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CD33 Targeted Immunoliposomal Delivery of OSU-2S, a Non-Immunosuppressive FTY720 Derivative, Mediates Selective Cytotoxicity in Acute Myeloid Leukemia
Swagata Goswami, MS, Rajeswaran Mani, DVM PhD, Chi-Ling Chiang, MS, Frank W Frissora, M.S., Xiaokui Mo, PhD MAS, Zhiliang Xie, Donna Bucci, Amber Gordon, MLS, David M. Lucas, PhD, William Blum, MD, Alison R. Walker, MD MPH, Alice S. Mims, MD MSCR, Rebecca B Klisovic, MD, Ching-Shih Chen, PhD, Robert J Lee, PhD, John C. Byrd, MD, Mitch A. Phelps, PhD, Sumithira Vasu, MBBS, Natarajan Muthusamy, DVM, PhD
Blood (2016) 128 (22): 2748.
Eradicating acute myeloid leukemia in a Mll PTD/wt : Flt3 ITD/wt murine model: a path to novel therapeutic approaches for human disease
Kelsie M. Bernot, John S. Nemer, Ramasamy Santhanam, Shujun Liu, Nicholas A. Zorko, Susan P. Whitman, Kathryn E. Dickerson, Mengzi Zhang, Xiaojuan Yang, Kathleen K. McConnell, Elshafa H. Ahmed, Maura R. Muñoz, Ronald F. Siebenaler, Gabriel G. Marcucci, Bethany L. Mundy-Bosse, Daniel L. Brook, Sabrina Garman, Adrienne M. Dorrance, Xiaoli Zhang, Jianying Zhang, Robert J. Lee, William Blum, Michael A. Caligiuri, Guido Marcucci
Blood (2013) 122 (23): 3778–3783.
Tumor Antigen ROR1 Targeted Delivery Of FTY720 Derivative OSU-2S Prolongs Survival In ROR1 Engineered Mouse Model Of Chronic Lymphocytic Leukemia
Rajeswaran Mani, DVM, Yicheng Mao, PhD, Frank W Frissora, M.S., Chi-ling Chiang, Jiang Wang, Yuan Zhao, Yun Wu, Bo Yu, Ph.D., Ribai Yan, Xiaokui Mo, PhD, Sivasubramanian Baskar, PhD, Christoph Rader, Ph.D., Mitch A. Phelps, PhD, Robert J. Lee, Ph.D, Ching-Shih Chen, PhD, James Lee, PhD, John C. Byrd, MD, Natarajan Muthusamy, DVM, Ph.D
Blood (2013) 122 (21): 4168.
Targeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia
Bo Yu, Yicheng Mao, Li-Yuan Bai, Sarah E. M. Herman, Xinmei Wang, Asha Ramanunni, Yan Jin, Xiaokui Mo, Carolyn Cheney, Kenneth K. Chan, David Jarjoura, Guido Marcucci, Robert J. Lee, John C. Byrd, L. James Lee, Natarajan Muthusamy
Blood (2013) 121 (1): 136–147.
Includes: Supplemental data
Therapeutic Targeting of the RAS-Pathway by Synthetic Mir-181a Nanoparticles in Acute Myeloid Leukemia (AML).
Xiaomeng Huang, Sebastian Schwind, MD, Ann-Kathrin Eisfeld, MD, Bo Yu, Ph.D, Ramasamy Santhanam, Ph.D, Pia Hoellerbauer, Yan Jin, Ph.D, Christopher Hickey, Ph.D, Jiuxia Pang, Kenneth K. Chan, Ph.D, Danilo Perrotti, MD, Ph.D, Natarajan Muthusamy, DVM, Ph.D, John C. Byrd, MD, William Blum, MD, Clara D. Bloomfield, MD, Shujun Liu, Ph.D, Ramiro Garzon, MD, Robert J. Lee, Ph.D, L. James Lee, Ph.D, Guido Marcucci, MD
Blood (2012) 120 (21): 2422.
Targeted Delivery of MicroRNA-29b by Nanoparticles Provides Antileukemic Activity and Increases Sensitivity to the Hypomethylating Agent Decitabine (DAC) in Acute Myeloid Leukemia (AML)
Xiaomeng Huang, Sebastian Schwind, MD, Bo Yu, Ph.D, Jiuxia Pang, Ramasamy Santhanam, Ph.D, Kenneth K. Chan, Ph.D, Ramiro Garzon, MD, William Blum, MD, Clara D. Bloomfield, MD, Shujun Liu, Ph.D, Danilo Perrotti, MD, Ph.D, Robert J. Lee, Ph.D, John C. Byrd, MD, Natarajan Muthusamy, DVM, Ph.D, L. James Lee, Ph.D, Guido Marcucci, MD
Blood (2011) 118 (21): 81.
Milatuzumab immunoliposomes induce cell death in CLL by promoting accumulation of CD74 on the surface of B cells
Erin Hertlein, Georgia Triantafillou, Ellen J. Sass, Joshua D. Hessler, Xiaoli Zhang, David Jarjoura, David M. Lucas, Natarajan Muthusamy, David M. Goldenberg, Robert J. Lee, John C. Byrd
Blood (2010) 116 (14): 2554–2558.
Includes: Supplemental data
Immunoliposomes Incorporated with Humanized Monoclonal Antibody, Milatuzumab, Induce Cell Death in CLL by Retention of the CD74 Receptor On the Surface of B Cells.
Erin K Hertlein, PhD, Georgia Triantafillou, Joshua Hessler, Xiaoli Zhang, David Jarjoura, David M. Lucas, PhD, Robert J Lee, Natarajan Muthusamy, PhD, David M Goldenberg, ScD, MD, John C. Byrd, MD
Blood (2009) 114 (22): 721.
Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells
Rosa Lapalombella, Bo Yu, Georgia Triantafillou, Qing Liu, Jonathan P. Butchar, Gerard Lozanski, Asha Ramanunni, Lisa L. Smith, William Blum, Leslie Andritsos, Da-Sheng Wang, Amy Lehman, Ching-Shih Chen, Amy J. Johnson, Guido Marcucci, Robert J. Lee, L. James Lee, Susheela Tridandapani, Natarajan Muthusamy, John C. Byrd
Blood (2008) 112 (13): 5180–5189.
Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical
Xiaobin Zhao, Rosa Lapalombella, Trupti Joshi, Carolyn Cheney, Aruna Gowda, Martha S. Hayden-Ledbetter, Peter R. Baum, Thomas S. Lin, David Jarjoura, Amy Lehman, Donna Kussewitt, Robert J. Lee, Michael A. Caligiuri, Susheela Tridandapani, Natarajan Muthusamy, John C. Byrd
Blood (2007) 110 (7): 2569–2577.
NK Cells Contribute Significantly to the Innate Immune Effector Role of CD37-Specific SMIP in CLL and NHL.
Xiaobin B. Zhao, MS, Joshi Trupti, B.S., Rosa Lapalombella, Ph. D., Carolyn Cheney, B.S., Aruna Gowda, M.D., Martha S. Hayden-Ledbetter, Ph. D., Peter R. Baum, Ph.D., Thomas S. Lin, M.D., Ph.D., David Jarjoura, Ph.D., Amy Lehman, M.S., Robert J. Lee, Ph.D., Michael A. Caligiuri, M.D., Susheela Tridandapani, Ph.D., Natarajan Muthusamy, Ph.D., John C. Byrd, M.D.
Blood (2006) 108 (11): 135.
Recurrence Patterns of Non-Mycosis Fungoides Cutaneous Lymphoma Following Various Treatment Modalities.
Michael E. Confer, Jonathan D. Tward, M.D. Ph.D., Sherrie L. Perkins, M.D., Glen M. Bowen, M.D., Robert J. Lee, M.D., Martha J. Glenn, M.D., David K. Gaffney, M.D. Ph.D.
Blood (2006) 108 (11): 4676.
Novel Anti-CD37 Small Modular Immunopharmaceutical (SMIP) Induces B-Cell-Specific, Caspase-Independent Apoptosis in Human CLL Cells.
Xiaobin B. Zhao, MS, Sabyasachi Biswas, PhD, Andrew Mone, MD, PhD, Jeffrey Ledbetter, PhD, Martha Hayden Ledbetter, PhD, Laura Grosmaire, PhD, Erik Espling, PhD, Carolyn Cheney, Donn Young, PhD, Robert J. Lee, PhD, Natarajan Muthusamy, PhD, John C. Byrd, MD
Blood (2004) 104 (11): 2515.
Strategy for the treatment of acute myelogenous leukemia based on folate receptor β–targeted liposomal doxorubicin combined with receptor induction using all- trans retinoic acid
Blood (2002) 100 (2): 594–602.