna Milton, Sherry A. Pierce, Elias J. Jabbour, Marina Konopleva, Hagop Kantarjian, Farhad Ravandi
Journal: Blood
Blood (2021) 138 (Supplement 1): 696.
DOI: https://doi.org/10.1182/blood-2021-153571
Published: 2021
Journal Articles

Outcomes of Patients with Chronic Myelomonocytic Leukemia (CMML) Treated with Hypomethylating Agents

Sangeetha Venugopal, Kelly S. Chien, Danielle Hammond, Rashmi Kanagal-Shamanna, Koji Sasaki, Tapan M. Kadia, Courtney D. DiNardo, Marina Konopleva, Naval Daver, Farhad Ravandi, Naveen Pemmaraju, Nicholas J. Short, Ghayas C. Issa, Koichi Takahashi, Zeev E. Estrov, Sherry A. Pierce, Hagop Kantarjian, Guillermo Garcia-Manero, Guillermo Montalban-Bravo
Journal: Blood
Blood (2021) 138 (Supplement 1): 2613.
DOI: https://doi.org/10.1182/blood-2021-153475
Published: 2021
Journal Articles

Single-Cell RNA Sequencing Analysis Reveals Mechanisms of Initiation and Progression in Chronic Myelomonocytic Leukemia

Guillermo Montalban-Bravo, Feiyang Ma, Irene Ganan-Gomez, Rashmi Kanagal-Shamanna, Vera Adema, Yue Wei, Kelly S. Chien, Natthakan Thongon, Hui Yang, Carlos E. Bueso-Ramos, Hagop Kantarjian, Guillermo Garcia-Manero, Simona Colla
Journal: Blood
Blood (2021) 138 (Supplement 1): 2588.
DOI: https://doi.org/10.1182/blood-2021-151340
Published: 2021
Journal Articles

A Phase I/II Study of Venetoclax in Combination with 5-Azacytidine in Treatment-Naïve and Relapsed/Refractory High-Risk Myelodysplastic Syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMML)

Alexandre Bazinet, Elias J. Jabbour, Hagop Kantarjian, Kelly S. Chien, Courtney D. DiNardo, Maro Ohanian, Naval Daver, Rashmi Kanagal-Shamanna, Tapan M. Kadia, Koichi Takahashi, Lucia Masarova, Nicholas J. Short, Yesid Alvarado, Philip A. Thompson, Guillermo Montalban-Bravo, Musa Yilmaz, Farhad Ravandi, Steven M. Kornblau, Naveen Pemmaraju, Heather Schneider, Bailey Mirabella, Kiran Naqvi, Guillermo Garcia-Manero
Journal: Blood
Blood (2021) 138 (Supplement 1): 535.
DOI: https://doi.org/10.1182/blood-2021-153086
Published: 2021
Journal Articles

A Phase II Study of 5-Azacytidine (AZA) and Venetoclax As Maintenance Therapy in Patients with Acute Myeloid Leukemia (AML) in Remission

Alexandre Bazinet, Hagop Kantarjian, Gautam Borthakur, Musa Yilmaz, Prithviraj Bose, Elias J. Jabbour, Yesid Alvarado, Kelly S. Chien, Naveen Pemmaraju, Koichi Takahashi, Nicholas J. Short, Ghayas C. Issa, Nitin Jain, Alessandra Ferrajoli, Jan A. Burger, Debra Bull Linderman, Naval Daver, Courtney D. DiNardo, Marina Konopleva, Guillermo Garcia-Manero, Koji Sasaki, Farhad Ravandi, Tapan M. Kadia
Journal: Blood
Blood (2021) 138 (Supplement 1): 2326.
DOI: https://doi.org/10.1182/blood-2021-150573
Published: 2021
Journal Articles

Phase II Study of Cladribine, Idarubicin, Cytarabine (CLIA) Plus Gilteritinib in Patients with FLT3 Mutated Acute Myeloid Leukemia (AML)

Tareq Abuasab, Hagop Kantarjian, Guillermo Garcia-Manero, Guillermo Montalban-Bravo, Yesid Alvarado, Musa Yilmaz, Naveen Pemmaraju, Kelly S. Chien, Shehab Fareed Mohamed, Naval Daver, Steven M. Kornblau, Jan A. Burger, Nitin Jain, Rubiul Islam, Courtney D. DiNardo, Gautam Borthakur, Farhad Ravandi, Tapan M. Kadia
Journal: Blood
Blood (2021) 138 (Supplement 1): 2330.
DOI: https://doi.org/10.1182/blood-2021-151648
Published: 2021
Journal Articles

Azacitidine, Venetoclax and Pevonedistat As Frontline Therapy for Patients with Secondary Acute Myeloid Leukemia Who Are Unfit for Intensive Chemotherapy: Results from a Phase I/II Study

Nicholas J. Short, Guillermo Montalban-Bravo, Yesid Alvarado, Marina Konopleva, Elias J. Jabbour, Guillermo Garcia-Manero, Musa Yilmaz, Nitin Jain, Gautam Borthakur, Courtney D. DiNardo, Naval Daver, Ghayas C. Issa, Maro Ohanian, Naveen Pemmaraju, Koji Sasaki, Abhishek Maiti, Kelly S. Chien, Farhad Ravandi, Tapan M. Kadia, Michael Andreeff, Muharrem Muftuoglu, Ricardo Delumpa, Prithviraj Bose, Sherry A. Pierce, Lourdes Waller, Glenda Banks, Hagop Kantarjian, Jorge E. Cortes
Journal: Blood
Blood (2021) 138 (Supplement 1): 2349.
DOI: https://doi.org/10.1182/blood-2021-153682
Published: 2021
Journal Articles

Clinical Characteristics and Contemporary Outcomes of Acute Myeloid Leukemia Evolving from Chronic Myelomonocytic Leukemia

Danielle Hammond, Tapan M. Kadia, Courtney D. DiNardo, Marina Konopleva, Nicholas J. Short, Naval Daver, Farhad Ravandi, Naveen Pemmaraju, Elias J. Jabbour, Kelly S. Chien, Sherry A. Pierce, Hagop Kantarjian, Guillermo Garcia-Manero, Guillermo Montalban-Bravo
Journal: Blood
Blood (2021) 138 (Supplement 1): 1224.
DOI: https://doi.org/10.1182/blood-2021-153941
Published: 2021
Journal Articles

The Transcriptional and Epigenetic Reprogramming of Aged Hematopoietic Stem Cells Drives Myeloid Rewiring in Clonal Hematopoiesis-Associated Cytopenias

Irene Ganan-Gomez, Kelly S. Chien, Feiyang Ma, Hui Yang, Lin Tan, Philip Lorenzi, Guillermo Garcia-Manero, Simona Colla
Journal: Blood
Blood (2021) 138 (Supplement 1): 3273.
DOI: https://doi.org/10.1182/blood-2021-150663
Published: 2021
Journal Articles

A Phase I/II Study of Venetoclax in Combination with ASTX727 (cedazuridine/decitabine) in Treatment‐Naïve High‐Risk Myelodysplastic Syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMML)

Sangeetha Venugopal, Hagop Kantarjian, Abhishek Maiti, Nicholas J. Short, Guillermo Montalban-Bravo, Yesid Alvarado, Kelly S. Chien, Rashmi Kanagal-Shamanna, Naveen Pemmaraju, Naval Daver, Tapan M. Kadia, Gautam Borthakur, Elias J. Jabbour, Guillermo Garcia-Manero
Journal: Blood
Blood (2021) 138 (Supplement 1): 245.
DOI: https://doi.org/10.1182/blood-2021-153657
Published: 2021
Journal Articles

Transcriptomic Signitures of Azacitidine (AZA) and Decitabine (DAC) Resistance in MDS and CMML

Faezeh Darbaniyan, Caleb Class, Guillermo Montalban-Bravo, Rashmi Kanagal-Shamanna, Marcos Estecio, Yue Lu, Kelly A. Soltysiak, Kelly S. Chien, Hui Yang, Koji Sasaki, Irene Ganan-Gomez, Simona Colla, Kim-Anh Do, Guillermo Garcia-Manero, Yue Wei
Journal: Blood
Blood (2021) 138 (Supplement 1): 4652.
DOI: https://doi.org/10.1182/blood-2021-153698
Published: 2021
Journal Articles

Clinical Outcomes of Patients with Newly Diagnosed Myelodysplastic Syndrome with MLL Aberrations

Maria Siddiqui, Ghayas C. Issa, Koji Sasaki, Guillermo Montalban-Bravo, Kelly S. Chien, Elias J. Jabbour, Carlos E. Bueso-Ramos, Rashmi Kanagal-Shamanna, Hagop Kantarjian, Guillermo Garcia-Manero
Journal: Blood
Blood (2021) 138 (Supplement 1): 4673.
DOI: https://doi.org/10.1182/blood-2021-151670
Published: 2021