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Roland W. Herzog
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Journal Articles

Factor VIII trafficking to CD4 + T cells shapes its immunogenicity and requires several types of antigen-presenting cells

Radoslaw Kaczmarek, Annie R. Piñeros, Paige E. Patterson, Thais B. Bertolini, George Q. Perrin, Alexandra Sherman, Jameson Born, Sreevani Arisa, Matthew C. Arvin, Malgorzata M. Kamocka, Michelle M. Martinez, Kenneth W. Dunn, Sean M. Quinn, Johnathan J. Morris, Amelia R. Wilhelm, Tsuneyasu Kaisho, Maite Munoz-Melero, Moanaro Biswas, Mark H. Kaplan, Amelia K. Linnemann, Lindsey A. George, Rodney M. Camire, Roland W. Herzog
Journal: Blood
Blood (2023) 142 (3): 290–305.
https://doi.org/10.1182/blood.2022018937
Published: 2023
Includes: Multimedia, Supplemental data
Journal Articles

Oral Anti-CD3 and Bioencapsulated FVIII Therapy Exhibit Distinct Mechanisms That Suppress Inhibitor Formation in Hemophilia a

Moanaro Biswas, Thais Bertolini, Kaman So, Jyoti Rana, Sandeep R.P. Kumar, Sha Cao, Hongyu Gao, Xiaoling Xuei, Henry Daniell, Roland W. Herzog
Journal: Blood
Blood (2022) 140 (Supplement 1): 11273–11274.
https://doi.org/10.1182/blood-2022-169734
Published: 2022
Journal Articles

Antigen Trafficking and Possibly Intrinsic Immunostimulatory Properties Shape High Immunogenicity of Factor VIII

Radoslaw Kaczmarek, Lindsey A. George, Rodney M. Camire, Roland W Herzog
Journal: Blood
Blood (2022) 140 (Supplement 1): 967–968.
https://doi.org/10.1182/blood-2022-163879
Published: 2022
Journal Articles

Combination Therapy to Enable AAV Re-Dosing and Mitigate Transgene Immunity in Liver-Targeted Gene Therapy

Jyoti Rana, Sandeep RP Kumar, Maite Munoz, Kentaro Yamada, Thais Bertollini, David M Markusic, Manuela Corti, Barry J Byrne, Roland W Herzog, Moanaro Biswas
Journal: Blood
Blood (2022) 140 (Supplement 1): 311–312.
https://doi.org/10.1182/blood-2022-169848
Published: 2022
Journal Articles

Key Role of Kupffer Cells in IL-1 Dependent Activation of CD8 + T Cell Responses to AAV Transgene Product in Liver

Sandeep R.P. Kumar, Moanaro Biswas, Ype P. De Jong, Roland W. Herzog
Journal: Blood
Blood (2022) 140 (Supplement 1): 4928–4929.
https://doi.org/10.1182/blood-2022-168230
Published: 2022
Journal Articles

Immune complications and their management in inherited and acquired bleeding disorders

Valder R. Arruda, David Lillicrap, Roland W. Herzog
Journal: Blood
Blood (2022) 140 (10): 1075–1085.
https://doi.org/10.1182/blood.2022016530
Published: 2022
Journal Articles

Factor IX Delivery to the Skin Primes Inhibitor Formation and Sensitizes Hemophilia B Mice to Systemic Factor IX Administration

Radoslaw Kaczmarek, Thais Bertolini, Roland W Herzog, Alexandra Sherman
Journal: Blood
Blood (2021) 138 (Supplement 1): 3194.
https://doi.org/10.1182/blood-2021-154146
Published: 2021
Journal Articles

Helper T Cell Response to Factor VIII In Vivo Requires Several Anatomically Distinct Types of Antigen Presenting Cells

Radoslaw Kaczmarek, Annie R Pineros, Matthew Carl Arvin, Thais Bertolini, Rodney M. Camire, Roland W Herzog
Journal: Blood
Blood (2021) 138 (Supplement 1): 440.
https://doi.org/10.1182/blood-2021-146059
Published: 2021
Journal Articles

Cross Priming of Transgene Product-Specific CD8 + T Cells in Hepatic AAV Gene Transfer Depends on IL-1 Receptor and XCR1 + Dendritic Cells but Not TLR9

Sandeep Kumar, PhD, Moanaro Biswas, PhD, Annie R Pineros, PhD, Ype P De Jong, MD, Roland W Herzog, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–3.
https://doi.org/10.1182/blood-2020-142926
Published: 2020
Journal Articles

AAV Vector Dose Determines TLR9 Dependence of CD8+ T Cell Response to Transgene Product

Ning Li, Thais Bertolini, Roland W Herzog, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3.
https://doi.org/10.1182/blood-2020-141054
Published: 2020
Journal Articles

Revisiting the "Danger Theory": Toll-like Receptor 9 Stimulation Triggers Activation of Conventional CD8α + and Plasmacytoid Dendritic Cells En Route to Enhancing FVIII Inhibitor Formation

Radoslaw Kaczmarek, PhD, Thais Bertolini, Roland W Herzog, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1.
https://doi.org/10.1182/blood-2020-143259
Published: 2020
Journal Articles

Alternative Approaches to Oral Tolerance Induction to Factor FVIII

Thais Bertolini, Moanaro Biswas, PhD, Radoslaw Kaczmarek, PhD, Henry Daniell, PhD, Roland W Herzog, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-142661
Published: 2020
Journal Articles

Toll-like Receptor 9 Activation Accelerates Inhibitor Formation in Response to Factor VIII

Radoslaw Kaczmarek, Alexandra Sherman, DVM, Moanaro Biswas, PhD, Roland W Herzog, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1113.
https://doi.org/10.1182/blood-2019-125348
Published: 2019
Journal Articles

Update on clinical gene therapy for hemophilia

Clinical Trials & Observations
George Q. Perrin, Roland W. Herzog, David M. Markusic
Journal: Blood
Blood (2019) 133 (5): 407–414.
https://doi.org/10.1182/blood-2018-07-820720
Published: 2019
Journal Articles

Reprogrammed CD4 + T Cells That Express FoxP3 + Effectively Control Inhibitory Antibody Development in Hemophilic Mice

Moanaro Biswas, PhD, Veronica Kuteyeva, Roland W Herzog, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 175.
https://doi.org/10.1182/blood.V130.Suppl_1.175.175
Published: 2017
Journal Articles

Generation of FVIII-Specific Tregs Expressing a Chimeric Antigen Receptor (CAR) to Suppress Inhibitor Development in Hemophilia a Mice

Moanaro Biswas, PhD, Todd M Brusko, PhD, Roland W Herzog, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 176.
https://doi.org/10.1182/blood.V130.Suppl_1.176.176
Published: 2017
Journal Articles

Innate Immune Activation Via TLR9 May Enhance Antibody Formation Against Factors VIII and IX in Protein and Gene Therapy

Roland W Herzog, PhD, Alexandra Sherman, DVM, Brad E. Hoffman, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3651.
https://doi.org/10.1182/blood.V130.Suppl_1.3651.3651
Published: 2017
Journal Articles

Lettuce Plants Expressing High Levels of Factor VIII Antigen in the Chloroplast for Oral Tolerance in Hemophilia a

Roland W Herzog, PhD, Alexandra Sherman, DVM, Kwang-Chul Kwon, PhD, Wan-Jung Chang, MS, Henry Daniell, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 362.
https://doi.org/10.1182/blood.V130.Suppl_1.362.362
Published: 2017
Journal Articles

Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8 + T cells

Geoffrey L. Rogers, Jamie L. Shirley, Irene Zolotukhin, Sandeep R. P. Kumar, Alexandra Sherman, George Q. Perrin, Brad E. Hoffman, Arun Srivastava, Etiena Basner-Tschakarjan, Mark A. Wallet, Cox Terhorst, Moanaro Biswas, Roland W. Herzog
Journal: Blood
Blood (2017) 129 (24): 3184–3195.
https://doi.org/10.1182/blood-2016-11-751040
Published: 2017
Includes: Supplemental data
Journal Articles

Driving the hemophilia tolerance CAR

Roland W. Herzog
Journal: Blood
Blood (2017) 129 (2): 142–144.
https://doi.org/10.1182/blood-2016-11-753160
Published: 2017